Clinical trials: Neurosurgery
Infection, Surgery
Topical Vancomycin for Neurosurgery Wound Prophylaxis
This study is a collaboration between New York Presbyterian (NYP)-Columbia and NYP-Cornell that seeks to evaluate the use of topical vancomycin and its reduction on surgical site infection (SSI) in neurosurgical procedures.
- Conditions
- Infection, Surgery, Nervous System Diseases
- Trial name
- Vanguard (NCT02284126)
- Testing
- Vancomycin
- Where
- United States
- Volunteers
- 1,103 people
- Sponsor
- Columbia University
Hypothermia
Preventing Inadvertent Hypothermia in Paediatric Neurosurgery in Malawi
The investigators wish to undertake a randomized controlled non-inferiority trial to evaluate the ability of a simple and low-cost method (Hibler´s method of wrapping the patient in multiple insulating layers) to prevent…
- Trial name
- NCT02975817
- Testing
- Hibler's, Warm Air
- Where
- Malawi
- Volunteers
- 76 people
- Sponsor
- Oslo University Hospital
Post-operative Neurosurgery
Effect of Ventilation Mode on Lung Deposition of a Radiolabeled Aerosol During Mechanical Ventilation: Barometric Versus Volumetric
Controlling the respiratory pattern of mechanically ventilated patients in volume control mode is recommended during nebulization.
- Trial name
- NCT01879488
- Testing
- technetium-99m - Diethylenetriaminepentaacetic acid, Vibrating-mesh nebulizer, Gamma scintigraphy
- Where
- Belgium
- Volunteers
- 19 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Anesthesia, Craniotomy
Anesthesiological Strategies in Elective Craniotomy
This protocol, NeuroMorfeo, aims to assess equivalence between volatile and intravenous anesthetics for neurosurgical procedures.
- Conditions
- Anesthesia, Craniotomy, Neurosurgery
- Trial name
- Neuromorfeo (NCT00741351)
- Testing
- Sevoflurane + Fentanyl, Sevoflurane + Remifentanyl, Propofol + Remifentanyl
- Where
- 15 sites in Italy
- Volunteers
- 411 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Informed Consent, Health Literacy, Risk, Spinal Puncture, Neurosurgery
Communicating Risks: Consent for Lumbar Puncture
The goal of this randomized control trial is to compare the effect of visual aids on the recall of probabilistic risks in healthy participants.
- Trial name
- NCT05717465
- Testing
- Anatomy diagrams, Standard informed consent
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Anesthesia, Neurosurgery
Study of Post-anesthesia Management in Patients Undergoing Neurosurgery
The postoperative complications of neurosurgery are various and complex, which brings heavy economic and social burden to families.
- Conditions
- Anesthesia, Neurosurgery, Complication
- Trial name
- NCT04362709
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Tiantan Hospital
Surgery--Complications
Goal-directed Therapy in Neurosurgery.
The purpose of the study is to assess feasibility of future large randomised controled study aimed on assessment of effect of goal-directed therapy on incidence of complications in neurosurgery compared to standard care.
- Trial name
- NCT04754295
- Testing
- Goal-Directed Therapy, STANDARD
- Where
- Czechia
- Volunteers
- 34 people
- Sponsor
- Brno University Hospital
Intracranial Pressure, Neurosurgery
Parameters Analysis in Neurosurgical Critical Patients Through Big Data Acquisition
The PANDA trial is a multicenter prospective observational study designed to analyze various ICP derived parameters and clinical status in neurosurgical critical patients through a new big data acquisition system.
- Conditions
- Intracranial Pressure, Neurosurgery, Information Management
- Trial name
- PANDA (NCT03087981)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- RenJi Hospital
Ketamine; Depressive Symptom; Neurosurgery; Perioperative Period
Ketamine and Postoperative Depressive Symptom-PASSION
Perioperative depression symptom (PDS) is one of the common mental comorbidity, and influences the clinical outcomes and prognosis. However, there is no rapid acting treatment to deal with it during the limited hospital stay.
- Trial name
- NCT03086148
- Testing
- Ketamine, Normal saline
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Beijing Tiantan Hospital
Neurosurgery, Intracranial Hemorrhages
Arterial Pressure and Surgical Hemostasis in Elective Neurosurgery.
The objective of this observational study is to examine the impact of augmented arterial pressure during the hemostatic phase of elective supratentorial neurosurgery. The primary inquiries it seeks to address are as follows: 1.
- Conditions
- Neurosurgery, Intracranial Hemorrhages, Supratentorial Brain Tumor, Blood Pressure
- Trial name
- HemoStopArt (NCT05874050)
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Low Grade Glioma of Brain
Measure of the Potential Evoked by Electric Stimulation
This study is about an experimental biomedical monocentric search concerning twelves patients presenting a infiltrative glioma of low rank OMS type II and realizing a surgery awakened on the site of the CHU of Montpellier.
