Clinical trials: Neurocognitive Development
Alzheimer's Disease and Related Dementias
OPTIMAL in NH Residents With Dementia
The purpose of this study is to develop and refine OPTIMAL and evaluate its feasibility, fidelity, and usefulness. The OPTIMAL is designed to teach staff to effectively engage residents in eating using individualized…
- Trial name
- NCT05255068
- Testing
- OPTIMAL
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- University of Iowa
Alzheimer Disease
Enhancing Consent for Alzheimer's Research
The purpose of this study is to evaluate the efficacy of an enhanced consent procedure for patients with mild-to-moderate Alzheimer disease, and to identify factors and patient characteristics that predict the degree to which…
- Trial name
- BWP-AD (NCT00453544)
- Testing
- Enhanced Consent Procedure, Routine Consent Procedure
- Where
- United States
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Mild Cognitive Impairment, Healthy Aging
SHARE(D) Stage II: Alzheimer's Risk Disclosure Protocol Piloting
The goal of this study is to test efficacy and safety of person-centered, culturally-informed protocols for disclosure of different combinations of Alzheimer's dementia risk factors.
- Trial name
- SHARE(D) (NCT04309500)
- Testing
- Personalized DAT Risk Disclosure Protocol
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Cognitive Dysfunction, Mild Cognitive Impairment
Development and Evaluation of Virtual Reality Experiences for Cognitive Stimulation at the Sociosanitary Center El Carme
The goal of this clinical trial is to test a virtual reality (VR)-based program designed for cognitive stimulation in individuals attending the conventional cognitive rehabilitation program at the Day Hospital of CSSC (Centro…
- Trial name
- RTCSSC (NCT06155721)
- Testing
- Virtual Reality Cognitive Stimulation Program
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Badalona Serveis Assistencials
Fragile X Syndrome, FXS
A 2-Period Crossover Study of BPN14770 in Adults Males With Fragile X Syndrome
This is a single-center, randomized, double-blind, 2-period crossover study to explore the effects of BPN14770 on cognitive function and behavior in subjects with Fragile X Syndrome.
- Conditions
- Fragile X Syndrome, FXS, Fra(X) Syndrome
- Trial name
- NCT03569631
- Testing
- BPN14770
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Tetra Discovery Partners
Alzheimer Disease, Dementia
Development of NIC5-15 in the Treatment of Alzheimer's Disease
The purpose of this study is to evaluate the safety and efficacy of NIC5-15in the treatment of Alzheimer's Disease.
- Trial name
- NCT00470418
- Testing
- NIC5-15
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- VA Office of Research and Development
Alzheimer's Disease, Mild Cognitive Impairment
Cognition Platform Study in Participants at Risk for Alzheimer's Disease (AD) (MK-0000-413)
The main purpose of this study is to assess the ability of a repeated high-frequency site-based computerized cognitive assessment to evaluate the potential treatment effects of donepezil (MK-0000) compared with placebo among…
- Trial name
- NCT04730635
- Testing
- Donepezil
- Where
- 10 sites in United States, Australia
- Volunteers
- 44 people
- Sponsor
- Merck Sharp & Dohme LLC
Alzheimer's Disease
Valproic Acid in Subjects With Intact Cognition - Proof of Concept Study
The purpose of this study is to evaluate the safety of administration and effects of valproic acid on clusterin expression in cognitively-intact, healthy, elderly subjects.
- Trial name
- VPA (NCT01729598)
- Testing
- Valproic Acid
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Gregory Jicha, 323-5550
Dementia, Cognitive Impairment
LifeBio Memory Digital Reminiscence Platform
Non-pharmacological interventions and person-centered care strategies are important elements of care for people with Alzheimer's disease and related dementias.
- Trial name
- NCT04769466
- Testing
- LifeBio Memory
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- Benjamin Rose Institute on Aging
OSA, Sleep Apnea
Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?
Obstructive sleep apnea (OSA) is common in older adults and has recently been implicated in pathogenesis of Alzheimer's disease (AD). Research has shown that sleep disruptions have caused memory impairment.
- Conditions
- OSA, Sleep Apnea, Obstructive Sleep Apnea, Alzheimer Disease
- Trial name
- NCT05094271
- Testing
- Supplemental Oxygen, Continuous Positive Airway Pressure Machine, Room Air
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of California, San Diego
Autism, Cognition Disorder
The Effect of Donepezil (Aricept(Registered Trademark)) on REM Sleep in Children With Autism
This study will test whether donepezil (Aricept(Registered Trademark)), a drug that is approved by the Food and Drug Administration to treat Alzheimer's disease, can increase rapid eye movement (REM) sleep in children with autism…
- Trial name
- NCT00695136
- Testing
- Donepezil hydrochloride, Increase REM sleep percentage
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- National Institute of Mental Health (NIMH)
Alzheimer Disease
Socially Assistive Robots for Interaction With Older Adults With Dementia
A 12-month pilot study will be comprised of two groups of people diagnosed with mild Alzheimer's disease and related dementia for a total of 80 senior subjects.
- Trial name
- NCT04384978
- Testing
- Play Serious Games with a Social Robot (Ryan), Play Solitary Games Without a Social Robot
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- DreamFace Technologies, LLC
Alzheimer's Disease
Online Caregiver Psychoeducation and Support for Alzheimer's
This study is piloting an internet-based intervention to provide support for caregivers of VA patients with Alzheimer's disease or related memory difficulties (ADRD).
- Trial name
- NCT00416078
- Testing
- caregiver website support, caregiver brief supportive phone calls
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- US Department of Veterans Affairs
Mild Cognitive Impairment
Serious Game-based Interventions in Patients With Mild Cognitive Impairment Outside the Clinic
This study will evaluate the therapeutic efficacy of Neuro-World cognitive training games (Woorisoft, S. Korea) in patients with mild cognitive impairment.
- Trial name
- NCT04920123
- Testing
- Neuro-World
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- University of Massachusetts, Amherst
APOE 4
Network-Level Mechanisms for Preclinical Alzheimer's Disease Development
The purpose of this project is to test the hypothesis that AGB101 low dose levetiracetam extended release formulation can reduce abnormal hyperfunctional activity in the hippocampus in normal, healthy adults.
- Trial name
- NCT03461861
- Testing
- AGB101 220 mg
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Post Operative Pain
Parent Nurse Controlled Analgesic in Pediatric Patients With Developmental Delay
The purpose of this study is to compare, the safety, efficacy and level of parent and nurse satisfaction with three methods of opioid administration post-operatively in children (4-18 years of age) with developmental delay.
- Trial name
- PNCA (NCT00743730)
- Testing
- Pain and standard side effect management for PNCA with basal method., Pain and standard side effect management with PNCA without basal, Pain and standard side effect management with IV on an as needed basis method.
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Medical College of Wisconsin