Clinical trials: Nicotine Use
Oxygen Deficiency, Desaturation of Blood
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Use in Pediatric Procedures
THRIVE (Transnasal Humidified Rapid-Insufflation Ventilatory Exchange) refers to the use of high-flow nasal cannula to augment the ability to oxygenate and ventilate a patient under general anesthesia.
- Conditions
- Oxygen Deficiency, Desaturation of Blood, Hypoventilation, Anesthesia; Adverse Effect
- Trial name
- NCT03430206
- Testing
- High-flow nasal cannula
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Stanford University
Smokeless Tobacco Use
Nicotine Lozenges for Treatment of Smokeless Tobacco Addiction
This study will be a randomized, blinded, placebo-controlled two-group clinical trial. The independent variable is treatment assignment (active 4-mg nicotine lozenge vs.
- Trial name
- NCT00392379
- Testing
- Nicotine Lozenges
- Where
- 2 sites in United States
- Volunteers
- 270 people
- Sponsor
- Mayo Clinic
Nicotine Addiction
Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches
The goal of this study is to assess the effects of nicotine concentration and its interplay with pH on sensory experience, product appeal, and abuse liability of NPs among young adults NP users.
- Trial name
- NCT07165808
- Testing
- Nicotine pouch: Low dose, Nicotine pouch: High dose, Low pH
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Emory University
Nicotine Dependence
The Effects of Craving and Abstinence From Cigarettes on Brain Metabolism in Smokers
Craving and withdrawal from smoking cigarettes are major factors for relapse. We investigated craving for cigarettes in smokers undergoing pharmacological treatment with Bupropion (Zyban).
- Trial name
- NCT00267813
- Testing
- Bupropion (Zyban)
- Where
- Israel
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Tobacco Use, Tobacco Use Cessation
Metabolism-informed Care for Smoking Cessation
Nicotine mediates smoking's addictive effects in the brain. The ratio of 3-hydroxycotinine to cotinine, known as the nicotine metabolite ratio, or NMR, is a genetically- informed biomarker reflecting hepatic CYP2A6 activity and…
- Trial name
- NCT03227679
- Testing
- Nicotine Metabolite Ratio, Varenicline, Bupropion
- Volunteers
- 82 people
- Sponsor
- Vanderbilt University Medical Center
Smoking
Neurobiology of Nicotine and Non-nicotine Components of Tobacco Addiction
In the present study the investigators will measure the effects of nicotine and non-nicotine factors on brain function during cognitive processes that are differentially sensitive to these factors.
- Trial name
- NNN (NCT01056926)
- Testing
- Quit smoking, Nicotine patch
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Duke University
Tobacco Use Disorder
Treating Schizophrenic Smokers: Effects on Craving, Cues and Withdrawal
This is a clinical research protocol to study the efficacy of combined varenicline (Chantix) and motivational interviewing (MI) for smoking cessation in a sample of smokers who have been diagnosed with schizophrenia or…
- Trial name
- NCT00781755
- Testing
- varenicline, Adaptation of Motivational Interviewing
- Where
- United States
- Sponsor
- VA Boston Healthcare System
Tobacco Use Disorder, Tobacco Dependence
Equitable Smoking Relapse Prevention
The goal of this clinical trial is to test a GPS (Global Positioning System)-enabled smartphone app (QuitBuddy) in current smokers.
- Trial name
- NCT05625685
- Testing
- Quitbuddy, Control, SDoH Augmentation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bryan W. Heckman
Nicotine Addiction, Smoking Cessation
Computer-Facilitated 5A's for Smoking Cessation in Primary Care
This study tests the use of handheld computer tablets to promote the integration of 5A's (Ask, Advise, Assess, Assist, Arrange) for smoking cessation in academic and community primary care clinics.
- Trial name
- NCT02046408
- Testing
- Computer Tablet
- Where
- 2 sites in United States
- Volunteers
- 961 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Dependence
Bioequivalence Between Two New Oral Nicotine Replacement Therapy Products and Nicorette® Microtab
The purpose of this study is to assess the bioequivalence between two new oral nicotine replacement therapy products and Nicorette® microtab.
- Trial name
- NCT01238640
- Testing
- Code STD, Code STE, Nicorette Microtab
- Where
- Sweden
- Volunteers
- 84 people
- Sponsor
- McNeil AB
Electronic Cigarette Use
Nicotine Uptake, Measures of Abuse Liability, and Puffing Topography With Use of RELX ENDS Products by ENDS Consumers
This study is being conducted to evaluate nicotine uptake, the potential abuse liability, and puffing topography associated with the use of an electronic nicotine delivery system (ENDS) with tobacco- and menthol-flavored…
- Trial name
- NCT04620616
- Testing
- RELX ENDS Tobacco Flavor, RELX ENDS Menthol Flavor, Subject Usual Brand ENDS
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Cheerain HK Limited
Smoking Cessation, Pulmonary Disease, Chronic Obstructive
Impact of Primary Care COPD Screening Strategies on the Smoking Cessation Process (DISCO-SET)
The general practitioner is confronted with unselected smokers whose attempts to quit smoking are often repeated over time before leading to a definitive cessation.
- Trial name
- DISCO-SET (NCT04833933)
- Testing
- Phone survey about smoking cessation process since intervention in DISCO trial
- Where
- 12 sites in France
- Volunteers
- 120 people
- Sponsor
- Rennes University Hospital
Tobacco Use Cessation, Tobacco Use
Integrating Tobacco Use Cessation Into HIV Care and Treatment in Kisumu County, Kenya
People living with HIV (PLHIV) have higher rates of tobacco use than the general population and higher rates of disease and death compared with PLHIV who do not use tobacco.
- Trial name
- NCT05351606
- Testing
- Tobacco Use Cessation Counselling Sessions, Bupropion, Nicotine patch
- Where
- Kenya
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Coronary Artery Disease, Coronary Atherosclerosis
Effects of Switching From Cigarettes to Tobacco Heating System on Coronary Atherosclerosis Progression
Objective: To evaluate the impact of heated versus combustion tobacco products on progression of atherosclerosis in patients with CAD unable(unwilling) to quit smoking.
- Conditions
- Coronary Artery Disease, Coronary Atherosclerosis, Nicotine Dependence
- Trial name
- SWITCH (NCT05660798)
- Testing
- heated tobacco - lifestyle intervention
- Where
- Poland
- Volunteers
- 180 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Tobacco Use
A Study to Evaluate Changes in Smokers Using An Oral Tobacco-Derived Nicotine Product
The purpose of this study was to estimate changes in biomarkers of exposure (BOE) in adult cigarette smokers using an oral tobacco-derived nicotine (OTDN) product relative to adult smokers who continue smoking exclusively.
- Trial name
- NCT04079933
- Testing
- Oral tobacco-derived nicotine product (OTDN)
- Where
- 3 sites in United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Altria Client Services LLC
Nicotine Dependence, Cigarettes, With Withdrawal
A Dietary Supplement for Early Cigarette Withdrawal
The purpose of this study is to determine whether a dietary supplement (DS) is effective in protecting against sad mood during early cigarette withdrawal.
- Trial name
- CIGAR (NCT02042521)
- Testing
- Dietary Supplement
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Centre for Addiction and Mental Health
Tobacco Use Disorder
Fresh Lime Alone for Smoking Cessation
The purpose of this study is to determine whether fresh lime alone is effective for smoking cessation.
- Trial name
- LIM (NCT01333202)
- Testing
- Fresh lime
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Thai Health Professional Alliance Against Tobacco
Tobacco Dependence
Project 1, Study 1: Investigating the Impact of Nicotine Using Spectrum Cigarettes
Project 1, Study 1 will evaluate the relationship between nicotine yield of very low nicotine content cigarettes and cigarettes smoked per day, nicotine exposure, discomfort/dysfunction, other health-related behaviors…
- Trial name
- P1S1 (NCT01681875)
- Testing
- very low nicotine content cigarettes
- Where
- 9 sites in United States
- Volunteers
- 839 people
- Sponsor
- Wake Forest University Health Sciences
Smoking Cessation, Cigarette Smoking
Quit With Sense: Using Mindful Smoking and Wearable Device for Smoking Cessation
This pilot randomized controlled trial will test the feasibility of a smoking cessation intervention using mindful smoking practice and a smartphone-based sensor-band among adults who regularly smoke cigarettes.
- Conditions
- Smoking Cessation, Cigarette Smoking, Tobacco Use, Nicotine Dependence
- Trial name
- NCT07789496
- Testing
- Mindful Smoking and Sensor-Band Intervention, Smoking Cessation Information
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Electronic Cigarette Use
Effects of Social Media Use on Young Adults' E-Cigarette Use
The goal of this clinical trial is to test the effects of social media use on e-cigarette use in young adults who use e-cigarettes.
- Trial name
- NCT06142877
- Testing
- Social Media Use Reduction
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma