Clinical trials: Neuron Specific Enolase
Out-of-Hospital Cardiac Arrest, Hypoxic-Ischemic Brain Injury
Minimal Sedation Versus Standard Continuous Sedation After Out-of-Hospital Cardiac Arrest
Most patients resuscitated from out-of-hospital cardiac arrest (OHCA) remain comatose on hospital admission and are routinely managed with continuous sedation.
- Conditions
- Out-of-Hospital Cardiac Arrest, Hypoxic-Ischemic Brain Injury, Post-Cardiac Arrest Syndrome
- Trial name
- NCT07895771
- Testing
- Minimal sedation, Standard continuous sedation
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana
Out of Hospital Cardiac Arrest, Brain Injury
Therapeutic Hypothermia and eArly Waking
Unconscious survivors of cardiac arrest who are treated with intravenous therapeutic hypothermia for 24 hours will be assessed after 12 hours for appropriateness to be woken early and extubated whilst continuing to receive…
- Trial name
- THAW (NCT03065946)
- Testing
- Early wakening
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Cardiac Arrest, Hypothermia
Neuron Specific Enolase (NSE) as Outcome Parameter of Cooling Therapy After Survived Sudden Cardiac Death
Sudden cardiac death remains one of the major leading causes of death. Therapeutic hypothermia is a validated standard procedure to avoid or minimize cognitive deficits after cardiac arrest.
- Trial name
- NCT01102153
- Testing
- Coolgard, ArcticSun
- Where
- 2 sites in Germany
- Volunteers
- 108 people
- Sponsor
- University of Leipzig
Brain Damage, Postoperative Cognitive Dysfunction
Liver Transplant Does it Affect the Brain
Neuronal damage caused by neuroinflammation in patients undergoing major surgery is the most determinant factor of postoperative cognitive disfunction (POCD).
- Conditions
- Brain Damage, Postoperative Cognitive Dysfunction, Neuron Specific Enolase, Glial Fibrillary Acidic Protein
- Trial name
- NCT04368052
- Testing
- Mini Mental Test (MMT), S-100 beta, Neuron specific enolase and Glial fibrillary acidic protein
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Ege University
Donor Site Complication, Delirium
s100β, NSE n GFAP in Living Donor Hepatectomy and Delirium
The post-operative delirium picture is a serious and common complication seen after any major surgery, including hepatic resection.
- Conditions
- Donor Site Complication, Delirium, Uremic Encephalopathy, Neurologic Manifestations
- Trial name
- NCT04422925
- Testing
- Living Donor Hepatectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Cervical Compression Myelopathy, Ischemia
Clinical Trial of Remote Preconditioning in Patients Undergoing Cervical Decompression Surgery
The purpose of this study is to assess whether a large clinical trial testing the effect of RIPC on neurologic outcome in patients undergoing elective cervical decompression surge is warranted.
- Conditions
- Cervical Compression Myelopathy, Ischemia, Reperfusion Injury, Spinal Cord Injury
- Trial name
- NCT00778323
- Testing
- limb remote ischemic preconditioning (LRIPC)
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Xijing Hospital
Generalized Epilepsy
Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy
Epilepsy is one of the most common and frequently encountered neurological conditions that impose a huge burden on the healthcare systems.
- Trial name
- NCT03590197
- Testing
- Melatonin 3 mg
- Where
- India
- Volunteers
- 104 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Spinal Injury
Neuromarker S-100B as Diagnostic Tool
The hypothesis of this study is to find evidence if there is an influence of spine surgery on the serum levels of two proteins secreted from neuronal cells.
