Clinical trials: Nociplastic Pain
Nociplastic Pain, Chronic Primary Pain
Pain Reprocessing Therapy for Chronic Primary Pain
Approximately 30% of adult Norwegians experience chronic pain, with its prevalence rising across demographics, including children and adolescents Chronic pain contributes to significant personal suffering and substantial societal…
- Trial name
- PRIME-PRT (NCT07287072)
- Testing
- Pain Reprocessing Therapy
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- University of Oslo
Rheumatoid Arthritis (RA, Chronic Pain
Integrative AI-Based Multiomic and Neurophysiological Profiling of Chronic Pain in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease in which pain remains the most prominent and burdensome symptom from the patient's perspective.
- Trial name
- RA-PAIN-AI (NCT07769619)
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland
Chronic Primary Orofacial Pain (CPOP), Persistent Idiopathic Facial Pain (PIFP)
An Innovative Cognitive-Behavioral Treatment For Chronic Orofacial Pain
Use these resources to provide understandable information about this study to patients, families, and health care providers: The present randomized clinical trial (RCT), conducted at the IRCCS Carlo Besta Neurological Institute…
- Trial name
- FACE-PRT (NCT07123233)
- Testing
- Pain Reprocessing Therapy, Usual Therapy
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Fibromyalgia
Fibromyalgia Sleep A to ZZZ Study
This research study is testing whether changes in sleep timing and morning light therapy may have an impact on symptoms related to fibromyalgia.
- Trial name
- NCT06567886
- Testing
- Light Therapy, Sleep Stabilization
- Where
- United States
- Volunteers
- 390 people
- Sponsor
- University of Michigan
Mast Cell Activation Syndrome, Mast Cell Activation Disorder Idiopathic
Safety and Efficacy of FSD201 for the Treatment of Chronic Pain Associated With Idiopathic MCAS (MCAD)
This study will determine if FSD201 reduces the average daily 24-hour recall pain intensity after 28 and 56 days of treatment in adults with chronic widespread musculoskeletal nociplastic pain.
- Trial name
- NCT05652907
- Testing
- FSD201
- Where
- 3 sites in United States, Canada
- Volunteers
- 2 people
- Sponsor
- Quantum Biopharma
Chronic Low-back Pain (cLBP)
Pain Phenotypes in Individuals With Chronic Low Back Pain
This observational cross-sectional study aims to determine pain phenotypes in individuals with chronic low back pain (CLBP). Participants will be classified according to a mechanism-based clinical pain phenotyping algorithm as…
- Trial name
- NCT07766200
- Testing
- Pain classification method
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Kutahya Health Sciences University
Pes Planus, Flatfoot
Central Sensitization and Nociplastic Pain in Pes Planus
Background: Pes planus, commonly known as flatfoot, is a condition characterized by the collapse of the medial longitudinal arch of the foot.
- Conditions
- Pes Planus, Flatfoot, Central Sensitization, Nociplastic Pain
- Trial name
- NCT07125781
- Where
- Turkey (Türkiye)
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Bozok University
Chronic Pain
"MecPain", a New Questionnaire to Assess Chronic Pain Mechanisms.
Validation of a new clinical questionnaire, called 'MecPain', including 12 questions, aimed at better defining the pathophysiological mechanisms of a chronic pain condition.
- Trial name
- MecPain (NCT05713604)
- Where
- 2 sites in France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Grenoble
Fibromyalgia, Lupus Erythematosus, Systemic
Brief Pain Exposure Therapy (BPET) For Nociplastic Pain
This study is intended to test whether a brief Zoom-based behavioral treatment can help adults with fibromyalgia (FM), Lupus, chronic pelvic pain, and chronic low back pain learn effective strategies for reducing pain, disability…
- Conditions
- Fibromyalgia, Lupus Erythematosus, Systemic, Chronic Pelvic Pain, Chronic Low Back Pain (CLBP)
- Trial name
- BPET (NCT06208514)
- Testing
- Brief pain exposure therapy (BPET)
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Michigan
Frozen Shoulder, Adhesive Capsulitis
USG-Guided Shoulder Injections in Frozen Shoulder
Frozen shoulder (adhesive capsulitis) is characterized by pain and a progressive restriction of both active and passive shoulder range of motion, significantly impairing daily activities and quality of life.
- Conditions
- Frozen Shoulder, Adhesive Capsulitis, Shoulder Pain, Nociplastic Pain
- Trial name
- NCT07493213
- Testing
- USG-guided suprascapular nerve block, USG-Guided suprascapular nerve block plus subacromial injection.
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Konya Beyhekim Training and Research Hospital
Chronic Pain, Nociplastic Pain
Different Treatments in Chronic Pain Patients.