- Trial name
- PE&CE (NCT02509442)
- Testing
- Diffusion of direct electric stimulation
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Montpellier
Metopic Craniosynostosis, Craniosynostosis
Frontal Reconstruction Without Orbital Advancement for Moderate Metopic Craniosynostosis
Metopic craniosynostosis is a condition caused by the early fusion of the metopic suture, leading to restricted frontal bone growth and a triangular head deformity termed trigonocephaly.
- Conditions
- Metopic Craniosynostosis, Craniosynostosis, Metopic Synostosis
- Trial name
- NCT07837453
- Testing
- Frontal vault remodelling without orbital advancement
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Assiut University
Arteriovenous Malformation, Bleeding
Clinical Study on Emergency Treatment of Cerebral Arteriovenous Malformation Bleeding
Cerebral arteriovenous malformation (AVM) is the leading cause of brain hemorrhage in young adults, characterized by sudden onset and rapid progression.
- Trial name
- NCT07118631
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Beijing Tiantan Hospital
Carotid Artery Stenosis, Glioma
Detection of Microplastics and Nanoplastics in Neurosurgery Patients (DT-MiNi)
Plastic particles are a ubiquitous pollutant in the living environment and food chain, so far, plenty of studies have reported the internal exposure of microplastics and nanoplastics in human tissues and enclosed body fluids.
- Conditions
- Carotid Artery Stenosis, Glioma, Intracranial Aneurysm, Intracranial Hemorrhages
- Trial name
- DT-MiNi (NCT05968053)
- Testing
- biological samples analysis
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Tiantan Hospital
Malignant Brain Tumors
Magnetic Resonance (MR) Guided Focused Ultrasound in the Treatment of Brain Tumors
Focused Ultrasound Focused ultrasound is an attractive method for non-invasive thermal ablation of soft tissue tumors. Treatment begins by acquiring a series of MR images of the target organ.
- Trial name
- FUS-Tumor (NCT01698437)
- Testing
- Non-invasive intervention with focused ultrasound (ExAblate 4000)
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- University Children's Hospital, Zurich
Motor Evoked Potential Monitoring, General Anesthesia
Comparison of the Effects of Vecuronium and Cisatracurium on Electrophysiologic Monitoring During Neurosurgery
Recently intraoperative motor evoked potential monitoring (MEP) is widely used to reduce neural damage during neurosurgery. As neuromuscular blockade(NMB) during MEP monitoring decreases the amplitude of MEP, partial NMB is…
- Conditions
- Motor Evoked Potential Monitoring, General Anesthesia, Neurosurgery, Brain Tumor
- Trial name
- NCT01690364
- Testing
- MEP monitoring with continuous infusion of vecuronium during general anesthesia, MEP monitoring with continuous infusion of cisatracurium during general anesthesia
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Samsung Medical Center
Supratentorial Brain Tumor
Spectrum of Serum Sodium Disturbances in Patients With Non-sellar/Suprasellar Supratentorial Tumors
This study was designed to quantify the incidence of hyponatremia in patients of supratentorial/supra-sellar lesions and observe their effect on neurological morbidity and mortality.
- Trial name
- NCT03570203
- Testing
- Serum Sodium
- Volunteers
- 173 people
- Sponsor
- National Institute of Mental Health and Neuro Sciences, India
Neurosurgery, Brain Cancer
DEXmedetomidine for Postoperative Analgesia and Delirium Prevention After NEUROsurgery (DEX-NEURO Trial)
Post-craniotomy pain is common and often undertreated. Inadequate analgesia can lead to patient discomfort and higher opioid consumption, which may result in respiratory depression, sedation risks and impaired neurological…
- Conditions
- Neurosurgery, Brain Cancer, Meningioma
- Trial name
- DEX-NEURO (NCT07398066)
- Testing
- Dexmedetomidine, Normal Saline (0.9% NaCl)
- Volunteers
- 60 people
- Sponsor
- University of Malaya
300 Students of University of Milan School of Medicine
Psychological Assessment and Skills Training by Simulation in Neurosurgery
The subject of Safety in Health is assuming in time a predominant position with those of high social, economic and political relevance.
- Trial name
- PASSION (NCT06792669)
- Testing
- Simulation training to evaluate the participants' manual skill improvement
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
ERAS, Craniotomy
A Greek-designed ERAS Protocol in Elective Craniotomy
The implementation of ERAS protocol in elective cranial neurosurgical cases in a tertiary hospital.
- Trial name
- ERAS (NCT05962684)
- Testing
- ERAS
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- University of Thessaly