Clinical trials: Nerve Compression Syndromes
Charcot Marie Tooth Disease
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others
This is an observational longitudinal study to determine the natural history and genotype-phenotype correlations of disease causing mutations in Charcot Marie Tooth disease (CMT) type 1B (CMT1B), 2A (CMT2A), 4A (CMT4A), and 4C…
- Trial name
- INC-6601 (NCT01193075)
- Where
- 24 sites in United States, Australia and 4 more
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Michael Shy
Carpal Tunnel Syndrome (CTS)
Investigation of the Effectiveness of Cervicothoracic Exercises in Individuals With Carpal Tunnel Syndrome
This randomized, parallel-group controlled clinical trial evaluated the effects of adding cervicothoracic exercises to conventional physiotherapy on symptoms, functional status, pain, grip strength, and wrist range of motion in…
- Trial name
- NCT07410819
- Testing
- Conventional Physiotherapy Group, Cervicothoracal Exercise Group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Medipol University
Piriformis Syndrome
Effects of Hip Abductor Strengthening Exercises in Patients With Piriformis Syndrome
The study was conducted to determine the effects of hip abductor strengthening exercises on pain, range of motion, and lower extremity function in patients with piriformis syndrome.
- Trial name
- NCT07484373
- Testing
- Progressive Hip Abductor Strengthening Exercises, conventional physiotherapy treatment
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- Riphah International University
CIDP (Chronic Inflammatory Demyelinating Polyradiculoneuropathy), CMT (Charcot Marie Tooth Disease)
Diffusion Tensor Imaging in Chronic Inflammatory Demyelinating Polyneuropathy (PIDC)
The main purpose of this study is to assess the clinical feasibility of diffusion tensor imaging (DTI) for the diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).
- Trial name
- PIDC (NCT03460951)
- Testing
- cervical MRI
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Hereditary Spastic Paraplegia, SPG47
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia
The Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia (HSP) is focused on gathering longitudinal clinical data as well as biological samples (skin and/or blood and/or saliva) from male and female…
- Conditions
- Hereditary Spastic Paraplegia, SPG47, SPG50, SPG51
- Trial name
- HSP (NCT04712812)
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Carpal Tunnel Syndrome
Lipografting Versus Steroid Injections for Treatment of Carpal Tunnel Syndrome
This study applies the regenerative properties of autologous fat transfer to treat mild to moderate carpal tunnel syndrome in comparison to the current standard of care, corticosteroid treatment.
- Trial name
- NCT03722303
- Testing
- Fat Injection, Steroid Injection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Columbia University
Carpal Tunnel Syndrome
Ibuprofen Arginine and Neural Mobilization Versus Ibuprofen Arginine in the Treatment of Carpal Tunnel Syndrome
In the present investigation the pain reduction effects of a physiotherapy technique combined with pharmaceutical ibuprofen arginine treatment will be compared to those produced by ibuprofen (only) treatment, in subjects who…
- Trial name
- NCT06778759
- Testing
- median nerve neural mobilization combined with oral ibuprofen arginine, Ibuprofen Arginine
- Where
- Venezuela
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
Hereditary Transthyretin Amyloidosis, Carpal Tunnel Syndrome
Hereditary Transthyretin Amyloidosis Polyneuropathy in Patients With Carpal Tunnel Syndrome in Russia
This is a multicenter observational study consisting of retrospective and prospective phases. The retrospective phase will entail secondary data collection from electronic or paper medical records of patients who underwent…
- Conditions
- Hereditary Transthyretin Amyloidosis, Carpal Tunnel Syndrome, Polyneuropathy, Amyloidosis
- Trial name
- LOCUS (NCT06414746)
- Where
- 13 sites in Russia
- Volunteers
- 721 people
- Sponsor
- AstraZeneca
Relapsing Multiple Sclerosis
Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS) (REMODEL-2)
To compare the efficacy and safety of remibrutinib versus teriflunomide in patients with relapsing multiple sclerosis (RMS)
- Trial name
- NCT05156281
- Testing
- Remibrutinib, Teriflunomide
- Where
- 223 sites in United States, Argentina and 25 more
- Volunteers
- 1,007 people
- Sponsor
- Novartis Pharmaceuticals
Hereditary Spastic Paraplegia
Disease Natural History and Biomarkers of SPG3A, SPG4A, and SPG31
Background: Hereditary spastic paraplegia (HSP) usually progresses slowly. Researchers want to learn more about how its symptoms change over time.
- Trial name
- NCT02859428
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cardiac Arrest (CA), Intensive Care Unit (ICU) Admission
Kinetics and Prognostic Value of NeuroFilament Light in Post-cardiac Arrest: A Prospective Multicenter Study
The purpose of this study is to assess the prognostic value of absolute value and kinetic of neurofilament light chain (NFL) collected at different time points (at admission, 12h, 24h, 48h, 72h, 96h, and day 7 after ICU…
- Conditions
- Cardiac Arrest (CA), Intensive Care Unit (ICU) Admission, Return of Spontaneous Circulation, Comatose
- Trial name
- CINEFIL (NCT07760636)
- Testing
- Value of neurofilament light chain (NFL) at different time points
- Where
- France
- Volunteers
- 270 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Carpal Tunnel Syndrome (CTS)
Combined Stellate Ganglion Block With Median Nerve Hydrodissection Versus Median Nerve Hydrodissection Only in Carpal Tunnel Syndrome
the study aims to compare clinical and electrophysiological outcomes of combined stellate ganglion block plus median nerve hydrodissection versus hydrodissection alone in carpal tunnel syndrome, assessing pain, function…
- Trial name
- NCT07839611
- Testing
- combined stellate ganglion block procedure and median nerve hydrodissection, Ultrasound-Guided Median Nerve Hydrodissection Procedure only
- Volunteers
- 80 people
- Sponsor
- Fayoum University
Ulnar Nerve Entrapment, Cubital Tunnel Syndrome
Comparison of Kinesio Taping Techniques in Ulnar Nerve Entrapment
The purpose of this study is to investigate and compare the efficacy of space-correction kinesio taping and neural technique kinesio taping-when added to a home exercise program-versus placebo taping with exercise in individuals…
- Conditions
- Ulnar Nerve Entrapment, Cubital Tunnel Syndrome, Ulnar Neuropathy at Elbow
- Trial name
- NCT07863830
- Testing
- Kinesio Taping with Space-Correction Technique, Kinesio Taping with Neural Technique, Home Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Antalya Training and Research Hospital
Carpal Tunnel Syndrome
Radial Extracorporeal Shock Wave Therapy in the Treatment of Carpal Tunnel Syndrome
Carpal tunnel syndrome (CTS) is the most common of all entrapment syndromes with a prevalence of 1-5%. Electrodiagnostic testing is used to make a definite diagnosis.
- Trial name
- NCT04416867
- Testing
- splint and home exercise, RESWT, physical therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 95 people
- Sponsor
- Erzurum Regional Training & Research Hospital
Piriformis Syndrome, Corticosteroid Injection
Effect of Ultrasound-guided Piriformis Muscle Corticosteroid Injection Versus Extracorporeal Shock Wave Therapy for Piriformis Syndrome: a Randomized Control Trial
In this study, the investigators aim to compare the effect of extracorporeal shockwave therapy with ultrasound-guided piriformis coticosteroid injection in treatment of PS.
- Conditions
- Piriformis Syndrome, Corticosteroid Injection, Extracorporeal Shockwave Therapy, Therapeutic Exercise
- Trial name
- NCT04684537
- Testing
- Extracorporeal shockwave therapy (ESWT), Ultrasound-guided piriformis steroid injection
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Thoracic Outlet Syndrome
Clinical Routine in Thoracic Outlet Syndrome
Transversal recording and analysis of investigations performed in patients referred for suspected thoracic outlet syndrome (TOS)
- Trial name
- SKIPA (NCT04376177)
- Testing
- Ultrasound, angiography, questionnaires
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Angers
Carpal Tunnel Syndrome
Turkish Version of the Hand20 Questionnaire With Carpal Tunnel Syndrome
The questionnaire will be investigated by administering the Hand-20 questionnaire and the Boston Carpal Tunnel Syndrome Questionnaire to patients with carpal tunnel syndrome, one week apart.
- Trial name
- NCT05263128
- Testing
- Investigation of the validity of the Hand-20 Questionnaire in individuals with carpal tunnel syndrome
- Sponsor
- Hasan Kalyoncu University
Carpal Tunnel Syndrome
Phonophoresis, Low-Level Laser Therapy and Exercise in the Treatment of Carpal Tunnel Syndrome
Carpal tunnel syndrome (CTS) is the most common peripheral nerve compression syndrome. There is insufficient evidence about the efficacy and superiority of conservative treatment methods.
- Trial name
- NCT05213819
- Testing
- Carpal Tunnel Syndrome
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Carpal Tunnel Syndrome
Novel Decision Aid for Carpal Tunnel Patients
A questionnaire will be given to patients who are considering undergoing hand surgery as a treatment for Carpal Tunnel Syndrome to help participants decide between two surgical options- Wide-Awake-Local-Anesthesia-no-Tourniquet…
- Trial name
- NCT04693273
- Testing
- Decision Aid for Surgical Modality Choice
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Henry Ford Health System
Carpal Tunnel Syndrome
Assessment of the Effectiveness of Ultrasound-guided Acupuncture in the Management of Carpal Tunnel Syndrome
In clinical practice, carpal tunnel syndrome (CTS) is the common disease of peripheral neuropathy and usually happened to female, mid-age population, overweight persons, and those who overused their hands for work or production.
- Trial name
- NCT02870673
- Testing
- SHINCORT, XYLOCAINE, electroacupuncture
- Volunteers
- 72 people
- Sponsor
- Taipei Medical University Hospital