- Trial name
- SpineSurgery (NCT01840397)
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Cardiac Surgery, Postoperative Cognitive Dysfunction
The Effects of Dexmedetomidine on Postoperative Cognitive Function in Open Heart Surgery
To assess the impact of Dexmedetomidine on postoperative cognitive function and serum Neuron Specific Enolase levels as an indicator of neuronal injury in patients undergoing open heart surgery
- Conditions
- Cardiac Surgery, Postoperative Cognitive Dysfunction, Neurologic Manifestations
- Trial name
- NCT06655025
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Sohag University
Heart; Surgery, Heart, Functional Disturbance as Result
The Use of Cooling Helmet for Neuroprotection Management in Open Heart Surgery
To know the relationship between the use of cooling helmet with the changes of NSE level and postoperative delirium event in open heart surgery
- Trial name
- NCT05264766
- Testing
- Cooling helmet on, Cooling helmet off
- Where
- Indonesia
- Volunteers
- 26 people
- Sponsor
- Universitas Indonesia
Out-of-hospital Cardiac Arrest (OHCA), Post-Cardiac Arrest Syndrome
Pulse Pressure and Outcomes After Out-of-Hospital Cardiac Arrest
STEP-PRESS is a predefined exploratory observational substudy nested within the STEPCARE trial. The study will evaluate whether early low pulse-pressure burden after out-of-hospital cardiac arrest is associated with early…
- Trial name
- STEP-PRESS (NCT07586878)
- Where
- Sweden
- Volunteers
- 3,500 people
- Sponsor
- Region Skane
Postoperative Cognitive Dysfunction, NEURON SPECIFIC ENOLASE
EFFECT OF ANESTHESİA TECHNIQUES ON POSTOPERATİVE COGNİTİVE DYSFUNCTION FOR MMSE AND NSE LEVEL
The aim of this study is to compare the effects of total intravenous anesthesia and inhalation anesthesia methods on postoperative cognitive dysfunction according to Mini Mental State Examination scores and Neuron Specific…
- Conditions
- Postoperative Cognitive Dysfunction, NEURON SPECIFIC ENOLASE, MINI MENTAL STATE EXAMINATION TEST
- Trial name
- NCT04279132
- Testing
- POSTOPERATIVE COGNITIVE DYSFUNCTION
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Erzincan University
Silent Stroke, Coronary Disease
Evaluation of Brain Damage Due to Coronary Angioplasty in Percutaneous Intervention Patients
This study examines the formation mechanism and patient-related factors of silent cerebral infarcts, whose importance has become increasingly recognized in patients undergoing percutaneous coronary intervention.
- Trial name
- NCT04734587
- Testing
- Blood serum Neuron-specific Enolase measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ondokuz Mayıs University
Trauma, Brain
Impact of Amantadine on Traumatic Brain Injury
The aim of this study is to evaluate whether the addition of amantadine to the management regimen of traumatic brain injury patients would have a favorable effect on recovery and neurological complications in association with…
- Trial name
- NCT04527289
- Testing
- Amantadine (100mg) as add on therapy.
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Damanhour University
Out-Of-Hospital Cardiac Arrest, Postcardiac Arrest Syndrome
Steroid, Thiamine and Ascorbic Acid for Comatose Out-of-hospital Cardiac Arrest Survivors
The mortality and neurological outcomes among out-of-hospital cardiac arrest survivors have not improved despite the medical advances. The whole body ischemia/reperfusion injuries after cardiac arrest mainly damaged the brain.
- Trial name
- NCT04921189
- Testing
- The combined supplement of Ascorbic acid, Thiamine, and Cortisol
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Asan Medical Center
Congenital Heart Disease (CHD), Hypoxic Encephalopathy
Early Detection of Brain Injury After Congenital Heart Surgery in Infants
Infants with congenital heart disease undergoing cardiac surgery with extracorporeal circulation are at risk for perioperative hypoxic-ischaemic brain injury.
- Trial name
- NCT07424976
- Testing
- Observational study: blood analisys, EEG, MRI
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Carcinoma, Non-Small-Cell Lung
NSE/Alb as a Prognostic Biomarker for Lung Cancer
The incidence and mortality rate of lung cancer is the highest in the world. Current studies have found that tumor markers, inflammatory or nutritional indicators have a good predictive value for the prognosis of patients with…
- Trial name
- NARPBLC (NCT03724604)
- Testing
- Neuron-Specific Enolase to Albumin Ratio
- Where
- China
- Volunteers
- 202 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Traumatic Brain Injury
Safety of Darbepoetin Alfa Treatment in Patients With Severe Traumatic Brain Injury
The purpose of this study is to see if the treatment of severely brain injured patients with darbepoetin (a long acting form of erythropoietin) will be safe, and will reduce brain damage by decreasing harmful levels of chemicals…
- Trial name
- NCT00375869
- Testing
- Darbeopoetin
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- Royal Alexandra Hospital
Peri-operative Injury, Newborn, Infant, Disease
Cerebral Oxymetry and Neuronal Markers in Newborns and Infants Undergoing Surgery
The purpose of this study is to assess whether peri-operative period in neonates and infants is associated with an increase in blood biomarkers, specific for neuronal injury, and to correlate them with clinical variables and…
- Trial name
- NEMARKO (NCT02423369)
- Testing
- Cerebral near infrared spectroscopy, S-100B protein in serum, NSE protein in serum
- Where
- Lithuania
- Volunteers
- 49 people
- Sponsor
- Lithuanian University of Health Sciences
Advanced Non Small Cell Lung Cancer (NSCLC)
Clinical Effects of Alpha-Lipoic Acid in Advanced NSCLC
Non-small cell lung cancer (NSCLC) is a common and aggressive type of lung cancer often diagnosed at advanced stages, with limited treatment options and poor prognosis.
- Trial name
- ALA /NSCLC (NCT07574684)
- Testing
- Alpha Lipoic Acid 600mg
- Volunteers
- 60 people
- Sponsor
- Ain Shams University