Clinical trials: Nephrectomy
Renal Transplant Donor of Left Kidney, Renal Transplant Donor of Right Kidney
Lowering Uric Acid in Live Kidney Donors
Recently there was described an increase in left ventricular mass after kidney donation. It is uncertain whether this is reversible or not.
- Trial name
- AL-DON (NCT03353298)
- Testing
- Allopurinol 300 mg
- Where
- Norway
- Volunteers
- 71 people
- Sponsor
- Oslo University Hospital
Nephrectomy / Methods, Intraoperative Hypothermia
Effect of Preoperative Prewarming on Serum Lactate Levels in Patients Undergoing Elective Nephrectomy
The goal of this observational study is to learn whether warming patients before surgery, called "prewarming," affects blood lactate levels (a marker of how well tissues are getting oxygen) and recovery in adults having planned…
- Conditions
- Nephrectomy / Methods, Intraoperative Hypothermia, Hyperlactatemia
- Trial name
- NCT07702487
- Testing
- Preoperative active warming (prewarming)
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Beyzanur Aydoğdu
Living Donor Nephrectomy, Living Kidney Donation
Long-term Risk of Cardiovascular Disease in Living Kidney Donors
The investigative team will conduct a population-based, matched retrospective cohort study across Ontario, Alberta, and British Columbia using linked administrative healthcare databases to evaluate the long-term risk of major…
- Conditions
- Living Donor Nephrectomy, Living Kidney Donation, Living Kidney Donor, Living Kidney Donors
- Trial name
- NCT07431515
- Testing
- Nephrectomy
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Regional Blocks, Renal Surgery
Preoperative Versus Postoperative Quadratous Lunborum Block in Nephrectomy
A multimodal analgesia regimen is suggested after nephrectomy, although some patients still report agonising pain. Regional anesthesia approaches may improve postoperative pain management and reduce the requirement for opioids…
- Trial name
- NCT05860309
- Testing
- quadratous lumborum block
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Pentafecta, Laparoscopic
Current Role of Pentafecta Outcomes in Open and Laparoscopic Partial Nephrectomy for Localized Renal Tumors
This study aimed to identify predictive factors associated with the achievement of pentafecta outcomes following partial nephrectomy.
- Conditions
- Pentafecta, Laparoscopic, Partial Nephrectomy, Renal Tumors
- Trial name
- NCT06969131
- Testing
- Open Partial Nephrectomy, Laparoscopic Partial Nephrectomy
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- South Valley University
Cancer of Kidney
Valveless Trocar Versus Standard Trocar in Robot-assisted Complex Partial Nephrectomy
The goal of this clinical trial is to compare two kind of trocar in patients undergoing complex robot-assisted partial nephrectomy.
- Trial name
- NCT05732857
- Testing
- valveless trocar, standard trocar
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- Regina Elena Cancer Institute
Analgesic Efficacy, External Oblique Intercostal Block
Analgesic Efficacy of External Oblique Intercostal Block vs Subcostal Transversus Abdominis Plane Block in Open Surgical Nephrectomy
To compare the efficacy of unilateral ultrasound-guided oblique subcostal transversus abdominis plane block with unilateral ultrasound-guided external oblique intercostal plane block in providing intraoperative and postoperative…
- Conditions
- Analgesic Efficacy, External Oblique Intercostal Block, Subcostal Transversus Abdominis Plane Block, Open
- Trial name
- NCT06584695
- Testing
- Transversus abdominis plane block, External Oblique Intercostal Plane Block, Control group
- Where
- Egypt
- Volunteers
- 63 people
- Sponsor
- Cairo University
Regional Anesthesia for Postnephrectomy Pain
Ultrasound- Guided Mid Point Transverse Process to Pleura Block
Radical nephrectomy is the surgical process for the resection of malignant tumors of the kidney necessitating a subcostal flank incision.Mild to severe pain is observed in the postoperative period Ineffective pain management…
- Trial name
- NCT05806229
- Testing
- Mid transverse process to pleura block (MTP)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Renal Disease
Transvaginal NOTES Nephrectomy Versus Conventional Laparoscopic Nephrectomy
Recent reports have suggested that transvaginal NOTES nephrectomy is feasible, yet comparative studies are lacking. The aim of this study was to compare the surgical outcomes of transvaginal NOTES nephrectomy to conventional…
- Trial name
- NCT02398110
- Testing
- transvaginal NOTES nephrectomy, conventional laparoscopic nephrectomy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of Gannan Medical University
Narcotic Use, Renal Transplant Donor of Left Kidney
Postoperative Pain Protocol Limiting Narcotics for Laparoscopic Hand-assisted Donor Nephrectomy
Kidney donors represent healthy patients and their anticipated postoperative course should be uncomplicated and brief. This study looks to optimize the perioperative pain regimen of laparoscopic donor nephrectomy patients by…
- Trial name
- NCT06458842
- Testing
- Ketamine
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Renal Cell Carcinoma (Kidney Cancer), Renal Cell Carcinoma (RCC)
Efficacy and Safety of Finerenone and Empagliflozin in Delaying Renal Function Progression After Radical Nephrectomy in High-Risk CKD Patients: A Multicenter RCT
The goal of this clinical trial is to evaluate whether Finerenone and Empagliflozin, either alone or in combination, can delay the progression of renal function decline in patients at high risk for chronic kidney disease (CKD)…
- Conditions
- Renal Cell Carcinoma (Kidney Cancer), Renal Cell Carcinoma (RCC), Nephrectomy, Chronic Kidney Disease(CKD)
- Trial name
- EmFin-Nx (NCT06818305)
- Testing
- Finerenone (BAY 94-8862), Empagliflozin 10 mg
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Jinling Hospital, China
Abdomen Cancer, Pancreas Adenocarcinoma (MSI-H)
Implementation of a Pain Management Plan in Major Open Abdominal Surgeries.
Introduction: Major abdominal surgery encompasses a broad range of surgical procedures in heterogeneous patient populations.Management of postoperative pain has received keen attention in recent years with considerable concurrent…
- Conditions
- Abdomen Cancer, Pancreas Adenocarcinoma (MSI-H), Colectomy Left/Right/Total Under Laparotomy, Hepatectomy
- Trial name
- NCT07901582
- Testing
- Epidural administered opioid
- Where
- Greece
- Volunteers
- 58 people
- Sponsor
- National and Kapodistrian University of Athens
Anesthesia, Analgesia
Subcostal Approach to Anterior Quadratus Block Versus Thoracic Paravertebral Block for Laparoscopic Nephrectomy
In this study, it was aimed to evaluate the effects of subcostal anterior quadratus lumborum block (S-QLB3) and thoracic paravertebral block (TPVB) on postoperative acute pain scores and opioid consumption in the first 24 hours…
- Conditions
- Anesthesia, Analgesia, Acute Pain, Patient Controlled Analgesia
- Trial name
- NCT05191966
- Testing
- Subcostal Anterior Quadratus Lumborum Block, Thoracic Paravertebral Block
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ondokuz Mayıs University
Clear Cell Renal Cell Carcinoma, Stage I Renal Cell Cancer
Pazopanib Hydrochloride Before Surgery in Treating Patients With Kidney Cancer
RATIONALE: Pazopanib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving pazopanib hydrochloride before surgery may make the tumor smaller and reduce the amount of…
- Conditions
- Clear Cell Renal Cell Carcinoma, Stage I Renal Cell Cancer, Stage II Renal Cell Cancer, Stage III Renal Cell Cancer
- Trial name
- NCT01158521
- Testing
- pazopanib hydrochloride, therapeutic conventional surgery
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Case Comprehensive Cancer Center
Erector Spinae Plane Block, Nephrectomy
Efficacy of Ultrasound-Guided Erector Spinae Block for Postoperative Pain Management in Nephrectomy
This clinical trial aims to evaluate the effectiveness of the ultrasound-guided erector spinae plane (ESP) block in managing postoperative pain for patients undergoing open nephrectomy (kidney removal surgery).
- Conditions
- Erector Spinae Plane Block, Nephrectomy, Postoperative Pain
- Trial name
- NCT07560267
- Testing
- Ultrasound-Guided Erector Spinae Plane (ESP) Block
- Where
- Bangladesh
- Volunteers
- 66 people
- Sponsor
- Bangladesh Medical University
Renal Cell Carcinoma, Robotic Surgical Procedures
Evaluation of the Safety of Reoperation for Ipsilateral Recurrent Tumors After Nephron-sparing Partial Nephrectomy
To evaluate the safety of reoperation in patients with renal tumors who have ipsilateral tumor recurrence after nephron-sparing partial nephrectomy.
- Trial name
- LiangAH (NCT06317207)
- Volunteers
- 15 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Intracranial Pressure Increase
Effect of Acetazolamide on Optic Nerve Sheath Diameter in Laparoscopic Donor Nephrectomies
The purpose of the trial is to study the effect of acetazolamide administered via Ryle's tube on optic nerve sheath diameter in laparoscopic live donor nephrectomy patients.
- Trial name
- NCT03005665
- Testing
- Acetazolamide, Normal Saline
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Kidney Cancer
Post-immunotherapy Nephrectomy for Metastatic Kidney Cancer After Complete or Major Response to Systemic Therapy
In the current era of immune checkpoint inhibitors (ICI), the role and timing of nephrectomy remains unknown, particularly in cases of residual kidney disease after a major response at metastatic sites.
- Trial name
- NAMECAR (NCT06882486)
- Testing
- nephrectomy
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Institut Paoli-Calmettes
Postoperative Pain
Thoracic Paravertebral Block in Pain Management After Renal Surgery
Objective: The objective of the study was to assess the usefulness of ThPVB in postoperative pain management after open renal resection surgery.
- Trial name
- NCT02840526
- Testing
- Paravertebral blockade (PVB), Sopodorm, Propofol WZF
- Where
- Poland
- Volunteers
- 58 people
- Sponsor
- Silesian University of Medicine
Kidney Neoplasm, Renal Mass up to 7cm
Hyperspectral Imaging in Robot-Assisted Partial Nephrectomy
The goal of this prospective observational study is to learn about the use of a novel imaging technique called hyperspectral imaging in adult participants who are having surgery for removing a tumor from their kidney.
- Trial name
- HSI-Renal (NCT07803315)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Leipzig