Clinical trials: Neurophysiology
Depression
Beta-CIT-SPECT and Neurophysiology in Depression
Aim of this project is to investigate the effects of escitalopram on monoamine transporter (SERT, DAT) availabilities as assessed by b-CIT and SPECT, and on neurophysiological parameters such as the loudness dependence of…
- Trial name
- NCT00145132
- Testing
- β-CIT-SPECT, Neurophysiology
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Aging, Muscle Physiology
Longitudinal Neuromuscular and Metabolic Changes With Aging
Ageing is characterized by a decline in neuromuscular control and a progressive loss of muscle mass, strength and power, leading to reduced mobility, loss of independence, higher hospitalizations rate, and increased all-cause…
- Conditions
- Aging, Muscle Physiology, Neurophysiology, Exercise Training
- Trial name
- TrajectorAGE (NCT06168591)
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Pavia
Knowledge, Attitude
Pain Neurophysiology Education for Sport Therapy Students
The effect of a 70 minute Pain Neurophysiology Education session on Sport Therapy Students Knowledge, Attitudes and Clinical Behaviour Towards Athletes With Chronic Pain
- Conditions
- Knowledge, Attitude, Behavior
- Trial name
- NCT03002181
- Testing
- Education
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Teesside University
Healthy Subjects
The Impact of Pain Neuroscience Education on Physical Therapy Students' Knowledge, Attitudes, Beliefs, and Behaviors Towards Pain: A Randomized Controlled Trial
This study investigates the effect of pain neuroscience education (PNE) on pain knowledge, attitudes, beliefs and behaviors among undergraduate physiotherapy students in Jordan
- Trial name
- NCT06821022
- Testing
- Pain Neuroscience Education, Red Flags Education
- Where
- Jordan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Hashemite University
Functional Neurological Disorder, Motor Symptoms
Investigating the Neurophysiology of the Motor System and the Feasibility of Vagus Nerve Stimulation in Functional Neurological Disorder (FND)
This clinical study will test if adding a non-invasive stimulation of the vagus nerve through the ear during physiotherapy brings an improvement to FND (Functional Neurological Disorder) patients with motor symptoms.
- Trial name
- TMS-VNS (NCT07710677)
- Testing
- Vagial Nerve Stimulation (VNS) active stimulation
- Where
- Switzerland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Fribourg
Bipolar Disorder, Mood Disorders
Child & Adolescent Bipolar Disorder Brain Imaging and Treatment Study
This research protocol seeks to learn more about bipolar disorder in children and adolescents ages 6-17. Researchers will describe the moods and behaviors of children with bipolar disorder and use specialized testing and brain…
- Conditions
- Bipolar Disorder, Mood Disorders, Attention Deficit Hyerpactivity Disorder
- Trial name
- NCT00006177
- Where
- United States
- Volunteers
- 1,303 people
- Sponsor
- National Institute of Mental Health (NIMH)
Neck Pain
Pain Neurophysiology Education and Exercise for Adolescents With Chronic Idiopathic Neck Pain
This study compared the effectiveness of pain neurophysiology education and neck/shoulder exercises with no intervention in adolescents with chronic idiopathic neck pain (CINP).
- Trial name
- NCT02827994
- Testing
- neurophysiology of pain education and exercises
- Volunteers
- 43 people
- Sponsor
- Aveiro University
Neck Pain, Pain Knowledge
Reliability of the Neurophysiology of Pain Questionnaire in the Neck Pain the Cross-validation Study
The aim of this study is to study the validity and reliability of the Modified Pain Neurophysiology Questionnaire in patients with neck pain.
