Clinical trials: Negative Pressure Therapy
Complications Wounds, Negative Pressure Wound Therapy
Incisional Negative Pressure Wound Therapy in High Risk Patients Undergoing Panniculectomy: A Prospective Randomized Controlled Trial
Incisional negative pressure therapy (INPWT) has previously been shown in certain patient populations to decrease wound healing complications, decrease the rate of hematomas and seromas, as well as have better scar quality.
- Conditions
- Complications Wounds, Negative Pressure Wound Therapy, Wound Healing Delayed, Incisional
- Trial name
- NCT03010137
- Testing
- Incisional Negative Pressure Wound Therapy, Standard Closure with Skin Glue, PICO (Smith&Nephew)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Wound, Infection
PICO Above Incisions After Vascular Surgery
The wound infection rate in the groin after vascular surgery has been denoted to be high since the wound surveillance register started in 2005.
- Trial name
- NCT01913132
- Testing
- Negative pressure wound therapy with PICO (Smith & Nephew)
- Where
- Sweden
- Volunteers
- 644 people
- Sponsor
- Stefan Acosta
Infection
Salvage of Infected Cardiovascular Implantable Electronic Devices (CIED) by Localized High-dose Antibiotics
Following previous positive experience with regulated CITA-RNPT of infected CIEDs, we suggest increasing the number of recruited patients and that CITA-RNPT can be administered prophylactically to patients prior to replacement of…
- Trial name
- NCT01770067
- Testing
- CITA-RNPT, Extraction of infected CIED
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hillel Yaffe Medical Center
Postoperative Wound Complications
Negative Pressure Wound Therapy in Cesarean Section
The investigators propose a prospective, randomized trial evaluating the use of negative pressure wound therapy (NPWT) with high risk obstetrical patients.
- Trial name
- NPWTCS (NCT02289157)
- Testing
- Negative pressure wound therapy
- Where
- United States
- Volunteers
- 441 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Upper Extremity Wound, Lower Extremity Wound
VAC Bioburden Wound Care Assessment
The purpose of this study is to compare the microbiologic burden and need for further operative debridement of patients undergoing primary surgical debridement of infected tissue, soft tissue abscesses, or traumatic wounds of the…
- Conditions
- Upper Extremity Wound, Lower Extremity Wound, Soft Tissue Abscesses, Traumatic Wounds
- Trial name
- NCT04826965
- Testing
- Wound Vac is applied
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Duke University
OSA, iNAP
Comparison for Oral Negative Pressure Therapy and CPAP for OSA Under Sleep Endoscopy Assistance: A Randomized Controlled Trial
This is the study entitled "Comparison for oral negative pressure therapy and CPAP for OSA under sleep endoscopy assistance: A randomized controlled trial".
- Conditions
- OSA, iNAP, DISE
- Trial name
- NCT04626700
- Testing
- iNAP, CPAP
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
Wound Infection
Comparing Outcomes for Prontosan Versus Normal Saline for Negative Pressure Wound Therapy With Instillation
This is a prospective, randomized trial comparing the outcomes for Prontosan versus normal saline as the solution for negative pressure wound therapy with instillation (NWPTi).
- Trial name
- NCT01939145
- Testing
- Normal saline, Prontosan
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Georgetown University
Complete Vertical Midline Sternotomy / Cardiac Surgery
Prevention of the Risk of Complete Sternotomy Scar Dehiscence in Cardiac Surgery: A Clinical Investigation Comparing Negative Pressure Wound Therapy (NPWT) vs. Standard Dressing
Mediastinitis is the most feared infectious complication after cardiac surgery. Several risk factors are known such as: obesity, diabetes, chronic obstructive pulmonary disease, double breast sampling, immunodeficiency…
- Trial name
- PRISTER (NCT06207630)
- Testing
- Dressing Device
- Where
- 5 sites in France
- Volunteers
- 660 people
- Sponsor
- Poitiers University Hospital
Dental Pulp Necrosis, Pulpitis
Metagenomic Analysis and Postoperative Pain in Infected Root Canals Using Different Irrigation Protocols
Achieving effective root canal disinfection while minimizing postoperative pain is a critical goal in endodontic therapy. Advanced irrigation protocols, such as ultrasonic activation, laser activation, negative pressure…
- Trial name
- NCT07546773
- Testing
- Ultrasonic Irrigation Activation, Laser-Activated Irrigation, Mechanical Irrigation Activation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Suez Canal University
Surgical Wound Infection
Comparison of Surgical Site Infection Rate Between Primary, Delayed Primary and Vacuum Assisted Closures.
The objective of the study is to compare infection rates between primary, delayed primary and vacuum assisted closures in contaminated and dirty/infected laparotomy wounds.
- Trial name
- NCT02649543
- Testing
- Primary Closure, Vacuum Assisted Closure, Delayed Primary Closure
- Where
- Mexico
- Volunteers
- 81 people
- Sponsor
- Eduardo Flores Villalba
NPWT, Latissimus Dorsi Flap
Role of Negative Pressure Wound Therapy in Latissimus Dorsi Flap Donor Site Seroma Prevention
The use of NPWT as a post-operative dressing significantly reduces the incidence of seroma formation after harvesting LD flap.
