Clinical trials: Necrotic Pulp
Bacterial Viability of Necrotic Pulp With Asymptomatic Apical Periodontitis
Molecular Analysis of Intracanal Microbes After Chemomechanical Procedure and Root Canal Medication: A Randomized Controlled Trial
This study aimed to evaluate clinically the intracanal microbes at molecular level after using established root canal medicament Calcium hydroxide and potential root canal medicament Glycyrrhizin.and Decontamination Analysis of…
- Trial name
- NCT06291623
- Testing
- Glycyrrhizin
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Endodontic Disease
Effect of Different Irrigation Solutions on Postoperative Pain and Lesion Healing
In this study researchers plan to conduct, three different irrigation solutions that are responsible for the release of growth factors necessary for the success of regenerative endodontic treatments will be used.
- Trial name
- NCT06386991
- Testing
- Using ethylenediaminetetraacetic acid (EDTA), citric acid ((MONO/ANH) and etidronic acid (HEBP) to clean root canals during regenerative endodontic treatments
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Pulp Necrosis
Treatment Outcome With a Revascularization Protocol Using the Triple Versus Double Antibiotic Paste
The purpose of this study is to determine the treatment outcomes in permanent teeth with necrotic pulp and immature root development that undergo a regenerative procedure using a triple antibiotic paste (ciprofloxacin…
- Trial name
- NCT00881491
- Testing
- Double Antibiotic Paste, Triple Antibiotic Paste, Mineral Trioxide Aggregate
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Pulp and Periapical Tissue Disease, Patients With Pulp Necrosis and Apical Periodontitis
Interleukin 8 and10 Levels Changes in Teeth With Necrotic Pulp and Apical Periodontitis
The goal of this observational study is to evaluate changes in interleukin 8 (IL-8) and interleukin 10 (IL-10) levels in gingival crevicular fluid (GCF) and periapical fluid during root canal treatment in patients with necrotic…
- Trial name
- NCT06713174
- Testing
- Assessment of Interleukin 8 and 10 Level Changes Before and During Root Canal Treatment for Necrotic Pulp with Apical Periodontitis
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Pulp Necroses
Assessment of Post-operative Pain After Different Instrumentation Techniques in Pulpectomy Treatment of Primary Molars
The goal of this clinical trial is to compare the post operative pain after using three different instrumentation techniques in pulpectomy treatment of pediatric participant.
- Trial name
- NCT06256250
- Testing
- pulpectomy treatment will be done using the adaptive xp endo shaper., pulpectomy treatment will be done using FANTA AF baby files., pulpectomy treatment will be done using hand k files.
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Pulp Necroses
Laser Activated Irrigation Versus Passive Ultrasonic Irrigation
assessment of bacterial reduction and post-operative pain following Laser activated irrigation using sodium hypochlorite and a 980 nm diode laser device as an adjunct to conventional root canal treatment, and comparing it with…
- Trial name
- NCT04035083
- Testing
- Laser activated irrigation, Passive ultrasonic irrigation
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulp Necrosis, Root Canal Infection
Frankincense Versus Sodium Hypochlorite for Root Canal Disinfection
This research study is being done to find out if a natural ingredient called frankincense can clean infected root canals as effectively as the standard cleaning solution currently used in dentistry.
- Conditions
- Pulp Necrosis, Root Canal Infection, Apical Periodontitis
- Trial name
- FSHRCD: RCT (NCT07823868)
- Testing
- Sodium hypochlorite 3%, Frankincense-based irrigant
- Where
- Oman
- Volunteers
- 30 people
- Sponsor
- Oman Dental College
Apexification, Root Canal Therapy
Antimicrobial Pastes and Clinical Cases of Apexogenesis
The aim of this study was to perform a clinical and microbiological evaluation of teeth with incomplete apexogenesis and traumatic necrosis that were treated with a revascularization technique, evaluating the microbial reduction…
- Conditions
- Apexification, Root Canal Therapy, Dental Trauma
- Trial name
- NCT03112291
- Testing
- Apexification
- Where
- Brazil
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Adriana Kelly de Sousa Santiago Barbosa
Intracanal Medication, N-acetylcystine
Effect of N-acetylcysteine Versus Calcium Hydroxide Used as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Levels of MMP -9 in Periapical Fluids in Patients With Necrotic Pulp
To compare the effect of N-acetylcysteine versus calcium hydroxide as intra canal medication on: Intensity of postoperative pain. Bacterial load reduction. levels of MMP -9 in Periapical Fluids.
- Conditions
- Intracanal Medication, N-acetylcystine, Calcium Hydroxide, Mediators
- Trial name
- NCT05666089
- Testing
- N-acetyl cysteine, Calcium hydroxide
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Immature Permanent Teeth With Open Apex, Pulp Necrosis
Efficiency of Asiaticoside as Intracanal Medication in Revascularization Process
This study assess the ability of Asiaticoside based Intracanal medication compared to the commonly used Intracanal medicament ( calcium hydroxide Ca(OH) 2) on the outcome of the revascularization process in immature permanent…
- Trial name
- NCT07802340
- Testing
- Intracanal medication
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Mansoura University
Necrotic Pulp, Acute Apical Periodontitis of Pulpal Origin
Clinical Efficacy of Novel Jasminum-based Calcium Hydroxide Medicament
A triple-blind, parallel group, randomized trial with an allocation ratio of 1:1. Participants randomly allocated into two groups A and B.
- Trial name
- NCT06653608
- Testing
- Nano-reinforced calcium hydroxide medicament, Calcium hydroxide without nanoparicles
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Tooth, Nonvital
Pain Following One-visit Versus Two-visit Root Canal of Necrotic Teeth Using Protaper Next
To evaluate the incidence and severity of postoperative pain after root canal therapy of necrotic teeth in one appointment versus two appointments using Protaper next instrument.
- Trial name
- NCT02984488
- Testing
- single visits, two visits
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Necrotic Pulp With Symptomatic Apical Periodontitis
Assessment of Postoperative Pain After Using Two Formulations of Calcium Hydroxide Intracanal Medication .
Calcium hydroxide is advocated as an intracanal medication for various purposes, including prevention of post-treatment symptoms.
- Trial name
- NCT05021809
- Testing
- Calcium hydroxide intracanal medication application
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Suez Canal University
Necrotic Pulp
Effect of Etidronate in Sodium Hypochlorite Versus Sodium Hypochlorite on the Intensity of Postoperative Pain
To compare the effect of using Etidronate in sodium hypochlorite versus sodium hypochlorite irrigating solution on: Postoperative pain in patients with necrotic pulp.
- Trial name
- NCT04035330
- Testing
- etidronate in sodium hypochlorite, sodium hypochlorite
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University
Endodontic Disease
Outcome of Regenerative Endodontic Procedures
Clinical management of immature non-vital (necrotic) permanent teeth is challenging, due to inherent structural weakness. Earlier management of such teeth relied on the traditional calcium hydroxide (Ca(OH)2) apexification…
- Trial name
- NCT05612451
- Testing
- Regenerative Endodontic Procedures, non-setting calcium hydroxide, modified triple antibiotic paste
- Where
- Jordan
- Volunteers
- 45 people
- Sponsor
- King Abdullah University Hospital
Effects of the Elements
Post-operative Pain Reduction
Recruited patients with necrotic pulp after application of conventional calcium hydroxide paste are assigned to group, Calcium hydroxide nanoparticle group and Combined Calcium hydroxide with silver nanoparticle group and record…
- Trial name
- NCT04338633
- Testing
- Conventional calcium hydroxide paste, Calcium hydroxide nanoparticle, Combined Calcium hydroxide with silver nanoparticle
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Minia University
Type 2 Diabetes Mellitus (T2DM), Necrotic Pulp
Photodynamic Therapy in Root Canal Treatment of T2DM Patients: Microbiome Analysis Via Next-Gen Sequencing
This clinical study investigates the effectiveness of antimicrobial photodynamic therapy (aPDT) as an additional disinfection method in root canal treatment of patients with Type 2 Diabetes Mellitus (T2DM) who have apical…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Necrotic Pulp, Apical Periodontitis
- Trial name
- NCT06931678
- Testing
- aPDT
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Dental Pulp Necrosis
Antimicrobial Efficacy of Four Different Irrigation Protocols
proper disinfection of root canal system before obturation is a must for long term success of endodontic treatment, therefore a proper irrigant is mandatory, therefore investigators are studying the antibacterial effects of 4…
- Trial name
- NCT03668899
- Testing
- irrigation
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Pulp Necrosis
Effect Of Different Lining Materials in Stepwise Excavation
Deep carious lesions will encounter the dentist with the challenge of selecting a treatment method that could avoid the pulpal exposure and maintain the pulp vitality.Conventional restorative treatments suggest complete removal…
- Trial name
- NCT01730287
- Testing
- Control, Calcium Hydroxide, Mineral Trioxide Aggregate(MTA)
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Azad University of Medical Sciences
Dental Pulp Necrosis, Pulpitis
Metagenomic Analysis and Postoperative Pain in Infected Root Canals Using Different Irrigation Protocols
Achieving effective root canal disinfection while minimizing postoperative pain is a critical goal in endodontic therapy. Advanced irrigation protocols, such as ultrasonic activation, laser activation, negative pressure…
- Trial name
- NCT07546773
- Testing
- Ultrasonic Irrigation Activation, Laser-Activated Irrigation, Mechanical Irrigation Activation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Suez Canal University