- Trial name
- NCT05606666
- Testing
- reliability of the NPQ
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Istanbul Arel University
Neck Pain, Chronic Pain
Brain, Brainstem, and Spinal Cord fMRI
New advances in medical imaging have allowed for the measurement of brain activity related to chronic pain. In addition to the brain, the investigators aim to use functional magnetic resonance imaging to investigate pain…
- Trial name
- NCT02356315
- Testing
- Functional Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Pain, Chronic, Whiplash Injury
Efficacy of Pain Neurophysiology Education in Combination With Psychologic Inoculation in Chronic Whiplash
With the present study the investigators wish to examine if reconceptualisation of pain, by educating chronic whiplash-associated disorders (CWAD) patients on the neurophysiology of pain, in combination with psychologic…
- Trial name
- NCT01544075
- Testing
- Pain neurophysiology education (PNE) and psychologic inoculation (PI), Neck school (NS)
- Where
- Belgium
- Volunteers
- 36 people
- Sponsor
- Vrije Universiteit Brussel
Major Depressive Disorder, Depression
Investigating Biological Markers, Targets, and Intervention for Mood Disorders
This multi-modal methods study will investigate neurophysiological, endocrinological, cognitive, psycho-social-emotional markers of disease, and targets for integrative health treatments in mood disorders.
- Conditions
- Major Depressive Disorder, Depression, Stress
- Trial name
- NCT04632498
- Testing
- Mindfulness Based Intervention
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Healthy
Neurophysiological Effects of Mind-body Exercise in Healthy Adults
There is some clinical evidence showing that Baduanjin (BDJ) practice, a type of mind-body based physical exercise, can improve executive function (EF).
- Trial name
- NCT06337344
- Testing
- Baduanjin, Exercise, Video Viewing
- Where
- Hong Kong
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Adults With Variability in Their Mood
Restorative Neurophysiology: Backing up and Restoring the Brain (BandR)
Study to examine the extent to which neurophysiological states recorded for a specific person on one day can be induced on a subsequent day
- Trial name
- BandR (NCT07252011)
- Testing
- Transcranial alternating current stimulation (tACS), Neuro/biofeedback, Recall
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Usher Syndrome, Cochlear Implantation
Auditory Neural Function in Implanted Patients With Usher Syndrome
Usher syndrome (USH) causes extensive degeneration in the cochlear nerve (CN), especially in CN fibers innervating the base of the cochlea.
- Trial name
- NCT04906135
- Testing
- Experimental manipulation of stimulation parameters
- Where
- 4 sites in United States
- Volunteers
- 29 people
- Sponsor
- Ohio State University
Intracranial Hemorrhages, Prematurity
Neurophysiology and Anatomy of Severe Intraventricular Hemorrhage (IVH)
Currently, when premature infants develop severe intraventricular hemorrhage (IVH), a type of intracerebral bleed, there are no proven therapeutic interventions to prevent the devastating consequences of this event.
- Trial name
- NCT00817310
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University
Neurophysiology, Physiology
Functional Implication of Corpus Callosum in Voluntary Strength in COPD Patients
Patients with COPD have lower capability of activating their muscles. At the cortical level, force production is not only controlled by contralateral primary motor cortex but also by ipsilateral motor cortex.
- Trial name
- NCT03807258
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- 2 sites in France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- 5 Santé
Aging
Development of Clinical Methods to Evaluate Neural Function in Aging
A primary focus of the University of Florida (UF) Claude D. Pepper Older Americans Independence Center (OAIC) is to build a comprehensive understanding of the causes and consequences of declining physical function and disability…
- Trial name
- MIND (NCT02073201)
- Testing
- High-functioning older adults, Lower-functioning older adults, Young adults
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Florida
Parkinson Disease
Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease
Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking.
- Trial name
- NCT06911229
- Testing
- Deep Brain Stimulation (DBS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Florida
Ischemic Stroke, Acute, Treatment Outcome
Effect of Early Versus Late Initiation of Edaravone Dexborneol on Neural Function in Patients With Acute Ischemic Stroke
The primary objective of this study was to evaluate the efficacy and safety of initiation of edaravone dextivel therapy compared with placebo in patients with acute ischaemic stroke (early and late) and to explore the optimal…
- Trial name
- EARLYS (NCT05885919)
- Testing
- Edaravone Dexborneol Concentrated Solution for injection
- Where
- 3 sites in China
- Volunteers
- 212 people
- Sponsor
- Xiangya Hospital of Central South University
Musculoskeletal Physiology
Training for Diagnosing Neurological Disorders
This training protocol has two objectives: 1) to train NINDS fellows in specialized techniques for diagnosing neurological disorders, and 2) to gather data from healthy volunteers and from patients with various disorders needed…
- Trial name
- NCT00132353
- Where
- United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)