Clinical trials: Myocardial Infarction (MI), active
SCAD, Myocardial Infarction (MI)
Norwegian Spontaneous Coronary Artery Dissection Study
The Norwegian Spontaneous Coronary Artery Dissection Study (NOR-SCAD) is a national, multicenter prospective observational study conducted at major hospitals in Norway.
- Conditions
- SCAD, Myocardial Infarction (MI), Women
- Trial name
- NOR-SCAD (NCT07317323)
- Where
- 3 sites in Norway
- Volunteers
- 300 people
- Sponsor
- Oslo University Hospital
Myocardial Infarction, Coronary Stenosis
Study of Microvascular Dysfunction, CFR and Cardioprotective Effect of Early Administration of Esmolol in MI
Study rationale: to evaluate clinical and prognostic relevance of microvascular dysfunction, coronary flow reserve and cardioprotective effects of iv administration of esmolol in patients with myocardial infarction.
- Conditions
- Myocardial Infarction, Coronary Stenosis, Coronary Microvascular Dysfunction
- Trial name
- ESMO-VASCMI (NCT06376630)
- Testing
- Esmolol Hcl 10Mg/Ml Inj
- Where
- Russia
- Volunteers
- 300 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Coronary Artery Disease, NSTEMI - Non-ST Segment Elevation MI
FFR Driven Complete Revascularization Versus Usual Care in NSTEMI Patients and Multivessel Disease
To compare FFR guided complete revascularization during the index procedure with usual care in non-STEMI patients with multivessel disease.
- Conditions
- Coronary Artery Disease, NSTEMI - Non-ST Segment Elevation MI, Fractional Flow Reserve, Myocardial, Myocardial Revascularization
- Trial name
- SLIM (NCT03562572)
- Testing
- Ischemia driven revascularization, Usual care group
- Where
- 9 sites in Czechia, Hungary and 1 more
- Volunteers
- 476 people
- Sponsor
- Zuyderland Medisch Centrum
Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function.
- Trial name
- NCT06383390
- Testing
- Retatrutide
- Where
- 742 sites in United States, Argentina and 25 more
- Volunteers
- 10,000 people
- Sponsor
- Eli Lilly and Company
ECMO Treatment, ARDS (Acute Respiratory Distress Syndrome)
Ciprofol's Impact on Oxygenator Function in Extracorporeal Membrane Oxygenation (ECMO) Patients
This study evaluates the safety and effectiveness of Ciprofol, a new sedative, in critically ill patients receiving Extracorporeal Membrane Oxygenation (ECMO), a life-support system for heart or lung failure.
- Conditions
- ECMO Treatment, ARDS (Acute Respiratory Distress Syndrome), ECMO and Acute MI, Respiratory Failure Patients Treated With ECMO
- Trial name
- CIP-OXY (NCT06934811)
- Testing
- Ciprofol, Midazolam
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Acute Coronary Syndromes, ST Elevation Myocardial Infarction
Smartphone AI Assistance for Prehospital ECG Interpretation
Prehospital providers interpret 12-lead electrocardiograms (ECGs) under time pressure and without immediate expert support. Missed acute coronary occlusion - occlusion myocardial infarction (OMI) - delays reperfusion, while false…
- Conditions
- Acute Coronary Syndromes, ST Elevation Myocardial Infarction, Non-ST Elevated Myocardial Infarction, Myocardial Infarction (MI)
- Trial name
- ECG-IA (NCT07810686)
- Testing
- Smartphone large language model assistance (GPT-4o, version-locked)
- Where
- Switzerland
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- École Supérieure de Soins Ambulanciers - College of Higher Education in Prehospital Care
Coronary Bypass Graft Occlusion
Diagnostic and Prognostic Value of Cardiac Biomarkers for Early Coronary Bypass Occlusion in Patients Undergoing Coronary Revascularization
This study is to evaluate the correlation between hs-cTn level as cardiac biomarker for ischemia and early graft occlusion as assessed by CCT in patients undergoing coronary bypass surgery.
- Trial name
- NCT04595630
- Testing
- data collection from the hospital records
- Where
- 3 sites in Croatia, Poland and 1 more
- Volunteers
- 480 people
- Sponsor
- University Hospital, Basel, Switzerland
Acute Coronary Syndrome, Myocardial Infarction (MI)
Tailoring Post Discharge - Remote Education and Access for Cardiac Health
Heart attacks are one of the top causes of death in Canada, with over 2,100 cases treated each year in Manitoba. Even though hospital care has improved, the period after going home is still risky.
- Trial name
- TPD-REACH (NCT07171580)
- Testing
- Remote Home Monitoring - Education, Remote Home Monitoring - Education and Support
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- St. Boniface Hospital
Myocardial Infarction (MI)
Can Wearable Technology be Used to Predict Exercise Intensity
There is a knowledge gap in the literature around using watts to measure exercise intensity in walking and running, this is largely due to new technological developments.
- Trial name
- (CWTPEI) (NCT06871943)
- Testing
- Incremental Shuttle Walk Tests
- Volunteers
- 24 people
- Sponsor
- Keele University
Cardiogenic Shock Acute, Bypass, Cardiopulmonary
Prognosis of Patients With Mixed Cardiogenic-Vasoplegic Shock
Mixed cardiogenic-vasoplegic shock (M-CS) represents a distinct and severe phenotype of cardiogenic shock characterized by concomitant myocardial dysfunction and inappropriate systemic vasodilation.