The goal of this observational study is to compare different treatment options in a chronic pain population. The main questions it aims to answer are: What is the effectiveness of the different therapy options in the pain center…
- Trial name
- EC_PC_AZSTL (NCT05768477)
- Testing
- Consultation, Interventions, Baxter therapy
- Where
- Belgium
- Volunteers
- 1,000 people
- Sponsor
- University Ghent
Frozen Shoulder, Adhesive Capsulitis
Efficacy of Chemically Distinct Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Pain Phenotypes in Adhesive Capsulitis
Patients aged 18-75 years who present to a tertiary rehabilitation hospital with shoulder pain and restricted range of motion, and who consent to participate, will be included in the study.
- Conditions
- Frozen Shoulder, Adhesive Capsulitis, Shoulder Pain, NSAID (Non-Steroidal Anti-Inflammatory Drug)
- Trial name
- NCT07493226
- Testing
- Propionic acid deriaves, acetic acid derivatives, oxicam derivatives
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Konya Beyhekim Training and Research Hospital
Chronic Shoulder Pain
Nociplastic Pain in Patients With Chronic Shoulder Pain
The aim of this study was to investigate predictors of nociplastic shoulder pain. Factors of psychological distress, functionality, fitness, quality of life, quality of sleep, functioning of the parasympathetic system, and…
- Trial name
- NCT05481710
- Testing
- Nociplastic Pain Criteria
- Where
- 2 sites in Greece
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Paraskevi Bilika
Fibromyalgia Syndrome, Myofascial Pain Syndrome (MPS)
COMT and IL6 Genotype-Phenotype Associations in Fibromyalgia and Myofascial Pain Syndrome
Fibromyalgia (FM) and myofascial pain syndrome (MPS) are chronic pain conditions that may share some clinical features but differ in the distribution and extent of pain and associated symptoms.
- Trial name
- NCT07840963
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul Aydın University
Chronic Pain, Persistent Pain
Pleasant Touch Perception in Persistent Pain.
The goal of this observational study is to learn how individuals with chronic pain experience pleasant touch and how often they are exposed to such touch in their daily lives.
- Trial name
- NCT07551687
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Göteborg University
Central Sensitisation, Low Back Pain
Nociplastic Pain Symptoms and Sensory Profiles in Low Back Pain
Assessing associations between Sensory profiles and nociplastic pain symptoms, and assessing the prognostic value of sensory profiles in the development of nociplastic pain symptoms in a low back pain population.
- Trial name
- NCT05592405
- Where
- Netherlands
- Volunteers
- 103 people
- Sponsor
- Vrije Universiteit Brussel
Stroke Sequelae, Chronic Pain
Transcraneal Magnetic Stimulation for Treatment of Non-nociceptive Pain in Chronic Diseases
Background: Chronic non-nociceptive or nociplastic pain and neurological sequelae following stroke are associated with substantial functional impairment and reduced quality of life.
- Conditions
- Stroke Sequelae, Chronic Pain, Fibromyalgia, Long COVID19
- Trial name
- FATMAGPAIN (NCT07888673)
- Testing
- Transcraneal Magnetic Stimulation (rTMS)
- Where
- 2 sites in Spain
- Volunteers
- 47 people
- Sponsor
- Hospital Donostia
Bladder Pain Syndrome, Chronic Pelvic Nociplastic Pain
Venlafaxine Combined With Education and Behavioral Intervention for Bladder Pain Syndrome
This study aims to compare two treatment plans for adults with bladder pain syndrome (also called interstitial cystitis), a disease that causes long-lasting bladder pain, frequent urination and urgent need to pee.
- Conditions
- Bladder Pain Syndrome, Chronic Pelvic Nociplastic Pain, Interstitial Cystitis
- Trial name
- VEN-BPS (NCT07698626)
- Testing
- Venlafaxine oral tablet combined with Education and Behavioral Modification Program (EBMP), Education and Behavioral Modification Program (EBMP) only
- Volunteers
- 140 people
- Sponsor
- Beijing Tiantan Hospital
Neuropathic Pain, Nociplastic Pain
Efficacy of Home-delivered Transcranial Direct Electrical Stimulation or Chronic Pain
This clinical investigation aims to evaluate the efficacy and safety of a home-based device providing electrical stimulation of the brain named transcranial direct current stimulation (tDCS ) , in patients with chronic pain who…
- Trial name
- Homestim-DC (NCT07211256)
- Testing
- tDCS of the motor cortex
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Hospital Ambroise Paré Paris
Neuropathic Pain, Nociplastic Pain
Evolution of Different Sensitivity Levels in Patients With Chronic Neuropathic Pain in the Pelvi-perineal Region After Treatment With High-concentration Capsaicin Patches
The primary objective of this study will be to demonstrate a change in pain sensitization parameters before and after the application of the high-concentration capsaicin patch.
- Trial name
- CAPSASENS (NCT07660510)
- Testing
- Quantitative Sensory Testing and questionnaires
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital