Clinical trials: Neurological Development
Developmental Delay
Head Start Family Navigator Intervention
Headstart (HS) is an early childhood education program for low-income children. Preliminary analyses of Hamilton County HS preschoolers with developmental concerns identified 26% with "severe concern" necessitating developmental…
- Trial name
- HeadStartNav (NCT03499405)
- Testing
- Family Navigator Intervention
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Scoliosis
Effect of Early Morphine Administration on the Development of Acute Opioid Tolerance During Pediatric Scoliosis Surgery
The purpose of this study is to examine if morphine administered by bolus before initiating Remifentanil by infusion decreases the incidence of acute post-operative opioid tolerance as demonstrated by decreased post - operative…
- Trial name
- NCT00737997
- Testing
- Morphine, Saline
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- The Hospital for Sick Children
Bone Diseases, Pain
Denosumab Treatment for Fibrous Dysplasia
Objectives: The primary objective of this study is to evaluate the effect of denosumab on bone turnover in individuals with fibrous dysplasia (FD).
- Trial name
- NCT03571191
- Testing
- Denosumab
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder
Teacher Help for Children and Youth With Mental Health Disorders
Currently, Canadian school systems are struggling to meet the needs of children with mental health disorders. It is particularly challenging to meet the needs of students with neurodevelopmental disorders (NDDs) within the…
- Conditions
- Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder, Learning Disabilities
- Trial name
- TeacherHelp (NCT02919215)
- Testing
- Teacher Help Intervention
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- IWK Health Centre
Specific Developmental Disorders of Speech and Language, Specific Learning Disorder
Ambulatory Screening for Specific Learning Disabilities (SLD) and Developmental Coordination Disorder (DCD).
To evaluate, in primary care, the sensitivity of Heterophory-Vertical-Labile (HV-Labile) in ambulatory screening for Specific Learning Disabilities (SLD) and Developmental Coordination Disorder (DCD).
- Conditions
- Specific Developmental Disorders of Speech and Language, Specific Learning Disorder, Dyslexia, Developmental, Developmental Coordination Disorder
- Trial name
- TDys (NCT04122820)
- Testing
- Diagnostic of specific learning disabilities or of Developmental Coordination Disorder
- Where
- France
- Volunteers
- 1,800 people
- Sponsor
- CNGE IRMG Association
Development
Neurodevelopmental Outcomes of Preterm Infants Treated for Pain Management With Repeated Doses of Sucrose 24%
The purpose of this study is to determine the effect of sucrose 24% for pain prevention on preterm infants. Our hypothesis is that repeated doses of sucrose 24%, given prior to painful procedure,do not impair neurodevelopmental…
- Trial name
- NCT01742520
- Testing
- multiple doses of sucrose, Formula or breast milk
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Acute Myocardial Infarction, Stable Angina
Development and Efficacy Evaluation of Integrated Chronic Care and Health Promotion Model for Patients With Coronary Artery Disease in Taiwan
The hypothesis of this project is to examine whether the integrated health care program as the intervention group can reduce the recurrence and mortality of coronary artery-related diseases than the traditional one as the…
- Trial name
- NCT01357096
- Testing
- Integrated health care team, Traditional group
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Intellectual Disability, Developmental Disability
Research Engagement With People With Intellectual and Developmental Disabilities
The objectives of this project are to to build sustainable regional communities of Intellectual or Developmental Disabilities (IDD) stakeholders to provide ongoing input to research priorities, methodological processes, and…
- Conditions
- Intellectual Disability, Developmental Disability, Chronic Conditions, Multiple
- Trial name
- PCORI (NCT04182347)
- Testing
- Health Research ToolKit Development
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
CLIFAHDD, Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay
Aprepitant for the Treatment of CLIFAHDD
There are no drug treatments for individuals with Congenital Contractures of the Limb and Face, Hypotonia, and Developmental Delay (CLIFAHDD), an ultra-rare and severe neurodevelopmental disease.
- Conditions
- CLIFAHDD, Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay, NALCN Channelopathy, Ataxia - Other
- Trial name
- NCT07845825
- Testing
- Aprepitant Powder for Oral Suspension
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Cerebellar Ataxia, Healthy Adults
Circular Timed Up and Go (cTUG) for Ataxia: Development and Validation
Cerebellar ataxia (CA) is a collection of signs and symptoms caused by cerebellar dysfunction, which can be the result of different disease processes including hereditary and acquired conditions.
- Trial name
- cTUG (NCT05132647)
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Post-Traumatic Stress Disorder, Chronic, Depressed Mood
An Interrupted Time-Series Pilot Trial of LGBTQ-Affirming Cognitive Processing Therapy for Interpersonal and Developmental Trauma
The researchers are testing a single-group cognitive-behavioral intervention for treating traumatic stress related to interpersonal and developmental trauma in LGBTQ adults.