- Conditions
- Cardiogenic Shock Acute, Bypass, Cardiopulmonary, Septic Shock, Mechanical Circulatory Support
- Trial name
- PROMIX (NCT07354568)
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Coronary Artery Disease, Myocardial Infarction
Foundation Model for Post-MI Cardiovascular Event Alert Using Huawei Watch
The goal of this randomized controlled trial is to evaluate whether a HUAWEI smartwatch integrated with a foundation model can enhance daily monitoring and management of AMI patients during outpatient cardiac rehabilitation after…
- Trial name
- NCT07395648
- Testing
- Smartwatch + AI assisted, Smartwatch only, Conventional care
- Volunteers
- 1,050 people
- Sponsor
- Tongji Hospital
Myocardial Infarction, STEMI
Breisgau PHENO-HEART MI
Coronary heart disease and its acute complication, myocardial infarction (MI), represent the leading causes of death in Europe and the United States.
- Conditions
- Myocardial Infarction, STEMI, NSTEMI
- Trial name
- NCT06166407
- Testing
- no intervention
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- University Hospital Freiburg
Ethics, Cardiac Rehabilitation
The Role of 4 Different Consent Approaches on a Pilot Study to Increase Cardiac Rehabilitation Attendance
Cardiac Rehabilitation is a lifestyle and exercise program for patients with heart disease. Cardiac Rehabilitation is strongly recommended in guidelines, but only 30% of eligible patients attend.
- Conditions
- Ethics, Cardiac Rehabilitation, Coronary Heart Disease (CHD), Heart Failure
- Trial name
- MOST-CR (NCT07123480)
- Testing
- Usual Care Group, More Support and Tools
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Baystate Medical Center
Atrial Fibrillation (AF), Cerebral Vascular Accident (CVA)
Pilot Study to Determine the Optimal Protocol for Preoperative Transcutaneous Vagal Neurostimulation
Post-operative atrial fibrillation (POAF) is a frequent complication of surgical aortic valve replacement, affecting 38 to 63% of patients, and increasing risks of stroke, heart failure, and long-term mortality.
- Conditions
- Atrial Fibrillation (AF), Cerebral Vascular Accident (CVA), Heart Failure, Myocardial Infarction (MI)
- Trial name
- VAGASTIMA-PILT (NCT07891390)
- Testing
- tVNS session on the left earlobe
- Where
- 3 sites in France
- Volunteers
- 64 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Acute Cardiovascular Disease, ST-segment Elevation Myocardial Infarction (STEMI)
MAchine Learning to Boost the Early Diagnosis of Acute Cardiovascular Conditions
The research project aims to develop clinical decision support tools integrating established diagnostic variables and machine learning (ML) models for rapid diagnosis of acute life-threatening cardiovascular conditions in…
- Conditions
- Acute Cardiovascular Disease, ST-segment Elevation Myocardial Infarction (STEMI), NSTEMI - Non-ST Segment Elevation MI
- Trial name
- MALBEC (NCT06927791)
- Testing
- Machine learning based development of a diagnostic tool for acute cardiovascular disease
- Where
- Switzerland
- Volunteers
- 200,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Myocardial Infarction (MI), Cardiovascular Events
Aspirin Continuation or Interruption in Patients at Moderate Risk for Cardiovascular Events Undergoing Colonoscopy and/or Polypectomy
One in 4 adults between 50 and 80 reports taking regular aspirin. The prevalence of aspirin uses increases with age as well as co-morbid vascular diseases.
- Conditions
- Myocardial Infarction (MI), Cardiovascular Events, Post Polypectomy Bleeding in Antiplatelet Patients
- Trial name
- NCT07052799
- Testing
- Aspirin 80mg
- Where
- Hong Kong
- Volunteers
- 2,514 people
- Sponsor
- Chinese University of Hong Kong
Myocardial Infarction (MI)
Impact of Pre-Hospital and Hospital Delays on Myocardial Infarction Outcomes
The goal of this prospective observational study is to investigate the impact of pre-hospital and hospital delays on the outcomes of myocardial infarction (MI) patients admitted to Al-Kadhimiya Teaching Hospital, Baghdad.
- Trial name
- PHHD-MI (NCT06738498)
- Where
- Iraq
- Volunteers
- 200 people
- Sponsor
- Al-Nahrain University
Angina (Stable), CAD - Coronary Artery Disease
Advanced NanoTherapies Dual-API DCB to Treat De-Novo and ISR Lesions in Patients With Symptomatic Coronary Artery Disease
The study objectives are: 1. To evaluate the safety and performance of the SirPlux Duo PTCA to treat coronary ISR lesions 2.00-4.00 mm (inclusive) in diameter in patients with symptomatic coronary artery disease. 2.
- Conditions
- Angina (Stable), CAD - Coronary Artery Disease, Unstable Angina, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- ADVANCE-DUO (NCT07368933)
- Testing
- SirPlux Duo™ Dual API-Coated PTCA Balloon Catheter
- Where
- 3 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Advanced NanoTherapies
Myocardial Infarction (MI)
Contribution of Myocardial Perfusion Imaging in the Initial Assessment of Acute Coronary Syndromes Without ST Elevation for the Diagnosis of Myocardial Infarction or Differential Diagnoses
Patients with myocardial infarction require invasive treatment involving coronary angiography to confirm the diagnosis and, in most cases, treatment by angioplasty/stenting.
- Trial name
- APRICOT (NCT07112820)
- Testing
- perfusion ultrasound
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Myocardial Infarction (MI)
Optimize Risk Prediction After Myocardial Infarction: The ORACLE Study
Background. Myocardial infarction (MI) is a leading cause of death worldwide. After MI, longterm antithrombotic therapy is crucial to prevent recurrent events, but increases bleeding, that also impacts morbidity and mortality.
- Trial name
- ORACLE (NCT06993415)
- Testing
- data collection
- Where
- Spain
- Volunteers
- 750 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud