Clinical trials: Neuralgia
Spinal Stenosis Lumbar, Neuropathic Pain
Neuropathic Pain Severity and Its Association With Radiological Findings in Lumbar Spinal Stenosis
This cross-sectional observational study aims to evaluate neuropathic pain severity in patients with lumbar spinal stenosis (LSS) and to investigate its association with radiological findings.
- Trial name
- NCT07855445
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Marmara University
Painful Diabetic Peripheral Neuropathy
The Effects of Ceylon Cinnamon (Cinnamomum Verum) Supplementation on Blood Glucose, Lipid Profile Levels, Body Mass Index, and Pain Intensity Among Adult Individuals With Painful Diabetic Peripheral Neuropathy
Background: Painful diabetic peripheral neuropathy (PDPN) is a severe, disabling complication of type 2 diabetes mellitus (T2DM), closely associated with insulin resistance, chronic neuroinflammation, and oxidative stress.
- Trial name
- PDPN- CC-RCT (NCT07743073)
- Testing
- Ceylon Cinnamon Supplement
- Where
- Jordan
- Volunteers
- 164 people
- Sponsor
- JAWAD AHMAD ABU-SHENNAR
Neuropathic Pain, Diabetes Mellitus, Type 2
A Randomized, Active-controlled, Parallel, Open-label, Multicenter, Phase 4 Study to Compare the Efficacy and Safety of Pregabalin Sustained Release Tablet and Pregabalin Immediate Release Capsule in Type II Diabetic Patients With Peripheral Neuropathic Pain
This study is to compare the efficacy and safety of pregabalin sustained release tablet and pregabalin immediate release capsule in type II diabetic patients with peripheral neuropathic pain.
- Trial name
- NCT05624853
- Testing
- pregabalin sustained release tablet, pregabalin immediate release capsule
- Where
- 8 sites in South Korea
- Volunteers
- 130 people
- Sponsor
- Yuhan Corporation
Neuropathic Pain
The Significance of Peripheral Input
The investigators want to examine trigger point injections of local anesthetics, in patients with post operative neuropathic pain, determine changes in sensory disturbances such as allodynia, hyperalgesia and thermal sensitivity…
- Trial name
- NCT04764045
- Testing
- Ropivacaine
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Bispebjerg Hospital
Morton's Neuroma
Study to Evaluate the Safety and Tolerability of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma)
The purpose of this study is to confirm that the local anesthetic applied to subjects with Morton's Neuroma satisfactorily mitigates procedure pain and ensures that post-procedure discomfort or pain will not result in bias or…
- Trial name
- NCT02550756
- Testing
- CTNX-4975
- Volunteers
- 11 people
- Sponsor
- Centrexion Therapeutics
Sciatica, Lumbar Disc Herniation
Trial of Pulsed Radiofrequency for Sciatica and Disc Herniation
Transforaminal epidural injection of treatments, commonly steroids (TFESI), is offered to people with sciatica and might improve symptoms, reduce disability and speed up return to normal activities (NICE guidelines)…
- Trial name
- PRATS (NCT04209322)
- Testing
- pulsed Radiofrequency, Transforaminal Epidural Steroid Injection
- Where
- 2 sites in Italy
- Volunteers
- 250 people
- Sponsor
- University of Roma La Sapienza
Cryo Analgesia, Pectus Surgery
Long Term Safety of Preoperative Percutaneous Intercostal Cryoneurolysis
Follow up of patients who underwent percutaneous cryoneurolysis for pectus excavatum repair (the Nuss procedure) pain management
- Trial name
- CRYOFUP (NCT07657845)
- Testing
- Self-report Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) Questionnaire - Pediatric Quality of Life Inventory (PedsQL™) Questionnaire - Patient Self-Assessment Sensory Scale
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Papa Giovanni XXIII Hospital
Trigeminal Neuralgia, Trigeminal Neuralgia, Idiopathic
CT-guided vs Fluoroscopy-guided Trigeminal Ganglion Radiofrequency Thermocoagulation for Idiopathic Trigeminal Neuralgia
The goal of this clinical trial is to compare the effectiveness and safety of CT-guided versus fluoroscopy-guided trigeminal ganglion radiofrequency thermocoagulation (TG-RFT) in treating idiopathic trigeminal neuralgia (TN) in…
- Trial name
- NCT06620172
- Testing
- CT-guided Radiofrequency Thermocoagulation (RFT), Fluoroscopy-guided Radiofrequency Thermocoagulation (RFT)
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Zagazig University
Persistent Spinal Pain Syndrome Type II, Failed Back Surgery Syndrome
Persistent Post-Lumbar Surgery Pain Syndrome (PSPS) Type II is a Common Condition Encountered in Pain Units, With Limited Available Therapeutic Options. Epidural Pulsed Radiofrequency (PRF) Administered Via Catheter Has Demonstrated Greater Efficacy Compared to the Transforaminal Approach. This Rand
This study is for people who continue to have low back pain after spinal surgery, a condition called persistent spinal pain syndrome type II. Current treatments, such as epidural injections, often provide only limited relief.
- Conditions
- Persistent Spinal Pain Syndrome Type II, Failed Back Surgery Syndrome, Chronic Low Back Pain, Post-Laminectomy Syndrome
- Trial name
- EPIPUL (NCT07156513)
- Testing
- Epidural Pulsed Radiofrequency, Betamethasone (Epidural Corticosteroid Injection)
- Where
- 4 sites in Spain
- Volunteers
- 131 people
- Sponsor
- Puerta de Hierro University Hospital
Neuropathic Pain
BMS-741672 for Diabetic Neuropathic Pain
The purpose of the study is to determine whether BMS-741672 improves neuropathic pain in diabetic patients.
- Trial name
- NCT00683423
- Testing
- BMS-741672
- Where
- 8 sites in United States
- Volunteers
- 50 people
- Sponsor
- Bristol-Myers Squibb
Facet Joints; Degeneration, Neuropathy
MRI-Guided Cryoablation to Alleviate Pain in Head, Neck and Spine
The objective of this study is to provide pain relief to patients with facet joint disease or head and neck pain related to compression of a nerve root.
- Conditions
- Facet Joints; Degeneration, Neuropathy, Neuralgia
- Trial name
- NCT01788410
- Testing
- Cryoablation under image guidance, MRI Seednet Cryotherapy System (Galil Medical)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Neuropathic Pain, Vitamin B 12 Deficiency
Pre- and Post-Treatment Investigation of B12 and Folic Acid (Folate) Levels in Patients Receiving Antiepileptic (Anticonvulsant) Treatment for Neuropathic Pain
Neuropathic pain (NeP) is a disorder of the nervous system resulting from altered mechanisms operating at the peripheral nervous system, spinal cord and supraspinal levels and is defined by the International Association for the…
- Trial name
- NCT07013318
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Pain, Low Back Pain
Low Level Laser Therapy in the Dorsal Root Ganglion in the Treatment of Chronic Low Back Pain
Chronic axial low back pain is a public health problem and has a high socioeconomic impact. The dorsal ganglion of the second spinal nerve (GDL2) is a cluster of neuronal bodies responsible for sensory afferent inputs from more…
- Conditions
- Pain, Low Back Pain, Nociceptive Pain, Neuropathic Pain
- Trial name
- NCT02529670
- Testing
- Laser, Drug: Lidocaine, Radiofrequency
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- University of Nove de Julho
Polyneuropathies, Peripheral Nerve Injuries
Peripheral Physiological Measures as Determinants of Pain Risk
This study evaluates peripheral nervous system function using Multiple Excitability Measures (MEM) to obtain "electrophysiological pain phenotypes"
- Conditions
- Polyneuropathies, Peripheral Nerve Injuries, Peripheral Nervous System Diseases, Chemotherapy Effects
- Trial name
- DOLORiskWP51 (NCT02985294)
- Testing
- Multiple Excitability Measures of peripheral nerves
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Neuroscience Technologies SLP, Barcelona
Multiple Sclerosis With Central Neuropathic Pain
Analgesic Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) for Central Neuropathic Pain in Multiple Sclerosis
This study is designed to evaluate the effect of repetitive Transcranial Magnetic Stimulation (rTMS) in the resolution of chronic pain.
- Trial name
- STIMASEP (NCT02059096)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- 3 sites in France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Clermont-Ferrand
Peripheral Neuropathic Pain
Response Profiles to High-concentration Capsaicin Desensitization in Patients with Peripheral Neuropathic Pain with or Without Allodynia: a Regional Multicenter Prospective Cohort
Prospective multicenter cohort to determine patient profiles (associated factors, including allodynia) with a better response to pain desensitization by capsaicin delivered in the form of a high concentration patch (8%), in a…
- Trial name
- CAPSICAURA (NCT05817591)
- Testing
- Questionnaires
- Where
- 10 sites in France
- Volunteers
- 400 people
- Sponsor
- Centre Hospitalier Annecy Genevois
Phantom Limb Pain, Neuropathic Pain
Intrathecal Dexmedetomidine and Acute Neuropathic Pain After Lower Limb Amputation
This randomized controlled trial evaluated the effect of adding intrathecal dexmedetomidine (10 µg) to hyperbaric bupivacaine (11 mg) for spinal anesthesia in patients undergoing lower limb amputation.
- Conditions
- Phantom Limb Pain, Neuropathic Pain, Lower Limb Amputation
- Trial name
- DEX-RCT (NCT07565662)
- Testing
- Hyperbaric Bupivacaine plus Saline, Hyperbaric Bupivacaine plus Dexmedetomidine
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Universidad Juárez Autónoma de Tabasco
Mandibular Nerve Injury
Study on the Risk of Inferior Alveolar Nerve Damage During Lower Third Molar Surgery
Objective The present study aimed to evaluate which factors were statistically associated with a greater probability of inferior alveolar nerve (IAN) damage during lower third molar surgery.
- Trial name
- NCT04807946
- Testing
- lower third molar extraction
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Diabetic Neuropathy
Understanding Risk Factors and Determinants for Neuropathic Pain
Understanding risk factors and determinants for neuropathic pain.
- Trial name
- Neuropathic (NCT02402361)
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Rambam Health Care Campus
Chronic Pain, Complex Regional Pain Syndromes
The Success of Lumbar Sympathetic Ganglion Block Using Lower Extremity Perfusion Index
The patient, who is experiencing chronic pain in the lower extremities persisting for more than three months, is scheduled to undergo lumbar sympathetic ganglion block.
- Conditions
- Chronic Pain, Complex Regional Pain Syndromes, Peripheral Neuropathy, Post Herpetic Neuralgia
- Trial name
- NCT06241820
- Testing
- Lumbar Sympathetic Ganglion Block
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Jeongsoo Kim