Clinical trials: Neural Tube Defects
Neural Tube Defects (NTDs)
First-Trimester Screening of Open Neural Tube Defects Using Biometrics and Maternal Serum Markers
Open neural tube defects are congenital malformations associated with significant morbidity. Early detection during the first trimester remains a key challenge.
- Trial name
- BIMAS (NCT07864142)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Neural Tube Defects
Patch vs. No Patch Fetoscopic Meningomyelocele Repair Study
The purpose of the study is to compare the maternal, fetal and neonatal outcomes of a cohort of 60 patients in whom a multilayer closure with a Durepair patch is performed with a prior cohort of patients in whom a standardized…
- Trial name
- NCT03794011
- Testing
- fetoscopy
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Baylor College of Medicine
Neural Tube Defects, Congenital Abnormalities
Birth Outcomes In Eswatini After Transition To Dolutegravir-Based Treatment
The goal of this observational study is to assess the birth outcomes of HIV-positive women delivering in hospitals in Eswatini who are receiving dolutegravir (DTG) or other anti-retroviral (ARV) drug regimens.
- Conditions
- Neural Tube Defects, Congenital Abnormalities, Teratogens
- Trial name
- NCT05883761
- Where
- 5 sites in Eswatini
- Volunteers
- 50,075 people, healthy volunteers welcome
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
Neural Tube Defect
Fetoscopic Meningomyelocele Repair Study
The purpose of the study is to evaluate the maternal and fetal outcomes of a new technique for the fetoscopic repair of fetal MMC at Texas Children's Hospital Pavilion for Women.
- Trial name
- fMMC (NCT02230072)
- Testing
- fetoscopy
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Baylor College of Medicine
Folate Deficiency, Neural Tube Defects
Folic Acid Salt Study (FISFA Zambia)
Question: How effective is fortified iodized salt with folic acid (FISFA) in increasing serum and red blood cell folate in non-lactating, non-pregnant women of reproductive age in the country of Zambia who do not have active food…
- Trial name
- NCT06734611
- Testing
- Fortified Iodized Salt with Folic Acid (FISFA)
- Where
- 2 sites in United States, Zambia
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Tethered Cord, Tethered Cord Syndrome
Investigation of Surgical Sectioning of the Filum Terminale in Treating Occult Tethered Cord Syndrome Patients
The investigators hypothesize that surgical release of the filum terminale (strand of fibrous tissue at the end of the spinal cord) is a more efficacious treatment option for symptomatic relief than medical management in subjects…
- Conditions
- Tethered Cord, Tethered Cord Syndrome, Occult Spina Bifida, Spina Bifida Occulta
- Trial name
- OCCULT (NCT05163899)
- Testing
- Release of filum terminale
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
Neural Tube Defects, Spina Bifida
In-Utero Endoscopic Correction of Spina Bifida
The purpose of this study is to evaluate the feasibility and effectiveness of performing fetoscopic surgical correction of fetal spina bifida.
- Conditions
- Neural Tube Defects, Spina Bifida, Myelomeningocele
- Trial name
- NCT04362592
- Testing
- In Utero Endoscopic Correction of Myelomeningocele IDE - Percutaneous Technique, In Utero Endoscopic Correction of Myelomeningocele IDE - Laparotomy/Uterine Exteriorization Technique
- Where
- 2 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Spina Bifida, Myelomeningocele
Fetoscopic Repair of Isolated Fetal Spina Bifida
The purpose of this investigation is to evaluate maternal and fetal outcomes following fetoscopic repair of fetal spina bifida at the Johns Hopkins Hospital.
- Conditions
- Spina Bifida, Myelomeningocele, Chiari Malformation Type 2, Neural Tube Defects
- Trial name
- NCT03090633
- Testing
- Fetoscopy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Neural Tube Defects
Safety and Efficacy of Devices Used in Fetoscopic Neural Tube Defect Repair Cases
The purpose of the study is to evaluate the safety and efficacy of devices used in patients undergoing fetoscopic neural tube defect repair.
