Clinical trials: Musculoskeletal Injuries
Shoulder Injury
Blood Flow Restriction Therapy Following Acute Shoulder Injury Patients
Atrophy and weakness of the shoulder are a common problem following treatment of a number of shoulder and elbow pathologies. Even with relatively short periods of reduced activity, the magnitude of muscle loss can be quite…
- Trial name
- BFR (NCT06223373)
- Testing
- Blood Flow Restriction
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Wake Forest University Health Sciences
Osteopenia, Osteoporosis
Extension Study to Evaluate the Long Term Safety and Efficacy of Denosumab in the Treatment of Osteoporosis
The primary objective was to describe the safety and tolerability of up to 10 years or 7 years denosumab administration as measured by adverse event monitoring, immunogenicity and safety laboratory parameters in participants who…
- Trial name
- NCT00523341
- Testing
- Denosumab
- Volunteers
- 4,550 people
- Sponsor
- Amgen
Spinal Cord Injury, Muscle Spasticity
Safety and Efficacy of Oral Fampridine-Sustained Release (SR) for the Treatment of Spasticity Resulting From Spinal Cord Injury
Normally, nerve fibers carry electrical impulses through the spinal cord, providing communication between the brain and the arms and legs.
- Trial name
- NCT01683838
- Testing
- Fampridine-SR
- Where
- 30 sites in United States, Canada
- Volunteers
- 204 people
- Sponsor
- Acorda Therapeutics
Full-thickness Skin Defects, Degloving Injuries
RECELL® System Combined With Meshed Autograft for Reduction of Donor Skin Harvesting in Soft Tissue Reconstruction
A prospective randomized within-subject controlled study to compare the clinical performance of conventional autografting with and without the RECELL system on acute non-burn full-thickness skin defects.
- Conditions
- Full-thickness Skin Defects, Degloving Injuries, Crush Injuries, Laceration of Skin
- Trial name
- NCT04091672
- Testing
- Control Intervention (Conventional Autograft), Investigational Intervention (RECELL + more widely meshed autograft)
- Where
- 18 sites in United States
- Volunteers
- 65 people
- Sponsor
- Avita Medical
Knee Osteoarthritis, Hip Osteoarthritis
Use of Knotless Suture for Closure of Total Hip and Knee Arthroplasties
Barbed sutures offer several potential advantages in layered wound closure of hip and knee replacement surgeries. It use is gaining increased acceptance across many of the other surgical disciplines at this time.
- Trial name
- NCT00834483
- Testing
- Knotless suture for wound closure, Layered traditional wound closure (monocryl)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Patient Satisfaction, Sports Injury
Virtual Phone Visits Compared to In-Person Physical Visits for Post-Operative Follow-Up at a Sports Medicine Clinic
This study will compare patient reported outcomes (PROs) of patients seen at virtual phone visits compared to in-person visits for 6 weeks, 12 weeks, and 6 months post-operative follow up at a sports medicine clinic.
- Conditions
- Patient Satisfaction, Sports Injury, Surgery, Orthopedic Disorder
- Trial name
- NCT05998148
- Testing
- virtual phone appointment visits
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Jonathan Wu
Osteoporosis
Secondary Prevention of Osteoporosis
The purpose of this study is to develop and implement an evidence based protocol for the secondary prevention of osteoporotic fractures and falls, and to determine how compliance with this intervention improves muscle strength…
- Trial name
- NCT00421343
- Testing
- alendronate with cholecalciferol, calcium carbonate with cholecalciferol, Falls prevention measures
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Hebrew SeniorLife
Rotator Cuff Injuries, Shoulder Pain
ASHCOM Shoulder System and Its Related Instruments
The objectives of this study are to confirm safety, performance and clinical benefits of the ASHCOM Shoulder System and its related instruments by analysis of standard scoring systems, radiographs and adverse event records.
- Conditions
- Rotator Cuff Injuries, Shoulder Pain, Arthropathy; Traumatic, Arthroplasty Complications
- Trial name
- NCT04258605
- Testing
- ASHCOM Shoulder System
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Zimmer Biomet
Shoulder Dislocation
Open-Label Study for Shoulder Dislocation Using MG-1
To evaluate the efficacy and safety of arthroscopic Bankart repair using MG-1 for dislocation of shoulder
- Trial name
- MG-1 (NCT01528319)
- Testing
- MG-1
- Where
- 2 sites in Japan
- Volunteers
- 24 people
- Sponsor
- Johnson & Johnson K.K. Medical Company
Subacromial Impingement Syndrome
Shoulder Eccentric External Rotator Training for Subacromial Pain Syndrome
The purpose of this study is to examine the effects of eccentric exercise to the shoulder muscles for people with shoulder pain.
