Clinical trials: Neostigmine
Neuromuscular Block
Sugammadex and Neostigmine at Shallow Neuromuscular Blockade
This study is designed to compare recovery times after reversal of a residual neuromuscular block (TOF-ratio 0.5) with different doses of either neostigmine or sugammadex.
- Trial name
- SUNDRO (NCT00895609)
- Testing
- Sugammadex, Neostigmine, Saline
- Where
- Germany
- Volunteers
- 99 people
- Sponsor
- Technical University of Munich
Spine Surgery
Speed of Recovery of Reversal of Neuromuscular Blockade in Geriatric Patients Undergoing Spine Surgery
Spine surgery is one of the most common operative procedures in the United States. It is performed in the prone position (a patient laying on belly).
- Trial name
- NCT03112993
- Testing
- sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Missouri-Columbia
Postoperative Complications, Postoperative Urinary Retention
Acupuncture for Postoperative Urinary Retention After Hemorrhoidectomy: a Randomized Controlled Trial
The goal of this study is to examine the efficacy of acupuncture in the management of acute postoperative urinary retention. Clinical question: Is acupuncture efficacious for postoperative urinary retention after hemorrhoidectomy…
- Trial name
- NCT05898919
- Testing
- Acupuncture, Neostigmine Injectable Product
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Residual Neuromuscular Blockade
Incidence and Severity of Residual Neuromuscular Blockade
This prospective study will take place at Harborview Medical Center (HMC) and the University of Washington Medical Center (UWMC), and will enroll adult patients undergoing abdominal surgery.
- Trial name
- NCT02660398
- Testing
- Standardized NMBD Management
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Washington
Sugammadex
Comparative Efficacy and Safety of Sugammadex and Neostigmine
Along with unconsciousness and analgesia, use a muscle relaxant (Neuromuscular blocking agent NMBA) is now part of the classic triad of anesthesia.
- Trial name
- NCT04997759
- Testing
- Neostigmine and Sugammadex
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Labor Pain
Epidural Neostigmine for Labor Pain
The purpose of this study is to see which dose of epidural neostigmine is the best additive to use with the numbing medication used in an epidural during labor.
- Trial name
- NCT00779467
- Testing
- Neostigmine, Bupivacaine, fentanyl
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Wake Forest University
Postoperative Gastrointestinal Dysfunction (POGD), Postoperative Ileus
Neuromuscular Blocking Agents on Gastrointestinal Function Following Colorectal Surgery
This study is a clinical research project conducted at Xijing Hospital to compare the effects of two different neuromuscular blockade reversal strategies on the recovery of gastrointestinal (GI) function after colorectal surgery.
- Conditions
- Postoperative Gastrointestinal Dysfunction (POGD), Postoperative Ileus, Colorectal Surgery
- Trial name
- NCT07271875
- Testing
- Neostigmine + Atropine, Sugammadex
- Volunteers
- 560 people
- Sponsor
- Xijing Hospital
Neuromuscular Blockade
Deep Neuromuscular Blockade During Robotic Radical Prostatectomy
Basic requirement for safe performance of the robotic intra-abdominal surgery is a calm and clear surgical field after the introduction of a capnoperitoneum. That can be enabled by a neuromuscular blockade.
- Trial name
- NCT02513693
- Testing
- Standard neuromuscular blockade, Deep neuromuscular blockade
- Where
- 2 sites in Czechia
- Volunteers
- 80 people
- Sponsor
- Palacky University
Cirrhosis and Chronic Liver Disease
Sugammadex Versus Neostigmine in Patients With Liver Cirrhosis Undergoing Liver Resection
Liver cirrhosis is a progressive disease characterized by loss of functional hepatocytes that substantially affects drug pharmacokinetics.
- Trial name
- NCT02414880
- Testing
- Sugammadex, Neostigmine, Rocuronium
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Analgesia
Neostigmine as an Adjuvant in Tranversus Abdominis Plane (TAP) Block in Cesarean Section Under Spinal Anesthesia
Cesarean birth is a common surgical procedure. After cesarean birth, postsurgical pain may delay recovery, interfere with maternal-newborn bonding, and reduce the breastfeeding if not adequately controlled.
- Trial name
- TAB (NCT05785377)
- Testing
- Bupivacaine-Neostigmine, Bupivacaine
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Mansoura University
Acute Pancreatitis, Intra-abdominal Hypertension
Neostigmine Treatment of Acute Pancreatitis Combined With Intra-abdominal Hypertension
Acute pancreatitis(A) often complicated with Intra-abdominal Hypertension. After the onset of acute pancreatitis, capillary leakage causing ascites,upper gastrointestinal tract obstruction and paralytic ileus leading to an…
- Trial name
- NCT02543658
- Testing
- Neostigmine Methylsulfate 1 MG/ML, Conservative treatment
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Knee Injuries
Intra-articular Dexmedetomidine Versus Neostigmine After Knee Arthroscopy (a Comparative Study)
Knee arthroscopy is a minimally invasive day case procedure which may be done for diagnosis, meniscectomy or debridement. Arthroscopic surgery is associated with a variable degree of postoperative pain, which is caused by an…
- Trial name
- NCT03212495
- Testing
- dexamedetomidine, neostigmine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Anesthesia, Obstetric
Regional Anaesthesia
Spinal anesthesia is an established technique used in obstetric surgeries, It provides adequate analgesia both intra and post-operative and also avoids complications associated with general anesthesia for mother and fetus.
- Trial name
- NCT06055101
- Testing
- DEXMEDETOMIDINE, Neostigmine, Bupivacaine
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Reham Ali Abdelhaleem Abdelrahman
Anesthesia, General
Comparison of Sugammadex With Neostigmine During Laparoscopic Cholecystectomy or Appendectomy (P05699)
The current trial was designed to demonstrate faster recovery from a neuromuscular blockade (NMB) induced by rocuronium after reversal at 1-2 Post Tetanic Count (PTC) by 4.0 mg.kg-1 sugammadex compared to 50 µg.kg-1 neostigmine…
- Trial name
- NCT00724932
- Testing
- Rocuronium, Sugammadex, Neostigmine
- Volunteers
- 140 people
- Sponsor
- Merck Sharp & Dohme LLC
Residual Neuromuscular Blockade
Reversal of Neuromuscular Blockade in Thoracic Surgical Patients
The majority of patients undergoing surgery receive neuromuscular blocking agents (NMBAs) in the operating room. Reversal of neuromuscular blockade at the conclusion of a general anesthetic is accomplished with cholinesterase…
- Trial name
- NCT01837498
- Testing
- Neostigmine, Sugammadex
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Endeavor Health
Neuromuscular Blockade, Arthroplasty, Replacement, Hip
Reversal of Neuromuscular Blockade With Sugammadex or Usual Care in Hip Fracture Surgery or Joint (Hip/Knee) Replacement (P07038)
This study will assess the effect of reversal of neuromuscular blockade with sugammadex compared with reversal according to usual care (neostigmine or spontaneous reversal) on the incidence of post-surgical bleeding events and on…
- Conditions
- Neuromuscular Blockade, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Blood Coagulation
- Trial name
- NCT01422304
- Testing
- Sugammadex, neostigmine and glycopyrrolate or atropine
- Volunteers
- 1,198 people
- Sponsor
- Merck Sharp & Dohme LLC
Critically Ill Cirrhotics
To Study the Efficacy of Intravenous Neostigmine in Resolution of Acute GI Paralysis in Critically Ill Cirrhotics
Aim: To determine the efficacy of intravenous neostigmine in the resolution of acute GI paralysis in patients with Critically Ill Cirrhosis (CIC).
- Trial name
- NCT06462872
- Testing
- observational study
- Where
- India
- Volunteers
- 48 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Respiratory-Gated Imaging Techniques
Functional Respiratory Imaging After Neostigmine or Sugammadex
The use of neuromuscular blocking agents (NMBAs) is still associated with postoperative pulmonary complications. The investigators rely on acceleromyography (AMG) of a peripheral nerve/muscle to assess the patients' breathing…
- Trial name
- FRINeoS (NCT02284412)
- Testing
- Neostigmine, Sugammadex, Water for injection
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- Onze Lieve Vrouw Hospital
Emergence Agitation, Nasal Surgery
Emergence Agitation
The impact of sugammadex on agitation upon emergence following adult nasal surgeries is an issue which needs to be studied that links anesthetic management with postoperative recovery.
- Trial name
- Sugamadex (NCT07253428)
- Testing
- Neostigmine + Atropine, Sugamadex
- Where
- Saudi Arabia
- Volunteers
- 486 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Thyroid Diseases, Surgical Injury
Feasibility of Neostigmine for Intraoperative Neuromonitoring in Thyroid Surgery
For successful intraoperative neuromonitoring (IONM), adequate reversal of neuromuscular blocking agent is a prerequisite in thyroid surgery with .
- Conditions
- Thyroid Diseases, Surgical Injury, Nerve Monitoring
- Trial name
- NCT04873531
- Testing
- Neostigmine, Normal saline
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Hospital