Clinical trials: NPS
Nasal Polyps
Study of Efficacy of Fevipiprant in Patients With Nasal Polyposis and Asthma
A Phase 3b Proof-of-Concept study to evaluate the ability of fevipiprant 150 mg and 450 mg, compared with placebo, as add-on to nasal spray standard-of-care (SoC), in reducing endoscopic nasal polyp score in adult (≥ 18 years)…
- Trial name
- THUNDER (NCT03681093)
- Testing
- Fevipiprant 150 mg, Fevipiprant 450 mg
- Where
- 25 sites in United States, Argentina and 7 more
- Volunteers
- 98 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Rhinosinusitis With Nasal Polyps
A Study to Investigate NPS and Symptoms in Chinese Adult Participants With CRSwNP Initiating Treatment With Tezepelumab
This is a multicentre, open-label, single-arm, Phase 3b study to assess nasal polyps score and symptoms in Chinese adult participants with chronic rhinosinusitis with nasal polyposis initiating treatment with tezepelumab.
- Trial name
- BIFANG (NCT07520162)
- Testing
- Tezepelumab
- Where
- 34 sites in China
- Volunteers
- 230 people
- Sponsor
- AstraZeneca
Dentine Hypersensitivity
Efficacy of Novel Titania Nanoparticles Enriched Mouth Wash in Treating Dentine Hypersensitivity
Randomized Clinical trial to compare the reduction in dentin hypersensitivity after incorporating biogenically fabricated titania nanoparticles enriched Mouth Wash and Conventional Mouth Wash.Participants ranging between 20-50…
- Trial name
- NCT06790953
- Testing
- Group- A Conventional Sensed Mouth Wash, Group-B Novel Titania nanoparticles enriched Mouth Wash
- Where
- Pakistan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Carotid Artery Diseases, Carotid Atherosclerosis
The ENROUTE Transcarotid Neuroprotection System (ENROUTE Transcarotid NPS) DW-MRI Evaluation
The goal of this evaluation is to document the incidence of post procedure DW-MRI lesions (relative to baseline) in patients treated with the transcarotid artery revascularization (TCAR) procedure.
- Conditions
- Carotid Artery Diseases, Carotid Atherosclerosis, Carotid Stenosis, Carotid Artery Plaque
- Trial name
- DW-MRI-US (NCT03982420)
- Testing
- Transcarotid Revascularization (TCAR)
- Where
- 6 sites in United States, Spain
- Volunteers
- 55 people
- Sponsor
- Silk Road Medical
BCC - Basal Cell Carcinoma, BCC
CellFX Treat & Resect Low-Risk BCC Feasibility Study
This prospective, multicenter, study is designed to evaluate the safety and effectiveness of the CellFX System in adults subjects with low-risk basal cell carcinoma (superficial and nodular) for complete histological clearance of…
- Conditions
- BCC - Basal Cell Carcinoma, BCC, Excision Margin
- Trial name
- NCT04918381
- Testing
- CellFX System
- Where
- 5 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pulse Biosciences, Inc.
Connective Tissue Disease, Dissecting Aneurysm
Study of Heritable Connective Tissue Disorders
The purposes of this study are to identify the genes responsible for inherited connective tissue disorders and learn about the range of medical problems they cause.
- Conditions
- Connective Tissue Disease, Dissecting Aneurysm, Ehlers Danlos Syndrome, Marfan Syndrome
- Trial name
- NCT00001641
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Alzheimer Disease, Dementia
HEARS-NPS: Addressing Hearing Loss as a Common Unmet Contributor of Neuropsychiatric Symptoms
This randomized controlled trial study aims to evaluate a revised hearing care intervention for older adults with Alzheimer's Disease and Related Dementias (ADRD).
- Conditions
- Alzheimer Disease, Dementia, Hearing Loss, Cognitive Impairment
- Trial name
- HEARS-NPS (NCT06930560)
- Testing
- HEARS-NPS device, HEARS-NPS program
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Lesion Skin, Seborrheic Keratosis
Nano-Pulse Stimulation (NPS) in Seborrheic Keratosis Optimization Study
Primary study objective is to evaluate the optimization of Nano-Pulse Stimulation (NPS) energy settings for lesion clearance of Seborrheic Keratosis (SKs) from off-facial areas of healthy adults.
- Conditions
- Lesion Skin, Seborrheic Keratosis, Skin Lesion, Benign Skin Tumor
- Trial name
- NCT04249115
- Testing
- Nano-Pulse Stimulation (NPS)
- Where
- 7 sites in United States
- Volunteers
- 175 people
- Sponsor
- Pulse Biosciences, Inc.
Internal Carotid Artery Stenosis
MICHI™ Neuroprotection System (NPS+f) Filter Debris Analysis Study (The F-1 Study)
This study will be conducted in up to 10 hospitals in Europe, up to 75 patients will be enrolled. The purpose of the study is to evaluate any debris that may be captured in the inline filter of the MICHI(TM) Neuroprotection…
- Trial name
- NCT01877174
- Testing
- MICHI(TM) NPS+f, transcarotid stenting
- Where
- 6 sites in Belgium, Germany and 1 more
- Volunteers
- 24 people
- Sponsor
- Silk Road Medical
Drug Action Increased
A Randomized Controlled Trial Comparing Urea Loaded Nanoparticles to Placebo: a New Concept for Cataract Management
Cataract is the leading cause of vision loss and blindness in the world,surgery is the only available option to correct the problem and the major reasons for low cataract surgical rates include low demand because of fear of…
- Trial name
- NCT03001466
- Testing
- urea-loaded nanoparticles eye drops, Balance Salt Solution eye drops
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Carotid Artery Diseases
A Single-arm, Pivotal Study to Evaluate Acute Device and Technical Success of the CGuard Prime Carotid Stent System When Used in Conjunction to the ENROUTE Transcarotid Neuroprotection System in Patients Undergoing Carotid Artery Stenting Via the Transcarotid Artery Revascularization Approach
The objective of this study is to evaluate acute device and technical success of the CGuard Prime™ Carotid Stent System (80cm) when used in conjunction with the Enroute NPS during Transcarotid Artery Revascularization procedures…
- Trial name
- NCT06653387
- Testing
- CGuard Prime 80cm stent system
- Where
- 8 sites in United States
- Volunteers
- 50 people
- Sponsor
- InspireMD
Skin Lesion, Skin Abnormalities
Nano-Pulse Stimulation (NPS) in Sebaceous Hyperplasia
This prospective, open label, muti-center study evaluates the use of Nano-Pulse Stimulation (NPS) in the treatment of Sebaceous Hyperplasia (SH) lesions less than 2.5mm in size.
- Conditions
- Skin Lesion, Skin Abnormalities, Sebaceous Hyperplasia
- Trial name
- NCT03612570
- Testing
- Nano-Pulse Stimulation Device
- Where
- 5 sites in United States
- Volunteers
- 72 people
- Sponsor
- Pulse Biosciences, Inc.
Alzheimer Disease, Agitation,Psychomotor
Clinical Trial on Agitation in Alzheimer's Dementia
The purpose of this study is to assess the efficacy of the oral medication IGC-AD1, a THC-based (Delta-9-Tetrahydrocannabinol) formulation administered twice a day on Agitation in patients with mild to severe dementia from…
- Conditions
- Alzheimer Disease, Agitation,Psychomotor, Care Giving Burden, NPS
- Trial name
- CALMA (NCT05543681)
- Testing
- IGC-AD1-Active
- Where
- 28 sites in United States, Canada and 1 more
- Volunteers
- 164 people
- Sponsor
- IGC Pharma, LLC
Acute Respiratory Failure
Neural Pressure Support for Low Pulmonary Compliance
With this interventional prospective study, we aim at comparing the effectiveness of Neural Pressure Support (NPS) in reducing respiratory work and patient-ventilator asynchronies as compared with standard Pressure Support…
- Trial name
- NPS_LowCrs (NCT05566652)
- Testing
- Neural Pressure Support, Pressure Support Ventilation
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Policlinico Hospital
Postoperative Delirium
Naples Prognostic Score for Predicting Postoperative Delirium
Naples Prognostic Score (NPS) originally developed to predict outcomes in inflammatory and malignant conditions; we asked if it can effectively predict postoperative delirium (POD) in elderly patients undergoing hip surgery? NPS…
- Trial name
- NCT07297017
- Where
- Egypt
- Volunteers
- 168 people
- Sponsor
- South Valley University
Warts, Warts Hand
CellFX Comparison to Cryosurgery in Cutaneous Non-Genital Common Warts
This prospective, multicenter, single-blinded, randomized comparison study is designed to compare the safety and effectiveness of the CellFX System to Cryosurgery for the clearance of cutaneous non-genital common warts on all…
- Conditions
- Warts, Warts Hand, Verruca
- Trial name
- NCT04738734
- Testing
- CellFX System Device, Cryosurgery Liquid Nitrogen Sprayer
- Where
- 10 sites in United States
- Volunteers
- 150 people
- Sponsor
- Pulse Biosciences, Inc.
Sebaceous Hyperplasia, Skin Abnormalities
Nano-Pulse Stimulation (NPS) in Sebaceous Hyperplasia Optimization Study
Primary study objective is to evaluate the optimization of Nano-Pulse Stimulation (NPS) energy settings for lesion clearance of Sebaceous Hyperplasia (SH) lesions from facial areas of healthy adult subjects.
- Conditions
- Sebaceous Hyperplasia, Skin Abnormalities, Skin Lesion
- Trial name
- NCT04253418
- Testing
- Nano-Pulse Stimulation (NPS)
- Where
- 6 sites in United States
- Volunteers
- 125 people
- Sponsor
- Pulse Biosciences, Inc.
Adenine Phosphoribosyltransferase Deficiency, AH Amyloidosis
National Registry of Rare Kidney Diseases
The goal of this National Registry is to is to collect information from patients with rare kidney diseases, so that it that can be used for research.
- Conditions
- Adenine Phosphoribosyltransferase Deficiency, AH Amyloidosis, AHL Amyloidosis, AL Amyloidosis
- Trial name
- RaDaR (NCT06065852)
- Where
- United Kingdom
- Volunteers
- 35,000 people
- Sponsor
- UK Kidney Association
Skin Lesion, Skin Abnormalities
Comparative Study Between CellFX and Electrodessication in Sebaceous Hyperplasia (SH) Lesions
This study is designed as a multi-center, single-blinded, prospective, randomized, study to compare the safety and effectiveness of the CellFX System to the comparator group, Electrodessication for the treatment of SH lesions in…
- Conditions
- Skin Lesion, Skin Abnormalities, Sebaceous Hyperplasia
- Trial name
- NCT04539886
- Testing
- CellFX System, Intralesional Electrodesiccation
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Pulse Biosciences, Inc.
Locally Recurrent Retroperitoneal Soft Tissue Sarcoma
A Study of Ta-NPs Plus Radiotherapy for Locally Recurrent Retroperitoneal Sarcoma
This prospective, single-arm, open-label phase I study evaluates the safety and tolerability of intratumoral injection of tantalum nanoparticles (Ta-NPs) followed by radiotherapy in patients with locally recurrent retroperitoneal…
- Trial name
- NCT07578506
- Testing
- Ta-NPs (2% Tumor Volume), Ta-NPs (5% Tumor Volume), Ta-NPs (10% Tumor Volume)
- Where
- China
- Volunteers
- 9 people
- Sponsor
- West China Hospital