Clinical trials: Musculoskeletal Disorders
Osteoarthritis, Knee
A Phase 2 Study to Evaluate the Efficacy and Safety of JointStem in Treatment of Osteoarthritis
This study is a double-blind, randomized, controlled study with two arms to evaluate JointStem as a treatment for subjects with osteoarthritis.
- Trial name
- NCT02674399
- Testing
- JointStem, Synvisc-One
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Nature Cell Co. Ltd.
Rheumatoid Arthritis
A Phase III Study of BMS-188667 in Subjects With Active Rheumatoid Arthritis
The purpose of this clinical research study is to learn if abatacept is safe when co-administered with other approved rheumatoid arthritis medications.
- Trial name
- NCT00048932
- Testing
- Double-blind Abatacept, Open-label Abatacept
- Where
- 44 sites in United States
- Volunteers
- 1,795 people
- Sponsor
- Bristol-Myers Squibb
Malocclusion, Anxiety
Patient Education Before Orthognathic Surgery
To evaluate the effectiveness in the use of an educational material through: Assessment of knowledge about post-operative orthognathic surgery; assessing levels of anxiety with the survey of Anxiety Inventory-STATE-TRAIT…
- Conditions
- Malocclusion, Anxiety, Micrognathism, Prognathism
- Trial name
- NCT01803204
- Testing
- Booklet - Preoperative Educational
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- University of Sao Paulo
Arthritis, Rheumatoid
Comparative Analysis of Outcomes Among Patients Treated With Xeljanz vs Biologics
To compare rheumatoid arthritis (RA) patient characteristics, adherence, and costs between patients treated with tofacitinib (IR, XR and combined groups) to patients treated with each of the bDMARDs.
- Trial name
- NCT03964649
- Where
- United States
- Volunteers
- 7,308 people
- Sponsor
- Pfizer
Hypoparathyroidism, DiGeorge Syndrome
Effects of PTH Replacement on Bone in Hypoparathyroidism
Hypoparathyroidism is a rare condition associated with a low level of parathyroid hormone (PTH) in the blood. Hypoparathyroidism can be genetic and show up in childhood, or it can occur later in life.
- Trial name
- NCT00395538
- Testing
- PTH 1-34
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Rheumatoid Arthritis
Observational Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid Arthritis
This multi-center, observational study will evaluate the clinical practice patterns, efficacy and safety of RoActemra/Actemra in patients with rheumatoid arthritis who have had an inadequate response (or were intolerant to)…
- Trial name
- NCT01579006
- Testing
- Tocilizumab
- Where
- 14 sites in Israel
- Volunteers
- 184 people
- Sponsor
- Hoffmann-La Roche
Sjogren's Syndrome
Assessment of Inflammatory Biomarkers Expressed in a Sjogren's Population: Effect of a Topical Steroid Intervention
The primary purpose of this study is to quantify the change in expression of biomarkers on the ocular surface of Sjogren's Syndrome participants after treatment with Maxidex.
- Trial name
- NCT00631358
- Testing
- Maxidex, No treatment
- Where
- 2 sites in Canada
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Clubfoot
A Randomized Controlled Trial of Three Non-pharmacologic Analgesic Techniques for Casting of Clubfoot Infants
While it has been shown that sucrose or milk ingestion decreases pain responses in heel sticks, no study up to this point has determined the best intervention for decreasing the pain response during casting for clubfoot…
- Trial name
- NCT02395185
- Testing
- Milk bottle administration, Water bottle administration, Sucrose bottle administration
- Volunteers
- 33 people
- Sponsor
- Shriners Hospitals for Children
Femoroacetabular Impingement
A Physical Therapy Program Versus Surgery for Femoroacetabular Impingement: Randomized Clinical Trial
The purpose of this study is to compare the outcomes for patients that receive two different treatments used for FAI (Femoroacetabular Impingement).
- Trial name
- NCT01993615
- Testing
- Arthroscopic Surgery, Physical Therapy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Madigan Army Medical Center
Temporomandibular Disorders
Conservative Treatment of Patients With Temporomandibular Disorders
At any given time, 10 million Americans suffer from temporomandibular disorders (TMD), with a lifetime prevalence of 45% and costs for direct care exceeding $2 billion/year.
- Trial name
- D1P2-TMD (NCT01021306)
- Testing
- Chiropractic w/Activator & Self Care, Dental Care & Self Care, Self-Care Only Group
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Palmer College of Chiropractic
Facioscapulohumeral Muscular Dystrophy
Bone Health in Facioscapulohumeral Muscular Dystrophy
This is a cross-sectional single visit study to determine bone health in individuals with FSHD.
