Clinical trials: Myocarditis
Myocarditis, Inflammatory Cardiomyopathy
Cardiac MRI in Myocarditis and Inflammatory Cardiomyopathy
Myocarditis and inflammatory cardiomyopathy represent a broad spectrum of myocardial inflammatory disorders with highly variable clinical presentations and outcomes, ranging from spontaneous recovery to progressive heart failure…
- Trial name
- CMR-MYOINF-PRO (NCT07325968)
- Volunteers
- 5,000 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Heart Failure With Preserved Ejection Fraction (HFPEF)
Hearts on Fire: Targeting Inflammation in Heart Failure With Preserved Ejection Fraction
Subjects undergo a gadolinium-based CMR followed by an iron infusion and then a repeat CMR in 72 hours
- Trial name
- NCT07634640
- Testing
- Ferumoxytol infusion
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Florida
ICI-myocarditis
Genetic Determinants of Myocarditis Induced by Immune-checkpoint Inhibitors
Immune checkpoint inhibitors (ICI) are active in multiple cancers. Their main drawback is the incidence of immune related adverse events; among which ICI-myocarditis (ICIM) is rare but can be the most life-threatening (up to 50%…
- Trial name
- GICICA-Control (NCT06734689)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myocarditis, Sudden Cardiac Death
Occurrence, Trends, Management and Outcomes of Patients Hospitalized With Myocarditis
The epidemiology of myocarditis is largely unknown and based mainly on small single-center studies. The study aim to evaluate the current incidence, clinical characteristics and outcomes of patients hospitalized due to…
- Conditions
- Myocarditis, Sudden Cardiac Death, Cardiomyopathies, Arrythmia
- Trial name
- MYO-PL (NCT04827706)
- Where
- Poland
- Volunteers
- 19,978 people
- Sponsor
- Medical University of Warsaw
Myocarditis, Cardiomyopathy
Recurrent Acute Myocarditis Registry
The association between myocardial inflammation (clinically represented by acute myocarditis episodes) and the later development of an arrhythmogenic cardiomyopathy is widely elusive.
- Trial name
- RAM (NCT04589156)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Cardiogenic Shock, Acute Myocardial Infarction
Oxidant-antioxidant Activity, Free Radicle Activity, Immune Response and Biomarkers in Extracorporeal Membrane Oxygenation (ECMO) Patients
We would like to investigate novel diagnostic methods or biomarkers to early predict the success of ECMO therapy for cardiogenic shock patients during the early stage after ECMO treatment.
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction, Myocarditis, Cardiomyopathy
- Trial name
- ECMO (NCT01089036)
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Myocarditis Acute, Ventricular Arrythmia
Ventricular Arrhythmia After Myocarditis in Sportsman
The study aims to assess the prevalence of ventricular rhythmic disorder after an acute myocarditis in sportsmen. 50 patients with acute myocarditis, confirmed by MRI, will be assessed by ECG Holter and Treadmill stress test…
- Trial name
- ARYMYS (NCT03842592)
- Testing
- Treadmill Stress test
- Where
- 4 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Angers
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Feasibility and Safety of Total Percutaneous Closure of Femoral Arterial Access Sites in the Veno-arterial ECMO Patients
The most frequent access site for veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is the common femoral artery (CFA), using either an open or percutaneous technique.
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation, Myocarditis, Hypertension, Pulmonary
- Trial name
- NCT04689451
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cardiomyopathies
Magnetocardiography as a Diagnostic Screening Tool for Myocarditis and Other Types of Cardiomyopathy
Accurate and rapid screening is an unmet medical need to address the increasing demand for advanced diagnostic workup in patients with suspected cardiomyopathy.
- Trial name
- MagMa (NCT06689098)
- Testing
- Magnetocardiography scan
- Where
- Germany
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- German Heart Institute
Myocarditis Acute
French Registry of CMR Late Gadolinium Enhancement in Myocarditis
Acute myocarditis is a major cause of death in young adults and carries substantial morbidity, including a significant risk of progression to dilated cardiomyopathy.
- Trial name
- MYOCARDITI-LGE (NCT07394543)
- Volunteers
- 5,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myocarditis Acute, Cancer
Abatacept in Immune Checkpoint Inhibitor Myocarditis
The primary aim is to test whether abatacept, as compared to placebo, is associated with a reduction in major adverse cardiac events (MACE) among participants hospitalized with myocarditis secondary to an immune checkpoint…
- Trial name
- ATRIUM (NCT05335928)
- Testing
- Abatacept plus
- Where
- 31 sites in United States, Canada
- Volunteers
- 390 people
- Sponsor
- Massachusetts General Hospital
Patients With Suspected Acute Myocarditis
Evaluation of Spectral Cardiac CT for the Diagnosis of Acute Myocarditis
Spectral cardiac CT scan performed in an emergency setting in patients with suspected acute myocarditis and presenting one selves with an acute chest pain, allows the non-invasive assessment of both the coronary arteries and the…
- Trial name
- MYOCARDITESCAN (NCT02905721)
- Testing
- Spectral cardiac CT scan
- Where
- France
- Volunteers
- 136 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiomyopathies, Myocarditis
CMP-MYTHiC Trial and Registry - CardioMyoPathy With MYocarditis THerapy With Colchicine
Two-parallel groups randomized, single-blinded, multi-center phase III controlled trial in patients with chronic inflammatory cardiomyopathy to assess the efficacy of colchicine and associated prospective registry to assess the…
- Conditions
- Cardiomyopathies, Myocarditis, Inflammatory Cardiomyopathy, Heart Failure
- Trial name
- CMP-MYTHiC (NCT06158698)
- Testing
- Colchicine
- Where
- 10 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Niguarda Hospital
Myocarditis
FDG-PET/CT Images Comparing to MRI and Endomyocardial Biopsy in Myocarditis
Fifty hospitalized consecutive patients with clinically suspected myocarditis (MC) who meet the inclusion/exclusion criteria will be enrolled to the study.
- Trial name
- STREAM (NCT04085718)
- Volunteers
- 50 people
- Sponsor
- Medical University of Warsaw
Immune Checkpoint Inhibitor-Related Myocarditis
Monitoring and Rehabilitation for ICIACI Rehabilitation：A Cohort Study
Immune checkpoint inhibitor-associated cardiac injury (ICIACI) is a low-incidence but highly fatal adverse event. A significant knowledge gap exists regarding the disease characteristics and recovery status of patients during the…
- Trial name
- NCT07278817
- Volunteers
- 340 people
- Sponsor
- China-Japan Friendship Hospital
Myocarditis
A Study to Assess Long-term Outcomes of Myocarditis Following Administration of COVID-19 mRNA Vaccine (SPIKEVAX)
The main goal of this study is to characterize presentation, clinical course, and long-term outcomes of myocarditis temporally associated with administration of mRNA-1273 (SPIKEVAX) COVID-19 vaccine.
- Trial name
- NCT06189053
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- ModernaTX, Inc.
Cardiac Imaging Techniques, Cardiac Imaging
Role of Spectral CT in the Diagnosis of Myocarditis/MINOCA in Patients Undergoing cardioCT Investigations for Acute Chest Pain
It is a spontaneous, observational cross-sectional and single-center imaging (CT and MRI) study, coupled with clinical-laboratory data.
- Conditions
- Cardiac Imaging Techniques, Cardiac Imaging, Myocardial Disease, Myocarditis Acute
- Trial name
- NCT06804278
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Myocarditis Acute
Multicenter Retrospective Observational Study of Acute Myocarditis in Korea
In this study, the investigators analyze the clinical characteristics and prognosis of patients with acute myocarditis in South Korea
- Trial name
- NCT05933902
- Where
- South Korea
- Volunteers
- 841 people
- Sponsor
- Samsung Medical Center
Myocarditis, Pericarditis
A Study on the Clinical Course, Outcomes and Risk Factors of Myocarditis and Pericarditis After Moderna COVID-19 Vaccine
The main goal of this study is to describe the clinical course, outcomes and risk factors for myocarditis and pericarditis associated with Moderna vaccination targeting SARS-CoV-2.
- Trial name
- NCT06113692
- Testing
- mRNA-1273
- Where
- 5 sites in Denmark, Norway and 2 more
- Volunteers
- 1,169 people
- Sponsor
- ModernaTX, Inc.
Acute Myocarditis, Cardiac Sarcoidosis
Somatostatin Receptor Imaging in Acute Myocarditis and Cardiac Sarcoidosis
This prospective imaging study investigates the diagnostic ability of Gallium-68 DOTA-TOC (68Ga-DOTA-TOC) positron emission tomography/computed tomography (PET/CT) in the clinical work-up of patients with 1) clinically suspected…
- Trial name
- NCT04206163
- Testing
- 68Ga-DOTA-TOC PET/CT, Blood sample
- Where
- Sweden
- Volunteers
- 78 people
- Sponsor
- Vastra Gotaland Region