Clinical trials: Myringoplasty
Post-operative Analgesia, CSOM - Chronic Suppurative Otitis Media
Preemptive Pregabalin in Myringoplasty
The aim of this study was to investigate the effect of preemptive pregabalin on post-operative pain reduction after myringoplasty.
- Trial name
- NCT03603626
- Testing
- Pregabalin 150mg
- Where
- Nepal
- Sponsor
- Dhulikhel Hospital
Tympanic Membrane Perforation, Conductive Hearing Loss
Outcomes of Cartilage Tympanoplasty in Children
This study evaluates the anatomical and hearing outcomes of cartilage tympanoplasty in pediatric patients with chronic tympanic membrane perforations.
- Conditions
- Tympanic Membrane Perforation, Conductive Hearing Loss, Chronic Otitis Media
- Trial name
- NCT07866222
- Testing
- Cartilage Tympanoplasty
- Volunteers
- 35 people
- Sponsor
- Assiut University
Tympanoplasty, Myringoplasty
NLR and Sevoflurane Use in Ear Surgeries: Flow Comparison
This retrospective study aims to compare the effects of low-flow and high-flow anesthesia techniques on intraoperative hemodynamics, neutrophil-to-lymphocyte ratio (NLR), and postoperative outcomes in patients undergoing…
- Conditions
- Tympanoplasty, Myringoplasty, Neutrophil-to-Lymphocyte Ratio, Low-flow Anesthesia
- Trial name
- ANFLUX (NCT07064642)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Eda KAZANÇ ÖZDEN
Chronic Suppurative Otitis Media
Comparison of Topical Use of Platelet-rich Plasma Versus Hyaluronic Acid During Endoscopic Fat Graft Myringoplasty: a Randomized Clinical Study
This study aimed to compare the effect of adding HA versus PRP to endoscopic FGM in cases of small or medium-sized central TM perforation in the form of: 1. Evaluation of the graft uptake rate. 2.
- Trial name
- NCT06505252
- Testing
- enoscopic Myringoplasty
- Volunteers
- 60 people
- Sponsor
- Assiut University
Tympanic Membrane Perforation, Tympanoplasty
Comparison of Results of Myringoplasty Using Biodesign - an Otologic Graft Made From Porcine Small Intestinal Submucosa, Temporalis Fascia, or Tragal Perichondrium - a Retrospective Cohort Analysis
The goal of this observational, retrospective study is to learn whether a ready-made graft patch (Biodesign, made from porcine small intestinal submucosa) works as well as a participant's own tissue graft (such as tragal…
- Conditions
- Tympanic Membrane Perforation, Tympanoplasty, Myringoplasty
- Trial name
- Biodesign (NCT07698171)
- Testing
- tympanoplasty using Biodesign, tympanoplasty using autologous tissue graft
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Wolfson Medical Center
Post Operative Wound Infection, Graft Uptake
Does Antibiotics Use During Surgery Help to Decrease Wound Infection and Increase Success After Ear Surgery in Children
This study assess whether there is any role of antibiotics to decrease wound infection and increase the success of surgery
- Conditions
- Post Operative Wound Infection, Graft Uptake, Myringoplasty
- Trial name
- NCT03700814
- Testing
- Co-amoxiclav
- Volunteers
- 60 people
- Sponsor
- Tribhuvan University, Nepal
Tympanic Membrane Perforation, Eardrum Perforation
Biodesign® Otologic Repair Graft
The post-market follow-up clinical trial of the Cook® Biodesign® Otologic Repair Graft will follow patients up to 3 months post-implantation to determine the percent of patients with complete closure of the tympanic membrane.
- Trial name
- NCT04635228
- Testing
- Biodesign Otologic Repair Graft
- Where
- 5 sites in United States, United Kingdom
- Volunteers
- 87 people
- Sponsor
- Cook Research Incorporated
Tympanic Membrane Perforation
Perf-Fix Study for Chronic Tympanic Membrane Repair
The purpose of the study is to assess the effectiveness of Perf-Fix as a gel patch to aid in the natural healing process to close chronic, >25% tympanic membrane perforation.
- Trial name
- NCT06083181
- Testing
- Perf-Fix Otologic Gel Patch
- Where
- 7 sites in United States
- Volunteers
- 71 people
- Sponsor
- Tympanogen
Tympanic Membrane Perforation
Repair of Tympanic Membrane Perforation Using Tachosil Under Local Anesthesia
Tympanic membrane perforations are common medical problem that encounters a lot of patients in all age groups. The gold standard for treatment of perforations is tympanic membrane closure procedure (tympanoplasty) which is done…
- Trial name
- NCT04428463
- Testing
- Tachosil, fascia and cartilage
- Volunteers
- 27 people
- Sponsor
- HaEmek Medical Center, Israel
Post-Op Complication, Otologic Disease
Interest of Wicking for Ossicular Surgery and Myringoplasty
Myringoplasties and ossicular surgery are very common procedures. Following these otological surgeries, most surgeons install a wicking.
- Trial name
- MECH-ORL (NCT05269368)
- Testing
- Wicking, No wicking
- Where
- 6 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Tours
Tympanic Membrane Perforation
Tragal Perichondrium Versus Pretragal Fascial (SMAS) Graft for Endoscopic Myringoplasty
1. Examine the treatment outcomes of the pretragal (SMAS) fascia as a new graft when used in endoscopic myringoplasty. 2. Compare the results when using the tragal pericondrium as a graft in endoscopic myringoplasty regarding…
- Trial name
- NCT04687995
- Testing
- Endoscopic myringoplasty
- Volunteers
- 40 people
- Sponsor
- Assiut University
Tympanic Membrane Perforation, Otitis Media
Does Adding a Fascial Layer to the Cartilage in Tympanoplasty for Large Tympanic Membrane Perforation Affect the Overall Results?
Large tympanic membrane (eardrum) perforations present a surgical challenge and are historically associated with lower graft take rates compared to smaller perforations.
- Conditions
- Tympanic Membrane Perforation, Otitis Media, Suppurative Otitis Media, Chronic Suppurative Otitis Media
- Trial name
- NCT07834892
- Testing
- Conchal Cartilage and Perichondrium Tympanoplasty, Conchal Cartilage, Perichondrium, and Temporalis Fascia Tympanoplasty
- Volunteers
- 50 people
- Sponsor
- Assiut University
Tympanic Membrane Perforation
Fat Graft Myringoplasty With and Without Platelet Rich Plasma (PRP) for Treating Smaller Tympanic Membrane Perforations
The current standard treatment for chronic tympanic membrane perforations (TMP) involves having fat grafted from the patient and inserted into the ear, through the perforation, to promote healing using the fat graft myringoplasty…
- Trial name
- NCT01958749
- Testing
- Fat graft with Platelet Rich Plasma
- Where
- 4 sites in Canada, United Kingdom
- Sponsor
- Nova Scotia Health Authority
Tympanic Membrane Perforation, Tympanic Membrane Inflammation
Effect of Chitodex Gel in Tympanoplasty Surgery
The general purpose of this study is to compare Chitosan-dextran (Chitodex) gel versus current standard of care, Gelfoam, as a middle ear (ME) and external auditory canal (EAC) packing agent as part of tympanoplasty…
- Conditions
- Tympanic Membrane Perforation, Tympanic Membrane Inflammation, Surgery, Otitis Media
- Trial name
- NCT06260618
- Testing
- Gelfoam, Chitodex
- Where
- 2 sites in Australia
- Volunteers
- 44 people
- Sponsor
- Central Adelaide Local Health Network Incorporated
Chronic Suppurative Otitis Media, Mastoid Cavity
Study the Impact of the Mastoid and Middle Ear Volume on the Success of Type 1 Tympanoplasty in Pediatric Age, With Comparing Using Cartilage and Fascial Grafts Through This, Strength the Hypothesis of That Total Tympanometry Volume Correlates With Ventilated Mastoid Air Cells Volume on CT Scans
The goal of this observational study is to know the impact of the mastoid and middle ear volume on the success of type 1 tympanoplasty in pediatric age, with a closer view on the comparison of using cartilage and fascial grafts…
- Conditions
- Chronic Suppurative Otitis Media, Mastoid Cavity, Pneumatization, Tympanoplasty
- Trial name
- NCT07806461
- Testing
- tympanoplasty type 1, Audiological Evaluation, HRCT scan temporal bone
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Azhar University
Chronic Otitis Media Tympanic Membrane Perforation
Effect of Platelet-Rich Plasma on Eardrum Healing and Hearing After Tympanoplasty in Adults
This single-center controlled trial evaluated whether intraoperative application of autologous platelet-rich plasma (PRP)-impregnated absorbable gelatin sponge improves graft take rates and audiological outcomes in adults…
- Trial name
- NCT07664319
- Testing
- Autologous platelet-rich plasma (PRP)-impregnated Spongostan, Dry Spongostan (absorbable gelatin sponge)
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ebubekir Toprak
Tympanic Membrane Perforation
Eustachian Tube Function and Myringoplasty/Tympanoplasty
This study will determine whether the likely success of closing a hole in the eardrum can be predicted by testing Eustachian tube function.
- Trial name
- NCT01766856
- Testing
- Eustachian tube function testing
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Pittsburgh
Hearing Loss,Conductive
Half-thickness Tragal Cartilage Graft vs Temporalis Fascia Graft Tympanoplasty Type I
The rationale of this study is to find out the surgical outcome and success rates of tragal cartilage and temporalis fascia, subsequently to develop guide line in light of the results of this study for our department as our…
- Trial name
- PTA (NCT03817242)
- Testing
- Tympanoplasty using tragal cartilage graft, Tympanoplasty using temporalis fascia graft
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Lady Reading Hospital, Pakistan
Myringoplasty
A Comparative Study of Temporalis Fascia Graft and Periosteal Graft in Myringoplasty
A Comparative Study of Temporalis Fascia Graft and Periosteal Graft in Myringoplasty
- Trial name
- NCT06691139
- Testing
- Myringoplasty using periosteal graft and myringoplasty using Temporalis fascia graft in patients ages from 12 years to 40 years, Myringoplasty using Temporalis fascia graft and myringoplasty using periosteal graft, Myringoplasty operation using periosteal graft and myringoplasty using Temporalis fascia graft
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mohamed Soltan Nada