Clinical trials: Neuromuscular Signs and Symptoms
Piriformis Syndrome
Comparative Effects of PIR and PFS on Pain, Hip ROM, and Disability in Piriformis Syndrome
This randomized clinical trial evaluates the effectiveness of Post-Isometric Relaxation (PIR) and Post-Facilitation Stretching (PFS) for managing pain, improving hip abduction and internal rotation, and enhancing functional…
- Trial name
- PIR-PFS RCT (NCT07255053)
- Testing
- Post Isometric Relaxation (PIR), Post Facilitation Stretching (PFS)
- Where
- Pakistan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Faisalabad
Muscle Atrophy, Insulin Sensitivity
Metabolic and Muscular Adaptations During Inactivity in 3 Days of Bed-rest
Space flight is associated with detrimental changes to the human body, including bone and muscle loss, fluid changes and deconditioning of muscles in the heart and blood vessels.
- Trial name
- NCT03495128
- Testing
- Bed Rest, Reconditioning
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Hemiplegia, Spastic, Spastic
Wearable Robotic System and Robotic Mirror Therapy in Spastic Hemiplegia Post Botulinum Toxin Injection
The purpose of this project is to examine and compare the immediate and long-term effects of combined Botulinum toxin type A(BoNT-A) injection with wearable robotic hand system (RT) and Robotic mirror therapy (RMT) in patients…
- Trial name
- NCT04826900
- Testing
- BoNT-A injections, Robotic therapy (RT), Robotic mirror therapy (RMT)
- Where
- Taiwan
- Volunteers
- 31 people
- Sponsor
- Chang Gung Memorial Hospital
Neuralgia
Botulinum Toxin Type A for Neuropathic Pain in Patients With Diabetic Peripheral Polyneuropathy
The purpose of this study is to determine whether botulinum toxin A is effective in the treatment of neuropathic pain in patients with diabetic peripheral polyneuropathy.
- Trial name
- BTXADMPPNP (NCT02460107)
- Testing
- Botulinum toxin type A, Normal saline
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Catholic University of Korea Saint Paul's Hospital
Spinal Cord Injuries, Neurological Injury
Physiological Changes Induced Through MEP Conditioning in People With SCI
The study team is currently recruiting volunteers who are interested in participating in a brain-spinal cord-muscle response training study that aims to better understand the changes that take place in the nervous system as a…
- Conditions
- Spinal Cord Injuries, Neurological Injury, Paralysis, Spasticity, Muscle
- Trial name
- NCT04286191
- Testing
- Operant Conditioning, Control Group
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Medical University of South Carolina
Healthy
Novel Positron Emission Tomography (PET) Radiotracer to Image Phosphodiesterase-4B (PDE4B)
Background: The new drug 18F-PF-06445974 has a little radioactivity. This can be seen by a positron emission tomography (PET) scan. The drug helps researchers see a protein, PDE4B, in the brain.
- Trial name
- NCT03030391
- Testing
- PET, MRI
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Systemic Lupus Erythematosus (SLE), Idiopathic Inflammatory Myopathy (IIM)
Safety Study of CC312 in Autoimmune Disease Patients
This study is an open-label, multiple-dose escalation, Investigator-Initiated Trial (IIT) clinical trial designed to evaluate the safety and tolerability of CC312 in adult patients with relapsed and refractory autoimmune…
- Conditions
- Systemic Lupus Erythematosus (SLE), Idiopathic Inflammatory Myopathy (IIM), Systemic Sclerosis (SSc), Rheumatoid Arthritis (RA)
- Trial name
- NCT06888960
- Testing
- CC312
- Where
- China
- Volunteers
- 18 people
- Sponsor
- CytoCares Inc
Spinal Cord Injuries
Vibration for Muscle Spasms After Spinal Cord Injury
This study uses closed-loop control of tendon vibration to implement clinically meaningful management of muscle spasms after spinal cord injury (SCI), and to understand the mechanisms responsible for spasm generation change in…
- Trial name
- NCT03598504
- Testing
- Wearable EMG/Vibration device
- Where
- United States
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Mental Fatigue, Fatigue
Effect of Ginko and Cistanche Against Fatigue Symptoms
To evaluate the efficacy of Nutrilite® ginkgo biloba cistanche tablets in relieving the symptoms of chronic fatigue syndrome(CFS), the investigators randomly recruit189 subjects with CFS, aged 35-60 yrs.
- Conditions
- Mental Fatigue, Fatigue, Chronic Fatigue Syndrome
- Trial name
- GkoCist (NCT02807649)
- Testing
- Experimental: Nutrilite® Low dose, Experimental: Nutrilite® High dose
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Access Business Group
Pain, Peripheral Neuropathy
Effects of Neurofeedback on Neural Function, Neuromodulation, and Chemotherapy-Induced Neuropathic Pain
The goal of this study is to learn if using a non-invasive therapy called "neurofeedback training" can help teach patients ways to modify their own brain waves to decrease the perception of pain and improve quality of life.
- Trial name
- NCT01278225
- Testing
- EEG biofeedback (BF) Group, Wait-List Control (WLC) Group, Follow UP Questionnaires
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- M.D. Anderson Cancer Center
Chronic Fatigue Syndrome, Coping
Coping With Chronic Fatigue Syndrome: Development of a Community-based Patient Education Program
The aim of the study is to develop, carry out, evaluate and measure the effects of a new patient education program for patients with Chronic Fatigue Syndrome (CFS)in primary healthcare.
- Conditions
- Chronic Fatigue Syndrome, Coping, Patient Education
- Trial name
- NCT01765725
- Testing
- Patient education program
- Where
- Norway
- Volunteers
- 146 people
- Sponsor
- Oslo University Hospital
Thyroid Diseases, Cognition Disorders
Mohawk Culture, Behavior, Toxicant Exposure and Health
This study will determine the pathways between Mohawk cultural identification and specific behaviors related to pollutant exposure, and determine the effects of these factors and the pollutant exposure on physiologically and…
- Trial name
- NCT00043238
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Myofascial Pain Dysfunction Syndrome
Lidocaine Versus Magnesium Sulphate in Management of Myofascial Pain Dysfunction Syndrome
The goal of this clinical trial is to investigate the effectiveness of Magnesium Sulphate in the management of myofascial pain dysfunction syndrome in comparison to Lidocaine and Saline.
- Trial name
- NCT06595017
- Testing
- Magnesium sulphate, Lidocaine (drug), Saline
- Volunteers
- 75 people
- Sponsor
- Misr University for Science and Technology
Multiple Sclerosis
Safety and Efficacy Study of Oral Fampridine-SR in Patients With Multiple Sclerosis
Multiple Sclerosis (MS) is a disorder of the body's immune system that affects the Central Nervous System (CNS). Normally, nerve fibers carry electrical impulses through the spinal cord, providing communication between the brain…
- Trial name
- NCT00053417
- Testing
- 10 milligram (mg) fampridine-SR (4-aminopyridine, 4-AP), 15 mg fampridine-SR (4-aminopyridine, 4-AP), 20 mg fampridine-SR (4-aminopyridine, 4-AP)
- Where
- 25 sites in United States, Canada
- Volunteers
- 206 people
- Sponsor
- Acorda Therapeutics
Sarcopenic Obesity, Acupuncture Treatment
The Effect of Acupuncture on Sarcopenia and Obesity in Patients With Sarcopenic Obesity.
Sarcopenia is defined by the European Working Group on Sarcopenia in Older People (EWGSOP) as "a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength, carrying a risk of adverse outcomes…
- Conditions
- Sarcopenic Obesity, Acupuncture Treatment, Exercise
- Trial name
- Sarcopenia (NCT07797140)
- Testing
- Diet and exercise, Acupuncture
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Ayşe Ukbe Baykut
Sarcopenia in Elderly, Chronic Heart Failure
Effects of Resistance Training on Sarcopenia in Older Patients With Chronic Heart Failure
The goal of study is to evaluate the effects of an eight-week machine-based resistance training program on managing sarcopenia in older outpatients with chronic heart failure (HF) at Military Hospital 175.
- Trial name
- NCT06785168
- Testing
- Machine-based Resistance Training
- Where
- 2 sites in Vietnam
- Volunteers
- 146 people
- Sponsor
- Kieu Dang Phuong Nguyen
Cachexia
The Impact of Oligo-Fucoidan in Cancer Cachexia and Sarcopenia
Fucoidan also ameliorates tumour and chemotherapy-induced muscle atrophy and -related cachectic symptoms in vivo and in vitro. To evaluate the effect of fucoidan in cancer cachexia or sarcopenia in cancer patients.
- Trial name
- OFCS (NCT05623852)
- Testing
- fucoidan
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Medical University WanFang Hospital
Cirrhosis, Myosteatosis
Protocol for Muscle Attenuation Cut-offs in Cirrhosis
The goal of this observational study is to learn if new muscle attenuation cut-offs for the definition of myosteatosis can better predict survival in patients with cirrhosis.
- Conditions
- Cirrhosis, Myosteatosis, Sarcopenia, Sarcopenia in Liver Cirrhosis
- Trial name
- Myocirrhosis (NCT06593015)
- Testing
- Radiological tool for the diagnosis of myosteatosis
- Where
- Italy
- Volunteers
- 1,296 people
- Sponsor
- University of Roma La Sapienza
Liver Cirrhosis, Sarcopenia
A Study to Assess the Efficacy, Safety, and Tolerability of Oral LPCN 1148 in Male Subjects With Cirrhosis of the Liver and Sarcopenia
This is a randomized, double-blind, placebo-controlled study to assess the efficacy, safety, and tolerability of LPCN 1148 in men with cirrhosis of the liver and sarcopenia.
- Trial name
- NCT04874350
- Testing
- LPCN 1148
- Where
- 10 sites in United States
- Volunteers
- 30 people
- Sponsor
- Lipocine Inc.
Delayed Onset Muscle Soreness (DOMS), Inflammation
Effects of Immediate and Delayed Repeated Cold Exposure After Physical Exertion
The goal of this clinical trial is to learn if applying cold therapy can reduce swelling, inflammation, and pain after physical activity in adults who experience muscle soreness (Delayed Onset Muscle Soreness, or DOMS).
- Conditions
- Delayed Onset Muscle Soreness (DOMS), Inflammation, Muscle Pain, Muscle Damage
- Trial name
- NCT06813690
- Testing
- Cold Therapy with Axanova Cold Hot Pearls Maxi Pack
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences and Arts of Southern Switzerland
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