Clinical trials: Nasal Obstruction
Anesthesia
Postdural Puncture Headache Relief With Aminophylline and SPGB
The purpose of the study is to compare Sphenopalatine ganglion block (SPGB) and aminophylline in the efficacy and safety management of PDPH.
- Trial name
- NCT05552404
- Testing
- conservative therapy, Aminophylline, trans nasal sphenopalatine ganglion block
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Nasal Valve Collapse, Nasal Breathing
Latera RCT - Latera vs. Sham Control for Lateral Nasal Valve Collapse
The primary objective of the LATERA RCT is to demonstrate the superiority of the Latera Implant to improve nasal breathing, compared with a Sham Control procedure.
- Trial name
- NCT03400787
- Testing
- Latera Implant
- Where
- 11 sites in United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Spirox, Inc.
Rhinoplasty, Nasal Obstruction
Outcome Analysis in Septorhinoplasty
A prospective observational cohort study that measures pre- and postoperative outcome of septorhinoplasty by means of patient-related outcome measures (PROMS: NOSE, FACE-Q, Utrecht Questionnaire, SCHNOS and BDDQ-AS) as well as…
- Conditions
- Rhinoplasty, Nasal Obstruction, Esthetics
- Trial name
- NCT03925389
- Testing
- External septorhinoplasty
- Where
- Belgium
- Volunteers
- 750 people
- Sponsor
- FRANK DECLAU
Sleep Disorders, Congestion, Nasal
Exploratory Subjective Sleep Study of a Prototype Nasal Dilator
The purpose of this exploratory study is to evaluate the subjective measures of congestion and sleep quality in subjects who suffer from chronic nasal congestion and report trouble with their sleep.
- Trial name
- NCT01122849
- Testing
- Prototype Nasal Dilator, Marketed Nasal Strip
- Where
- 2 sites in United States
- Volunteers
- 61 people
- Sponsor
- GlaxoSmithKline
Nasal Congestion and Inflammations
Safety and Effectiveness of Sonu for Pediatric Nasal Congestion
To demonstrate the safety and effectiveness of Sonu for the treatment of pediatric patients with moderate to severe nasal congestion.
- Trial name
- NCT06773013
- Testing
- Acoustic Resonance (Sound) Therapy
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Third Wave Therapeutics
Nasal Congestion, Non-allergic Rhinitis
Investigation of Kinetic Oscillation Stimulation by the Chordate System S101 in the Treatment of Non Allergic Rhinitis
This is an interventional, multicenter, double-blind, placebo-controlled trial in which patients diagnosed with non-allergic rhinitis will be randomized to either intranasal stimulation, or placebo treatment with the Chordate…
- Trial name
- KOSNAR (NCT03399721)
- Testing
- Chordate S101
- Where
- 13 sites in Czechia, Finland and 4 more
- Volunteers
- 279 people
- Sponsor
- Chordate Medical
Hypoxia, Hypercapnia
To Determine the Efficacy of the TwinGuard in Oxygen Delivery During and Post Endoscopic Procedure
A comparative study which compares the end-tidal carbon dioxide and oxygen saturation levels of patients during endoscopy which have used either the new oral-nasal oxygenating device (TwinGuard), or a standard bite block plus…
- Trial name
- NCT00619606
- Testing
- TwinGuard, Standard endoscopic bite block, Standard nasal cannula
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Trawax Pty Limited
Chronic Nasal Obstruction
Comparison Between Turbinoplasty Techniques in Chronic Nasal Obstruction Microdebrider Coblation andSubmucosalBipolarDiathermyTechniquesduetohypertrophoidturbinate
Chronic nasal obstruction is one of the most common complaints in otorhinolaryngology practice, with inferior turbinate hypertrophy being a major anatomical cause that significantly impairs nasal airflow and quality of life.(1)…
- Trial name
- NCT07832916
- Testing
- Submucosal Bipolar Diathermy Assisted Turbinoplasty, Coblation-Assisted Turbinoplasty, Microdebrider-Assisted Turbinoplasty
- Volunteers
- 66 people
- Sponsor
- Assiut University
Nasal Airway Obstruction
InFlux System for Nasal Breathing Improvement
Pilot Study of the Aerin Medical Wand used for Improvement in Nasal Breathing
- Trial name
- NCT01960816
- Testing
- Procedure: thermal coagulation of tissue in the nasal airway
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- Aerin Medical
Seasonal Allergic Rhinitis
POPULAR (Preference Of Patient Using Levocetirizine in Allergic Rhinitis)
Comparative study on clinical efficacy and safety of levocetirizine and desloratadine as measured by the subject's satisfaction/dissatisfaction after one week of treatment
- Trial name
- NCT00160537
- Testing
- Levocetirizine
- Volunteers
- 200 people
- Sponsor
- UCB Pharma
Nasal Obstruction
Design and Application of Vitamin D Films for Burn Healing After Cauterizing Surgery
One of this method's drawbacks is the healing of cauterized cartilage after processing. It was reported that the healing is so slow as no dosage form can reach this place in addition to the scares produced from healing is very…
- Trial name
- NCT05142072
- Testing
- Vitamin D3
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Deraya University
Common Cold/Flu, Nasal Congestion
Fixed-dose Combination of 1000 mg Dipyrone Monohydrate + 60 mg Caffeine + 4 mg Chlorpheniramine Maleate in Improving Symptoms of the Common Cold and Flu in Adults
Phase III clinical trial to evaluate the efficacy and safety of a fixed-dose combination of 1000 mg dipyrone monohydrate + 60 mg caffeine + 4 mg chlorpheniramine maleate in improving symptoms of the common cold and flu in adults.
- Conditions
- Common Cold/Flu, Nasal Congestion, Nasal Obstruction
- Trial name
- PANAMA (NCT07626437)
- Testing
- dipyrone monohydrate 1000 mg + chlorpheniramine maleate 4 mg + caffeine 60 mg, dipyrone monohydrate 500 mg + chlorpheniramine maleate 2 mg + caffeine 30 mg
- Where
- 15 sites in Brazil
- Volunteers
- 620 people
- Sponsor
- Brainfarma Industria Química e Farmacêutica S/A
Agitation States as Acute Reaction to Gross Stress
Efficacy of External Nasal Nerve Block in Prevention of Postoperative Agitation Following Nasal Surgeries
Emergence agitation following general anaesthesia may lead to serious complications like self-extubation or removal of catheters, which can lead to hypoxia, aspiration pneumonia, bleeding or reoperation.
- Trial name
- NCT03069027
- Testing
- External nasal nerve block, saline adrenaline, Xylocaine, adrenaline
- Where
- Saudi Arabia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Al Jedaani Hospital
Persistent Allergic Rhinitis
Oxymetazoline Bridge Therapy With Intranasal Corticosteroids in Pediatric Allergic Rhinitis
Persistent allergic rhinitis in children is commonly treated with intranasal corticosteroids (INS), which are considered first-line therapy.
- Trial name
- NCT07593898
- Testing
- Mometasone Furoate (MF) Metered Dose Inhaler (MDI), 100 mcg, Oxymetazoline 0.05% nasal solution
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Seasonal Allergic Rhinitis
Evaluation of the Beneficial Effects of a Nasal Spray of Resveratrol in Children With Seasonal Allergic Rhinitis
The aim of this study is to evaluate whether treatment with a nasal spray based on resveratrol has some benefit in patients with seasonal allergic rhinitis, mild, moderate, or severe.
- Trial name
- NCT02130440
- Testing
- Resveratrol nasal spray
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Campania Luigi Vanvitelli
Chronic Rhinosinusitis (CRS), Emergence Agitation
Trans-nasal Sphenopalatine Ganglion Block for Prevention of Emergence Agitation Following Functional Endoscopic Sinus Surgery
This randomized double-blind controlled trial aims to evaluate whether bilateral trans-nasal sphenopalatine ganglion block (SPGB) using bupivacaine reduces the incidence of emergence agitation following Functional Endoscopic…
- Trial name
- SPGB-EA (NCT07645521)
- Testing
- Bilateral Trans-nasal Sphenopalatine Ganglion Block
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Nasal Congestion
A Nasal Spray for Relief of Nasal Congestion in Infants and Toddlers With Common Cold
The study will evaluate the safety and efficacy of the study medical device plus standard of care versus standard of care in subjects between 3 and 48 months (inclusive) presenting symptoms of a common cold.
- Trial name
- NCT05365789
- Testing
- Blocked Nose Baby nasal spray, Standard of care
- Where
- Poland
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Church & Dwight Company, Inc.
Nasal Obstruction
The Effectiveness of Nasal Corticosteroids Versus Placebo in Nasal Obstruction in Patients With Nasal Septal Deviation
The purpose of this project is to determine if intranasal corticosteroids have an effect on nasal obstruction in patients with nasal septal deviation.
- Trial name
- NCT02877485
- Testing
- Triamcinolone Acetonide, Ayr saline nasal mist
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Stanford University
Chronic Rhinosinusitis Phenotype With Nasal Polyps (CRSwNP), Smell Loss
Olfactory Cleft Obstruction and Electrophysiological Field Potentials Predict Olfactory Restoration by Dupilumab in CRSwNP Patients.
The goal of this observational study is to learn what can predict the return of the sense of smell in patients with chronic rhinosinusitis with nasal polyps being treated with dupilumab.
- Trial name
- NCT06892704
- Testing
- Dupilumab - Standard Dose
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwestern University
Allergic Rhinitis
Effects of AkPharma's Calcium Glycerophosphate Nasal Spray Wash
Over 20 million Americans have allergic nasal symptoms including stuffiness, sneezing and a "runny" nose. AkPharma's Calcium Glycerophosphate used as a nasal spray wash is believed to improve these symptoms without side effects…
- Trial name
- NCT01647633
- Testing
- Calcium Glycerophosphate Nasal Spray Wash
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Drexel University