Clinical trials: Non-invasive Ventilation Support
Respiratory Failure
Pressure Support Ventilation (PSV) Versus Neurally Adjusted Ventilator Assist (NAVA) During Acute Respiratory Failure (ARF)
Acute respiratory failure (ARF) is a life-threatening emergency which occurs due to impaired gas exchange. In the US, the number of hospitalisations owing to acute respiratory failure was 1,917,910 in the year 2009.(1) The…
- Trial name
- NCT03271671
- Testing
- NAVA during Non invasive ventilation, PSV during Non invasive ventilation
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Chronic Hypercapnic Respiratory Failure, Obesity Hypoventilation Syndrome
Efficacy of Average Volume Assured Pressure Support With Bi-Level Pressure Support Nocturnal Ventilation
Patients with chronic hypercapnic respiratory failure can be successfully treated with home nocturnal non-invasive ventilation. Bi-level pressure support ventilators are at present the most frequently used ventilators for long…
- Conditions
- Chronic Hypercapnic Respiratory Failure, Obesity Hypoventilation Syndrome, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT00479284
- Testing
- Average volume assured pressure support (AVAPS)
- Where
- Switzerland
- Volunteers
- 14 people
- Sponsor
- University Hospital, Geneva
Covid19
Early Use of Hyperimmune Plasma in COVID-19
The study assesses the efficacy of early administration of hyperimmune plasma in covid-19 patients who are on CPAP or intubated. Efficacy is measured as a 2 point decrease in the WHO scale
- Trial name
- COV-II-PLA (NCT04721236)
- Testing
- hyperimmune plasma
- Where
- Italy
- Volunteers
- 260 people
- Sponsor
- Catherine Klersy
Non-invasive Mechanical Ventilation
Audio Books Effects on Anxiety and Vital Sings
Objectives: This study aimed to investigate the effect of audio book use on anxiety and vital signs in patients receiving non-invasive mechanical ventilation (NIMV) support.
- Trial name
- NCT06378970
- Testing
- Audio Book Application
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ege University
Care, Palliative, Respiratory Failure
RENOVATE Palliative: HFNC vs. Standard Respiratory Support in Patients With Do-Not-Intubate Order and ARF
Randomized clinical trial in which the main objective is to compare High Flow Nasal Cannula (HFNC) versus the standard respiratory care in the alleviation of dyspnea perception in patients with do-not-intubate (DNI) order.
- Trial name
- NCT04269681
- Testing
- High Flow Nasal Cannula, Standard respiratory support
- Where
- Brazil
- Volunteers
- 3 people
- Sponsor
- Hospital do Coracao
Acute Respiratory Failure
NIV NAVA Versus NIV-PS in Pediatric Patients - Pilot Study
This pilot study will be an observational no randomize study in which the NiNAVAped protocol will be applied solely to the NIV NAVA arm.
- Trial name
- NINAVAPed (NCT01873261)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario La Paz
Obesity
Non Invasive Pressure Support Ventilation (NIPPV) Versus Recruitment Maneuver (RM) and Preoxygenation
The purpose of this study is to compare the effects of noninvasive pressure support ventilation and early alveolar recruitment maneuver during anesthesia induction of morbidly obese patients on both oxygenation and functional…
- Trial name
- NCT00852384
- Testing
- NIPPV and IRM
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Preoxygenation, Anaesthesia Induction
An Algorithmic Approach to Preoxygenation
The aim of this randomized controlled trial is to evaluate an algorithmic approach to gradually adding pressure-supported ventilation and end-tidal positive pressure when conventional tidal volume breathing is insufficient for…
- Conditions
- Preoxygenation, Anaesthesia Induction, Non-invasive Positive Pressure Ventilation
- Trial name
- NCT06736197
- Testing
- Group TVB, Group PSV, Group PSV+PEEP
- Where
- Turkey (Türkiye)
- Volunteers
- 378 people
- Sponsor
- Pamukkale University
Pulmonary Edema Cardiac Cause
HF vs NIV in Acute Cardiogenic Pulmonary Edema
The study's primary aim is to compare the effects of two different ventilation modalities, non-invasive positive-pressure ventilation (NPPV) and high-flow nasal cannulae (HFNC), in the acute cardiogenic pulmonary edema (ACPE)…
- Trial name
- HFvsNIV (NCT05989139)
- Testing
- NPPV/HFNC, HFNC/NPPV
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Neonates, Respiratory Distress
Non-invasive Secondary Respiratory Support in Late Preterm and Term Infants
The aim of the present work is to compare between various modes of non-invasive respiratory support (including NCPAP, NIPPV, and NHFOV) as secondary respiratory support modes in late preterm and term neonates as regards the need…
- Conditions
- Neonates, Respiratory Distress, Non- Invasive Ventilation
- Trial name
- NCT07000071
- Testing
- NCPAP, NIPPV, NHFOV
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Respiratory Insufficiency, Acute Respiratory Insufficiency
NIV-NAVA vs NIV-PS/PC in Respiratory Insufficiency
This study evaluates the difference between Non Invasive Ventilation with Neurally Adjusted Ventilatory Assist (NIV-NAVA) and Conventional Non Invasive Ventilation with Pressure Support (PS) or Pressure Control (PC).
- Trial name
- NCT02592512
- Testing
- NIV-NAVA, NIV-PS/PC
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Vejle Hospital
Acute Respiratory Failure, Respiratory Insufficiency
HERMES: Quality and Safety of Advanced Respiratory Support During Patient Transport
The HERMES Phase III study is an international, multicenter, prospective observational investigation designed to characterize the quality and safety of patient transport during advanced respiratory support.
- Conditions
- Acute Respiratory Failure, Respiratory Insufficiency, Respiratory Distress, Critical Illness
- Trial name
- HERMES (NCT07805603)
- Testing
- Advanced Respiratory Support During Patient Transport
- Where
- 4 sites in Colombia, Egypt and 2 more
- Volunteers
- 565 people
- Sponsor
- Medipol University
Chronic Obstructive Pulmonary Disease
Comparative Effects of Different Noninvasive Ventilation Mode on Neural Respiratory Drive in Recovering AECOPD Patients
Background: The efficiency of Neural respiratory drive (NRD)expressed by a ratio of ventilation to the diaphragm electromyogram (EMGdi) decreases in patients with COPD .Improving the neural respiratory drive efficiency of COPD…
- Trial name
- NCT01782768
- Testing
- noninvasive positive pressure ventilation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Respiratory Distress Syndrome (RDS), Newborn
Noninvasive High Frequency Oscillatory Ventilation Versus Nasal Intermittent Mandatory Ventilation for Respiratory Distress Syndrome in Preterm Neonates
The goal of this clinical trial is to learn if nasal high frequency oscillatory ventilation (nHFOV) works no worse than nasal intermittent mandatory ventilation (NIMV) as early breathing support.
- Conditions
- Respiratory Distress Syndrome (RDS), Newborn, Premature Birth
- Trial name
- NOV-RDS (NCT07837141)
- Testing
- Noninvasive High Frequency Oscillatory Ventilation, Nasal Intermittent Mandatory Ventilation
- Where
- Pakistan
- Volunteers
- 158 people
- Sponsor
- Aga Khan University
Mechanical Ventilation Complication
Neural Pressure Support and Non-invasive Estimation of Transpulmonary Pressure in Spontaneous Ventilation Modes
The transition from controlled mechanical ventilation to assisted ventilation is one of the most complex and compromised phases of the ventilatory management during mechanical ventilation, affected by factors such as…
- Trial name
- EADITRAP (NCT05574829)
- Testing
- Esophageal manometry and monitoring of electrical activity of the diaphragm
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Acute Hypoxemic Respiratory Failure
HNFO With or Without Helmet NIV for Oxygenation Support in Acute Respiratory Failure Pilot RCT
This Randomized Control Trial will directly compare helmet non-invasive ventilation (NIV) combined with high flow nasal oxygen (HFNO) versus HFNO alone in patients with Acute Hypoxemic Respiratory Failure (AHRF).
- Trial name
- HONOUR (NCT05078034)
- Testing
- Helmet Non-Invasive Ventilation (HNIV), High Flow Nasal Oxygen
- Where
- 11 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Sunnybrook Health Sciences Centre
Preterm Infant, Delivery Room
Feasibility and Reliability of Synchronized Non-invasive Intermittent Positive Pressure Ventilation in Preterm Infants After Birth
The aim of this prospective observational study (pilot study) is to test if synchronized noninvasive positive pressure ventilation (S-NIPPV) is feasible and works appropriately during transition from intrauterine to extrauterine…
- Conditions
- Preterm Infant, Delivery Room, Respiratory Support, Synchronized Noninvasive Positive Pressure Ventilation (SNIPPV)
- Trial name
- SenSyNoPP (NCT05399914)
- Testing
- S-NIPPV
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University Hospital Tuebingen
Acute Respiratory Failure (ARF), Non Invasive Ventilation
Monitoring Respiratory Muscle Function in Acute Respiratory Failure Patients on Non Invasive Respiratory Support
Acute respiratory failure is a common, life-threatening condition where the lungs cannot provide enough oxygen to the body. Many patients are treated with non-invasive respiratory support (NRS) such as high-flow nasal oxygen…
- Trial name
- MONITOR-NIV (NCT07423338)
- Testing
- Advanced respiratory monitoring
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Queen Mary University of London
Intubated Infants Were Intend to Extubation Using Noninvasive Ventilation Strategies
A Trial Comparing Noninvasive Ventilation Strategies in Preterm Infants Following Extubation
Respiratory distress syndrome (RDS) is the main cause of respiratory failure in preterm neonates, its incidence varying from 80% to 25% depending on gestational age.When optimal prenatal care is provided, the best approach to…
- Trial name
- NCT03181958
- Testing
- NHFOV, NCPAP, NIPPV
- Where
- China
- Volunteers
- 1,493 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Hypercapnic Respiratory Failure
Use of Nasal High Flow Oxygen During Breaks of Non-invasive Ventilation for Patients With Hypercapnic Respiratory Failure
Chronic respiratory insufficiency and COPD are the third leading cause of death worldwide. Patients decompensate at various stages of their disease and exhibit acute-on-chronic respiratory failure (ACRF), a frequent cause of ICU…
- Trial name
- HIGH FLOW ACRF (NCT03406572)
- Testing
- HFHO Group, Standard O2
- Where
- France
- Volunteers
- 161 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris