Clinical trials: Myocardial Viability
Ischemic Heart Disease (IHD)
XTR003 PET Radiotracer for the Detection of Viable Myocardium
The study was designed to explore the clinical feasibility of XTR003, a PET myocardial fatty-acid tracer, for the detection of viable myocardium in patients with ischemic heart disease (IHD).
- Trial name
- NCT05885854
- Testing
- XTR003
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Sinotau Pharmaceutical Group
STEMI - ST Elevation Myocardial Infarction, Myocardial Dysfunction
Percutaneous Revascularization in Infarction With Late Presentation and Absence of Viability: Effects on Left Ventricular Remodeling and Contractility
The purpose of this study is to evaluate whether late recanalization in patients with ST elevation myocardial infarction (STEMI) without Viability on Cardiovascular Magnetic Resonance Image (MRI) can reduce the reverse remodeling…
- Conditions
- STEMI - ST Elevation Myocardial Infarction, Myocardial Dysfunction, Percutaneous Coronary Intervention
- Trial name
- NCT05160311
- Testing
- Optimized Medical Treatment (OMT), Drug Eluting Stent (DES) Coronary Angioplasty
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Ischemic Heart Disease, Myocardial Infarction
Initial Human Validation of Simultaneous Dual-Tracer Cardiac PET Imaging
Positron emission tomography (PET) scans can be used to evaluate whether parts of the heart muscle are alive but receiving inadequate blood supply.
- Trial name
- NCT02003456
- Testing
- Cardiac PET scan w/18F-Fluorodeoxyglucose and rubidium-82
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan
Cardiovascular Diseases, Heart Diseases
Cardiovascular Magnetic Resonance for the Occluded Infarct-Related Artery Treatment
The purpose of this study is to determine whether opening an occluded infarcted artery 3-28 days after an acute myocardial infarction in high-risk asymptomatic patients with preserved infarct zone viability improves left…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Myocardial Infarction, Heart Failure
- Trial name
- COAT (NCT00968383)
- Testing
- Beta adrenergic blockers, Platelet inhibitors, Statins
- Where
- Poland
- Volunteers
- 11 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Ischemic Heart Disease
By Pass Surgery With Stem Cell Therapy in Chronic Ischemic Cardiopathy
Surgical revascularization has proven its efficacy in term of morbidity and mortality in patients with multivessel coronary disease and poor left ventricular function.
- Trial name
- NCT00690209
- Testing
- Autologous bone marrow derived stem cells myocardial transplantation
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Clermont-Ferrand
Hypertension
Subendocardial Viability Ratio in Hypertension
The aim of the research is to evaluate the Subendocardial Viability Ratio (SEVR) in hypertensive patients, using non-invasive arterial tonometry, and to establish the influencing factors and the possibility of predicting…
- Trial name
- SEVR-HT (NCT06309511)
- Testing
- Arterial tonometry
- Where
- 5 sites in Italy
- Volunteers
- 3,000 people
- Sponsor
- Istituto Auxologico Italiano
Acute Myocardial Infarction, Heart Failure
Inflammation-mediated Coronary Plaque Vulnerability, Myocardial Viability and Ventricular Remodeling
VIABILITY study aims to investigate the link between systemic inflammation, pancoronary plaque vulnerability (referring to the plaque vulnerability within the entire coronary tree), myocardial viability and ventricular remodeling…
- Trial name
- VIABILITY (NCT03830944)
- Testing
- Blood sampling, transthoracic echocardiography, Late Gadolinium-Enhancement Cardiac Magnetic Resonance
- Where
- Romania
- Volunteers
- 150 people
- Sponsor
- Cardio Med Medical Center
CABG, Myocardial Viability
Impact of Del Nido Versus Blood Cardioplegia on Myocardial Viability Assessed With Magnetic Resonance Imaging
Myocardial protection during surgical myocardial revascularization is crucial for reducing perioperative myocardial injury and improving postoperative outcomes.
- Trial name
- NCT07637266
- Testing
- Del Nido Cardioplegia Solution for myocardial protection, Blood Cardioplegia Solution for myocardial protection
- Where
- 2 sites in Croatia
- Volunteers
- 60 people
- Sponsor
- Klinički Bolnički Centar Zagreb
Myocardial Ischemia
Electromechanical Mapping to Evaluate Heart Muscle
Patients with narrowed heart arteries who undergo coronary angiography (imaging of the heart's blood vessels) may participate in this "heart mapping" study designed to gain information about the condition of different areas of…
- Trial name
- NCT00001895
- Testing
- FDG, NH(3)
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
TDI Preejection Velocities and Myocardial Viability
The purpose of the study is to test accuracy of positive preejection velocity to predict left ventricular remodeling and long-term prognosis after revascularization in 200 patients with chronically dysfunctional myocardium.
- Trial name
- NCT00231205
- Testing
- Revascularization
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- Charles University, Czech Republic
Cardiovascular Diseases, Coronary Disease
Heart Muscle Viability and Remodeling in Individuals Post-Heart Attack
The purpose of this study is to assess the effect of heart muscle viability on left ventricular (LV) remodeling after a heart attack; to explore the relationships between retained viability of the area of tissue death (infarct…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Myocardial Infarction, Heart Diseases
- Trial name
- NCT00099411
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Tufts Medical Center
Cardiovascular Disease, Cardiomyopathy
Statin Therapy for Ischemic and Nonischemic Cardiomyopathy
The purpose of this study is to see if taking a cholesterol lowering drug Lipitor (Atorvastatin Calcium)will increase the number of endothelial progenitor cells (EPC's) circulating in the blood of heart failure patients taking…
- Conditions
- Cardiovascular Disease, Cardiomyopathy, Heart Disease, Myocardial Disease
- Trial name
- NCT00701220
- Testing
- Atorvastatin Calcium
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Philip Binkley
Ischemic Cardiomyopathy, Heart Failure
PET Myocardial Fatty-acid Metabolic Imaging With XTR003 Injection and 18F-FDG to Assess Myocardial Viability in Ischemic Cardiomyopathy
This is a prospective, multicenter, randomized, open-label, parallel-controlled Phase IIb study to investigate the diagnostic-prognostic utility of XTR003 Injection integrated with 18F-FDG as an exploratory clinical trial.
- Trial name
- STB-XTR-003 (NCT07443696)
- Testing
- Fasting XTR003/¹⁸F-FDG PET myocardial metabolic imaging, Glucose-loaded ¹⁸F-FDG PET Myocardial Metabolic Imaging
- Where
- 3 sites in China
- Volunteers
- 40 people
- Sponsor
- Sinotau Pharmaceutical Group
Coronary Artery Disease
Magnetic Resonance Imaging (MRI) Viability: Comparison of Myocardial Viability by Positron Emission Tomography and MRI
The purpose of this study is to compare cardiac MRI with positron emission tomography (PET) with fluorodeoxyglucose (FDG) to determine if cardiac MRI images are as good as, or better, than PET with FDG.
- Trial name
- NCT00166179
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Emory University
Dilated Cardiomyopathy
Combination of Olmesartan Effect on Myocardial Viability of Patients With Dilated Cardiomyopathy
The study proceeds with prospective, randomized, open and controlled clinical trials. The subject of the investigator's study was the first patient diagnosed with dilated cardiomyopathy.
- Trial name
- NCT04174456
- Testing
- FDG PET
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Dong-A University
Cardiogenic Shock
Viability of Pulsioflex Monitoring in ICU
Goal of the Study is to Study the precision of semi-invasive cardiac index monitoring by means of the ProAQT (PULSION Medical Systems SE) sensor, whereby the pulmonary artery catheter will serve as gold standard.
- Trial name
- NCT04911985
- Testing
- Measurement of the Cardiac Output/ Cardiac Index
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- University of Zurich
Myocardial Ischemia, Myocardial Viability
Assessment of Lesion-Associated Myocardial Ischemia Based on Fusion Coronary CT Imaging
The aim of the Fused-Heart study is to investigate the impact of a coronary artery stenosis on myocardial function and viability, based on advanced fusion imaging techniques derived from CCTA.
- Conditions
- Myocardial Ischemia, Myocardial Viability, Coronary Stenosis, Vulnerable Coronary Plaques
- Trial name
- FUSE-HEART (NCT04680689)
- Testing
- 128 Multislice CT coronary angiography, 2D Cardiac Transthoracic Echocardiography, Laboratory Blood tests
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Cardio Med Medical Center
Myocardial Infarction
Evaluation of Myocardial Viability : Dual Energy Cardiac CT vs. Cardiac MRI
The purpose of this study is therefore to show that associated with cardiac angiography echocardiography, in myocardial seen late, would provide the information necessary for the decision revascularization, in a timely manner.
- Trial name
- InfarctusGSI (NCT02360150)
- Testing
- second propeller arm scanner
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Rouen
Coronary Artery Disease, Ventricular Dysfunction, Left
PET and Recovery Following Revascularization (PARR 2)
Rationale: Patients with severe ventricular dysfunction and coronary disease have high morbidity and mortality. They may benefit from revascularization, but have significant peri-operative morbidity and mortality.
- Trial name
- NCT00385242
- Testing
- Positron emission tomography: FDG viability imaging, PET imaging
- Where
- Canada
- Volunteers
- 430 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Coronary Artery Disease
Multicenter Myocardial Viability Trial
The purpose of this study is to test the hypothesis of whether contrast enhanced Magnetic Resonance Imaging can be used to predict improvement of the wall motion in regions of the heart with abnormal movement following bypass…
- Trial name
- NCT00661232
- Where
- 7 sites in United States, Belgium and 4 more
- Volunteers
- 235 people
- Sponsor
- CHI St. Luke's Health, Texas