Clinical trials: Nicotine
Nicotine Dependence, Major Depressive Disorder
Behavioral Activation and Varenicline for Smoking Cessation in Depressed Smokers
Persons who struggle with depression smoke at high rates and experience low quit rates in treatment. The best way to improve cessation treatment for this underserved population remains unknown.
- Trial name
- NCT02378714
- Testing
- Varenicline, BASC, Standard treatment
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Northwestern University
Sarcoidosis
Nicotine Treatment for Pulmonary Sarcoidosis: A Clinical Trial Pilot Study
The purpose of this study is to determine if nicotine treatment is beneficial for the treatment of sarcoidosis. Sarcoidosis is a disease of unknown cause that leads to inflammation. This disease affects your body's organs.
- Trial name
- NCT02265874
- Testing
- Habitrol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ohio State University
Pulmonary Disease, Autonomic Dysfunction
Meditative Movement for COPD Symptoms in Non-Smoking Flight Attendants
This study will explore the a Qigong based exercise intervention, here referred to as Meditative Movement (MM), to ameliorate the symptoms associated with chronic obstructive pulmonary disease (COPD) and its co-morbidities.
- Conditions
- Pulmonary Disease, Autonomic Dysfunction, COPD
- Trial name
- MMforFA (NCT02612389)
- Testing
- Meditative Movement taught via DVD
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Smoking Cessation
Progesterone Augmentation of Nicotine Replacement Therapy Study
This will be a double-blind, placebo-controlled, pilot, randomized clinical trial. A total of 50 women who smoke and have regular menstrual cycles will be randomized to either progesterone (200 mgs BID) + Transdermal Nicotine…
- Trial name
- PANS (NCT02685072)
- Testing
- Progesterone (200 mgs BID)
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Yale University
Nicotine, Oxidative Stress
Switching to Low Oxidant Content Cigarettes in Adult Smokers
The overall objective of this clinical study is to determine if smokers who switch from their usual high reactive oxygen and nitrous oxide species (ROS/NOS) products to a low ROS/NOS product exhibit increased or decreased levels…
- Trial name
- NCT03102931
- Testing
- Reduced ROS/RNS content products, Typical to high (ROS/NOS) products
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Tobacco Use Cessation, Smoking Cessation
Implementation of HIT-Enhanced Tobacco Treatment for Hospitalized Smokers
This study will implement and test the effectiveness and cost-effectiveness of a tobacco cessation intervention (Academic Detailing + Integrated Tobacco Order Set - AD + ITOS) for adults admitted to the hospital.
- Conditions
- Tobacco Use Cessation, Smoking Cessation, Smoking, Tobacco Use Disorder
- Trial name
- NCT01691105
- Testing
- AD + Integrated Tobacco Order Set
- Where
- United States
- Volunteers
- 1,044 people
- Sponsor
- Yale University
Nicotine Dependence, Tobacco Toxicity
Cigarette Harm Reduction With Electronic Cigarette Use
This is an observational, crossover study that will be examine use behaviors, chemical exposures, and biological effects of SREC compared to TC use in subjects confined to a research ward setting.
- Conditions
- Nicotine Dependence, Tobacco Toxicity, Nicotine Dependence, Cigarettes, Cardiovascular Risk Factor
- Trial name
- NIDA-SREC (NCT03473483)
- Testing
- SREC
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Use Disorder
To Assess the Bioequivalence of the 4mg Prototype Mini Nicotine Lozenge to the Reference Product (Nicorette) in Healthy Smokers
This study will assess the bioequivalence of the test product (Nicotine Prototype Mini lozenge 4 milligrams [mg]) to a commercial reference product (nicotine polacrilex mini lozenge 4mg) in healthy smokers under fasting…
- Trial name
- NCT03543137
- Testing
- Nicotine Prototype Mini lozenge, Nicorette Mini Lozenge
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Smoking Cessation
STAND Community College Tobacco Cessation Trial
Community colleges have 45% of the nation's undergraduates and have a higher smoking prevalence rate than 4-year colleges. California's community colleges comprise the nation's largest higher education system, and Sacramento has…
- Trial name
- NCT03002883
- Testing
- Usual Care, Brief Motivational Interviewing, Direct referral to quitline
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Vaping, Vaping Cessation
Social Media Support Groups for Adolescent Vaping Cessation
The purpose of this study is to pilot test feasibility and acceptability of the Quit the Hit Toolkit, a social media-based nicotine vaping cessation program for adolescents and young adults, adapted for use in community settings.
