Clinical trials: Musculoskeletal Physiology
Aging, Physical Fitness
Myogenic and Osteogenic Responses to eXercise and Ibuprofen
The purpose of this study is to determine if the use of ibuprofen blocks the benefits of exercise to build bone and muscle mass.
- Trial name
- MOXI (NCT00462722)
- Testing
- Ibuprofen, musculoskeletal-loading exercise
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Osteoarthritis of the Knee, Coagulopathy
Trial to See if Topical Pennsaid for Knee Pain Affects Coagulation Values in Patients Who Are Also Taking Anticoagulants
The purpose of this study is to see if using a topical nonsteroidal antiinflammatory drug (Pennsaid) to treat osteoarthritis knee pain will affect coagulation values in patients who are also taking anticoagulant or antithrombotic…
- Trial name
- ATCCTCP-1 (NCT01511939)
- Testing
- Pennsaid
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Nathan Wei, MD, FACP, FACR:
Cancer, Skin Fibroblasts
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome
Background: Nicotinamide riboside (NR) is a vitamin B3 dietary supplement. It may help improve muscle function, that may in turn may improve a person s exercise capacity.
- Conditions
- Cancer, Skin Fibroblasts, Muscle Weakness
- Trial name
- NCT03789175
- Testing
- Nicotinamide Riboside (NR)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Diabetic Neuropathies
Effect of Educational Booklet for Foot-related Exercises for Prevention and Treatment in People With Diabetic Neuropathy
The main objective of this trial is to investigate the effect of an educational booklet foot-related exercise in diabetic neuropathy status, functional outcomes and gait biomechanics in people with diabetic neuropathy.
- Trial name
- FOCA-II (NCT04008745)
- Testing
- Educational and home-based physical therapy by foot-related exercises
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo General Hospital
Jaw, Edentulous
Peri-Implant Healing Around Two Different Machined-Collar Designs After 25 Years of Function
Brånemark System® dental implant osseointegration was introduced in 1965 as a novel approach to the replacement of missing teeth.
- Trial name
- NCT03862482
- Testing
- Brånemark® 2, Swede-Vent® 2, Screw-Vent® 1 (Configuration 1), Brånemark® 1, Swede-Vent® 2, Screw-Vent® 2 (Configuration 2), Brånemark® 2, Swede-Vent® 1, Screw-Vent® 2 (Configuration 3)
- Where
- Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
Duchenne Muscular Dystrophy
Use of Dynamic Arm Supports to Promote Activities of Daily Living in Individuals With DMD
This study is a longitudinal, randomized control trial evaluating the use of two commercially available dynamic arm support devices (1) Armon Ayura-Kinova and 2) JAECO WREX) to promote participation in activities of daily living…
- Trial name
- NCT03531788
- Testing
- Armon Ayura (Kinova), JAECO Wrex
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Roxanna Marie Bendixen
Axial Spondyloarthritis
A Post-Marketing-Observational Study (PMOS) to Determine the Effectiveness of Combined Adalimumab Treatment and Active Supervised Training in Patients With Axial Spondyloarthritis (axSpA)
This study is a non-interventional, longitudinal and non-confirmatory study to compare an active supervised training (AST) with standard of care (SOC) physiotherapy in patients with axial spondyloarthritis and stable response to…
- Trial name
- Treat & Train (NCT03258814)
- Testing
- Active Supervised Training (AST), Standard of Care (SOC) Physiotherapy
- Where
- 6 sites in Germany
- Volunteers
- 17 people
- Sponsor
- AbbVie
Chronic Pain
Low Level Laser Therapy With Physical Therapy for Chronic Musculoskeletal Pain
1. Examine the use of low level therapeutic laser (LLLT) combined with physical therapy for improvements in pain, range of motion, and function in individuals with chronic pain from musculoskeletal conditions. 2.
- Trial name
- NCT02785432
- Testing
- Active low level laser
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Texas Southwestern Medical Center
Subacromial Bursitis, Shoulder Pain
Relationship to Dose of Triamcinolone Acetonide and Methylyprednisolone to Improvement in Subacromial Bursitis
It is currently unknown whether or not the improvement in pain and function related to a "steroid shot" for shoulder pain due to subacromial bursitis is important.
