Clinical trials: Musculoskeletal Model
Osteoarthritis, Knee, Hypertension
The Clinical Impact of Diet on Medical Conditions Treated Within Bundled Payment Models: a Pilot Study
Diet interventions (e.g., low-energy diets) are recommended as a treatment for obesity, obese patients with osteoarthritis, hypertension (HTN), and type 2 diabetes (T2D).
- Conditions
- Osteoarthritis, Knee, Hypertension, Type 2 Diabetes, Obesity
- Trial name
- NCT05735873
- Testing
- Low-energy diet
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Clubfoot
Gait Analysis in Children With Clubfoot Treated With Tibialis Anterior Tendon Transfer
Patients with clubfoot treated with the Ponseti method and undergoing Tibialis Anterior tendon transfer from a prospective database are evaluated using gait analysis including the Oxford foot model and compared to a group of…
- Trial name
- NCT03953430
- Testing
- Gait analysis
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Orthopedic Hospital Vienna Speising
Tendinopathy, Musculoskeletal Diseases or Conditions
Human Tendon Tissue Collection
The goal of this study is to improve understanding of tendon health and disease by using surplus tendon tissue that is routinely removed during planned orthopaedic surgeries in adults.
- Conditions
- Tendinopathy, Musculoskeletal Diseases or Conditions, ACL Surgery, Achilles Tendon Surgery
- Trial name
- NCT07606092
- Where
- 2 sites in United Kingdom
- Volunteers
- 400 people
- Sponsor
- Queen Mary University of London
Prosthetic Joint Infection, Osteomyelitis
Population Pharmacokinetic Model of Rifampicin in Staphylococcal Osteoarticular Infections
Staphylococcal osteoarticular infections (OAIs), including prosthetic joint infections and chronic osteomyelitis, represent a major cause of morbidity.
- Conditions
- Prosthetic Joint Infection, Osteomyelitis, Staphylococcal Infections
- Trial name
- Ciné-RIF (NCT07788404)
- Testing
- This study focuses on the pharmacokinetics of rifampicin and levofloxacin or ciprofloxacin, which are used in the treatment of osteoarticular infections caused by susceptible staphylococci as part of
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Fibromyalgia
The Effectiveness Of BETY In Fibromyalgia
Fibromyalgia Syndrome (FMS) is a nonarticular, chronic rheumatic disorder of unknown etiology characterized by widespread musculoskeletal pain, impaired sleep quality, fatigue and the presence of identified tender points.
- Trial name
- NCT07034417
- Testing
- Exercise, Home exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Aysima Barlak
Knee Osteoarthritis
Community Based Rehabilitation Model After Total Knee Replacement
To investigate the clinical efficacy of community-based early stage knee replacement rehabilitation program as compared with usual care in acute hospital outpatient clinic
- Trial name
- NCT06270446
- Testing
- Community based physiotherapy, Outpatient physiotherapy
- Where
- Singapore
- Volunteers
- 59 people
- Sponsor
- Tan Tock Seng Hospital
Musculoskeletal Pain Disorder, Spinal Pain
Single Session Compared to Multiple Sessions of Education and Exercise for Older Adults With Spinal Pain in an Advanced Practice Physiotherapy Model of Care
Objectives: To assess the effectiveness and cost-effectiveness of a single session compared to multiple sessions of education and exercise for older adults with spinal pain treated conservatively in an advanced practice…
- Trial name
- NCT04868591
- Testing
- Single session of education and exercise provided by an advanced practice physiotherapist., Multiple session of education and exercise provided by an advanced practice physiotherapist.
- Where
- Canada
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Psoriasis, Psoriatic Arthritis
Discovery of Arthritis in Psoriasis Patients for Early Rheumatological Referral
Rationale: Psoriasis (PsO) is a common inflammatory skin disease. Besides the skin, it is recognized that this disease can affect multiple domains such as nails, joints and entheses.
- Conditions
- Psoriasis, Psoriatic Arthritis, Psoriasis Vulgaris, Psoriatic Nail
- Trial name
- DAPPER (NCT03816917)
- Testing
- cutaneous parameters of psoriasis (exposure), comorbidity (exposure), family history (exposure)
- Where
- Netherlands
- Volunteers
- 304 people
- Sponsor
- Radboud University Medical Center
Rheumatic Arthritis
Exercise Training and Knee Joint Proprioception in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic disorder that affects 0.5% to 1% of adults and is the result of an autoimmune attack against joint tissues.