- Conditions
- Vaping, Vaping Cessation, Nicotine Dependence
- Trial name
- NCT07540780
- Testing
- Social Media Intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Smoking Cessation
Cumulative Skin Irritation Potential of a New 15 mg Nicotine Patch
An investigation on the cumulative skin irritation potential of a newly developed 15 mg nicotine patch. Evaluation of skin irritation of a newly developed 15 mg nicotine transdermal patch.
- Trial name
- NCT00965913
- Testing
- Nicotine Patch, Nicotine Patch Comparator
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- McNeil AB
Nicotine Withdrawal, Tobacco Abstinence
Effects of Transcranial Direct Current Stimulation on Tobacco Withdrawal Symptoms
We hypothesize that transcranial direct current stimulation will reduce tobacco withdrawal symptoms of tobacco dependent smokers abstinent from smoking for more than 10 hours.
- Trial name
- tDCSsmokers (NCT01567982)
- Testing
- tDCS, prefrontal cortex and parietal cortex
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yale University
Tobacco Use Cessation
An Evidence Based Smoking Cessation Program for Persons Living With HIV/AIDS (Project Legacy)
The goal of this research study is to compare 2 different phone-based programs for quitting smoking for people with HIV/AIDS.
- Trial name
- NCT02029612
- Testing
- Nicotine Patch, Phone Counseling, Questionnaires
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Substance Dependence
A Pilot Clinical Trial of Varenicline as a Treatment for Alcohol Dependence
Purpose: This is an outpatient, randomized, double-blinded, placebo-controlled study in which either varenicline (twice daily) or placebo will be administered over a 12 week study period to examine genetic influences on treatment…
- Trial name
- NCT01011907
- Testing
- varenicline
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- University of California, San Francisco
Depression
Thrive Care: Internet CBT for Depression
This project will study the effectiveness of computerized cognitive behavioral therapy (CBT) in reducing depression symptoms. The design is a two-arm randomized controlled trial comparing (i) control arm, which is treatment as…
- Trial name
- NCT03079895
- Testing
- Thrive
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- Kaiser Permanente
Nicotine Dependence, Cigarettes
Acute Oral Effects of Heated Tobacco Products
Heated tobacco products (HTP) are devices which heat, but not burn tobacco. They do not produce cigarette smoke but rather an aerosol. HTPs are marketed as less harmful alternatives to smoking.
- Trial name
- NCT05538702
- Testing
- IQOS 3.0 DOU with bland taste unit (Heated Tobacco Product), IQOS 3.0 DUO with menthol taste unit (Heated Tobacco Product), Marlboro Gold (Conventional cigarette)
- Where
- Hungary
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Nicotine Dependence Tobacco Product
Comparing SMS and E-mail Reminders in an Online Smoking Cessation Intervention
The primary purpose of the current study is to compare the effect of SMS-textmessage vs e-mail reminders on user engagement and proportion of reported quit attempts in an online smoking cessation intervention.
- Trial name
- NCT03276767
- Testing
- Endre
- Where
- 2 sites in Czechia, Norway
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Severe Mental Illness, Nicotine Dependence
Electronic Decision Support Systems for Smokers With Severe Mental Illness
This randomized clinical trial among SMI smokers assessed whether the EDSS with carbon monoxide monitor and health-checklist feedback lead to higher rates of initiation of smoking cessation treatment, days of smoking abstinence…
- Conditions
- Severe Mental Illness, Nicotine Dependence, Schizophrenia, Tobacco Use Disorder
- Trial name
- NCT01412866
- Testing
- EDSS with CO feedback and health checklist, EDSS with health checklist feedback alon
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Nicotine Dependence, Nicotine Dependence, Cigarettes
Clinical Study Comparing 7 ENDS Products and 1 Combustible Cigarette Using 2 Delivery Methods.
A Randomized Study Comparing Nicotine Pharmacokinetics of Seven Electronic Cigarette Products and One Traditional Cigarette Across Two Delivery (10 puff and ad- libitum) Conditions, in Healthy Adult Smokers
- Conditions
- Nicotine Dependence, Nicotine Dependence, Cigarettes, Tobacco Use, Tobacco Smoking
- Trial name
- NCT03700112
- Testing
- JUUL Virginia Tobacco flavored 5.0% ENDS, PMI iQOS Heat sticks, Reynolds VUSE Solo ENDS - Original
- Where
- New Zealand
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
Pain, Chronic, Breast Cancer
Optimizing Psychological Treatment for Pain After Breast Cancer: A Pilot Study
The present study is a pilot study that aims to evaluate the feasibility, validity, and preliminary efficacy of three psychological treatment components for pain after breast cancer, which will be evaluated in a larger trial…
- Trial name
- NCT04841928
- Testing
- Mindful attention, Decentering, Value-based action
- Where
- Denmark
- Volunteers
- 31 people
- Sponsor
- University of Aarhus
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