Clinical trials: Neurological Impairment
Mild Cognitive Impairment
Water-based Activity to Enhance Recall in Veterans
This two-year study will evaluate the feasibility of an exercise training augmentation for cognitive training intervention to improve memory performance in Veterans with a diagnosis of amnestic Mild Cognitive Impairment (aMCI).
- Trial name
- WATER-VET (NCT02614092)
- Testing
- Water-based Activity + Cognitive Training
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Bronchopulmonary Dysplasia, Encephalomalacia
Randomized Trial of Hydrocortisone in Very Preterm High-Risk Infants
The purpose of this study is to determine whether treatment of very preterm infants at high-risk for lung and brain injury with low dose hydrocortisone results in improved pulmonary and neurologic outcomes.
- Conditions
- Bronchopulmonary Dysplasia, Encephalomalacia, Premature Birth
- Trial name
- NCT00167544
- Testing
- Hydrocortisone
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Nationwide Children's Hospital
Sleep Disorder
Melatonin CR for the Treatment of Impaired Sleep Maintenance in 4-8 Year Old Children With Autism Spectrum Disorders
The purpose of this research is to see the effects (good and bad) of Melatonin CR on sleep in 4-8 year old children with autism spectrum disorders and sleep problems.
- Trial name
- NCT01033565
- Testing
- Natrol
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Nebraska
Developmental Language Disorder and Language Impairment, Specific Language Impairment
Retrieval-Based Word Learning in Developmental Language Disorder During Book Reading II
Children with developmental language disorder (DLD; also referred to as specific language impairment) experience a significant deficit in language ability that is longstanding and harmful to the children's academic, social, and…
- Conditions
- Developmental Language Disorder and Language Impairment, Specific Language Impairment, Language Development
- Trial name
- NCT07048392
- Testing
- Retrieval-based word learning: Repeated Spaced Retrieval condition, Retrieval-based word learning: Repeated Study condition
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Purdue University
Breast Cancer, Postoperative Pain
The Effect of Rhomboid Intercostal Block and Serratus Anterior Plane Block on Postoperative Respiratory Functions
Rhomboid intercostal block is used to block lateral cutaneous branches of intercostal nerves between T3 and T9 dermatomes. Serratus anterior plane block is used to block lateral cutaneous branches of intercostal nerves between T2…
- Conditions
- Breast Cancer, Postoperative Pain, Respiratory Function Impaired
- Trial name
- RIBSAB (NCT05547932)
- Testing
- RIB+SAP blocks
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Muğla Sıtkı Koçman University
Vision Impairment, Eye Diseases
The Proactive Ophthalmic Examination Cohort
The Proactive Ophthalmic Examination Cohort of Older Adults is a prospective cohort study recruiting community-dwelling older adults aged 65 years or older.
- Trial name
- POEC (NCT05851287)
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Healthy, Teenagers
Effect of an Audio Instructional Program Regarding Puberty on Self-Concept and Healthy Behaviors of Teenage Girls With Visual Impairment
Background: Teenage girls, who are a vulnerable group, require special care and attention, particularly when puberty begins. A consistent teaching program about menstruation should be offered to adolescent girls with visual…
- Conditions
- Healthy, Teenagers, Girls, Self-concept
- Trial name
- Teen Audio (NCT07496606)
- Testing
- structured audio instructional program regarding puberty
- Where
- Palestinian Territories
- Volunteers
- 46 people
- Sponsor
- Al-Quds University
Hearing Impaired
Effects of Stimulus Validity on Speech Recognition
The effects of talker variability will be investigated with four groups of listeners (young normal-hearing; old normal-hearing; young hearing-impaired; old hearing-impaired).
- Trial name
- NCT00013364
- Testing
- Talker variability
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- US Department of Veterans Affairs
Motor Impairments, Orthopaedic Injuries
Gait Characteristics Following a Fall
The purpose of this study is to quantify the safety degree of the patient's gait, to detect the reason for the fall and quantify the biomechanical parameters related to fall.
- Conditions
- Motor Impairments, Orthopaedic Injuries, Neurological Conditions
- Trial name
- NCT01631604
- Testing
- Walking aids and devices, Muscle/nerve injection, Corrective surgery
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Coronary Artery Disease, Cognitive Impairment
Cerebral Oxygenation and Neurological Functioning After Cardiac Surgery
The overall goal of this research program is to determine quantitative predictors of quantitative long-term neurological functioning following different cardiac surgery procedures.
- Conditions
- Coronary Artery Disease, Cognitive Impairment, Delirium
- Trial name
- CONFUSE (NCT04081649)
- Where
- Canada
- Volunteers
- 95 people
- Sponsor
- Dr. Gordon Boyd
Delirium, Dementia
Delirium and Cognitive Impairment Development in Hospitalized Older Adults Under Isolation Conditions
The goal of this observational study is to examine if older patients who need to be under isolation precautions due to multidrug resistant bacteria or other reasons have an increased risk of suffering from delirium or cognitive…
- Conditions
- Delirium, Dementia, Cognitive Impairment
- Trial name
- DELiso (NCT07114458)
- Where
- Germany
- Volunteers
- 404 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Memory Disorders, Mild Cognitive Impairment
Physical Exercise for Prevention of Dementia
The principal aim of this study is to verify whether a program of supervised, multimodal physical exercise improves cognitive function and/or reduces the rate of cognitive decline in older adults
- Conditions
- Memory Disorders, Mild Cognitive Impairment, Aging
- Trial name
- EPD (NCT02236416)
- Testing
- Intervention group, Control group
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Molise
Stroke, Hemiplegia
Virtual Reality-Based Mirror Therapy and FES-Cycling in Stroke Rehabilitation
This randomized controlled, assessor-blinded study aimed to compare the effects of virtual reality-based mirror therapy (VRBMT) and functional electrical stimulation-assisted cycling (FES-cycling) when combined with conventional…
- Conditions
- Stroke, Hemiplegia, Upper Extremity Impairments
- Trial name
- NCT07666308
- Testing
- Conventional Rehabilitation, Virtual Reality-Based Mirror Therapy, Functional Electrical Stimulation-Assisted Cycling
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara City Hospital Bilkent
Gastric Cancer Stage, Esophageal Cancer
Development and Validation of a Risk Prediction Model for Gastric Retention in Patients Undergoing Sedated Gastroscopy
Gastric retention not only compromises the quality of endoscopic examination but also significantly increases the risk of reflux and aspiration in sedated patients.
- Conditions
- Gastric Cancer Stage, Esophageal Cancer, Gastroparesis
- Trial name
- NCT07104214
- Where
- 3 sites in China
- Volunteers
- 5,000 people
- Sponsor
- Zhejiang University
Retinal Degeneration, Vision Impairment and Blindness
Multicenter Study of Transcranial Magnetic Stimulation on Vision Restoration
The goal of this clinical trial is to learn if transcranial magnetic stimulation (TMS) works to restore vision in adults with severe retinal degeneration. It will also learn about the safety of TMS treatment.
- Trial name
- NCT07425717
- Testing
- Transcranial magnetic stimulation targeting occipital visual cortex
- Where
- 4 sites in China
- Volunteers
- 136 people
- Sponsor
- Shanghai High Myopia Study Group
Neurodegenerative Diseases, Parkinson Disease
Neurodegenerative Diseases Progression Markers (MARKERS-NDD)
MARKERS-NDD is a prospective, observational, longitudinal study, which aims to collect data from patients affected by neurodegenerative diseases (NDD) followed longitudinally for routine examinations performed as part of normal…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Synucleinopathies, Lewy Body Disease
- Trial name
- MARKERS-NDD (NCT06596746)
- Testing
- Observation
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Casa di Cura San Raffaele Cassino
Stroke, Hemiparesis
Personalized Robotic Telerehabilitation for Upper Limb Functional Recovery After Stroke in a Home-Based Setting
Stroke is a leading cause of long-term disability worldwide, with upper-limb impairment representing a major determinant of functional limitation and reduced independence.
- Conditions
- Stroke, Hemiparesis, Upper Extremity Paresis, Motor Impairment
- Trial name
- ROBOHOME (NCT07590349)
- Testing
- Robotic-Assisted Telerehabilitation Virtual Reality-Based Telerehabilitation, Virtual reality-based rehabilitation platform without robotic assistance
- Volunteers
- 70 people
- Sponsor
- University of Campania Luigi Vanvitelli
Mild Cognitive Impairment, Alzheimer Disease
Understanding Brain Mechanisms Involved in Autobiographical Memory
The overall objective of this project is to characterize the spatiotemporal dynamics of brain oscillations underpinning autobiographical memory (ABM) and the modulation of the memory network using non-invasive brain stimulation.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Memory Loss
- Trial name
- NCT05710549
- Testing
- high-density electroencephalography (hdEEG), Transcranial alternating current stimulation (tACS)
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Lucie Bréchet
Preterm Birth, Visual Impairment
Eye and Growth in Adolescents Born Moderate-to-late Preterm
During recent years, the interest in studying the risks of being born moderate-to-late preterm (MLP), defined as birth between gestational week 32 to 36, has increased.
- Conditions
- Preterm Birth, Visual Impairment, Eye Abnormalities
- Trial name
- NCT04190147
- Testing
- Structural, functional and metabolic eye examinations
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Esophageal Motility Disorders, Gastric Motor Dysfunction
Gastrointestinal Dysmotility on Aspiration Risk
The hypothesis of this study is that esophageal and gastric dysmotility increase the risk of developing aspiration-associated symptoms in children with neurologic impairment.
- Conditions
- Esophageal Motility Disorders, Gastric Motor Dysfunction, Aspiration Pneumonia, Gastro Esophageal Reflux
- Trial name
- NCT05455359
- Testing
- Prucalopride, Famotidine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Boston Children's Hospital
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