Clinical trials: Nerve Damage
Peripheral Nerve Injury Digital Nerve Hand Left
Optimization of Peripheral Nerve Reconstruction: A Non-inferiority Trial
1. To analyse the outcome of different treatment options of peripheral nerve repair with no gap (group 1) and with a critical sized (>5mm) defect (group 2) in order to optimize peripheral nerve repair 2.
- Trial name
- NCT01573650
- Where
- Switzerland
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Multiple Sclerosis
Prognosis Value of the Neuronal Damage in Early Multiple Sclerosis
In this study the investigators will use PET and 11C-Flumazenil to visualize and quantify neuronal injury in the cortex and the deep gray matter of Multiple Sclerosis patients at an early stage.
- Trial name
- Flumatep_2 (NCT01651520)
- Testing
- PET with 11C-Flumazenil
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ischemic Heart Disease, Nerve Injury
Association Between Radial Artery Intervention and Development of Neuropathy in the Hand - A Prospective Study
Evaluation of potential nerve damage after radial CAG/PCI.
- Conditions
- Ischemic Heart Disease, Nerve Injury, Carpal Tunnel Syndrome
- Trial name
- ACCESS-IV (NCT05365282)
- Where
- Denmark
- Volunteers
- 400 people
- Sponsor
- Aarhus University Hospital Skejby
Multiple Sclerosis, Parkinson Disease
Biomarkers of Synaptic Damage in Multiple Sclerosis
A prospective and retrospective cohort study of about five years will be performed on blood and cerebrospinal fluid samples taken for diagnostic reasons from recruited patients within the Neuromed Neurology Unit.
- Conditions
- Multiple Sclerosis, Parkinson Disease, Amyotrophic Lateral Sclerosis, Alzheimer Disease
- Trial name
- NCT03217396
- Testing
- lumbar puncture
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Neuromed IRCCS
Peripheral Nerve Injury at Forearm Level (Diagnosis)
Effects of Motor Learning After Upper Limb Peripheral Nerve Injury
The outcome of peripheral nerve injury is related to age, level of injury, the injured nerve, the severity of injury, and the timing and the type of surgery interventions.
- Trial name
- NCT04087577
- Testing
- conventional physical therapy, mirror therapy
- Where
- 2 sites in Taiwan
- Volunteers
- 8 people
- Sponsor
- Chang Gung Memorial Hospital
Chemotherapeutic Agent Toxicity, Sarcoma
CYP3A5 Gene as a Risk Factor for Kidney Damage in Young Patients With Cancer Treated With Ifosfamide
RATIONALE: Studying the genes expressed in samples of blood from young patients with cancer treated with ifosfamide may help doctors identify risk factors for kidney damage.
- Conditions
- Chemotherapeutic Agent Toxicity, Sarcoma, Unspecified Childhood Solid Tumor, Protocol Specific
- Trial name
- NCT00514345
- Testing
- gene expression analysis, polymorphism analysis, management of therapy complications
- Where
- 21 sites in Ireland, United Kingdom
- Volunteers
- 300 people
- Sponsor
- Children's Cancer and Leukaemia Group
Peripheral Nerve Injuries
Mid-term Effect Observation of Biodegradable Conduit Small Gap Tublization Repairing Peripheral Nerve Injury
To observe the Mid-term clinical effect of biodegradable conduit small gap tublization to repair peripheral nerve injury in multi-center．
- Trial name
- NCT03359330
- Testing
- Degradable Conduit Small Gap Tublization
- Volunteers
- 150 people
- Sponsor
- Peking University People's Hospital
Nerve Injury
Autologous Fat in Peripheral Nerve Injury
The aim of this study is to assess the efficacy of autologous fat graft in enhancing peripheral nerve regeneration. The investigators hypothesize that fat grafting will allow for faster and greater recovery of motor and sensory…
- Trial name
- NCT04653129
- Testing
- Autologous Fat Grafting, Primary Nerve Repair
- Volunteers
- 44 people
- Sponsor
- Assiut University
Peripheral Nerve Injury, Postherpetic Neuralgia
Study of Capsaicin Patch for the Management of Peripheral Neuropathic Pain
The efficacy and safety of the low concentration [0.65% (50 µg/cm2) and 1.25% (100 µg/cm2)] capsaicin patches and compared them to conventional 0.075% capsaicin cream and placebo patch in patients suffering from peripheral…
- Trial name
- NCT02228928
- Testing
- CAPNP, 50 ug/cm2 capsaicin patch, CAPNP, 100 ug/cm2 capsaicin patch, 0.075% capsaicin cream
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samyang Biopharmaceuticals Corporation
Burn Hand, Rehabilitation
Effects of the EMG-driven Hand Robot Training in Patients With Hand Dysfunction Due to Nerve Damage From Burns
Hands are the most frequent burn injury sites. Appropriate rehabilitation is essential to ensure good functional recovery. The aim of this study was to investigate the effects of EMG driven robotic rehabilitation on hand…
- Trial name
- NCT06563336
- Testing
- EMG-driven hand robot training, conventional occupational training
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Hangang Sacred Heart Hospital
Vestibular Schwannoma, Acoustic Neuroma
Auditory Nerve Test System During Vestibular Schwannoma Resection
The Auditory Nerve Test System (ANTS) is a novel device that stimulates the auditory nerve much like a cochlear implant. The purpose of this study is to demonstrate feasibility of the ANTS during translabyrinthine surgery for…
- Conditions
- Vestibular Schwannoma, Acoustic Neuroma, Sensorineural Hearing Loss, Asymmetric Sensorineural Hearing Loss
- Trial name
- ANTS (NCT04241679)
- Testing
- Auditory Nerve Test System
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Washington University School of Medicine
Postherpetic Neuralgia, Nerve Trauma
Efficacy Study of Botox to Treat Neuropathic Pain
Objectives : to investigate the analgesic effects and safety of intradermal botulinum toxin A injection in the treatment of focal painful neuropathies (eg, postherpetic neuralgia, nerve trauma)
- Trial name
- NCT00527202
- Testing
- botulinum toxin A
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Hospital Ambroise Paré Paris
Retinal Disease, Age-Related Macular Degeneration
Stem Cell Ophthalmology Treatment Study II
This study will evaluate the use of autologous bone marrow derived stem cells (BMSC) for the treatment of retinal and optic nerve damage or disease.
