Clinical trials: Myopathy Critical Illness
Critical Illness Myopathy
NLRP3 Inflammasome and Physical Therapy in ICU-Acquired Weakness
The goal of this clinical trial is to study whether physical therapy can reduce NLRP3 inflammasome activation and muscle atrophy in patients with critical illness myopathy (CIM).
- Trial name
- PT-NLRP3-CIM (NCT07017517)
- Testing
- Motomed Letto® servo-assisted cycling + standard physiotherapy, Standard physiotherapy
- Where
- 3 sites in Chile
- Volunteers
- 24 people
- Sponsor
- University of Chile
Critical Illness Myopathy, Respiration, Artificial
Electrical Stimulation of the Quadriceps and Diaphragm in Critically Ill Patients
Subjects in MV will be included, divided into 3 groups: (a) Control Group (CG), (b) Stimulation of Quadriceps (Quadriceps Group - QG), (c) Stimulation of Diaphragm (Diaphragm Group - DG).
- Trial name
- NCT03352102
- Testing
- Electrical stimulation
- Where
- Brazil
- Volunteers
- 41 people
- Sponsor
- Pericles Almeida Delfino Duarte
Critical Illness, Respiratory Failure
Treatment of Muscle Weakness in Critically Ill Patients
Patients who are admitted to the intensive care unit and require mechanical ventilation frequently develop profound respiratory and limb muscle weakness.
- Conditions
- Critical Illness, Respiratory Failure, Myopathy, Weakness
- Trial name
- NCT02247895
- Testing
- Electrical stimulation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Gerald Supinski
Critical Illness, Muscle Weakness
Diaphragm Protective Ventilation in the Intensive Care Unit
Due to an accident, pneumonia or surgery, patients can have severe shortness of breath or lung damage to such an extent that it compromises vital functions. At such times, mechanical ventilation can be lifesaving.
- Conditions
- Critical Illness, Muscle Weakness, Muscle Damage, Respiration, Artificial
- Trial name
- DiaPro (NCT03527797)
- Testing
- Titration of support level
- Where
- Netherlands
- Volunteers
- 41 people
- Sponsor
- Amsterdam UMC, location VUmc
Critical Illness Myopathy, Critical Illness Polyneuropathy
Improved Recovery of Walking in Acquired Muscle Weakness
The aim of Re-Walk-Easy is to evaluate the effects of rehabilitation based on electrical stimulation on the motor performance of critically ill patients.
- Trial name
- Re-Walk-Easy (NCT06786390)
- Testing
- Rehabilitation protocol: FES, Rehabilitation protocol without FES
- Where
- Italy
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Critical Illness Myopathy
Rehabilitation Following Critical Illness
The principal research question to be answered by this study is whether an exercise based rehabilitative intervention following critical illness can generate improvements in exercise capacity and quality of life beyond current…
- Trial name
- NCT00976807
- Testing
- Pulmonary Rehabilitation
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Weakness, Muscle
Muscular Ultrasound and Production of ICUAW
Skeletal muscle weakness is a common complication of acute respiratory failure, shock and other manifestations of critical illness or injury.
- Trial name
- MUICUAW (NCT04864093)
- Testing
- muscular ultrasound
- Where
- Italy
- Volunteers
- 49 people
- Sponsor
- University of Milan
Chronic Respiratory Failure, Critical Illness Myopathy
Electric Muscle Stimulation for Patients With Chronic Respiratory Failure
Background: After mechanical ventilation, 5-20% of patients with acute respiratory failure would depend on ventilator support more than 14 days because of critical-illness weakness and their underlying diseases such as heart…
- Trial name
- NCT01930643
- Testing
- EMS
- Where
- Taiwan
- Volunteers
- 13 people
- Sponsor
- Mackay Memorial Hospital
Sarcopenia, Critical Illness
Prevalence of Sarcopenia in Patients Admitted to ICU and Its Progression During Hospitalization.