- Conditions
- Post-Traumatic Stress Disorder, Chronic, Depressed Mood, Depressive and Anxiety Disorders, Anxiety
- Trial name
- NCT07863817
- Testing
- Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Alabama at Birmingham
Microdeletion Syndromes, Trisomy 21
Development of Non-invasive Prenatal Test for Microdeletion and Other Genetic Syndromes Based on Cell Free DNA
The purpose of this study is to collect blood from families with a child who has been diagnosed with a chromosomal disorder including microdeletions in order to further develop a non-invasive prenatal screening test based on…
- Conditions
- Microdeletion Syndromes, Trisomy 21, Trisomy 18, Trisomy 13
- Trial name
- Microdel Triad (NCT02109770)
- Where
- 2 sites in United States
- Volunteers
- 216 people
- Sponsor
- Natera, Inc.
Nature, Human, Microbial Colonization
Biodiversity Interventions for Assisted Living Centers
Biodiversity is essential for nature and human well-being. Land use has reduced biodiversity in cities, which weakens the functionality of the urban ecosystems and the well-being of citizens.
- Conditions
- Nature, Human, Microbial Colonization, Well-Being, Psychological, Immune System and Related Disorders
- Trial name
- BIWE (NCT06390683)
- Testing
- Rewilding
- Where
- Finland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Natural Resources Institute Finland
Dravet Syndrome
A Phase 3, Placebo-Controlled Study to Investigate LP352 in Children and Adults With Dravet Syndrome (DS)
This (DEEp SEA Study) is a double-blind, randomized, placebo-controlled, multicenter study to investigate the efficacy, safety, and tolerability of LP352 in the treatment of seizures in children and adults with DS.
- Trial name
- NCT06660394
- Testing
- LP352
- Where
- 105 sites in United States, Australia and 16 more
- Volunteers
- 108 people
- Sponsor
- Longboard Pharmaceuticals
Developmental Delay
Effects of Rainbow Parachute Games on UE Strength and Social-Emotional Skills in Children With Developmental Delay
Conducted as a randomized trial, this study examines the impact of rainbow parachute games on upper extremity strength and social-emotional skills in children (ages 5-8) with developmental delays.
- Trial name
- NCT07756931
- Testing
- Rainbow parachute Games, Rhyming Activities
- Where
- Pakistan
- Volunteers
- 12 people
- Sponsor
- Riphah International University
Amblyopia, Anisometropic, Amblyopia Strabismic
Validation of New Virtual Reality Treatment for Children With Lazy Eye Using the Vedea Amblyopia Therapy (VAT)
The purpose of this clinical study is to validate the effectiveness of the Vedea Amblyopia Therapy (VAT) as a treatment for children with lazy eye.
- Conditions
- Amblyopia, Anisometropic, Amblyopia Strabismic, Amblyopia
- Trial name
- VAT (NCT05620173)
- Testing
- Vedea Amblyopia Therapy (VAT), Occlusion therapy
- Where
- 2 sites in Netherlands
- Volunteers
- 74 people
- Sponsor
- Vedea Healthware BV
Chronic Pain, Musculoskeletal Pain
Lessons in Affect Regulation to Keep Stress and Pain UndeR Control (LARKSPUR R34)
Chronic pain affects millions of Americans but integrative as well as conventional treatments fall short in terms of alleviating this pain.
- Trial name
- LARKSPUR (NCT03699553)
- Testing
- LARKSPUR; Online Positive Emotions Skills for Individuals with Chronic Musculoskeletal Pain, Emotion Reporting Control Group
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwestern University
Developmental Dyslexia
Orthophonic and / or Proprioceptive Treatment of Developmental Dyslexia.
To show the interest of the association of proprioceptive and orthophonic care of dyslexic children. The assumption is that proprioceptive support by correcting a centrally located spatial localization instability restores the…
- Trial name
- Pro-Pho-Dys (NCT03448237)
- Testing
- Speech Therapy, Proprioceptive treatment
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Scalab CNRS 9193
Intellectual Disability, Developmental Disability
Written Language Intervention for Adults With Intellectual and Developmental Disabilities
The purpose of this study is to evaluate the effects of a written language intervention using functional texts for young adults with intellectual and developmental disabilities.
- Trial name
- NCT05851937
- Testing
- Written language intervention
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Baylor University
Hearing Loss
Language Proficiency and Quality of Life After Receiving Cochlear Implantation as a Child
Treatment with cochlear implantation is now offered to proximately 95 % of children with deafness in Norway. More than 500 children have been operated at Oslo University Hospital.
- Trial name
- NCT01863875
- Where
- Norway
- Volunteers
- 530 people
- Sponsor
- Oslo University Hospital