Clinical trials: Neurodevelopment, open to volunteers
Metabolic Dysfunction-Associated Steatotic Liver Disease Infant Development
TUDCA in High-Risk Lactating Mothers Identified by Early Postpartum Milk Hydrophobicity Index
This is a randomized, double-blind, placebo-controlled Phase 2 proof-of-concept trial in mother-infant dyads. The study aims to evaluate the safety, tolerability, and biological effects of maternal oral tauroursodeoxycholic acid…
- Trial name
- MILK-HI-TUDCA (NCT07517276)
- Testing
- tauroursodeoxycholic acid (TUDCA)
- Volunteers
- 80 people
- Sponsor
- Peking University First Hospital
Neurodevelopmental Disorders, Developmental Delay
Development of Motility and Cognition in Infants
PILKE study uses wearables for assessing motor development in infants in order to define functional growth trajectories in the normal infants and infants at risk of neurological compromise.
- Conditions
- Neurodevelopmental Disorders, Developmental Delay, Development, Infant, Child Development
- Trial name
- PILKE (NCT05527080)
- Testing
- physiotherapy, brace
- Where
- Finland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Congenital Heart Disease, Cyanotic Congenital Heart Disease
Prenatal Maternal Mental Health and Neurodevelopment in Congenital Heart Disease
Congenital heart disease (CHD) is the leading cause of congenital malformations, representing 1% of live births. Progress in surgical care have led to the dramatic increase in the population of children and adults living with…
- Conditions
- Congenital Heart Disease, Cyanotic Congenital Heart Disease, d-Transposition of the Great Arteries, Hypoplastic Left Heart Syndrome
- Trial name
- Neuro-Moms (NCT06711666)
- Where
- 5 sites in France
- Volunteers
- 174 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Fetal Growth Retardation, Intrauterine Growth Restriction
Fetal Brain Care: Therapies for Brain Neurodevelopment in Fetal Growth Restriction
Singleton pregnancies being diagnosed of fetal growth restriction from 24 to 32.6 weeks of gestation will be randomized to two equally sized groups: maternal oral supplementation with Lactoferrin and DHA (Docosahexaenoic acid) or…
- Trial name
- NCT05038462
- Testing
- Lactoferrin and DHA
- Where
- 6 sites in Spain
- Volunteers
- 304 people
- Sponsor
- Institut d'Investigacions Biomèdiques August Pi i Sunyer
Invasive Ventilation, Infant Pain
Dexmedetomidine for Invasive Ventilation In the NEOnate
Despite the increasing use of non-invasive ventilation, a large majority of premature neonates still receive invasive ventilation during their NICU (neonatal intensive care unit) stay.
- Conditions
- Invasive Ventilation, Infant Pain, Infant Discomfort, Infant Neurodevelopment
- Trial name
- NCT07493785
- Testing
- Dexmedetomidine Injectable Solution, Glucose 5% Injectable Solution
- Where
- 12 sites in France
- Volunteers
- 246 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Premature Birth, Risk
The Effect of the Movement Imitation Therapy in Preterm (MIT-PB) in Motor Behavior's Quality.
This study aims to assess the effect of a parent-administered intervention program based on MIT-PB in preterm with abnormal general movements during the preterm period.
- Conditions
- Premature Birth, Risk, Early Intervention
- Trial name
- MIT-PB (NCT05319158)
- Testing
- MIT-PB, movement imitation therapy for preterm.
- Where
- 3 sites in Spain
- Volunteers
- 36 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Newborn Health, Multiple Micronutrient Deficiencies During Pregnancy
The MOM-CARE Trial : Evaluating Antenatal and Postnatal MMSPlus for Improved Infant Birth and Growth Outcomes
This clinical trial aims to learn if MMS Plus improves infant health compared to standard MMS during pregnancy and the postnatal period in women living in peri-urban areas of Karachi, Pakistan.
- Conditions
- Newborn Health, Multiple Micronutrient Deficiencies During Pregnancy, Nutrition During Pregnancy, Adaptive Trial
- Trial name
- MOM-CARE (NCT07029282)
- Testing
- MMS, MMS Plus, IFA
- Where
- Pakistan
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Iodine Deficiency, Nutrition Poor
Effects of Maternal Multiple Micronutrient Supplementation During Lactation on Child Development in Ethiopia
The goal of this clinical trial is to learn about the effects of iodine-containing multiple micronutrient supplements provided to breastfeeding mothers who live in settings with mild iodine deficiency.
- Conditions
- Iodine Deficiency, Nutrition Poor, Development, Infant, Breastfeeding
- Trial name
- EMECHAT (NCT05901766)
- Testing
- UNIMMAP Multiple Micronutrient Supplement
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Brown University
Gestational Diabetes Mellitus, Pregnancy Outcome
GDM and Its Consequences in Mothers and Offsprings
Gestational diabetes mellitus (GDM) is one of the most common disorders which occured during pregnancy. GDM is not only associated with short-term maternal and fetal adverse outcomes, but also related to a wide range of long-term…
- Conditions
- Gestational Diabetes Mellitus, Pregnancy Outcome, Neurodevelopment, Immune Development
- Trial name
- GDMCMO (NCT04529889)
- Where
- China
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Retinopathy of Prematurity
Retinal Microanatomy in Retinopathy of Prematurity (BabySTEPS2)
Retinopathy of prematurity (ROP) is a disorder of development of the neural retina and its vasculature that can impact vision in vulnerable preterm neonates for a lifetime.
- Trial name
- BabySTEPS2 (NCT04995341)
- Testing
- Investigational ultracompact OCT and OCTA system, retinal photographs
- Where
- 2 sites in United States
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Duke University
Sleep
Effects of Napping in Pregnant Women With Sleep Disturbances on Offspring Neurodevelopment
To examine the effects of napping in pregnant women with sleep disturbances on offspring neurodevelopment, the researchers will recruit 80 pregnant women with sleep disturbances.
- Trial name
- NCT06514833
- Testing
- lifestyle recommendations to nap regularly, No recommendations to nap regularly
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
ADHD, ADHD - Attention Deficit Disorder With Hyperactivity
A Clinical Trial Evaluating Fecal Microbiota Transplantation (FMT) in Adolescents With ADHD
The primary goals of this phase 2 clinical trial are to determine the feasibility, safety, and tolerability of oral Fecal Microbiota Transplantation (FMT) in adolescents (aged 13-17) with Attention-Deficit/Hyperactivity Disorder…
- Conditions
- ADHD, ADHD - Attention Deficit Disorder With Hyperactivity, ADHD - Combined Type
- Trial name
- FMT-ADHD-2026 (NCT07756255)
- Testing
- Fecal Microbiota Transplant (FMT), Nitazoxanide 500mg BID, Vancomycin 250mg BID
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Neonates and Preterm Infants, Neonates or Premature Babies
Prospective Study of the Feasibility of Brain Connectivity Imaging by Functional Ultrasound Imaging (fUS) in Newborn Infant
Neurodevelopmental disorders (NDD) affect how the brain develops and can lead to lifelong difficulties with movement, learning, behavior, and thinking.
- Trial name
- CONEXUS (NCT06940713)
- Testing
- Imaging Time
- Where
- France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Pregnancy Related, Mental Health Issue
MamaConecta: Digital Tool for Maternal Mental Health
The goal of this randomized controlled trial is to validate a digital health tool, Dana app, that enhances well-being and supports mental health monitoring for women during the perinatal period.
- Conditions
- Pregnancy Related, Mental Health Issue, Postpartum Depression, Postpartum Anxiety
- Trial name
- DDT (NCT06442774)
- Testing
- Mobile application, Monitoring via wearable
- Where
- 3 sites in Spain
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- A Thousand Colibris, S.L
Neurodevelopment Outcome, Linear Growth
Micronutrient Enhancement for Development and Health in Adolescents - The MEDHA Study
MEDHA is a randomized controlled trial among 10-18 year old girls to examine the use-case of the United Nations International Multiple Micronutrient Antenatal Preparation (UNIMMAP) multiple micronutrient supplement (MMS)…
- Conditions
- Neurodevelopment Outcome, Linear Growth, Micronutrient Status, Bone Mineral Density
- Trial name
- MEDHA (NCT07695883)
- Testing
- Iron (60 mg)- folic acid (400 ug) [IFA], Multiple micronutrient supplement [MMS], Multiple micronutrient supplement Plus [MMS+]
- Where
- Bangladesh
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
General Anesthetics Toxicity
Anesthesia Neurodevelopmental Impact in Congenital Scoliosis Children
In the past, a large number of animal studies have suggested that anesthesia exposure has potential neurotoxic effects, resulting in persistent cognitive and behavioral deficits.
- Trial name
- NCT06315933
- Testing
- General anesthesia
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital
Congenital Heart Disease (CHD)
Prenatally-initiated Psychological Intervention for Mothers of Infants With Congenital Heart Disease (CHD)
This is a two-arm, prospective, longitudinal, randomized controlled trial (RCT) that will compare usual care to usual care plus a prenatally initiated, virtually administered psychological intervention, called HeartGPS.
- Trial name
- NCT07582861
- Testing
- HeartGPS
- Where
- 17 sites in United States
- Volunteers
- 210 people
- Sponsor
- Carelon Research
Inflammation, HPA
Impacts of Cash Transfers on Child Neurodevelopment (Auxilio Brasil)
This study examines the impact of Auxilio Brasil (AB), a cash transfer program to mothers of school-age children, on resource-deprived populations in Brazil and its protective effects on child neurodevelopment and mental health.
- Conditions
- Inflammation, HPA, CBCL, Family Relations
- Trial name
- NCT05477901
- Testing
- Supplemental cash transfer
- Where
- 2 sites in United States, Brazil
- Volunteers
- 450 people
- Sponsor
- New York State Psychiatric Institute
Very Preterm Infant, Necrotizing Enterocolitis (NEC)
Effects of Enteral Feeding Regimens on NEC, Mortality, and Neurodevelopment in Very Preterm Infants
The goal of this clinical trial is to evaluate whether supplementing with pasteurized donor human milk (pHDM) or preterm formula (PTF) when own mother's milk (OMM) is insufficient can improve outcomes in very preterm infants born…
- Trial name
- NCT07045844
- Testing
- Pasteurized Donor Milk for Insufficient Breastfeeding, Preterm Formula for Insufficient Breastfeeding, Routine fortification
- Where
- 24 sites in China
- Volunteers
- 2,324 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Infant Sleep Problems, Circadian Rhythm
Chrononutrition in Preterm Infants: a Randomised Controlled Trial of Time-matched Breast Milk Feeding and Its Effects on Sleep and Circadian Development
This study investigates whether the timing of feeding expressed breast milk influences infant sleep and circadian (day-night) development in preterm infants.
- Conditions
- Infant Sleep Problems, Circadian Rhythm, Neurodevelopment
- Trial name
- NCT07533578
- Testing
- Chronobiologically Timed Feeding of Expressed Breast Milk, Usual Feeding Practice (Untimed Expressed Breast Milk)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Luzerner Kantonsspital