Clinical trials: Nervous System Cancer
Solid Tumor Cancer, Medulloblastoma
Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed).
Study in children and adolescents of 177Lu DOTATATE (Lutathera®) combined with the PARP inhibitor olaparib for treatment of recurrent or relapsed solid tumours expressing somatostatin receptors (SSTR) (LuPARPed)
- Conditions
- Solid Tumor Cancer, Medulloblastoma, High Risk Neuroblastoma, High Grade Gliomas
- Trial name
- LUPARPED (NCT06607692)
- Testing
- Olaparib; 177Lu-DOTATATE
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Fundación de investigación HM
Pain, Breast Cancer
Stanford Accelerated Recovery Trial (START)
The goal of this study is to determine whether administering Gabapentin prior to surgery affects duration of pain and opioid use post-surgery.
- Conditions
- Pain, Breast Cancer, Lung Cancer
- Trial name
- NCT01067144
- Testing
- Gabapentin, Lorazepam (active control)
- Where
- United States
- Volunteers
- 422 people
- Sponsor
- Stanford University
Breast Cancer, Postoperative Pain
The Effect of Rhomboid Intercostal Block and Serratus Anterior Plane Block on Postoperative Respiratory Functions
Rhomboid intercostal block is used to block lateral cutaneous branches of intercostal nerves between T3 and T9 dermatomes. Serratus anterior plane block is used to block lateral cutaneous branches of intercostal nerves between T2…
- Conditions
- Breast Cancer, Postoperative Pain, Respiratory Function Impaired
- Trial name
- RIBSAB (NCT05547932)
- Testing
- RIB+SAP blocks
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Muğla Sıtkı Koçman University
Refractory Myasthenia Gravis, Rituximab
Efficacy and Safety of Low-dose Rituximab in the Treatment of Refractory Myasthenia Gravis
This study is designed to evaluate the effectiveness and safety of low-dose rituximab in patients with refractory myasthenia gravis.
- Trial name
- NCT05332587
- Testing
- Rituximab
- Where
- China
- Volunteers
- 50 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Neurofibromatosis Type 1, Reading Disabilities
Neurobiology and Treatment of Reading Disability in NF-1
The goal of this trial is to determine if children with neurofibromatosis type 1 who have reading disabilities respond the same way-both behaviorally and neurobiologically-to specialized treatment programs as children with…
- Trial name
- NCT00624234
- Testing
- Tutoring Program I, Tutoring Program II
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Brain Metastases
Neoadjuvant Stereotactic Radiotherapy for Brain Metastasis
This multicentre proof-of-concept study, involving 4 centers, aims to establish the value of fractionated neoadjuvant stereotactic radiotherapy (NaSRT) as a new treatment paradigm for brain metastases (BM) in the frame of the…
- Trial name
- NeoSTROBE (NCT06933199)
- Testing
- Neoadjuvant Stereotactic Radiotherapy (NaSRT), Postoperative Stereotactic Radiotherapy (SRT)
- Where
- 4 sites in Czechia
- Volunteers
- 260 people
- Sponsor
- University Hospital Ostrava
Polycystic Ovary Syndrome
Polycystic Ovary Syndrome - Improving Outcomes
Polycystic ovary syndrome affects a striking 9-18% of Australian reproductive aged women and has been associated with a number of metabolic abnormalities.
- Trial name
- NCT01504321
- Testing
- Moxonidine
- Where
- Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Baker Heart and Diabetes Institute
Head and Neck Cancer Survivors, Cancer of the Head and Neck Surviors
Head and Neck Cancer Survivorship Ototoxicity Screening (SOS)
To evaluate the effectiveness, feasibility, acceptability, and appropriateness of an ototoxicity screening protocol among head and neck (H\&N) cancer patients followed in survivorship clinic that received cisplatin-based…
- Trial name
- NCT05789316
- Testing
- Ototoxicity Screening Protocol
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Washington University School of Medicine
Breast Cancer, Leptomeningeal Metastasis
Analyses of Exosomes in the Cerebrospinal Fluid for Breast Cancer Patients With Suspicion of Leptomeningeal Metastasis.
This is a multicenter, interventional, prospective study among breast cancer patients with a suspicion of metastatic meningitis.
- Trial name
- NCT03974204
- Testing
- Cerebrospinal fluid and blood sample collection at the initial diagnostic assessment, Cerebrospinal fluid and blood sample collection if conclusions of initial diagnostic assessment are "Lack of evidence" according to EANO-ESMO classification, Cerebrospinal fluid and blood sample collection if conclusions of initial diagnostic assessment are "confirmed", "probable" or "possible", leading to leptomeningeal metastase specific treatment
- Where
- 2 sites in France
- Sponsor
- Centre Oscar Lambret
Substance Use, Severe Mental Disorder
Validation of the Dutch Translation of the Tobacco, Alcohol, Prescription Medication and Other Substances (TAPS)-Tool
The aim of the study is to investigate the reliability and validity of the Dutch version of the TAPS-tool. This will be investigated in 2 groups: patients without intellectual disabilities treated in Flexible Assertive Community…
- Conditions
- Substance Use, Severe Mental Disorder, Intellectual Disability, Mild
- Trial name
- NCT05273021
- Testing
- TAPS
- Where
- 3 sites in Netherlands
- Volunteers
- 150 people
- Sponsor
- Birgit Seelen-de Lang
Chronic Pain
Feasibility Study of an Online Self-management Program for Chronic Non-cancer Pain
Based on a mixed-methods design, the objective of this trial is to assess the feasibility and acceptability of the "Agir pour moi" program, an 8-week online self-management program for chronic non-cancer pain (CNCP).
- Trial name
- NCT05319652
- Testing
- Pain self-management program
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- CHU de Quebec-Universite Laval
Heathy Volunteer, Parkinsonian Syndromes
Ultralow Dose PET Imaging of 18F-FDOPA
The goal of this clinical trial is to evaluate an investigational ultralow dose PET imaging technique for Parkinsonian syndromes, neuroendocrine tumors, and gliomas detection and monitoring.
- Conditions
- Heathy Volunteer, Parkinsonian Syndromes, Neuroendocrine (NE) Tumors, Gliomas
- Trial name
- NCT07542158
- Testing
- 18F-FDOPA
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Akiva Mintz
Surgery, Breast Cancer
Chronic Pain and Minor Breast Cancer Surgery
Breast cancer is the most frequent in women. Early diagnosis and recent treatments have improved overall mortality. However, chronic pain (pain lasting more than 3 months after surgery) remains a public health problem with impact…
- Conditions
- Surgery, Breast Cancer, Pain, Postoperative, Pain, Chronic
- Trial name
- DCPO Sein (NCT03912948)
- Where
- France
- Volunteers
- 205 people
- Sponsor
- Institut Claudius Regaud
Non-small Cell Lung Cancer
Central Nervous System Efficacy of Capmatinib in NSCLC With Brain Metastases With cfDNA Positive MET Alterations
This is a phase II single-arm open label trial to evaluate the intracranial efficacy of capmatinib in advanced stage NSCLC with asymptomatic BM with positive MET amplification or METΔex14 detected on cfDNA.
- Trial name
- NCT05567055
- Testing
- Capmatinib
- Sponsor
- Timothy Burns, MD, PHD
Brain Tumors, Central Nervous System Tumors
Combination Chemotherapy Plus Radiation Therapy in Treating Children With Newly Diagnosed Brain Stem Glioma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00003935
- Testing
- etoposide, vincristine sulfate, radiation therapy
- Where
- 110 sites in United States, Australia and 4 more
- Volunteers
- 31 people
- Sponsor
- Children's Oncology Group
Brain Tumor
Dexmedetomidine Versus Magnesium Sulphate in Patients Undergoing Craniotomy for Deeply Settled Intracranial Tumours
An intracranial tumor, is an abnormal mass of tissue in which cells grow and multiply uncontrollably, seemingly unchecked by the mechanisms that control normal cells.
- Trial name
- NCT05743725
- Testing
- Dexmedetomidine, Magnesium sulfate
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Myasthenia Gravis, Generalized
Holistic Assessment and Remote Digital MONitoring of mYasthenia Gravis Via MyoSense 360
The purpose of the HARMONY 360 investigation is to explore the feasibility of using MyoSense 360 digital measures to develop models capable of detecting clinically meaningful changes in generalized Myasthenia Gravis (gMG)…
- Trial name
- HARMONY 360 (NCT07323316)
- Testing
- MyoSense 360
- Volunteers
- 100 people
- Sponsor
- Ad scientiam
Breast Neoplasm Female, Arthralgia
Pilot Observational Study Examining the Effect of Endocrine Therapy on Aging
The goal of this pilot observational study is to learn about the feasibility of collecting patient-reported data and stool and blood samples from patients age 65 and older treated with aromatase inhibitor therapy for breast…
- Conditions
- Breast Neoplasm Female, Arthralgia, Aging
- Trial name
- BETA (NCT05700006)
- Testing
- Aromatase inhibitor
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- University of Michigan
Carpal Tunnel Surgery, Trigger Finger Disorder
NAC-REPAIR for Post-surgical Pain
This pilot asks whether peri-operative N-acetylcysteine (NAC) improves recovery after common outpatient hand/foot-ankle surgery-specifically, does NAC reduce pain and opioid use and enhance function by modulating…
- Conditions
- Carpal Tunnel Surgery, Trigger Finger Disorder, De Quervain Syndrome, Guyon's Canal
- Trial name
- NCT07227649
- Testing
- NAC
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Arizona
Breast Cancer, Anesthesia
Pain Control in Breast Surgery: Analgesia, Opioid Consumption and Inflammatory Response Evaluation
The serratus anterior muscle plane (SAM) block associated with pectoral nerve block type I (PEC I) may be a safe and effective alternative for the intraoperative of breast surgery, since there is evidence of pain reduction.
- Trial name
- NCT02647385
- Testing
- Block with lidocaine for SAM and PEC I block
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital Sirio-Libanes