Clinical trials: Neovascular Glaucoma
Glaucoma, Glaucoma, Open-Angle
Treatment Outcomes of MicroPulse Trans-scleral Cyclophotocoagulation in Uncontrolled Glaucoma
The goal of this study is to evaluate the efficacy and safety of the novel form of trans-scleral cyclophotocoagulation using micropulse diode laser and trans-pars plana treatment (Micropulse TSCPC, mTSCPC MP3, IRIDEX CYCLO G6™…
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Glaucoma, Neovascular, Glaucoma and Ocular Hypertension
- Trial name
- NCT03187418
- Testing
- MicroPulse® P3 Glaucoma Device (MP3)
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Neovascular Glaucoma, Rubeosis
Study to Evaluate the Effects of Ranibizumab (Lucentis) for Patients With Rubeosis and Neovascular Glaucoma
Proliferative ischemic retinopathies lead to a formation of abnormal vessels on the iris surface induced by an increased level of vascular endothelial growth factor (VEGF).
- Trial name
- LucNVG0108 (NCT01370135)
- Testing
- 0.5mg intraocular Ranibizumab (Lucentis)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Luebeck
Neovascular Glaucoma
Use of Intravitreal Aflibercept Injection for Neovascular Glaucoma
This 52 week study will assess the use of intravitreal aflibercept injections in patients with neovascular glaucoma (NVG) compared to standard of care panretinal photocoagulation.
- Trial name
- NCT01711879
- Testing
- Aflibercept
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Colorado, Denver
Neovascular Glaucoma
Comparative Study, Safety and Efficacy, Ahmed Glaucoma Drainage Device, Model M4 Model S2 in Neovascular Glaucoma
Objective: Prospectively evaluate the safety and efficacy of the Ahmed Glaucoma Drainage Device, model M4 compared with the model S2.
- Trial name
- NCT02260219
- Testing
- Surgical Implant of Ahmed Glaucoma Drainage Device, model M4 and S2
- Volunteers
- 42 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Glaucoma, Neovascular
Japanese Phase 3 Study of Aflibercept in Neovascular Glaucoma Patients
To assess the efficacy and safety of the administration of aflibercept by intravitreal injection in comparison to sham to control intraocular pressure in patients with neovascular glaucoma.
- Trial name
- VEGA (NCT02396316)
- Testing
- Aflibercept (Eylea, BAY 86-5321)
- Where
- 19 sites in Japan
- Volunteers
- 54 people
- Sponsor
- Bayer
Diabetic Retinopathy, Glaucoma, Neovascular
Intravitreal Ranibizumab Injection as Adjuvant in the Treatment of Postvitrectomy Diabetic Vitreous Hemorrhage Accompanied by Neovascular Glaucoma
To determine the efficacy of intravitreal ranibizumab injection as adjuvant therapy in the treatment of postvitrectomy diabetic vitreous hemorrhage (PDVH) accompanied by neovascular glaucoma (NVG) as a means of preventing…
- Trial name
- NCT02647515
- Testing
- ranibizumab
- Volunteers
- 18 people
- Sponsor
- Ruijin Hospital
Proliferative Diabetic Retinopathy, Macular Degeneration
Analysis of Aqueous and Vitreous Humor
Clinical Retina research studies often collect aqueous samples in hopes of estimating levels of drug or cytokines in the vitreous. Little is known about how well vitreous and aqueous correlate.
- Conditions
- Proliferative Diabetic Retinopathy, Macular Degeneration, Macular Hole, Neovascular Glaucoma
- Trial name
- ARK (NCT02067013)
- Testing
- Ranibizumab, No Ranibizumab
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- California Retina Consultants
IOP Decreased, Visual Impairment
Triple Procedure for Dense Cataractus Neovascular Glaucoma Patients
Background: One of the most difficult refractory glaucomas in treatment is the neovascular type and its association with dense cataract add to this difficulty.
- Trial name
- NVG (NCT04143620)
- Testing
- Procedure
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- Minia University
Neovascular Glaucoma
The Effect of Conbercept Injection Through Different Routes for Neovascular Glaucoma
The neovascular glaucoma (NVG) is a refractory type of secondary glaucoma and often lead to frustrated treatment and blindness. It has been confirmed high levels of vascular endothelial growth factor (VEGF) in NVG.
- Trial name
- NCT03154892
- Testing
- Intracameral injection, Intravitreal injection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Glaucoma, Rubeosis Iridis
Intraocular Bevacizumab (Avastin) for Rubeosis Iridis
Bevacizumab (Avastin®, Roche, Rio de Janeiro, Brazil) is an anti-VEGF recombinant humanized monoclonal IgG1 antibody used to treat colorectal cancers.
- Trial name
- NCT00557232
- Testing
- bevacizumab
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Instituto de Olhos de Goiania
Glaucoma, New Onset Glaucoma
Lucentis for New Onset Neovascular Glaucoma
Neovascular glaucoma is a potentially debilitating disease of the eye. Vascular eye disease such as diabetes and vein occlusions can cause the retina to release factors that promote the growth of abnormal blood vessels.
- Conditions
- Glaucoma, New Onset Glaucoma, Neovascular Glaucoma, New Onset Neovascular Glaucoma
- Trial name
- NVG (NCT00727038)
- Testing
- Ranibizumab (Lucentis)
- Sponsor
- University of Illinois Chicago
Glaucoma Open-Angle, Glaucoma Eye
INTEGRAL Study: A Longitudinal Study of Surgeries and Lasers in Glaucoma: Long-term Results and Success Predictors Analysed From a Large-scale Retrospective and Prospective Glaucoma Register
The study is an observational analysis of patients' medical data recorded in a large-scale register, both retrospective (for patients operated and data recorded before 2018) and prospective (for data collected after 2018) in…
- Conditions
- Glaucoma Open-Angle, Glaucoma Eye, Glaucoma; Drugs, Glaucoma, Angle-Closure
- Trial name
- NCT04381611
- Where
- Switzerland
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Dr. Kaweh Mansouri
Refractory Glaucoma
Ahmed Valve Glaucoma Implant With Adjunctive Subconjunctival Bevacizumab in Refractory Glaucoma
The investigators aim to demonstrate the efficacy and safety of subconjunctival injection of Avastin as an adjunctive therapy for Ahmed valve glaucoma implant in patients with refractory glaucoma.
- Trial name
- NCT01128699
- Testing
- Subconjunctival Avastin, Ahmed Valve implant
- Where
- Iran
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vanak Eye Surgery Center
Neovascular Glaucoma, Type 2 Diabetes
Observation of Iris Blood Flow Via OCTA in Diabetic Neovascular Glaucoma
The goal of this observational study is to quantify iris blood flow via non-invasive eye scanning for evaluating ocular lesions in adults aged 18 years and older, including healthy volunteers, patients with type 2 diabetes…
- Trial name
- NCT07722910
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Qilu Hospital of Shandong University
Neovascular Glaucoma
Effect of Subconjunctival 5-fluorouracil on the Outcome of Ahmed Valve in Neovascular Glaucoma
Neovascular glaucoma is a common and severe type of secondary closed-angle glaucoma. Topical treatments have variable effects and unfortunately often require surgery to control IOP.
- Trial name
- NCT05316142
- Testing
- AGV with intraoperation MMC and postoperative BSS, AGV with intraoperation MMC and post operation 5FU
- Where
- Iran
- Volunteers
- 70 people
- Sponsor
- Iran University of Medical Sciences
Glaucoma, Intraocular Pressure
the Pops-titration Versus the Slow-coagulation Cyclophotocoagulation in Treatment of Refractory Glaucoma
Transcleral cyclophotocoagulation (TSCPC) has long been used as refractory glaucoma management and is very easy to learn and easy to perform.
- Trial name
- NCT01774227
- Testing
- The pops-titration group, The slow-coagulation group
- Where
- Thailand
- Volunteers
- 98 people
- Sponsor
- Prince of Songkla University
Choroidal Neovascularization, Macular Edema
An Open-label Extended Clinical Protocol of Ranibizumab to Evaluate Safety and Efficacy in Rare VEGF Driven Ocular Diseases.
The pupose of this study is to evaluate the safety and the efficacy of ranibizumab in rare VEGF driven ocular diseases.
- Conditions
- Choroidal Neovascularization, Macular Edema, Glaucoma, Neovascular, Diabetic Retinopathy
- Trial name
- ECLIPSE (NCT01908816)
- Testing
- ranibizumab
- Where
- 39 sites in France
- Volunteers
- 270 people
- Sponsor
- Novartis Pharmaceuticals
Neovascular Glaucoma, Neovascularization
KDR2-2 Suspension Eyedrop in the Treatment of Neovascular Glaucoma (KDR-NVG) Trial
The clinical trial is aimed to evaluate the anti-neovascular effect of KDR2-2 suspension eyedrop in the treatment of neovascular glaucoma.
- Trial name
- KDR-NVG (NCT04844619)
- Testing
- 4mg/ml KDR2-2 suspension eyedrop, 16mg/ml KDR2-2 suspension eyedrop
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sun Yat-sen University
Glaucoma, Glaucoma Eye
MicroPulse TLT - UK Study
This Prospective Interventional Study will assess the efficacy of MPTLT in the UK.
- Conditions
- Glaucoma, Glaucoma Eye, Glaucoma, Open-Angle, Glaucoma Secondary
- Trial name
- MPTLTUKS (NCT05593354)
- Testing
- Micropulse Transscleral laser therapy
- Volunteers
- 250 people
- Sponsor
- Imperial College Healthcare NHS Trust
Ocular Melanoma
Prevention of Neovascular Glaucoma by Intravitreal Injections of Anti-VEGF in Patients Treated with Proton Therapy for a Large Choroidal Melanoma
The reference treatment of ocular melanoma is a conservative treatment by proton therapy. Its goal is to treat the tumor while preserving the eyeball and visual acuity.
- Trial name
- PROTECT (NCT03172299)
- Testing
- Aflibercept Injection, False injection
- Where
- France
- Volunteers
- 57 people
- Sponsor
- Centre Hospitalier Universitaire de Nice