This is a prospective, observational study at the ICU of Hospital Mútua de Terrassa, running from May to December 2025. The primary goal is to determine the prevalence of sarcopenia in adult patients requiring more than 48 hours…
- Conditions
- Sarcopenia, Critical Illness, Intensive Care (ICU) Myopathy, Body Composition Measurement
- Trial name
- SARC-ICU (NCT07303335)
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Mutua de Terrassa
Respiratory Failure
Early Mobilization in the ICU
To study all ICU patients with an independent baseline functional status , who experience a critical illness requiring intubation and mechanical ventilation evaluating long-term cognitive and executive function and long term cost…
- Trial name
- NCT01777035
- Testing
- early PT OT
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Chicago
Critical Illness, COVID-19
A Study of Healthy Microbiome, Healthy Mind
Researchers are doing this study to find out if a high fermented food diet is tolerable, and if it will help improve quality of life after surviving a critical illness, including severe COVID-19, by promoting gut health recovery…
- Conditions
- Critical Illness, COVID-19, PICS, Cognitive Impairment
- Trial name
- NCT06020703
- Testing
- Fermented Food Diet
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Acute Respiratory Failure
Treatment of Critical Illness Polyneuromyopathy
Acute respiratory failure is a heterogeneous disorder that results in more than 300,000 Americans requiring admission to an intensive care unit for invasive mechanical ventilatory support each year.
- Trial name
- Do-It-Now (NCT01058421)
- Testing
- intensive physical therapy, control group
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Colorado, Denver
Neuromuscular Disease in Post-Intensive Care Syndrome
Feasibility Study on the Use of a Walking Exoskeleton in the Intensive Care Unit
The purpose of this study is to evaluate the feasibility of using a lower-limb exoskeleton in the intensive care unit for early mobilization of participants with intensive care neuromyopathy.
- Trial name
- ExoRea (NCT07907237)
- Testing
- rehabilitation session assisted by an exoskeleton
- Volunteers
- 30 people
- Sponsor
- CHU de Reims
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Critical Illness
Effect of Electrical Muscle Stimulation in Critically Ill Patients
Electrical muscle stimulation (EMS) is the therapy used to passively activate muscles using electrodes on the surface of the skin.
- Trial name
- NCT01637467
- Testing
- Electrical muscle stimulation (EMS)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Critical Illness Polyneuropathy
Evaluation of Pediatric Critical Illness Neuropathy/Myopathy in Pediatric Intensive Care Unit
Intensive Care Unit Acquired Weakness(ICUAW) encompasses a spectrum of disorders characterized by generalized weakness developing after the onset of critical illness.
- Trial name
- NCT02763709
- Where
- India
- Volunteers
- 97 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Acute Kidney Injury, Intra-Abdominal Hypertension
Cumulative Intra-Abdominal Pressure Burden and Acute Kidney Injury After Emergency Abdominal Surgery
The goal of this observational study is to learn whether increased pressure inside the abdomen over time is associated with acute kidney injury in adults receiving intensive care after emergency abdominal surgery.
- Trial name
- IAP-AKI (NCT07891026)
- Testing
- Serial Intra-Abdominal Pressure Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Ugur Duman
Metabolomics, Critical Care
Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness
In this mono-center pilot trial, surgical patients who are at high risk to be admitted to intensive care will be screened and asked for participation.
- Conditions
- Metabolomics, Critical Care, Critical Illness, Critical Illness Myopathy
- Trial name
- MIRACLE I (NCT03810768)
- Where
- 3 sites in Austria, Germany
- Volunteers
- 20 people
- Sponsor
- Technical University of Munich
Cardiac Disease, Critical Illness
In-Bed Cycling in ICU Patients Post Cardiac Surgery
The purpose of this study is to determine if in-bed cycling is safe and feasible in critically-ill patients after open heart surgery.
- Conditions
- Cardiac Disease, Critical Illness, Critical Illness Polyneuropathy, Critical Illness Myopathy
- Trial name
- CardiO Cycle (NCT02976415)
- Testing
- In-Bed Cycling
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Hamilton Health Sciences Corporation
COVID-19, Muscle Atrophy
Electrical Stimulation for Critically Ill Post-Covid-19 Patients
Unfortunately, hospital-acquired weakness is highly prevalent among COVID-19 hospitalized patients, who often require prolonged bed-rest or paralytics for an extended period of time in order to maintain oxygenation.
- Conditions
- COVID-19, Muscle Atrophy, Muscle Weakness
- Trial name
- Phase II (NCT05198466)
- Testing
- Electrical Stimulation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Baylor College of Medicine