Clinical trials: Neuropathology
COVID 19
Neuropathology in Adults Intensive Care Unit Patients With COVID 19
This is a single center observational autopsy study, conducted during the first wave of the coronavirus disease (COVID-19) pandemic in France.
- Trial name
- NCT04453670
- Testing
- autopsy
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University of Versailles
Aicardi-Goutières Syndrome
Inhibition of Reverse Transcription in Aicardi-Goutières Syndrome
Aicardi-Goutières syndrome (AGS) is a disease of children, particularly affecting the brain and the skin. There is a close link between AGS and increased amounts of a chemical called interferon.
- Trial name
- AGS-RTI (NCT04731103)
- Testing
- Abacavir (ABC), Lamivudine (3TC), Abacavir (ABC)+Lamivudine (3TC)+Zidovudine (AZT)
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- University of Edinburgh
CNS Tumor, Neuropathology
Artificial Intelligence Neuropathologist
CNS tumor requires biopsy for pathological diagnosis, which is known as the "golden standard". We would like to achieve automated classification of brain tumors based on deep learning in digital histopathology images and…
- Trial name
- NCT05300113
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Huashan Hospital
Obstructive Sleep Apnoea, Inflammation
Investigating the Neuropathology of Obstructive Sleep Apnoea
Our multi-disciplinary research group works closely with people who have obstructive sleep apnoea. This is a life-long illness that causes breathing to stop during sleep, which leads to low-oxygen in the blood.
- Trial name
- INcOSA (NCT02967536)
- Where
- United Kingdom
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- King's College London
Neuropathology
Prospective Study Evaluating the Interest of Long-term Cardiac Recording in Cerebral Infarction
Cerebral infarction (CI) can be linked to atherosclerosis of large vessels, occlusion of small vessels intracerebral (gaps), a cardioembolic disease or other rare causes.
- Trial name
- SPIDERFLASH (NCT02778321)
- Testing
- Uses of SpiderFlash monitor
- Where
- France
- Volunteers
- 108 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Neuropathology
Assessment of the Prevalence of Small Fiber Peripheral Neuropathy Among Non-diabetic Obese Patients
Background / rational: Obesity is associated with significant comorbidities including type 2 diabetes (insulin resistance), heart disease, stroke, hypertension, sleep apnea syndrome, dyslipidemia, cancer, hepatobiliary diseases…
- Trial name
- NEUROBISITE (NCT02767583)
- Testing
- Exams
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Preclinical Imaging Biomarkers of Alzheimer's Disease Neuropathology in Young Adults With Youth-onset Diabetes: a Proof-of-concept Study
The goal of the study is to characterize preclinical Alzheimer's Disease and related dementias (AD/ADRD) neuropathology in a selected group of young adults with youth-onset diabetes, and an age-similar group of young adults…
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetes, Youth Onset
- Trial name
- NCT05350514
- Testing
- PI-2620 tracer
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Alzheimer's Disease
Memory Imaging of Normal Aging
The purpose of this study is to develop imaging techniques that can distinguish functional brain changes in people at high risk for dementia years prior to onset of clinical memory problems from those with normal changes of aging.
- Trial name
- NCT00315575
- Testing
- BOLD and Perfusion brain MRI
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Coma, Disorder of Consciousness
Development of a Point of Care System for Automated Coma Prognosis
Electroencephalogram/event-related potentials (EEG/ERP) data will be collected from 50 participants in coma or other disorder of consciousness (DOC; i.e., Unresponsive Wakefulness Syndrome [UWS] or Minimally Conscious State…
- Conditions
- Coma, Disorder of Consciousness, Minimally Conscious State, Vegetative State
- Trial name
- NCT03826407
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- McMaster University
Muscular Dystrophies, Muscle Myopathies
Genetic and Physical Study of Childhood Nerve and Muscle Disorders
Background: Some nerve and muscle disorders that start early in life (before age 25), like some forms of muscular dystrophy, can run in families. However, the genetic causes of these disorders are not known.
- Conditions
- Muscular Dystrophies, Muscle Myopathies, Hereditary Spastic Paraplegias, Inherited Neuropathies
- Trial name
- NCT01568658
- Where
- United States
- Volunteers
- 2,586 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Multiple Sclerosis, Parkinson Disease
Early Detection of Selected Neuropathologies in Motor Vehicle Drivers
This study aims to develop accessible methods for the early detection of selected neuropathologies in drivers, focusing on multiple sclerosis and Parkinson's disease.