- Trial name
- FSHD (NCT02413190)
- Where
- 2 sites in United States, Australia
- Volunteers
- 94 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Infectious Diseases
BAY 0 9867 Cipro Pediatric Use Study (QUIP)
Objective and subjective musculoskeletal evaluations will be performed to determine differences in the ciprofloxacin versus non-quinolone treated pediatric patients so that we can tell what the natural occurrence of such…
- Trial name
- NCT00761462
- Testing
- Ciprofloxacin, Non-quinolone antibiotic
- Where
- 67 sites in United States, Canada
- Volunteers
- 1,029 people
- Sponsor
- Bayer
Rheumatoid Arthritis
Long Term Evaluation of Sarilumab in Rheumatoid Arthritis Patients (SARIL-RA-EXTEND)
Main Study: Primary Objective: Assess the long term safety of sarilumab in participants with rheumatoid arthritis (RA). Secondary Objective: Assess the long term efficacy of sarilumab in participants with RA.
- Trial name
- NCT01146652
- Testing
- SAR153191 (REGN88)
- Where
- 335 sites in United States, Argentina and 38 more
- Volunteers
- 2,023 people
- Sponsor
- Sanofi
Rheumatoid Arthritis
Safety and Efficacy of Intravenous ACZ885 and Oral Methotrexate Therapy in Patients With Early Rheumatoid Arthritis
This study was intended to evaluate the safety and efficacy of intravenous (IV) ACZ885 and oral methotrexate (MTX) therapy in patients with early rheumatoid arthritis (RA)
- Trial name
- NCT00487825
- Testing
- Canakinumab (investigational), Methotrexate (MTX)
- Where
- 22 sites in United States, Belgium and 4 more
- Volunteers
- 78 people
- Sponsor
- Novartis
Treatment for Basal Cell Carcinomas (BCCs) in Gorlin Syndrome Patients
A Trial to Evaluate the Safety, Local Tolerability, Pharmacokinetics and Pharmacodynamics of LDE225 on Skin Basal Cell Carcinomas in Gorlin Syndrome Patients
Part I was a double-blind, randomized, vehicle-controlled Proof of Concept (PoC) study to evaluate the safety, local tolerability, pharmacokinetics and pharmacodynamics of multiple topical administrations of LDE225 (a specific…
- Trial name
- NCT00961896
- Testing
- Vehicle, LDE225 0.25%, LDE225 0.75%
- Where
- 3 sites in Austria, Switzerland
- Volunteers
- 18 people
- Sponsor
- Novartis Pharmaceuticals
Myositis, Interstitial Lung Disease
Abatacept for the Treatment of Myositis-associated Interstitial Lung Disease
A randomized, controlled pilot trial to evaluate the efficacy and safety of subcutaneous Abatacept in treating interstitial lung disease associated with the anti-synthetase syndrome.
- Trial name
- ATtackMy-ILD (NCT03215927)
- Testing
- Abatacept
- Where
- 5 sites in United States
- Volunteers
- 20 people
- Sponsor
- Rohit Aggarwal, MD
Osteoarthritis of the Knee
Effect Of Meloxicam Versus Placebo In Mainland Chinese Patients With Osteoarthritis Of The Knee
This study is to validate the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) tool in mainland Chinese patients with osteoarthritis of the knee .
- Trial name
- NCT01430559
- Testing
- Meloxicam
- Where
- 25 sites in China
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- Pfizer
Rheumatoid Arthritis
Study Conducted in Subjects With Rheumatoid Arthritis Who Have Moderate to Severe Disease Activity Despite Methotrexate Therapy With or Without Other Non Biologic Disease Modifying Antirheumatic Drugs (DMARDs)for at Least 12 Weeks Prior to Screening
To compare the maintenance of efficacy of the combination of etanercept 50 mg once weekly plus methotrexate with or without other disease modifying antirheumatic drugs therapy with that of methotrexate with or without other…
- Trial name
- NCT01578850
- Testing
- Etanercept
- Where
- 62 sites in Brazil, China and 17 more
- Volunteers
- 491 people
- Sponsor
- Pfizer
Osteogenesis Imperfecta
Safety of Fresolimumab in the Treatment of Osteogenesis Imperfecta
Osteogenesis Imperfecta (OI) is a rare disorder that causes bones to break easily. People with OI may have broken bones with little or no trauma, dentinogenesis imperfecta (DI), and, in adult years, hearing loss.
- Trial name
- NCT03064074
- Testing
- Fresolimumab
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Baylor College of Medicine
Osteoarthritis, Hip
Study to Evaluate a Procedure for Intra-articular Injection of FX006 in Patients With Osteoarthritis of the Hip
This is a multi-center, single-arm, open-label study of FX006 in patients with hip OA. A maximum number of approximately 30 patients may be enrolled in this protocol.
- Trial name
- NCT04065074
- Testing
- FX006 32 mg
- Where
- 5 sites in United States
- Volunteers
- 16 people
- Sponsor
- Pacira Pharmaceuticals, Inc