Clinical trials: Negative Affect
Parenting
Be Good Parents (Parent Education)
The collaborator has its vision as "To have children, individuals, families and migrants across countries live in dignity and harmony, and be contributing members to a just, humane and caring society." Parents are very…
- Trial name
- NCT02986009
- Testing
- Parenting, Information
- Where
- China
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- City University of Hong Kong
Depression, Anxiety
Brightline: Advancing Mental Health on Campus
This observational study will employ a multi-modal observation methodology, integrating data from wearable devices and smartphones to establish comprehensive digital biomarkers for identifying symptoms of mental health conditions…
- Conditions
- Depression, Anxiety, Stress, Positive Affect
- Trial name
- NCT06770075
- Testing
- Observational
- Where
- Singapore
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Autism Spectrum Disorder
The Use of Social Stories to Reduce Negative Affect and Improve Satisfaction in Adults Attending an ASD Assessment
Many people with Autism Spectrum Disorder (ASD) find the unpredictability of social situations emotionally distressing. It is likely that attending a diagnostic assessment is no exception.
- Trial name
- NCT03372421
- Testing
- Social Story, Standard Information
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Sheffield
Affect, Wellness, Psychological
The Effects of Walking in Nature (vs. an Urban Setting) on the Wellbeing of Postsecondary Students.
The goal of this randomized controlled trial is to examine the effects of a walking intervention (3 walks per week for a period of 4 weeks) in a nature vs. urban setting on the wellbeing of young adult postsecondary students.
- Conditions
- Affect, Wellness, Psychological, Depressive Symptoms, Anxiety Disorders and Symptoms
- Trial name
- NCT05889078
- Testing
- A 4-week walking intervention
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- McGill University
Advanced Solid Tumors
A First-in-human Study to Learn How Safe the Study Drug BAY3375968, an Anti-CCR8 Antibody, is, When Given Alone or in Combination With Pembrolizumab, How it Affects the Body, How it Moves Into, Through, and Out of the Body, and to Find the Best Dose in Participants With Advanced Solid Tumors
Researchers are looking for a better way to treat people who have advanced solid tumors. Advanced solid tumors are solid cancers that may have spread to nearby tissue, lymph nodes and/or to distant parts of the body and that are…
- Trial name
- NCT05537740
- Testing
- BAY3375968, Pembrolizumab
- Where
- 26 sites in United States, Belgium and 6 more
- Volunteers
- 129 people
- Sponsor
- Bayer
Depressive Disorder, Major
Effects of Tryptophan Depletion on Brain Processing of Emotions in Patients With Mood Disorders
This study will investigate how the brain process emotions in healthy people and in patients who have major depression in order to better understand the causes of depression.
- Trial name
- NCT00097175
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Bipolar Disorder, Bipolar I Disorder
Using Neuroplasticity-Based Computerized Training to Improve Emotion Regulation in Bipolar Disorder (BRAINS)
The goal of this study is to evaluate the feasibility and potential benefit of a behavioral intervention designed to improve emotion regulation in individuals with bipolar disorder.
- Conditions
- Bipolar Disorder, Bipolar I Disorder, Bipolar Affective Disorder, Bipolar Disorder I
- Trial name
- BRAINS (NCT05683431)
- Testing
- Cognitive Control of Emotion (CCE) Training
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Anorexia Nervosa, Atypical Anorexia Nervosa
Stress and Neurofeedback in Anorexia Nervosa
Anorexia nervosa (AN) and atypical AN (AAN) are severe psychiatric illnesses associated with high disease burden including high treatment costs and excessive mortality rates.
- Trial name
- NCT05834816
- Testing
- Negative Affect Task
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Perceived Stress, Positive and Negative Affect
Efficacy of Interactive Audio-based Mindfulness ChatGPT-Powered Intervention on Well-being
Brief mindfulness intervention is a short form is a form of short-duration practice, typically delivered for around 30 minutes or less (Howarth et al., 2019).
- Conditions
- Perceived Stress, Positive and Negative Affect, State Anxiety, Self Control
- Trial name
- NCT07333365
- Testing
- Interactive Mindfulness Breathing ChatGPT-Powered Intervention, Interactive Mind Wandering ChatGPT-Powered Intervention, Mindfulness Breathing Audio-only
- Where
- Singapore
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Singapore Management University
Mild-moderate Unipolar Depression; Persistent Negative Affect
Dismantling Mindfulness: Contributions of Attention vs. Acceptance
This study addresses NCCAM's request for research that investigates the neuropsychological mechanisms underlying mind-body therapies, and for precise criteria and better delineation of meditation practices.
- Trial name
- NCT01831362
- Testing
- Mindfulness-Based Cognitive Therapy, Focused Attention (FA), Open- Monitoring
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Brown University
Helicobacter Infections
Eradication Rates of Helicobacter Pylori and Its Affecting Factors
The purpose of this study is to investigate the trend of eradication rates of first-line triple therapy for Helicobacter pylori in recent ten years and clinical factors that affect the eradication in Korean.
- Trial name
- NCT01922505
- Testing
- PPI triple therapy
- Where
- South Korea
- Volunteers
- 2,500 people
- Sponsor
- Seoul National University Bundang Hospital
Chronic Low Back Pain, Negative Affectivity
Treating Negative Affect in Low Back Pain Patients
This study will examine how the use of antidepressant, physical therapy, and combination of both affects pain, function, and depression outcomes in chronic low back pain patients.
- Trial name
- TNA-LBP (NCT04747314)
- Testing
- Antidepressant, Enhanced Fear Avoidance Rehabilitation
- Where
- 3 sites in United States
- Volunteers
- 308 people
- Sponsor
- Ajay Wasan, MD, Msc
Healthy Volunteers (Intended Indication: Metastatic Patients With Triple Negative or HR+ Breast Cancer, or Hormone Sensitive Prostate Cancer)
A Study to Assess How Itraconazole Affects the Uptake and Elimination of Capivasertib in the Body
This study will be an open-label, fixed sequence study in healthy subjects (vasectomized males and females of non-childbearing potential), performed at a single study centre.
- Trial name
- NCT04712396
- Testing
- Capivasertib, Itraconazole
- Where
- Germany
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Depression, Anxiety
Affect Treatment for Depression and Anxiety
The purpose of this study is to evaluate the efficacy and mediators of change in Positive Affect Treatment, a psychotherapy specifically aimed at enhancing reward sensitivity in individuals with low positive affect (a core…
- Trial name
- NCT05203861
- Testing
- Positive Affect Treatment, Negative Affect Treatment
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of California, Los Angeles
Loneliness, Negative Affect
The Effects of Group Music Therapy on the Emotional Health of Residents in Long-Term Care Facilities: A Pilot Study
The goal of this pilot study is to learn whether group music therapy improves the emotional health of residents living in long-term care facilities.
- Conditions
- Loneliness, Negative Affect, Music Therapy, Long-term Care Facility
- Trial name
- NCT07536360
- Testing
- Group Music Therapy
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yu Chia Chang
Eating Disorder Symptom, Emotional Maladjustment
Testing if Reductions in Negative Affect Yield Decreased Emotional Eating Symptoms
The purpose of this study to test a computerized treatment designed to help people with high levels of emotional eating, which is when people eat to cope with negative emotions and/or stressful situations.
- Conditions
- Eating Disorder Symptom, Emotional Maladjustment, Negative Thoughts
- Trial name
- NCT03040076
- Testing
- Cognitive Bias Treatment, Relaxation Condition
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Florida State University
Psychosis, Complex Post-Traumatic Stress Disorder
Psychological Interventions for Complex PTSD And Schizophrenia-Spectrum Disorder: PICASSO Trial
Psychosis is a highly distressing mental health condition, affecting up to 3% of the population. Conceptually, it has much in common with complex post-traumatic stress disorder (CPTSD), a recently introduced condition in ICD-11.
- Conditions
- Psychosis, Complex Post-Traumatic Stress Disorder, Schizophrenia
- Trial name
- PICASSO (NCT05281640)
- Testing
- Affect Dysregulation intervention, Negative Self Concept intervention, Disturbed Relationships intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 57 people
- Sponsor
- Edinburgh Napier University
Chronic Pain, Low Back Pain
Development and Evaluation of Computerized Chemosensory Based Orbitofrontal Networks Training for Treatment of Pain
The overarching goal of this study phase, Phase I component is to configure Computerized Chemosensory-Based Orbitofrontal Networks Training (CBOT) into Computerized Chemosensory-Based Orbitofrontal Networks Training for Treatment…
- Trial name
- CBOT-Pain (NCT06218407)
- Testing
- Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT) short burst paradigm, Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT) long burst paradigm, Computerized Chemosensory-Based Orbitofrontal Cortex Training plus beta caryophyllene (CBOT-Plus)
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Evon Medics LLC
Anxiety, Depression
Effects of a High EPA Multinutrient Supplement on Negative Affect in Young Adults.
This is a 12-week-long, randomised, double-blind, placebo-controlled trial exploring the efficacy of a high-EPA multinutrient supplement in the management of sub-clinical anxiety and depression.
- Trial name
- NutriMOOD (NCT04844034)
- Testing
- High-EPA multinutrient supplement.
- Where
- United Kingdom
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Roehampton
Focus on Pain Regulation Mechanisms, Social Stress Mechanisms
The Effects of Mindfulness Training on Pain Regulation, Negative Affect, Attention, and Social Stress
The project's objective is to explore the impact of Mindfulness-Based-Stress-Reduction (MBSR) on pain regulation, social stress, basic affective and attention functions, and on the brain, immune, and endocrine mechanisms that…
- Conditions
- Focus on Pain Regulation Mechanisms, Social Stress Mechanisms, Basic Affective Mechanisms, Attention Mechanisms
- Trial name
- NCT01301105
- Testing
- Mindfulness Based Stress Reduction (MBSR), Health Enhancement Program (HEP)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison