Clinical trials: Neurodevelopmental Disorders (NDD)
SLC6A1 Neurodevelopmental Disorder (NDD), Developmental and Epileptic Encephalopathies (DEE)
SLC6A1-NDD Prospective Longitudinal Natural History Study
The overall objective of this prospective longitudinal natural history study is to collect clinical data to characterize and evaluate the natural course of SLC6A1-NDD and assess the feasibility of certain assessments for the…
- Trial name
- SPIRIT (NCT07531511)
- Where
- 3 sites in United States, France and 1 more
- Volunteers
- 60 people
- Sponsor
- UCB Biopharma SRL
Autism Spectrum Disorder, Autism Spectrum Disorder (ASD)
Intranasal Insulin for Autism Spectrum Disorder in Children and Young Adults Aged 4 to 21 Years
This observational study evaluates the real-world use of intranasal insulin in children and young adults with autism spectrum disorder (ASD) utilizing the ViaNase™ device developed by Kurve Therapeutics.
- Conditions
- Autism Spectrum Disorder, Autism Spectrum Disorder (ASD), Autism Spectrum Disorder High-Functioning, Autism Spectrum Disorder With Absence of Functional Language
- Trial name
- IN-INS-AUT (NCT07521371)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Healing Hope International
Autism Spectrum Disorder (ASD), Neurodevelopmental Disorders
Multi-observational Study for the Early Identification of Autism Spectrum Disorder (ASD) and Other Neurodevelopmental Disorders (NDD) in At-risk Populations
Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) that affects about 78 million people worldwide. Its prevalence and degree of impact on individuals and families place it among disorders of global importance.
- Trial name
- BABY@NET (NCT06915805)
- Where
- 5 sites in Italy
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- Istituto Superiore di Sanità
Neurodevelopmental Disorders (NDD)
Creative Processes and Children With a Neurodeveloppement Disorder
Neurodevelopmental disorders (NDDs) are associated with diverse cognitive profiles, including creative abilities that remain poorly documented.
- Trial name
- CREADEV (NCT07803146)
- Where
- France
- Volunteers
- 212 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ADHD
A Comparison of Group Cognitive Behavioural Therapy (CBT) and Structured Activity Group for Adults With Attention Deficit Hyperactivity Disorder (ADHD)
Many adults with attention deficit hyperactivity disorder (ADHD) experience difficulties with inattention, planning, impulsivity and emotion regulation that impacts work and social life negatively also after treatment with…
- Trial name
- NCT07834437
- Testing
- Group CBT based on DBT-skills training, Activity group
- Where
- 2 sites in Sweden
- Volunteers
- 120 people
- Sponsor
- Region Stockholm
Nonorganic Insomnia, Neurodevelopmental Disorders
Better Nights, Better Days for Children With Neurodevelopment Disorders
More than 90% of children with neurodevelopmental disorders (NDD) experience sleep problems, whereas less than 25% of typically developing children experience sleep problems.
- Conditions
- Nonorganic Insomnia, Neurodevelopmental Disorders, Primary Insomnia
- Trial name
- BNBD-NDD (NCT02694003)
- Testing
- BNBD-NDD Intervention
- Where
- Canada
- Volunteers
- 218 people
- Sponsor
- IWK Health Centre
Neurodevelopmental Disorders (NDD), Preschool Child Development
Efficacy of a Group-based and Digital Parent Sleep Intervention in HK Preschoolers With NDDs
Neurodevelopmental disorders (NDDs) in preschoolers are frequently accompanied by persistent sleep disturbances, such as delayed sleep onset and reduced sleep duration, which exacerbate behavioral problems, impair cognitive…
- Conditions
- Neurodevelopmental Disorders (NDD), Preschool Child Development, Sleep
- Trial name
- NCT07822490
- Testing
- Parent-based Group Face-to-face Intervention, Digital Self-help Intervention
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong
Heart Disease Congenital, Neurodevelopmental Disorder
Characterization and Support of Neurodevelopmental Disorders Associated With Congenital Cardiac malfoRmations - Neonatal
Congenital heart defects (CHD), as the leading cause of birth defects, affect 12 million people globally and approximately 41,000 newborns each year in Europe.
- Trial name
- CATAMARAN - NN (NCT06690151)
- Testing
- Neurodevelopmental assessment (Bayley-IV), Biological sampling, ELFE dietary questionnaire
- Where
- 8 sites in France
- Volunteers
- 450 people
- Sponsor
- Nantes University Hospital
Neurodevelopmental Disorder (Diagnosis)
Transdiagnostic Dimensional Profiling of Neurodevelopmental Disorders
In recent years, the growing awareness of the multifactorial nature of neurodevelopmental disorders has stimulated interest in transdiagnostic approaches aimed at investigating underlying etiological mechanisms beyond traditional…
- Trial name
- RDoC-CRAB (NCT07544199)
- Testing
- Neuropsychological assessment
- Volunteers
- 300 people
- Sponsor
- IRCCS Eugenio Medea
GRIN-related Neurodevelopmental Disorder
Beeline: A Phase 3 Study in GRIN-related Neurodevelopmental Disorder
The Phase 3 portion of Study RAD-GRIN-101 is a multinational, multicenter, randomized, double-blind, placebo-controlled trial followed by an open-label extension to evaluate the efficacy and safety of radiprodil in participants…
- Trial name
- NCT07224581
- Testing
- Radiprodil
- Where
- 34 sites in United States, Belgium and 8 more
- Volunteers
- 100 people
- Sponsor
- GRIN Therapeutics, Inc.
Stress, Mental Health
PPI and Mindfulness App for Parents of Children with a NDD
An app based on positive psychology and mindfulness to support the mental well-being of parents of children with a Neurodevelopmental Disorder (NDD) was developed and will be evaluated on effectiveness.
- Conditions
- Stress, Mental Health, Mental Well-being
- Trial name
- Adappt (NCT06248762)
- Testing
- Adappt
- Where
- Netherlands
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- University of Twente
Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD)
Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders
This observational study evaluates functional and developmental outcomes in pediatric participants undergoing a two week intensive multimodal neurorehabilitation program.
- Conditions
- Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD), Neurodevelopmental Disorders and Developmental Abnormalities, Developmental Delay (Disorder)
- Trial name
- GEN-HOPE (NCT07493096)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Healing Hope International
7q11.23 Microduplication Syndrome (7DUP), Autism Spectrum Disorder (ASD)
Characterization of the Natural History of Microduplication Syndrome 7q11.23
7q11.23 duplication syndrome (7q duplication syndrome/7DUP) is caused by a microduplication of the 7q11.23 chromosomal region, encompassing 26-28 genes, including the GTF2I gene.
- Conditions
- 7q11.23 Microduplication Syndrome (7DUP), Autism Spectrum Disorder (ASD), Neurodevelopmental Disorders (NDD)
- Trial name
- HINADU7 (NCT07469566)
- Testing
- clinical assessment, Parental questionnaires, Cognitive assessment
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- Hospices Civils de Lyon
Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder
FAB Programme for Parents of Children With NDD
The study aims to examine the effectiveness of a psychotherapy approach called Facilitator-guided Acceptance and Commitment Bibliotherapy (FAB) in improving the psychological health of parents of young children with…
- Conditions
- Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder, Neurodevelopmental Disorders, Intellectual Disability
- Trial name
- NCT05872737
- Testing
- Facilitator-guided Acceptance and Commitment Bibliotherapy (FAB), General Parenting Education and Advice
- Where
- 2 sites in Hong Kong
- Volunteers
- 154 people
- Sponsor
- Chinese University of Hong Kong