- Trial name
- NeuroDrive (NCT07360886)
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- University Hospital Olomouc
Epilepsy, Quality of Life
Idiopathic Generalized Epilepsy Cognitive and Emotional Profile
The primary goal of the study is to explore the neurocognitive, emotional-behavioral functioning, and quality of life of adolescents with IGE, identifying key factors that affect their overall well-being.
- Conditions
- Epilepsy, Quality of Life, Neuropathology, Emotional Problem
- Trial name
- NCT06782074
- Testing
- emotional and neuropsychological assessment
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Bipolar Disorder, Depression
Brain Tissue Collection for Neuropathological Studies
The purpose of this study is to collect and study the brain tissue of deceased individuals to learn more about the nervous system and mental disorders.
- Conditions
- Bipolar Disorder, Depression, Anxiety Disorders, Schizophrenia
- Trial name
- NCT00001260
- Where
- 3 sites in United States
- Volunteers
- 2,161 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Type 2 Diabetes, Alzheimer Disease
Relationship and Central Mechanism Between Diabetes and Cognitive Impairment Based on Simultaneous EEG-fMRI Approach and Peripheral Neuropathology Biomarkers Assay
This is a cross-sectional and longitudinal study to investigate the relationship and central mechanism between type 2 diabetes and cognitive impairment based on the simultaneous EEG-fMRI approach and peripheral neuropathology…
- Conditions
- Type 2 Diabetes, Alzheimer Disease, Cognitive Impairment
- Trial name
- NCT05545657
- Testing
- Cognitive assessments, Simultaneous EEG-fMRI scan, Multimodal magnetic resonance imaging
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Defecation Disorder, Neuropathology
Neuropathological Changes of the Intestinal Wall in Patients With Bowel Evacuation Disorders
Constipation and defecation disorders affect about 15% of the European population and of those up to 30% of the patients over 65 years of age.
- Conditions
- Defecation Disorder, Neuropathology, Autoimmune Diseases
- Trial name
- Constipation (NCT05016700)
- Testing
- blood sample
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Evangelisches Klinikum Köln Weyertal gGmbH
Unruptured Brain Arteriovenous Malformation
Exploratory Study of Cerebral Perfusion and Metabolic Alterations and Neurocognitive Disorders in Patients With Unruptured Arteriovenous Malformations Before and After Surgical Treatment
The goal of the clinical trial is to describe perfusion and metabolic alterations in different brain regions before and six months after surgical treatment of arteriovenous malformations in adult patients with unruptured…
- Trial name
- APEMMAV-NR (NCT07569887)
- Testing
- 18F-FDG PET imaging, Neuropsychological Assessment
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Montpellier
Aphasia, Development, Human
Cognitive Functioning in Adults With Somatic Diseases and General Population From a Biopsychosocial Perspective
The goal of this observational study is to investigate cognitive functioning profiles in adults with neurologically recognized aphasic syndromes and general population.
- Conditions
- Aphasia, Development, Human, Neuropathology
- Trial name
- NCT06365658
- Testing
- Psychological assessment
- Where
- Poland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Bartosz M. Radtke
Central Nervous System Tumor
Fluorescence Detection of Adult Primary Central Nervous System Tumors With Tozuleristide and the Canvas System
The purpose of this study is to examine the use of a single dose of tozuleristide (24 or 36 mg) and the Canvas imaging system during surgical resection of primary central nervous system (CNS) tumors: Primary gadolinium enhancing…
- Trial name
- NCT04743310
- Testing
- tozuleristide, Canvas imaging system, Surgical resection of tumor
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- John Yu
Glioblastoma Multiforme
Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma
The purpose of this study is to assess the safety/tolerability/feasibility of pembrolizumab and radiation therapy before surgical resection in patients with recurrent glioblastoma as defined by treatment-related AEs and the…
- Trial name
- NCT04977375
- Testing
- Pembrolizumab, Stereotactic Radiation Therapy, Surgical Resection
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Chirag G. Patil
Nervous System Diseases
Collection of Biological Samples From Patients With Rare Neurological Diseases
The aim of this project is to improve biological collections of patients presenting rare neurological disorders with known or suspected autoimmune origin.
- Trial name
- EXPLAINEUR (NCT04698421)
- Testing
- Blood collection on admission and longitudinally
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Toulouse