- Conditions
- Retinal Disease, Age-Related Macular Degeneration, Retinitis Pigmentosa, Stargardt Disease
- Trial name
- SCOTS2 (NCT03011541)
- Testing
- Arm 1
- Where
- 4 sites in United States, Austria and 1 more
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Comparison Between Ultrasound and Clinical Measurements
The Use of Novel us Device (Jetguide) to Measure the Distance to the Roof of the IAC (Inferior Alveolar Canal)
The purpose of this human clinical trial is to validate the accuracy of Jetguide® US device in detecting the inferior alveolar canal (IAC) and to compare it to measurements performed on computerized tomography images.
- Trial name
- NCT01505335
- Testing
- US depth measurements
- Where
- Israel
- Volunteers
- 25 people
- Sponsor
- Rambam Health Care Campus
Pain, Pain Syndrome
Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Traumatic or Post-operative Peripheral Neuropathy
Over the last years a rising medical need for treatment of chronic pain was identified. Based on previous findings indicating the pain modulating effects of cannabinoids in chronic pain disorders, this clinical trial investigates…
- Conditions
- Pain, Pain Syndrome, Pain, Chronic, Chronic Pain
- Trial name
- NCT06071988
- Testing
- Adezunap (AP707)
- Where
- Germany
- Volunteers
- 558 people
- Sponsor
- Apurano Pharmaceuticals GmbH
Painful Diabetic Peripheral Neuropathy (PDPN)
Efficacy and Safety of the N0750 Compared to Monotherapies in the Treatment of Painful Diabetic Peripheral Neuropathy
A phase 3, prospective, adaptive, randomized, multicenter, double-blind, triple-masked, parallel clinical trial to evaluate the efficacy and safety of N0750 in relieving pain associated with painful diabetic peripheral neuropathy…
- Trial name
- ENFORCE (NCT06715462)
- Testing
- N0750, Cymbalta®, Lyrica®
- Where
- Brazil
- Sponsor
- Eurofarma Laboratorios S.A.
Nerve Injury, Nerve Palsy
Deltoid Muscle Contribution to Shoulder Function
There is only one study in the literature about the quantitative effect of M. deltoideus on the movement of the shoulder. Here, the author described a 35-80% loss of abduction power after selective blockade of the N. axillaris.
- Trial name
- NCT03881462
- Testing
- Axillary nerve block for artificial deltoid muscle palsy
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Neuropathic Pain Caused by Lumbar Radicular Pain
Effect of Minocycline on Pain Caused by Nerve Damage
The purpose of this study is to determine if minocycline is effective in the treatment of neuropathic pain. The effect of minocycline will be compared to the effect of placebo and amitriptyline.
- Trial name
- EMON (NCT01869907)
- Testing
- Minocycline, Amitriptyline
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Ziekenhuis Oost-Limburg
Head and Neck Cancer, Neck Dissection
Porcine Extracellular Matrix Nerve Wrap in Neck Dissection for Head and Neck Cancer
Perform a preliminary efficacy study using the porcine extracellular matrix nerve wrap (AxoGuard Nerve Protector™, AxoGen Inc., Alachua, FL) to wrap the spinal accessory nerve (SAN) during neck dissections for head and neck…
- Conditions
- Head and Neck Cancer, Neck Dissection, Postoperative Complications
- Trial name
- NCT07268092
- Testing
- Porcine Extracellular Matrix Nerve Wrap (AxoGuard Nerve Protector™)
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Henry Ford Health System
Thyroid Diseases, Recurrent Laryngeal Nerve Injury
Endotracheal Tube Versus Transcartilage Needle Electrodes for Nerve Monitoring in Thyroid Surgery
Intraoperative neuromonitoring of the recurrent laryngeal nerve during thyroidectomy is most commonly performed with surface electrodes embedded in the endotracheal tube (ETT).
- Conditions
- Thyroid Diseases, Recurrent Laryngeal Nerve Injury, Vocal Cord Paralysis, Thyroid Nodule
- Trial name
- TRANSCOMP (NCT07902349)
- Testing
- Transcartilage needle electrode recording, Endotracheal tube surface electrode recording
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Marmara University