- Trial name
- NCT06887725
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 19 people
- Sponsor
- Aysima Barlak
Rheumatoid Arthritis
Alloimmune Response to Citrullinated Shared Epitope Sequence in Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) is an autoimmune and sistemic disease,characterized by joint sinovitis and the production of autoantibodies (Ab).
- Trial name
- ABSEC (NCT03506035)
- Testing
- Research new biomarker for RA
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Corporacion Parc Tauli
Knee Osteoarthritis, Pain
Effectiveness of the Transitional Care Model in Total Knee Arthroplasty Patients
The aim of this study was to determine the effectiveness of transitional care in patients with total knee arthroplasty on patients' functional status, perceived self-efficacy, and health care use.
- Conditions
- Knee Osteoarthritis, Pain, Self Efficacy, Health Care Utilization
- Trial name
- NCT05525793
- Testing
- Transitional care model
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Hasan Kalyoncu University
Bone Neoplasms
Localized Osteosarcoma in Upper Egypt: A Clinical Prediction Model
To assess survival outcome of pediatric patients with localized osteosarcoma of the extremities in Upper Egypt, identify factors of prognostic significance for survival, and to determine factors predictive of surgical methods…
- Trial name
- NCT03839095
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Femoroacetabular Impingement
3D Modeling to Improve Hip Arthroscopy Outcomes
This study will pilot the use of 3D printed models of the hip, for use in pre-operative planning and patient communication to improve clinical outcomes and patient engagement.
- Trial name
- NCT03995290
- Testing
- 3D Hip Model from Pre-operative CT scan
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- The Hawkins Foundation
Osteoporotic Fractures
Effectiveness of Adipose Tissue Derived Mesenchymal Stem Cells as Osteogenic Component in Composite Grafts
Failure rates of up to 30% are reported after proximal humeral fractures despite angular-stable devices. This may devastate not only the functional outcome but also the independence of elderly patients.
- Trial name
- ROBUST (NCT01532076)
- Testing
- Cellularized composite graft augmentation, Acellular composite graft augmentation
- Where
- Switzerland
- Volunteers
- 8 people
- Sponsor
- University Hospital, Basel, Switzerland
Osteoporosis
Development of Cellular Models for Osteoblast Response Study to Adipocytic Secretions in an Osteoporosis Context.
The recent studies suggest that secretions from medullary adipocytes are involved in the mechanisms of bone loss in osteoporosis (OP) through their actions on neighbouring osteoforming cells, the osteoblasts.
- Trial name
- ROSA (NCT04377880)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Lille
Pectus Carinatum, Chondromanubrial
Chest Compressor for Conservative Treatment of Pectus Carinatum: a Multicenter Study
Pectus carinatum (PC) is a congenital deformity of the chest wall whose prevalence is 0.6% of the population and although it does not cause cardio respiratory physiological damage, it has profound psychological effects on young…
- Trial name
- NCT04171063
- Testing
- Thoracic compressor
- Where
- 4 sites in Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Osteoarthritis, Knee, Healthy
Generate a Pharmacodynamic Model of Oxytocin for Peripheral Analgesic Effects
This is a study of participants that will receive an intravenous (IV) infusion of oxytocin (naturally occurring hormone that is made in the brain).
- Trial name
- NCT04431206
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Fibromyalgia, Fibromyalgia Syndrome
Slow Breathing and Resistance Exercise in Fibromyalgia
This randomized controlled trial investigates whether slow breathing techniques influence heart rate variability, exercise self-efficacy, and resistance exercise performance in women with fibromyalgia.
- Trial name
- Breath-fibro (NCT07404384)
- Testing
- Slow Breathing with Visual Pacer, Slow Breathing without Visual Pacer, Spontaneous Breathing (Active Control)
- Where
- 2 sites in Spain
- Volunteers
- 159 people
- Sponsor
- University of Malaga
Rheumatic Diseases
Al to Improve the Diagnosis of Rare Rheumatic Diseases
This trial aims to assess the impact of providing medical students with access to ChatGPT, a state-of-the-art large language model, in comparison to conventional diagnostic decision support tools, on their diagnostic accuracy for…
- Trial name
- AIDRARER (NCT06748170)
- Testing
- ChatGPT
- Where
- Germany
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Osteoporosis, Fragility Fracture
Image-guided Computational and Experimental Analyses of Fractured Patient's Bone (GAP)
Due to the increase in the average age of the population, the projections on the number of age-dependent bone fractures appear to be constantly increasing. They are mainly due to bone pathologies, including osteoporosis.
- Trial name
- GAP (NCT04787679)
- Testing
- Hip replacement surgery
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Laura Maria Vergani