Clinical trials: Nervous System Diseases
Cerebral Palsy, Spastic, Posture
The Effect of Trunk Control on Respiratory Muscle Strength
Cerebral palsy (CP) can be defined as a group of disorders of movement and posture, causing activity limitation that are attributed to nonprogressive deficits that take place in the immature brain.
- Conditions
- Cerebral Palsy, Spastic, Posture, Respiratory Muscle Strength, Activities of Daily Living
- Trial name
- NCT03209310
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Gazi University
Osteoporosis, Sarcopenia
Effectiveness of Creatine Supplementation and Exercise on Muscle and Bone
As we age, we experience a reduction in muscle and bone which inevitably decreases strength and the ability to perform tasks of daily living such as gardening, carrying groceries, and climbing stairs.
- Trial name
- NCT01057680
- Testing
- creatine monohydrate
- Where
- 2 sites in Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Brain Concussion
The Effect of Exercise on Neurorecovery Following Mild Traumatic Brain Injury
The study is a "proof-of-principle" project to examine the safety and feasibility of implementing a 1-week aerobic exercise program in the post-acute phase after mild traumatic brain injury (mTBI).
- Trial name
- NCT02276079
- Testing
- Aerobic Exercise, Non-Aerobic Exercise
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cerebral Small Vessel Disease and OCT Angio
OCT Angio in Cerebral Small Vessel Disease
The aim of the study is to: - detect changes in retinal structure and microvasculature in patients with cerebral small vessel disease using optical coherence tomography angiography , correlate these changes with brain imaging…
- Trial name
- NCT05052788
- Testing
- Optical coherence tomography angiography
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Migraine Headaches
Set Point Acupuncture for Migraines Using a Digital Assistant
The object of this research study is to test a standardized set of acupuncture points on migraine patients to reduce frequency and intensity of headaches.
- Trial name
- SPAMDA (NCT00714727)
- Testing
- acupuncture
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Memorial Medical Center
Stress, Anxiety
Cereset Research Long-Term Healthcare Worker Study
Randomized, controlled study of long-term maintenance Cereset Research after an initial 4-session intervention bolus versus usual care control following an initial 4-session intervention bolus.
- Conditions
- Stress, Anxiety, Autonomic Dysregulation, Acoustic Stimulation
- Trial name
- LT-HW (NCT05994261)
- Testing
- Cereset Research
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Postoperative Pain, Cataract
Midazolam Additive to Local Anesthetic in Peribulbar Block
Regional eye blocks are usually preferred for ophthalmic procedures. Peribulbar block (PBB) is a safe alternative for patients undergoing cataract surgery.
- Conditions
- Postoperative Pain, Cataract, Local Anaesthetic Complication, Midazolam
- Trial name
- NCT03397069
- Testing
- Peribulbar block (control), Peribulbar block(M1), Peribulbar block(M2)
- Where
- Saudi Arabia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Al Jedaani Hospital
MELAS Syndrome
Nitric Oxide Production in MELAS Syndrome
Introduction Baylor College of Medicine and Texas Children's Hospital are recruiting individuals with MELAS syndrome for a clinical study.
- Trial name
- NCT01339494
- Testing
- Arginine and citrulline supplementations
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Alzheimer Disease, Dementia
The A-LIST WMM Insights Series
The main purpose of the Study is to develop an understanding over time and through multiple research projects, including surveys, interviews, online focus groups, and other primary research methodologies (A-LIST Research…
- Conditions
- Alzheimer Disease, Dementia, Mild Cognitive Impairment
- Trial name
- NCT04466722
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- UsAgainstAlzheimer's
Spinal Cord Injury
Vitamin D and Calcium Study
Vitamin D aids in the body's ability to absorb calcium, it is a vital component in bone formation and break down. Reduced levels of vitamin D can indicate a vitamin deficiency and may depress serum calcium levels.
- Trial name
- NCT00857831
- Testing
- Vitamin D and Calcium
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Alzheimer Disease
Study to Compare the Pharmacokinetics of Daily Administration of Tricaprilin on Ketone Body Production
This is a Phase I, single center, open label, multiple dose, pharmacokinetic (PK) study recruiting healthy older subjects.
- Trial name
- NCT04268953
- Testing
- Tricaprilin
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cerecin
Anxiety, Carpal Tunnel Syndrome
Effect of High-quality Pre-operative Videos on Patient Anxiety Levels Prior to Ambulatory Hand Surgery
Previous research has shown that YouTube is a poor source of high-quality medical information. This is likely because there is no regulation of the content on YouTube and relatively little of the content is posted by qualified…
- Conditions
- Anxiety, Carpal Tunnel Syndrome, Trigger Finger, Engagement, Patient
- Trial name
- NCT04424810
- Testing
- High-quality, physician created video, Standard of care
- Where
- United States
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Dyslexia
Dyslexia, Motor Control and Proprioception
The investigators hypothesize that children with dyslexia present proprioceptive disorders and the purpose of the present study is to better understand relationships between motor control, proprioception and academic learnings.
- Trial name
- NCT03364010
- Testing
- Evaluation of proprioception, Evaluation of motor learning, Evaluation of written language
- Where
- France
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Amyotrophic Lateral Sclerosis (ALS)
A First in Human Study of ORT247 in Healthy Volunteers
This is a single center, double-blinded, randomized, placebo controlled single ascending dose clinical study, with the primary purpose of evaluating the safety, tolerability, pharmacokinetics (PK), and immunohistochemistry of…
- Trial name
- NCT06769620
- Testing
- ORT247
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Orthogonal Neuroscience Inc.
Parkinson Disease
Study To Assess the Safety and Tolerability of PBF-509 in Male Healthy Volunteers
No clinical trials with PBF-509 in humans have been performed to date. Only preclinical studies have been done to assess the pharmacology and pharmacokinetics, the safety and the toxicological profile of the PBF-509.
- Trial name
- NCT01691924
- Testing
- PBF-509
- Where
- 2 sites in Spain
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Stuttering, Stuttering, Adult
Exploring the Nature, Assessment and Treatment of Stuttering
The purposes of this study are to 1) investigate potential speech, language, and psychosocial contributions to the experience of stuttering in monolingual and multilingual speakers, and to 2) evaluate interdisciplinary…
- Conditions
- Stuttering, Stuttering, Adult, Stuttering, Childhood, Stuttering, Developmental
- Trial name
- NCT05908123
- Testing
- The Blank Center CARE Model(TM) for Individuals who Stutter
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Sleep Disorder
Evning Exposure to Computer Screen Disrupts Sleep, Attention and Biological Rhythms
Light exposure is on the rise in recent years. In large part because of unintentional illumination from screens that emit light directly into the eyes.
- Trial name
- NCT02957383
- Testing
- Wavelength, Intensity
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Assuta Medical Center
Myasthenia Gravis
Pilot Study: Use of the Saccadometer to Detect Characteristic Saccadic Peak Velocity in Myasthenia Gravis Patients
Fast eye movements have been shown to demonstrate characteristics that are specific to myasthenia gravis that are not present in other eye movement disorders.
- Trial name
- NCT06501794
- Testing
- Quantitative measurement of eye movements
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Hearing Loss
The Esteem® Hearing Implant Post Approval Study
The purpose of this study is to evaluate the long-term safety and efficacy of the Esteem® Hearing Implant in subjects suffering from moderate to severe hearing loss.
- Trial name
- NCT02666222
- Testing
- The Esteem Hearing Implant
- Where
- 5 sites in United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Envoy Medical Corporation
Subchondral Insufficiency Fracture
Study of the Associations Between Subchondral Insufficiency Fractures of the Knee and Pre-existing Health, Lifestyle, and/or Musculoskeletal Conditions
This prospective cohort study is designed to investigate possible association(s) between subchondral insufficiency fractures (SIFKs) of the knee and pre-existing health, lifestyle, and/or musculoskeletal conditions.
- Trial name
- NCT04953702
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
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