- Conditions
- NPWT, Latissimus Dorsi Flap, Breast Reconstruction
- Trial name
- NCT02442401
- Testing
- The negative pressure wound therapy
- Volunteers
- 40 people
- Sponsor
- Chulalongkorn University
Breast Cancer, Wound Complication
The Risk of Postoperative Wound Complications Following the Use of Negative Pressure Wound Therapy in Patients Undergoing Mastectomy
To evaluate the risk of postoperative wound complications following the use of Avelle negative pressure wound therapy in patients undergoing mastectomy and flap fixation, which might serve as a basis for a randomized controlled…
- Conditions
- Breast Cancer, Wound Complication, Wound Infection, Wound Dehiscence
- Trial name
- ALEX (NCT03942575)
- Testing
- Negative pressure wound therapy
- Where
- Netherlands
- Volunteers
- 162 people
- Sponsor
- Zuyderland Medisch Centrum
Split-thickness Skin Graft Donor Sites, Burns
Molecular, Histologic, and Clinical Analysis of Negative Pressure Wound Therapy (NPWT) for Split-thickness Skin Graft (STSG) Donor Sites
The purpose of this single-center, randomized, prospective cohort study is to evaluate the clinical outcome and negative-pressure wound therapy (NPWT) mediated modulation of the biologic milieu of a modified NPWT dressing on…
- Trial name
- NCT02712164
- Testing
- Modified NPWT dressing, Tegaderm
- Sponsor
- Brigham and Women's Hospital
Surgical Site Infection, Wound Complication
VAC Dressings for Colorectal Resections
Surgical Site Infections (SSIs) and wound complications are common occurrences following colorectal resection surgery. Incisional Negative Pressure Wound Therapy (iNPWT) has developing evidence for improving wound complication…
- Conditions
- Surgical Site Infection, Wound Complication, Wound Dehiscence, Seroma
- Trial name
- VACCRR (NCT02967627)
- Testing
- Incisional Negative Pressure Wound Therapy (iNPWT), Sterile Gauze Dressing
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Surgical Wound Infection
Negative Pressure Wound Therapy for Prevention of Poststernotomy Infection
This prospective study evaluates the role of negative pressure wound therapy or wound VAC as a dressing over the incision to prevent poststernotomy wound infection in high risk patients.
- Trial name
- NCT02020018
- Testing
- Prevena Incision Management System, Conventional sterile dry wound dressing
- Where
- United States
- Volunteers
- 1,869 people
- Sponsor
- Mayo Clinic
Obstructive Apnea, Sleep Apnea Syndrome, Obstructive
Pilot Study of Negative Pressure Neck Therapy (NPNT)
Obstructive sleep apnea (OSA) is a serious, chronic sleep-related breathing disease in which the upper airway repeatedly collapses during sleep, leading to intermittent oxygen deprivation.
- Conditions
- Obstructive Apnea, Sleep Apnea Syndrome, Obstructive, Sleep Disorder (Disorder)
- Trial name
- NCT07301567
- Testing
- Negative Pressure Neck Therapy (NPNT)
- Where
- 2 sites in Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Surgical Site Infection, Wound Heal
The Efficacy of Purse-string Skin Closure With Negative Pressure Wound Therapy (NPWT) After Ileostomy Reversal
Evaluating the effectiveness of the existing 'linear suture + wound drain placement' and 'purse-string suture + negative pressure wound therapy' through a prospective comparative study
- Trial name
- NCT04986111
- Testing
- Linear skin closure with wound drain, Purse-string skin closure with negative pressure wound therapy
- Where
- South Korea
- Volunteers
- 138 people
- Sponsor
- Seoul National University Bundang Hospital
Negative-Pressure Wound Therapy, Diabetic Foot
Comparison Between Negative Pressure Wound Therapy and Conventional Wound Dressings Before and After Split-Thickness Skin Grafting in Diabetic Foot Wounds
The aim of this thesis is to compare the efficacy of Vacuum assisted closure device versus conventional dressing before and after split thickness skin grafting in diabetic foot wounds.
- Trial name
- NCT05716503
- Testing
- Negative Pressure Wound Therapy (NPWT), Ordinary dressings with antibiotic ointment and gauze
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Sohag University
Ischemia Limb, Diabete Mellitus
Comparative Study of Negative-Pressure Wound Therapy Integrated With Silver Nanoparticle Spray Versus Negative-Pressure Wound Therapy in Post-Revascularization Diabetic Foot Wound Management
This was a prospective, parallel-group, randomized controlled trial conducted at the Vascular Surgery Department of Kafrelsheikh University Hospital, Egypt.
- Trial name
- SNIPS-FOOT (NCT07147790)
- Testing
- After successful revacularization, We will categorize patients into two groups : groups A (The patient's wound will be cleaned and irrigated with silver nanoparticle spray, then we will cover the woun, Silver Nanoparticles Irrigant
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Kafrelsheikh University
Wound Heal, Periprosthetic Joint Infection
Closed Incisional Negative Pressure Wound Therapy in Post-surgical Wound Care of Patients With Periprosthetic Joint Infection
In the proposed study, we will apply Prevena on the surgical wound right after closure of the wound in the operating theater. Prevena will be used for 7 days, unless there is ongoing infection or much wound drainage that requires…
- Trial name
- NCT05357287
- Testing
- PREVENA incision management system
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Chang Gung Memorial Hospital