- Trial name
- NCT02153827
- Testing
- Eccentric Shoulder External Rotator Training, General Shoulder exercise
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Nova Southeastern University
Pain
A Pilot Study of Switching From One Pain Medication to Another (Opioid Rotation)
The purpose of this study is to see if changing from one pain medication like morphine or oxycodone to another pain medication, oxymorphone (OPANA®), will be helpful to patients.
- Trial name
- NCT00580294
- Testing
- Oxymorphone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Fibromyalgia, Persian Gulf Syndrome
Effects of Low Dose Naltrexone in Fibromyalgia
Low Dose Naltrexone (LDN) has been reported anecdotally to reduce the symptoms of Fibromyalgia, a Chronic Multisystem Illness. The drug may work by regulating natural pain-reducing systems.
- Trial name
- NCT00568555
- Testing
- Low Dose Naltrexone
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Stanford University
Tennis Elbow
ITU Treatment for Chronic Epicondylitis Musculoskeletal Pain Reduction
This study evaluates the effectiveness, safety and patient tolerance for the use of Intense Therapeutic Ultrasound (ITU) for chronic, subcutaneous lateral Epicondylitis musculoskeletal tissue pain reduction began in July 2015 and…
- Trial name
- ITU (NCT03255733)
- Testing
- Intense Therapeutic Ultrasound Treatment
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Guided Therapy Systems
Dysplasia; Hip, Prosthesis Survival
Long-term Outcomes of Conical Tapered Stems in Cementless Total Hip Arthroplasty Due to Congenital Hip Pathologies
A retrospective consecutive population of patients treated with conical tapered stems in cementless total hip arthroplasty for osteoarthritis due to congenital hip pathologies will be selected.
- Trial name
- RetroCone (NCT04748458)
- Testing
- Conical tapered stem
- Where
- Italy
- Volunteers
- 85 people
- Sponsor
- Istituto Ortopedico Rizzoli
Lateral Elbow Pain
Corticosteroid Injection for Common Upper Extremity Problems
The purpose of the study is to compare the effectiveness of a steroid injection to a placebo (inactive substance) in the treatment of lateral elbow pain, deQuervain's tendonitis, or base of the thumb carpometacarpal (CMC)…
- Trial name
- NCT00438672
- Testing
- Steroid (dexamethasone) Injection
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Massachusetts General Hospital
Compression Fracture
Comparison of Treatments of Osteoporotic Compression Fracture Using Rigid Brace, Soft Brace, and no Brace
The treatment outcomes in the treatment without brace would be non-inferior to those in use of rigid or soft brace.
- Trial name
- NCT02049931
- Testing
- No brace treatment, Rigid brace, Soft brace
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Subchondral Cysts, Subchondral Bone Edema
SCP Hip Outcomes Study
Post-market clinical outcomes study to collect data on the short- and long-term outcomes for subjects who are undergoing or have undergone the Subchondroplasty® (SCP®) Procedure in the hip in a standard clinical setting.
- Conditions
- Subchondral Cysts, Subchondral Bone Edema, Bone Marrow Edema, Insufficiency Fractures
- Trial name
- NCT03494660
- Testing
- Subchondroplasty Procedure with AccuFill
- Where
- 6 sites in United States
- Volunteers
- 77 people
- Sponsor
- Zimmer Biomet
Acute Musculoskeletal Disease, Sprains
Efficacy of Lidocaine Patch in Acute Musculoskeletal Pain in the Emergency Department
This study evaluates the addition of a lidocaine patch to ibuprofen in the treatment of acute musculoskeletal pains. Half of the participants will get only ibuprofen for their pain, while other half will receive lidocaine patch…
- Conditions
- Acute Musculoskeletal Disease, Sprains, Sprains and Strains, Injuries
- Trial name
- NCT03571737
- Testing
- Ibuprofen, Lidocaine Patch 4%
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- East Carolina University
Upper Extremity Dysfunction
Movement Enhancing Device for Children
The purpose of this study is to assess: 1) how infants move their bodies to explore, play, and solve problems, 2) if this is different in a high-risk group of infants, and 3) if these abilities can be advanced in a high-risk…
- Trial name
- NCT01959581
- Testing
- Movement Enhancing Device
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Wounds and Injuries, Compartment Syndrome
Closure of Fasciotomy Wounds: A Prospective, Observational Study of a Continuous External Tissue Expander
Fasciotomy wounds are rarely able to be closed at the time of index surgery. They often require multiple returns to surgery for closure, and occasionally require skin grafting (i.e. they are never completely closed).
- Trial name
- NCT01171534
- Testing
- DermaClose fasciotomy closure, Vessel loop
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Missouri-Columbia