- Trial name
- NCT02242630
- Testing
- Methylprednisolone, 20 mg, Methylprednisolone, 40 mg, Triamcinolone, 20 mg
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Keesler Air Force Base Medical Center
Osteoarthritis (OA)
Effect of Chair Yoga on Elders With Osteoarthritis
The current study is a two-arm randomized controlled clinical trial to test the feasibility of recruiting, randomizing, and having older adults with osteoarthritis (OA) adhere to and safely complete the 8-week Sit 'N' Fit Chair…
- Trial name
- NCT02113410
- Testing
- Sit 'N' Fit Chair Yoga (SNFCY), Health Education Program (HEP)
- Where
- 2 sites in United States
- Volunteers
- 131 people
- Sponsor
- Florida Atlantic University
Chronic Pain, Osteoarthritis
Hormone Function in Men Treated for Pain With Opioids or Placebo
This study will examine hormone function in men with osteoarthritis pain and how it is affected by opioid medication (such as Percocet, Vicodin, MS Contin and morphine) versus placebo.
- Trial name
- NCT00737737
- Testing
- MS Contin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute of Nursing Research (NINR)
Growth Hormone Deficiency, Panhypopituitarism
Growth Hormone and Endothelial Function in Children
Objective: This study is designed to determine whether growth hormone treatment in children 8 to 18 years of age alters function of the lining of the arteries.
- Conditions
- Growth Hormone Deficiency, Panhypopituitarism, Short Stature
- Trial name
- NCT00373386
- Testing
- growth hormone
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Ohio State University
Osteoarthritis, Rehabilitation
Home Rehabilitation in Patients After Primary Total Knee Arthroplasty
The investigators include patients attending the outpatient clinic in the area of Orthopedics and Traumatology of the investigators hospital with a diagnosis of knee osteoarthritis, which treatment requires surgery.
- Trial name
- NCT02409719
- Testing
- Schedule, Verbal Information and Booklet
- Where
- Mexico
- Volunteers
- 76 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Gastroschisis
Evaluation of Glycerin Suppositories to Improve Bowel Function in Gastroschisis
Gastroschisis is a congenital defect of the abdominal wall that leads to evisceration of various amounts of the abdominal organs.
- Trial name
- NCT03355326
- Testing
- Glycerin Suppository
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Indiana University
Endothelial Function, Rheumatoid Arthritis
Cardiovascular Risk Markers in Patients With Rheumatoid Arthritis: Effect of Rituximab Therapy
The purpose of this investigation is to determine the effects of Rituxan therapy in individuals with rheumatoid arthritis on endothelial function and other markers of endothelial function
- Conditions
- Endothelial Function, Rheumatoid Arthritis, Inflammation
- Trial name
- NCT00844714
- Testing
- Rituxan
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Adolescent Idiopathic Scoliosis
MESA Rail™ AIS Study - Preservation of Curve Correction
To evaluate the restoration and maintenance of thoracic kyphosis and coronal curve correction demonstrated through the surgical implantation of the K2M MESA Rail™ Deformity System as compared to literature reported outcomes for…
- Trial name
- NCT02062606
- Testing
- MESA Rail™ Deformity System
- Volunteers
- 188 people
- Sponsor
- K2M, Inc.
Muscular Dystrophy, Duchenne, Ambulatory Care
Phase III Study of Idebenone in Duchenne Muscular Dystrophy (DMD)
The aim of this Phase III study was to assess the efficacy of idebenone on pulmonary function, motor function, muscle strength and quality of life in patients with DMD.
- Trial name
- DELOS (NCT01027884)
- Testing
- Idebenone
- Where
- 23 sites in United States, Austria and 8 more
- Volunteers
- 65 people
- Sponsor
- Santhera Pharmaceuticals
Arthritis, Pain
Non-cancer Pain and Cognitive Impairment: A Disabling Relationship
To compare the efficacy of long-acting oxycodone to extended-release acetaminophen in older persons with no and mild to moderate cognitive impairment and persistent moderate or higher intensity non-cancer lower extremity…
- Conditions
- Arthritis, Pain, Cognitive Impairment
- Trial name
- NCT01264965
- Testing
- long acting oxycodone, extra strength acetaminophen
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Chicago
Osteoarthritis, Knee, Arthritis
Evaluation of Electrical Nerve Stimulation (TENS) Therapy for Pain Relief Following Total Knee Arthroplasty (TKA)
Evaluation of Electrical Nerve Stimulation (TENS) Therapy for Pain Relieft Following Total Knee Arrhtoplasty (TKA)
- Conditions
- Osteoarthritis, Knee, Arthritis, Pain
- Trial name
- NCT01641471
- Testing
- EMPI Select TENS
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- The Cleveland Clinic
Intracranial Pressure Increase, Abdominal Compartment Syndrome
Vasopressin in Intraabdominal Pressure Elevation
The aim of this study is to investigate any direct correlation between increased intrathoracic pressure, intraabdominal pressure and intracranial pressure, following a controlled elevation in intraabdominal pressure and…
- Trial name
- NCT03707054
- Testing
- Study Arm
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic