Clinical trials: Myopia
Presbyopia, Near Vision
Phase 3 Efficacy Study of LNZ100 & LNZ101 for the Treatment of Presbyopia
Phase 3 Efficacy Study to evaluate the Safety and Efficacy of LNZ100 \& LNZ101 for the Treatment of Presbyopia
- Conditions
- Presbyopia, Near Vision, Refractive Error, Eye Diseases
- Trial name
- CLARITY 2 (NCT05728944)
- Testing
- Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Vehicle
- Where
- 17 sites in United States
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- LENZ Therapeutics, Inc
Myopia, Astigmatism
1-Week Dispensing Evaluation of Kalifilcon A Toric Contact Lenses Compared to Ultra for Astigmatism
This single-site, randomized, double-masked (participant and investigator), 2-way crossover, repeated-measures dispensing study evaluated the visual performance of kalifilcon A daily disposable toric (LD213001) contact lenses…
- Trial name
- NCT05320042
- Testing
- kalifilcon A daily disposable toric contact lenses, Ultra for Astigmatism (samfilcon A) contact lenses
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Myopia
Soft Lens Study: Biomedics 1 Day Extra Sphere and Clariti 1 Day Sphere
The aim of this study is to evaluate and compare the performance of two soft contact lenses.
- Trial name
- NCT06817785
- Testing
- Lens 1 (ocufilcon D), Lens 2 (somofilcon A)
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- CooperVision, Inc.
Refractive Errors, Myopia
Evaluation of Delefilcon A Contact Lenses
The purpose of the study is to evaluate the lens fit characteristics of delefilcon A contact lenses with different base curves and diameters.
- Trial name
- NCT06884202
- Testing
- Delefilcon A contact lenses with different base curves and diameters, Delefilcon A contact lenses with standard base curves and diameters
- Where
- 16 sites in United States
- Volunteers
- 267 people
- Sponsor
- Alcon Research
Refractive Error - Myopia Simple
Evaluation of the Safety and Efficacy of PEGAVISION Silicone Hydrogel Daily Disposable Soft Contact Lenses (G3)
The goal of this clinical trial is to learn if PEGAVISION Silicone Hydrogel Daily Disposable Soft Contact Lenses (G3) are safe and effective for vision correction in adults.
- Trial name
- NCT06995781
- Testing
- Experimental Intervention, Active Comparator Intervention
- Volunteers
- 69 people
- Sponsor
- Pegavision Corporation
Myopia
Low-Dose Atropine for Treatment of Myopia
Study Objectives The objectives for this randomized trial are: 1. To determine the efficacy of daily low-dose atropine (0.01%) for slowing myopia progression over a two-year treatment period in children aged 5 to less than 13…
- Trial name
- MTS1 (NCT03334253)
- Testing
- Atropine
- Where
- 13 sites in United States
- Volunteers
- 200 people
- Sponsor
- Jaeb Center for Health Research
Nearsightedness, Near Sightedness
The Safety and Efficacy of SYD-101 in Children With Myopia
Myopia, or nearsightedness, is the most common eye disorder, often affecting more than 40% of adults in Europe, Asia and the USA.
- Conditions
- Nearsightedness, Near Sightedness, Near-sightedness
- Trial name
- STAR (NCT03918915)
- Testing
- SYD-101 0.01%, SYD-101 0.03%, Vehicle
- Where
- 47 sites in United States, Austria and 1 more
- Volunteers
- 852 people
- Sponsor
- Sydnexis, Inc.
Myopia
Correction of Myopia Evaluation Trial 2
The purpose of the study is to determine if progressive addition lenses (PALs) versus single vision lenses (SVLs) slow the progression of low myopia in children with poor accommodative responses (i.e., large accommodative lags)…
- Trial name
- COMET2 (NCT00320593)
- Testing
- Progressive Addition Lenses (PALs), Single Vision Lenses (SVLs)
- Where
- 8 sites in United States
- Volunteers
- 118 people
- Sponsor
- Jaeb Center for Health Research
Hyperopia, Myopia
A Clinical Comparison of Two Soft Contact Lenses (C24-755)
The aim of this study is to compare the short-term clinical performance of two soft contact lenses.
- Trial name
- NCT06758076
- Testing
- Lens 1 (ocufilcon D), Lens 2 (somofilcon A)
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- CooperVision, Inc.
Myopia
Examination of Myopia Progression and Soft Bifocal Contact Lens Myopia Control
This project intends to provide important, previously unmet answers regarding biological associations with myopia (nearsightedness) progression in order to improve the ability to predict patients who are most likely to benefit…
- Trial name
- BLINK2 (NCT04080128)
- Testing
- Contact lenses
- Where
- 2 sites in United States
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Presbyopia, Refractive Error
Phase 3 Evaluation of the Safety and Efficacy of LNZ100 & LNZ101 for the Treatment of Presbyopia
Phase 3 study to evaluate the safety and effectiveness of LNZ100 \& LNZ101 for the treatment of Presbyopia.
- Conditions
- Presbyopia, Refractive Error, Eye Diseases, Near Vision
- Trial name
- CLARITY 1 (NCT05656027)
- Testing
- Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Brimonidine
- Where
- 25 sites in United States
- Volunteers
- 469 people, healthy volunteers welcome
- Sponsor
- LENZ Therapeutics, Inc
Presbyopia, Near Vision
Phase 3 Safety Study of LNZ100 and LNZ101 for the Treatment of Presbyopia Subjects
Safety Study of the Long-Term Safety of LNZ100 \& LNZ101 in Presbyopic Subjects
- Conditions
- Presbyopia, Near Vision, Refractive Error, Eye Diseases
- Trial name
- NCT05753189
- Testing
- Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Vehicle
- Where
- 40 sites in United States
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- LENZ Therapeutics, Inc
Myopia
Use of the VisuMax™ Femtosecond Laser
The objective of this clinical trial is to evaluate the safety and effectiveness of the Carl Zeiss Meditec VisuMax™ Femtosecond Laser lenticule removal procedure for the reduction or elimination of myopia from ≥ -1.00 D to ≤…
- Trial name
- NCT01638390
- Testing
- Treatment with the VisuMax™ Femtosecond Laser
- Where
- 5 sites in United States
- Volunteers
- 357 people, healthy volunteers welcome
- Sponsor
- Carl Zeiss Meditec, Inc.
Myopia
Patient Reported Outcomes With WaveLight LASIK
This study is a multi-site, single-arm, ambispective, observational study of subject satisfaction, after successful bilateral LASIK surgery. Subjects will be assessed 12+ months post-operatively.
- Trial name
- NCT06668909
- Testing
- WaveLight® EX500
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- OVO LASIK + Lens
Myopia, Myopic Astigmatism
Multicenter Clinical Trial of a Phakic Implantable Collamer® Lens (ICL)
This objective of this study is to evaluate the safety, and to collect supportive data on effectiveness of the EVO/EVO+ Visian® Implantable Collamer® Lens (ICL) in study participants who have a diagnosis of myopia or myopia with…
- Trial name
- NCT04283149
- Testing
- EVO/EVO+ Visian ICL
- Where
- 14 sites in United States
- Volunteers
- 327 people
- Sponsor
- Staar Surgical Company
Myopic Astigmatism
STAAR Visian Toric ICL Post-Approval Study
The objective of this study is to evaluate the long term (i.e. 24 months) clinical performance of the Visian® Toric Implantable Collamer® Lens (ICL).
- Trial name
- TICL-PAS (NCT04516772)
- Testing
- Visian TICL
- Where
- 8 sites in United States
- Volunteers
- 125 people
- Sponsor
- Staar Surgical Company
Myopia, Myopic Astigmatism
Post-Market Evaluation of the EVO ICL
The objective of this study is to assess the rate of early intraocular pressure (IOP) increases following implantation of EVO/EVO+ Implantable Collamer Lens (ICL).
- Trial name
- NCT05538754
- Testing
- EVO ICL
- Where
- 8 sites in United States
- Volunteers
- 205 people
- Sponsor
- Staar Surgical Company
Myopia
Phase I Clinical Trial to Evaluate the Safety and Tolerability of Ophtalmic Solution PRO-201
Evaluation of the safety and tolerability of PRO-201 (0.01% sulfate atropine) after its instillation on the ocular surface of healthy volunteers through the following variables: unexpected adverse events incidence and photophobia…
- Trial name
- PRO-201 (NCT05470881)
- Testing
- Atropine Sulfate
- Where
- Mexico
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Presbyopia, Astigmatism
Clinical Performance Evaluation of Two Frequent Replacement Silicone Hydrogel Multifocal Toric Contact Lenses
The purpose of this study is to evaluate on-eye clinical performance of the investigational contact lenses following 30 days of wear in the intended population.
- Trial name
- NCT06461455
- Testing
- Lehfilcon A multifocal for astigmatism contact lenses, Samfilcon A multifocal for astigmatism contact lenses, CLEAR CARE® Cleaning & Disinfecting Solution
- Where
- 11 sites in United States
- Volunteers
- 95 people
- Sponsor
- Alcon Research
Myopia
Investigation of Wearing Compliance of Spectacles for Myopia Control
The goal of this observational study was to compare the wearing patterns of spectacles prescribed for myopia control in juvenile wearers.
- Trial name
- NCT06590441
- Testing
- Myopia control spectacles
- Where
- 4 sites in United Kingdom
- Volunteers
- 53 people
- Sponsor
- CooperVision, Inc.