- Trial name
- NCT05672849
- Testing
- Modified Surgical Instruments/Devices (Sheaths and Irrigator)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Michael A Belfort
Postoperative Neurogenic Lower Urinary Tract Dysfunction Secondary to Tethered Cord Syndrome
Effectiveness of Electrical Pudendal Nerve Stimulation for Neurogenic Lower Urinary Tract Dysfunction in Pediatric Tethered Cord Syndrome Post-Surgery
The goal of this prospective observational study is to evaluate whether the addition of electrical pudendal nerve stimulation (EPNS) to standard conservative treatment can improve bladder function in pediatric patients with…
- Trial name
- NCT07062133
- Testing
- Electrical pudendal nerve stimulation, Conventional conservative treatment
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Sacral Myelomeningocele, Neural Tube Defects
In Utero Fetoscopic Repair Program for Sacral Myelomeningoceles and Mye-LDM
The purpose of the study is to evaluate the feasibility and the maternal, fetal and postnatal outcomes of sacral myelomeningocele (MMC) and Myelic Limited Dorsal Myeloschisis (MyeLDM) fetoscopic repair at Trousseau Hospital…
- Conditions
- Sacral Myelomeningocele, Neural Tube Defects, Spina Bifida
- Trial name
- PRIUM2 (NCT04770805)
- Testing
- Fetoscopy
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neural Tube Defects, Folic Acid Deficiency
Using Iodized Salt to Improve Serum Folate, B12 and Iron Levels
Question: How effective is fortified iodized salt in increasing serum concentrations of folate, B12 and iron among non-pregnant and non-lactating women of reproductive age? Hypothesis: Micronutrient fortified iodized salt can…
- Conditions
- Neural Tube Defects, Folic Acid Deficiency, Spina Bifida, Anencephaly-Spina Bifida
- Trial name
- NCT06904612
- Testing
- Micronutrient fortified iodized salt
- Where
- 2 sites in United States, India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hydrocephalus and Neuroscience Institute
Fetal Congenital Abnormalities, Fetoscopy
Fetoscopic Robotic Open Spina Bifida Treatment
Fetal spina bifida is a common birth defect that results in hydrocephalus, motor-, bowel-, bladder- and sexual dysfunction in the child. The condition is progressive in utero.
- Conditions
- Fetal Congenital Abnormalities, Fetoscopy, Fetal Surgery, Robotic Surgical Procedure
- Trial name
- FROST (NCT06907732)
- Testing
- Fetoscopic robotic open spina bifida closure
- Volunteers
- 15 people
- Sponsor
- Mount Sinai Hospital, Canada
Neural Tube Defects, Spina Bifida
Fetoscopic Neural Tube Defect Repair
This is a single-arm prospective study to record maternal and neonatal outcomes on subjects who undergo fetoscopic repair of Neural Tube Defects (NTD) at Oregon Health \& Science University (OHSU).
- Trial name
- NTD (NCT06946563)
- Testing
- Fetoscopic Neural Tube Defect Repair Devices
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Oregon Health and Science University
Spina Bifida, Myelomeningocele
Minimally Invasive Fetoscopic Regenerative Repair of Spina Bifida - A Pilot Study
Researchers are studying a new minimally invasive technique (fetoscopic repair) for repair of spina bifida (MMC) during the second trimester of pregnancy.
- Conditions
- Spina Bifida, Myelomeningocele, Neural Tube Defects
- Trial name
- NCT03936322
- Testing
- Minimally invasive fetoscopic repair of MMC
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Rodrigo Ruano
Recurrent Adult Tethered Cord Syndrome
A Randomized Controlled Trial for Surgical Treatment of Recurrent Adult Tethered Cord Syndrome
This trial compares detethering surgery and spinal column shortening surgery, two treatments for adults with recurrent tethered cord syndrome (TCS), a neurological disorder where the spinal cord becomes abnormally attached to…
- Trial name
- NCT06197399
- Testing
- Detethering Surgery, Spinal Column Shortening Surgery
- Where
- China
- Volunteers
- 222 people
- Sponsor
- Xuanwu Hospital, Beijing
Neural Tube Defects, Folic Acid Deficiency
Salt-FA to Increase Folate Levels
Question: How effective is folic acid-fortified iodized salt in increasing serum folate concentrations among non-pregnant and non-lactating women of reproductive age? Hypothesis: Folic acid-fortified iodized salt can increase…
- Conditions
- Neural Tube Defects, Folic Acid Deficiency, Spina Bifida, Anencephaly-Spina Bifida
- Trial name
- NCT06174883
- Testing
- Folic acid fortified iodized salt
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hydrocephalus and Neuroscience Institute
Neural Tube Defects, Folic Acid
Assessing Folic Acid in High-Risk Pregnancy for Neural Tube Defects
Aim of this study is to investigate and statistically reveal the prevalence and awareness of folic acid usage in pregnant women who have at least one of the risk factors for neural tube defects, to express the level of knowledge…
- Trial name
- NCT06135883
- Where
- Turkey (Türkiye)
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Neural Tube Defects, Folic Acid Deficiency
Feasibility, Acceptability and Directional Signal Effect on Blood Folate Levels of Iodized Salt Fortified With Folic Acid: Clinical Study
Aim 1: Assess directional signal of effect of fortified salt with folic acid and iodine on blood serum folate levels. It will be accomplished by feasibility pre-test/post-test clinical study by estimating mean and variability of…
- Conditions
- Neural Tube Defects, Folic Acid Deficiency, Fortification
- Trial name
- FASALT (NCT05935631)
- Testing
- Salt with folic acid and iodine
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Neural Tube Defects
Influence of "Espresso" on Adsorption of Myo-inositol
Neural Tube Defects (NTDs) are multifactorial (genetic/environmental) diseases that arise from failure of embryonic neural tube closure.
- Trial name
- NCT01244399
- Testing
- Inositol
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- AGUNCO Obstetrics and Gynecology Centre