Clinical trials: Myocardial Revascularization, open to volunteers
Coronary Disease
Prospective Evaluation of MyocaRdial PerFUSion ComputEd Tomography Trial
The purpose of this study is to evaluate safety and effectiveness of CTP(computed tomography perfusion) guided revascularization vs FFR(Fractional flow reserve) guided revascularization
- Trial name
- PERFUSERCT (NCT02208388)
- Testing
- computed tomography perfusion guided treatment, Fractional flow reserve guided treatment
- Where
- 7 sites in South Korea
- Volunteers
- 1,000 people
- Sponsor
- Young-Hak Kim, MD, PhD
Coronary Revascularization, Coronary Artery Disease
The CORE Platform Trial
Background: The leading cause of death worldwide is cardiovascular disease, with an estimated 19.8 million deaths per year. Coronary artery disease is a type of cardiovascular disease that can be treated with revascularisation…
- Trial name
- CORE (NCT07892976)
- Testing
- MIDCAB procedure, CABG procedure
- Where
- 3 sites in Belgium, Denmark and 1 more
- Volunteers
- 15,000 people
- Sponsor
- Copenhagen Trial Unit, Center for Clinical Intervention Research
Coronary Artery Bypass Grafting, Remimazolam
Remimazolam for Postoperative Atrial Fibrillation
Atrial fibrillation (AF) is the most common cardiac severe arrhythmia globally and is associated with an increased risk of mortality and morbidity, with a loss of 6.0 million disability-adjusted life-years worldwide in 2017…
- Trial name
- RePAF (NCT05891145)
- Testing
- Remimazolam, midazolam
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Yangzhou University
Coronary Bypass Graft Occlusion
Diagnostic and Prognostic Value of Cardiac Biomarkers for Early Coronary Bypass Occlusion in Patients Undergoing Coronary Revascularization
This study is to evaluate the correlation between hs-cTn level as cardiac biomarker for ischemia and early graft occlusion as assessed by CCT in patients undergoing coronary bypass surgery.
- Trial name
- NCT04595630
- Testing
- data collection from the hospital records
- Where
- 3 sites in Croatia, Poland and 1 more
- Volunteers
- 480 people
- Sponsor
- University Hospital, Basel, Switzerland
Acute Coronary Syndrome (ACS), High Bleeding Risk (HBR)
Optimization and Validation of Quality Control Indicators for Coronary Revascularization Based on Antiplatelet Therapy
Study Purpose Coronary heart disease (CAD) is a leading global cause of death, with Acute Coronary Syndrome (ACS) as its acute and life-threatening subtype.
- Conditions
- Acute Coronary Syndrome (ACS), High Bleeding Risk (HBR), Coronary Artery Disease (CAD)
- Trial name
- NCT07354828
- Where
- China
- Volunteers
- 3,500 people
- Sponsor
- Shenyang Northern Hospital
Myocardial Infarction, Acute, Multi-Vessel Coronary Artery Stenosis
Timing of FFR-guided PCI for Non-IRA in NSTEMI and MVD (OPTION-NSTEMI)
Many patients with non-ST-segment elevation myocardial infarction (NSTEMI) have multivessel coronary artery disease (MVD), which is associated with poor clinical outcomes.
- Conditions
- Myocardial Infarction, Acute, Multi-Vessel Coronary Artery Stenosis, Multi Vessel Coronary Artery Disease
- Trial name
- NCT04968808
- Testing
- Staged in-hospital complete revascularization, Immediate complete revascularization
- Where
- South Korea
- Volunteers
- 1,014 people
- Sponsor
- Chonnam National University Hospital
Frail Elderly Syndrome, Coronary Heart Disease
Frailty Syndrome in Daily Practice of Interventional Cardiology Ward
The impact of frailty on immediate and long term outcomes of invasive treatment of coronary artery disease is not fully characterized.
- Conditions
- Frail Elderly Syndrome, Coronary Heart Disease, Acute Coronary Syndrome, Coronary Artery Bypass Grafting
- Trial name
- FRAPICA (NCT03209414)
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- Medical University of Silesia
Percutaneous Coronary Intervention, Myocardial Revascularization
Clinical Study of Chinese Herbal Compound Qidan Xiaoke Granules in Patients After Coronary Revascularization
1. Evaluate the efficacy and safety of Qidan Xiaohe granules in patients after coronary revascularization surgery; 2. Develop a traditional Chinese medicine rehabilitation treatment plan and evaluation system for the use of Qidan…
- Conditions
- Percutaneous Coronary Intervention, Myocardial Revascularization, Coronary Artery Disease
- Trial name
- NCT07616544
- Testing
- Qidan Xiaoke Granules + Standard Medical Therapy
- Volunteers
- 164 people
- Sponsor
- Liu Qiang
Coronary Artery Disease, Elderly (Aged >70)
Development and Validation of a cCTA and Biomarker Based Risk Model for Coronary Revascularization in Elderly Patients With Coronary Artery Disease
This study is a prospective multi-center observational cohort involving elderly patients (≥70 years old) with multi-vessel coronary disease identified by coronary computed tomography angiography (cCTA) and scheduled for invasive…
- Trial name
- NCT07311954
- Testing
- No Intervention: Observational Cohort
- Volunteers
- 800 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Disease, Drug Eluting Balloon
Stents Versus PAclitaxel Coated Balloons for Revascularization of CompleX and Small Coronary Vessels (SPARX) Trial
The main objective of the SPARX trial is to compare paclitaxel-coated balloons to with contemporary DES in complex and small coronary artery lesions in patients with NSTEACS or CCS; the co-primary objective is to compare two…
- Conditions
- Coronary Artery Disease, Drug Eluting Balloon, Drug Eluting Stent
- Trial name
- SPARX RCT (NCT07397845)
- Testing
- Protégé and Protégé NC, Agent, Drug Eluting Stent
- Where
- Switzerland
- Volunteers
- 1,380 people
- Sponsor
- Translumina GmbH
Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI), Dual Anti-platelet Therapy
Aspirin-Free Strategy After 3-6 Month Dual Antiplatelet Therapy in Acute Coronary Syndrome
This randomized controlled trial aims to evaluate the safety and efficacy of an aspirin-free strategy after 3-6 months of dual antiplatelet therapy (DAPT) in patients with acute coronary syndrome (ACS) who have undergone complete…
- Trial name
- NCT07736196
- Testing
- Aspirin-Free Strategy, Dual Antiplatelet Therapy
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assiut University
Acute Coronary Syndrome
Guided Optimisation of Long-term Disease rEduction in secoNdary Prevention of CVD
The goal of this observational study is to evaluate the implementation of a 'first-time-right' pharmacological treatment strategy in patients hospitalized with coronary artery disease.
- Trial name
- GOLDEN (NCT06637657)
- Testing
- No intervention (observational study)
- Where
- Netherlands
- Volunteers
- 5,586 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Coronary Artery Disease
REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Minorities
This is a research study in minorities to compare the outcomes of two procedures that restore blood flow to the arteries of the heart.
- Trial name
- RECHARGE:M (NCT06399705)
- Testing
- Coronary artery bypass grafting, Percutaneous coronary intervention
- Where
- 18 sites in United States
- Volunteers
- 600 people
- Sponsor
- Weill Medical College of Cornell University
Coronary Artery Disease
A Prospective Multicenter Real-World Registry of Quantitative Flow Ratio-Guided Coronary REvascularization and QuAlity evaLuation
This prospective, multicenter observational registry aims to establish a QFR-based quality control standard system for coronary revascularization in patients with coronary artery disease.
- Trial name
- QFR-REAL (NCT07766434)
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Disease
Resting Full-cycle Ratio (RFR)-Guided Revascularization
The purpose of this study is to compare the clinical outcomes of a 2-year follow-up to determine whether RFR-guided coronary intervention is non-inferior to FFR-guided coronary intervention in patients with intermediate coronary…
- Trial name
- NCT06075160
- Testing
- Resting full-cycle ratio (RFR)-guided revascularization, Fractional flow ratio (FFR)-guided revascularization
- Where
- South Korea
- Volunteers
- 1,167 people
- Sponsor
- Sejong General Hospital
Carotid Stenosis, Coronary Artery Disease
Selective Coronary Revascularization in Carotid Artery Disease Patients After Carotid Revascularization (SCORECAD Trial)
The primary objective of this study is to determine whether among symptomatic and asymptomatic carotid artery stenosis (CAS) patients with no known coronary artery disease (CAD) who had undergone carotid artery revascularization…
- Trial name
- NCT06546761
- Testing
- Coronary CT angiography and FFRct analysis
- Where
- Latvia
- Volunteers
- 300 people
- Sponsor
- Pauls Stradins Clinical University Hospital
Coronary Artery Disease
CRIC Combined With MFT for Cardiovascular Adverse Events in Patients With Incomplete Revascularization of CAD
The main objective of this study is to demonstrate whether the combination of chronic remote ischemic conditioning and mindfulness therapy can reduce cardiovascular adverse events in patients with incomplete revascularization of…
- Trial name
- CRCMF (NCT06820970)
- Testing
- chronic remote ischemic conditioning, Mindfulness Therapy
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Myocardial Infarction, Stable Angina
Barts Revascularisation Registry
Despite the year-on-year decrease, coronary artery disease (CAD) still remains one of the leading cause of mortality worldwide. With advances in technology and our understanding of cardiac disease, we can now treat CAD using…
- Trial name
- NCT05255705
- Testing
- Observation only
- Where
- United Kingdom
- Volunteers
- 20,000 people
- Sponsor
- Queen Mary University of London
Stable Angina Pectoris, Coronary Artery Disease
Efficacy and Safety of Aspirin in Patients With Chronic Coronary Syndromes Without Revascularization
The purpose of this study is to evaluate the efficacy and safety aspirin in patients with chronic coronary syndromes without revascularization.
- Conditions
- Stable Angina Pectoris, Coronary Artery Disease, Ischemic Heart Disease
- Trial name
- ASA-IN (NCT05347069)
- Testing
- Aspirin, No aspirin
- Where
- Japan
- Volunteers
- 2,890 people
- Sponsor
- Takeshi Morimoto
Coronary Heart Disease
Glycocalyx and Oxidative Stress in Endothelial Function (Part 2)
The primary research objective of the project is to determine the role of eGC in microvascular reactivity in patients with coronary heart disease (CHD) before and after bypass grafting (cross-sectional study 2).The main objective…
- Trial name
- GlikoOxEND (NCT07451873)
- Where
- Croatia
- Volunteers
- 35 people
- Sponsor
- Josip Juraj Strossmayer University of Osijek