Clinical trials: Musculoskeletal Issues
Fibromyalgia, Anxiety
The Relationship Between Diaphragm Muscle Thickness and Fibromyalgia
Fibromyalgia syndrome is characterized by chronic pain, fatigue, sleep problems and functional symptoms. Fatigue, anxiety and depression disorders, poor quality of life, sleep disorders, decreased concentration, and impaired…
- Conditions
- Fibromyalgia, Anxiety, Depression, Diaphragm Issues
- Trial name
- NCT06396949
- Testing
- Fibromyalgia study form, Pulmonary function test, Ultrasonographic Diaphragm Thickness Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Polymyalgia Rheumatica, Effect of Drug
Tofacitinib as a GC Sparing Agent for Polymyalgia Rheumatica
Glucocorticoids are the cornerstone treatment for polymyalgia rheumatica but induce adverse events. The efficacy of the candidate drug Tofacitinib has not yet been demonstrated in controlled studies.
- Conditions
- Polymyalgia Rheumatica, Effect of Drug, Safety Issues
- Trial name
- NCT04799262
- Testing
- Tofacitinib 5 MG
- Where
- China
- Volunteers
- 14 people
- Sponsor
- RenJi Hospital
Pes Planus, Diaphragm Issues
The Relationship Between Pes Planus, Diaphragm, Postural Control, and Plantar Pressure
Our primary aim is to compare diaphragm function (resting thickness, activity/resting thickness ratio indicating contractility), postural control, and plantar pressure between individuals with pes planus and healthy controls…
- Conditions
- Pes Planus, Diaphragm Issues, Plantar Pressure, Postural Control
- Trial name
- NCT06491212
- Testing
- Determination of Foot Deformity Level, Foot Function Index, UFAA-International Physical Activity Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Alanya Alaaddin Keykubat University
Holoprosencephaly
Study of the Experiences and Needs of Parents Continuing a Pregnancy Following a Prenatal Diagnosis of Holopresencephaly
This study will examine the experiences of parents who decided to continue a pregnancy after receiving a prenatal diagnosis of holopresencephaly (HPE).
- Trial name
- NCT00005016
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Spine Deformity, Scoliosis
The Effect of Three-dimensional Exercise (Schroth Exercise) on Diaphragm Thickness in Adolescent Idiopathic Scoliosis Patients
Spinal deformity is common in childhood and adolescence, and can often present as scoliosis or increased thoracic kyphosis deformity with various etiologies.The diaphragm is the main respiratory muscle, and diaphragm contraction…
- Conditions
- Spine Deformity, Scoliosis, Scoliosis Idiopathic, Scoliosis; Adolescence
- Trial name
- NCT06417944
- Testing
- Scoliosis study form, Scoliosis X-ray (orthorontgenogram), Pulmonary function test
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Hyperkyphosis, Spine Deformity
Ultrasonographic Measurement of Diaphragmatic Thickness in Adolescents With Thoracal Hyperkyphosis
Spinal deformity is common in childhood and adolescence. Any spinal deformity, especially one that affects the thoracic spine, can affect lung function.The diaphragm is the main respiratory muscle, and diaphragm contraction is…
- Conditions
- Hyperkyphosis, Spine Deformity, Diaphragm Issues
- Trial name
- NCT06418334
- Testing
- Thoracal hyperkyphosis study form, Scoliosis graphy, Pulmonary function test
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Fatigue, Stress
The U.S. Embryologist Fatigue Study
The purpose of the study is to determine physical and mental health issues of U.S. embryologists related to their occupational characteristics, and how workplace fatigue and burnout may affect their quality of life, cynicism…
- Conditions
- Fatigue, Stress, Burnout, Professional, Musculoskeletal Pain
- Trial name
- FUSE (NCT05326802)
- Where
- United States
- Volunteers
- 246 people
- Sponsor
- TMRW Life Sciences
Diaphragm Issues, Mechanical Ventilation Complication
Diaphragm Atrophy and Dysfunction in Mechanical Ventilation
The gold standard of twitch transdiaphragmatic pressure recordings would ultimately clear the fog around the rate of development of Ventilator induced Diaphragm Dysfunction (VIDD) in mechanically ventilated patients over time.
- Conditions
- Diaphragm Issues, Mechanical Ventilation Complication, Respiratory Failure, Intensive Care (ICU) Myopathy
- Trial name
- DAM (NCT05211661)
- Testing
- Respiratory Muscle Testing
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- RWTH Aachen University
Diaphragm, Diaphragm Disease
Diaphragmatic Ultrasound and Weaning After Lung Transplant.
The prevalence and adverse effect of diaphragm dysfunction (DD) after bilateral-lung transplant (LT) are still unclear, despite a well-known negative impact on weaning and outcome in other cohorts of critically ill and surgical…
- Conditions
- Diaphragm, Diaphragm Disease, Diaphragm Issues, Weakness, Muscle
- Trial name
- NCT05670327
- Testing
- Diaphragmatic ultrasound assessment
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- University of Padova
Musculoskeletal Disorder, Mental Health Issue
An Integrated Approach to Health, Wellbeing, and Productivity at Work
The goal of the workplace intervention study 'An Integrated Approach to Health, Wellbeing, and Productivity at Work (ITASPA)' is to examine the effect of the Australian WorkHealth Improvement Network (WIN) program in a Danish…
- Conditions
- Musculoskeletal Disorder, Mental Health Issue, Work-related Illness, Safety Issues
- Trial name
- ITASPA (NCT05866978)
- Testing
- Integrated Approach to Health, Wellbeing, and Productivity at Work (ITASPA)
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Holbaek Sygehus
Inflammatory Disease, Drug Side Effect
Active Pharmacovigilance Study of the Medicine Rinvoq™ (Upadacitinib)
The LOOK-UP is an investigator-initiated clinical study with the aim of monitoring the post-marketing safety of the medicine Rinvoq™ (upadacitinib), which is indicated for the treatment of rheumatoid arthritis, psoriatic…
- Conditions
- Inflammatory Disease, Drug Side Effect, Drug Use, Adverse Drug Event
- Trial name
- LOOK-UP (NCT06498167)
- Testing
- Upadacitinib
- Where
- 3 sites in Portugal
- Volunteers
- 150 people
- Sponsor
- Universidade do Porto
Shoulder Pain, Diaphragm Issues
Functional Movement Analysis (FMS) of Diaphragmatic Breathing-Immediate Effect on Shoulder Mobility
The diaphragm is defined as a thin, smooth muscle that separates the thoracic and abdominal cavities. The shoulder and diaphragm muscle have a clear relationship through innervation and myofascial tissue connection.
- Trial name
- NCT05748522
- Testing
- Shoulder Mobility, Diaphragmatic Breathing
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Gastrointestinal Issues, Respiratory Issues
Real-world Observation of Medical Accuracy of a Novel AI-app
This study aims to evaluate the performance of the suggestions made by the WRA by comparing Ada's list of suggested conditions and advice level to usual care and a gold-standard in a Romanian clinical setting.
- Conditions
- Gastrointestinal Issues, Respiratory Issues, Cardiovascular Issues, Genitourinary Issues
- Trial name
- ROMAN-AI (NCT05194215)
- Testing
- Ada WRA
- Where
- Romania
- Volunteers
- 49 people
- Sponsor
- Ada Health GmbH
Sacroiliac Joint Dysfunction
Kinetic Control Exercises to Reduce Pain and Improve Balance, Walking, and Stamina in Sacroiliac Joint Issues
The goal of this clinical trial is to evaluate the effectiveness of the Kinetic control on pain, endurance, Gait and postural stability in patients suffering from chronic sacroiliac joint dysfunction.
- Trial name
- RCT (NCT07229287)
- Testing
- movement retraining/ kinetic control, Routine Physical therapy
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Rheumatic Disease, HIV Infections
COVID-19 CoronaVac in Patients With Autoimmune Rheumatic Diseases and HIV/AIDS
Patients with chronic rheumatic diseases (such as systemic lupus erythematosus [SLE], rheumatoid arthritis [RA], ankylosing spondylitis [AS], juvenile idiopathic arthritis [JIA], poly/dermatomyositis [PM/DM], systemic sclerosis…
- Conditions
- Rheumatic Disease, HIV Infections, AIDS, Safety Issues
- Trial name
- CoronavRheum (NCT04754698)
- Testing
- CoronaVac
- Where
- Brazil
- Volunteers
- 2,196 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Achondroplasia, Dwarfism
Issues Surrounding Prenatal Genetic Testing for Achondroplasia
Since the gene responsible for achondroplasia was identified in 1994, it has become possible to test for achondroplasia prenatally.
- Trial name
- NCT00001536
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Fibromyalgia Syndrome, Fibromyalgia
Pain & Reward Neuromodulation of CNS Circuits
This pilot feasibility study aims to evaluate transcranial magnetic stimulation (TMS) targeting the prefrontal cortex in patients with fibromyalgia syndrome (FMS).
- Conditions
- Fibromyalgia Syndrome, Fibromyalgia, Chronic Pain and Fatigue
- Trial name
- PRANCIR (NCT07525063)
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Bardet-Biedl Syndrome
Characterizing the Genotype and Phenotype in Adults With Bardet-Biedl Syndrome
Bardet-Biedl syndrome (BBS; OMIN #209900) is a rare genetic disorder characterized by six core features: rod-cone dystrophy (retinitis pigmentosa), polydactyly, obesity, genital anomalies, renal anomalies, and learning…
- Trial name
- NCT05400278
- Testing
- No intervention
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Oslo University Hospital
Schizoaffective Disorder, Bipolar Type, Bipolar Disorder
Psychoneuromentalism Disorder: A Medical Condition That Affects People With Psychological Impairments From Health Issues
Psychoneuromentalism Disorder is a disorder arising in the mind; that is related to the mental and emotional state of a person. It is the science of mental life. The body has a natural design to heal itself.
- Conditions
- Schizoaffective Disorder, Bipolar Type, Bipolar Disorder, ADHD - Combined Type, Dissociative Disorder
- Trial name
- PNMD (NCT06235177)
- Testing
- Decompartmentalization Framework, Liquid Herbal TInctures, Mental Imagery
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Essence of Integrative Health and Medicine Practice
Pharmacokinetics, Safety Issues
A Clinical Study With Adalimumab Biosimilar
The study aims to evaluate the pharmacokinetic profile, safety profile, and immunogenic potential of adalimumab of a new citrate-free formulation of adalimumab (Adalimumab Richmond) [Test Product] vs.
- Trial name
- NCT06291948
- Testing
- Humira® (adalimumab) AC Pen [Reference Product], Adalimumab Richmond [Test Product]
- Where
- Argentina
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Laboratorios Richmond S.A.C.I.F.