Clinical trials: Myocardial Inflammation
Cardiac Imaging Techniques, Cardiac Imaging
Role of Spectral CT in the Diagnosis of Myocarditis/MINOCA in Patients Undergoing cardioCT Investigations for Acute Chest Pain
It is a spontaneous, observational cross-sectional and single-center imaging (CT and MRI) study, coupled with clinical-laboratory data.
- Conditions
- Cardiac Imaging Techniques, Cardiac Imaging, Myocardial Disease, Myocarditis Acute
- Trial name
- NCT06804278
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Ischemic Heart Disease, Microvascular Coronary Artery Disease
The Cerebral-Coronary Connection (C3) Study
This is a prospective cohort blinded study with the aim to investigate the prevalence and clinical impact of coronary microcirculatory dysfunction (CMD) in patients with ischemic heart disease, and its association with cerebral…
- Conditions
- Ischemic Heart Disease, Microvascular Coronary Artery Disease, Depression, Endothelial Dysfunction
- Trial name
- C3 (NCT04131075)
- Testing
- Coronary Angiography and Multimodal Coronary Physiology Study (FFR, CFR, HMR)
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Instituto de Salud Carlos III
Acute Coronary Syndrome
Comparison of Ticagrelor vs. Prasugrel on Inflammation, Arterial Stiffness, Endothelial Function, and Circulating Endothelial Progenitor Cells in Diabetic Patients With Non-ST Elevation Acute Coronary Syndrome (NSTE-ACS) Requiring Coronary Stenting
To investigate pleiotropic effects of ticagrelor in addition to its antiplatelet effects in type 2 diabetic patients with non-ST elevation acute coronary syndrome by measuring inflammatory markers, circulating number of…
- Trial name
- NCT02487732
- Testing
- Ticagrelor, Prasugrel
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Korea University Anam Hospital
Coronary Artery Disease
Myocardial and Arterial Phenotype of Coronary Artery Disease
The CAD-MAP (Myocardial and Arterial Phenotype of Coronary Artery Disease) registry is initiated with the goal to describe the cardiac imaging map including epicardial coronary artery, coronary microcirculation and myocardium…
- Trial name
- CAD-MAP (NCT06202300)
- Testing
- Inflammation burden
- Where
- 2 sites in China
- Volunteers
- 5,000 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Heart Disease (CHD)
REsiduAL rISk Under Intensive Lipid-lowering Therapy In Coronary Heart Disease
Intensive lipid-lowering therapy is a cornerstone treatment for coronary heart disease (CHD). However, coronary plaque progression persists in a subset of patients even under intensive lipid-lowering therapy, which may be…
- Trial name
- REALISTIC (NCT06936111)
- Testing
- Assessment of residual cholesterol and inflammatory risk factors
- Where
- China
- Volunteers
- 900 people
- Sponsor
- Shanghai Zhongshan Hospital
Myocardial Infarction, Inflammation
SP16 Inflammatory Response Inhibition Trial
This study will evaluate the potential benefit of blocking inflammation during a heart attack using an investigational anti-inflammatory medicine called SP16.
- Trial name
- SPIRIT (NCT04225533)
- Testing
- SP16
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Serpin Pharma, LLC
Healthy Participants
SP16 SERPIN-like Peptide Administration in Healthy Individuals
This study is a randomized, double-blind, placebo-controlled Phase 1 Clinical Trial of 24 healthy individuals to test the safety, tolerability and pharmacokinetics of a single subcutaneous administration of Serpin Peptide 16…
- Trial name
- NCT03651089
- Testing
- SP16
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Serpin Pharma, LLC
Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction
Impact of Cardiac Rehabilitation Programs on Left Ventricular Remodeling After Acute Myocardial Infarction - the REHAB Trial
The aim of REHAB trial is to investigate the impact of early mobilization after AMI in reducing left ventricular remodeling, as assessed by cardiac magnetic resonance imaging.
- Conditions
- Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction, Systemic Inflammation, Ventricular Remodeling
- Trial name
- NCT04161378
- Testing
- Cardiac imaging, Laboratory analysis
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Cardio Med Medical Center
Patients With Acute Coronary Syndrome
Air Pollution, Inflammation and Acute Coronary Syndrome
The objectives of this study are: 1) To determine whether patients with acute coronary syndrome, the level of environmental exposure to particulate air pollutants in the week prior to admission, are related to concentrations of…
- Trial name
- AIRACOS (NCT01799148)
- Testing
- Particulate air pollutants
- Where
- Spain
- Volunteers
- 307 people
- Sponsor
- Fundación Canaria Rafael Clavijo para la Investigación Biomédica
Coronary Heart Disease
A Pharmacokinetic Study Of SB-681323 In Subjects With Coronary Heart Disease Undergoing Percutaneous Intervention
Study of SB-681323 (a novel p38 MAPkinase inhibitor) in subjects with documented coronary heart disease (CHD) undergoing elective percutaneous coronary intervention (PCI).
- Trial name
- NCT00291902
- Testing
- SB-681323
- Where
- 7 sites in Denmark, Poland
- Volunteers
- 80 people
- Sponsor
- GlaxoSmithKline
Cardiomyopathy, Heart Failure
International T1 Multicentre CMR Outcome Study
Myocardial fibrosis is the fundamental substrate for the development of heart failure. Cardiovascular magnetic resonance (CMR) allows non-invasive assessment of myocardial fibrosis based on late gadolinium enhancement (LGE) and…
- Conditions
- Cardiomyopathy, Heart Failure, Coronary Artery Disease, Chronic Kidney Diseases
- Trial name
- T1-CMR (NCT02407197)
- Where
- 4 sites in Australia, Germany and 1 more
- Volunteers
- 1,629 people
- Sponsor
- King's College London
Coronary Artery Disease, Atherosclerosis
Treatment of Patients With Atherosclerotic Disease With Paclitaxel-associated to LDL Like Nanoparticles
The investigators propose a prospective, randomized, double-blind, placebo-controlled study. The purpose of the study is to evaluate the safety and efficacy of an anti-proliferative agent paclitaxel in a cholesterol-rich…
- Conditions
- Coronary Artery Disease, Atherosclerosis, Inflammation
- Trial name
- PAC-MAN (NCT04148833)
- Testing
- LDE-Paclitaxel
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Myocardial Infarction
The Effects of mETHotrexate Therapy on ST Segment Elevation MYocardial InfarctionS (TETHYS Trial)
Experimental studies suggest that anti-inflammatory and immunomodulatory drugs could reduce the inflammatory profile in acute ischemic disease and reduce the area of ischemia.
- Trial name
- TETHYS (NCT01741558)
- Testing
- Methotrexate, Riboflavin
- Where
- 2 sites in Brazil
- Volunteers
- 80 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Myocardial Fibrosis, End Stage Renal Failure on Dialysis
MRI Assessment of Myocardial Fibrosis Associated With Monocyte Phenotype in End Stage Renal Failure
Firstly, this study aims to understand how cardiac fibrosis mediated by inflammatory microvascular disease evolves during advanced chronic kidney disease and end stage renal failure and importantly how this changes with…
- Conditions
- Myocardial Fibrosis, End Stage Renal Failure on Dialysis, Chronic Kidney Disease, Stage IV (Severe), Chronic Kidney Disease Stage V
- Trial name
- CM3 (NCT03857633)
- Testing
- Cardiac MRI 1 - With Gadolinium Contrast, Cardiac MRI 2 - With Gadolinium Contrast, Cardiac MRI 3 - Without Gadolinium Contrast
- Where
- United Kingdom
- Sponsor
- Imperial College London
Myocarditis, Cardiomyopathies
Clinical Study of Endocardial Myocardial Biopsy
In this study, patients with endocardial myocardial biopsy were selected to observe the safety of the operation, and pathological examination was performed.
- Conditions
- Myocarditis, Cardiomyopathies, Heart Failure, Cardiac Tumor
- Trial name
- NCT05718128
- Testing
- Endocardiomyocardial biopsy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cardiovascular Diseases, Heart Diseases
HDL-C in Cardiac Syndrome X
High density lipoprotein cholesterol (HDL-C) is in the centrum of the process of reverse cholesterol transport from peripheral cells to the liver[10].
- Conditions
- Cardiovascular Diseases, Heart Diseases, Myocardial Ischaemia, Unstable Angina
- Trial name
- HIRICS-X (NCT02095964)
- Volunteers
- 710 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Coronary Artery Disease
Safety and Efficacy of Meplazumab in Patients With Coronary Artery Disease
The development of coronary atherosclerosis is closely related to inflammation, and CD147 may play an important role in its process.
- Trial name
- REC-SAFECAD (NCT06572267)
- Testing
- Mepolizumab low dose group, Mepolizumab middle dose group, Mepolizumab high dose group
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Xijing Hospital
Sepsis, Septic Shock
Nucleosome Monitoring Relevance for Outcome Prediction in Critically Ill Patients
NUROPI is a single-centre, prospective, non-interventional study in the Intensive Care Unit (ICU) of Erasme Hospital (Hôpital Universitaire de Bruxelles, Brussels, Belgium).
- Conditions
- Sepsis, Septic Shock, Cardiac Arrest (CA), Pancreatitis
- Trial name
- NuROPI (NCT07184593)
- Testing
- Plasma H3.1 nucleosome measurement
- Volunteers
- 1,000 people
- Sponsor
- Erasme University Hospital
Acute Myocardial Infarction
IL-10 Levels and Remote Ischemic Preconditioning in Acute Myocardial Infarction
Remote ischemic preconditioning has proven beneficial in patients undergoing percutaneous coronary intervention and coronary artery bypass surgery.
- Trial name
- NCT01532206
- Testing
- Blood pressure cuff insufflation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation