Clinical trials: Musculoskeletal Disorders
Alveolar Bone Loss
The Influence of Cortical Bone Perforation on Guided Bone Regeneration in Humans
The purpose of this randomized clinical trial was to evaluate the effect of cortical bone decortication on the angiogenesis and osteogenesis of augmented ridge by GBR.
- Trial name
- NCT02741752
- Testing
- Decortication
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences
Genu Varum, Knee Osteoarthritis
Effect of RO On GB During TKR Severe Varus Deformity
Effect Of Reduction Osteotomy On Gap Balancing During Total Knee Replacement For Severe Varus Deformity
- Trial name
- NCT03065738
- Testing
- tibial reduction osteotomy in total knee replacement
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Jaw Cysts
Treatment of Mandibular Bone Cyst by Navigation and Endoscopy
In this study, with the assistance of endoscopic technology and intraoperative navigation technology, the removal and curettage of large odontogenic jaw cyst occurred in the mandible were performed to reduce the rate of…
- Trial name
- NCT06567535
- Testing
- Navigation and endoscopy
- Where
- China
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Inflammation, Systemic Lupus Erythematosus
Dose-escalation Trial of Anti-C5aR Antibody in Healthy Subjects
This trial is conducted in Europe. The aim of this trial is to develop a complement system targeted monoclonal antibody (mAb) to be used in treatment of subjects with chronic autoimmune diseases.
- Conditions
- Inflammation, Systemic Lupus Erythematosus, Rheumatoid Arthritis, Healthy
- Trial name
- NCT02151409
- Testing
- NNC 0151-0000-0000
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Bone Atrophy, Alveolar
Conventional and Ultrasonic Implant Site Preparation
multi center study with randomized controlled trial design, split mouth
- Trial name
- PI-DRI (NCT03357406)
- Testing
- ultrasound implant site preparation, conventional implant site preparation
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- International Piezosurgery Academy
Periapical Diseases, Periapical Periodontitis
Effect of Targeted Endodontic Microsurgery on Quality of Life and Healing on Mandibular Molars
Targeted endodontic microsurgery represents precise and advanced approach to resolving persisting chronic periapical periodontitis after non- surgical root canal treatment.
- Conditions
- Periapical Diseases, Periapical Periodontitis, Periapical Cyst, Periapical Granuloma
- Trial name
- NCT06643676
- Testing
- Targeted Endodontic Microsurgery Using 3d Printed surgical guide using the patient's CBCT data, Conventional Endodontic Microsurgery with a free hand procedure using bur and CBCT analysis
- Where
- India
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Maxillofacial Abnormalities
Impact of Maxillomandibular Deformities on Individuals' Nutritional Status
This cross-sectional study explores the influence of various types of maxillomandibular deformities on the nutritional status of individuals.
- Trial name
- NCT05936476
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Marmara University
Rheumatoid Arthritis
Assessment of 14-3-3 η (Eta) Protein Antibodies in the Serum of Rheumatoid Arthritis Patients and Its Relation to Atherosclerosis.
The aims of this study are: • To assess 14-3-3 η (eta) protein antibodies in the serum of rheumatoid arthritis patients and its relation to disease activity and severity.
- Trial name
- NCT04937140
- Testing
- 14-3-3 η (eta) protein antibodies in the serum of rheumatoid arthritis patients
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Sohag University
Improving the Early Diagnosis of Osteoporosis in Adults and Children Living in the Abay Region of Kazakhstan
Identification and Assessment of Risk Factors for the Development of Osteoporosis in Adults and Children Living in the Abay Region of the Republic of Kazakhstan Using the Method of Dual-energy X-ray Absorptiometry and Clinical and Epidemiological Research
A survey of people to identify risk factors for osteoporosis, which include age, gender, lifestyle, diet, physical activity, the presence or absence of somatic pathology.
- Trial name
- NCT06344598
- Where
- Kazakhstan
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Semey State Medical University
Osteoarthritis, Knee
All Polyethylene Versus Metal Backed Tibial Components in Knee Replacement
Total knee arthroplasty (TKA) is one of the most commonly performed orthopaedic procedures. Approximately 84,000 knee replacement procedures were recorded in the UK in 2012.
- Trial name
- NCT02482493
- Testing
- Sigma PFC
- Where
- United Kingdom
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Maidstone & Tunbridge Wells NHS Trust
Rheumatoid Arthritis
Alloimmune Response to Citrullinated Shared Epitope Sequence in Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) is an autoimmune and sistemic disease,characterized by joint sinovitis and the production of autoantibodies (Ab).
- Trial name
- ABSEC (NCT03506035)
- Testing
- Research new biomarker for RA
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Corporacion Parc Tauli
Temporomandibular Joint Disorders
Evaluation of Anterior Repositioning Guided Splint Combined With or Without I Platelet-rich Fibrin
The study aims to evaluate clinically and radiographically the effectiveness of arthrocentesis and injection of I-PRF with wearing ARS in comparison to arthrocentesis and ARS only.
- Trial name
- NCT06132802
- Testing
- Patients who received treatment involving ARS and arthrocentesis only, Patients who received treatment involving ARS, arthrocentesis, and an I-PRF injection
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mahmoud Mohammed Mahmoud Nasef
Joint Pain
NAtive Collagen Type II In Healthy VoluntEers With Joint Discomfort
Collagen Supplement is a natural ingredient that contains native collagen derived from chicken sternum. Collagen Supplement is efficacious and safe on healthy subjects as compared to placebo.
- Trial name
- ACTIVE (NCT05282992)
- Testing
- Native type II collagen
- Where
- Spain
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Bioiberica
Musculoskeletal Manipulations, Primary Prevention
Effects of Perineal Massage (PERMAS)
Perineal massage increases elasticity of myofascial perineal tissue and decreases the burning and perineal pain during labour, thus optimizing child birth, although an application protocol has not been standardized yet.
- Conditions
- Musculoskeletal Manipulations, Primary Prevention, Obstetric Labor Complications, Physical Therapy Modalities
- Trial name
- PERMAS (NCT05114811)
- Testing
- Self-provided perineal massage, Physiotherapist perineal massage: manual and instrumental (with EPI-NO)
- Where
- Spain
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Universidad de León
Osteoarthritis, Knee
A Long Term Follow-up Study of Subjects Who Received ICM-203 or Matching Placebo
This is an observational study of the long term safety and efficacy of ICM-203.
- Trial name
- NCT05752032
- Testing
- ICM-203
- Where
- 2 sites in Australia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- ICM Co. Ltd.
Degenerative Knee Disorders, Knee Osteoarthritis
Artificial Intelligence-Assisted Advanced Analysis of Knee Imaging and Outcome Prediction
This study aims to develop and validate an artificial intelligence (AI)-assisted platform for musculoskeletal knee ultrasonography and to establish an interpretable prediction model for clinical outcomes following…
- Conditions
- Degenerative Knee Disorders, Knee Osteoarthritis, Musculoskeletal Ultrasonography, Artificial Intelligence
- Trial name
- AI; R-CNN (NCT07721116)
- Testing
- artificial intelligence-assisted advanced analysis
- Where
- Taiwan
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Patellofemoral Pain Syndrome
Effects of Combined Physiotherapy Management and Education
This observational study aims to determine the effects of combined physiotherapy programs and education in patellofemoral pain syndrome.
- Trial name
- NCT06347406
- Testing
- Blood flow restriction combined with physiotherapy and education
- Where
- Malaysia
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Fakulti Sains Kesihatan
Avascular Necrosis, Femoral Head Collapse
Avascular Necrosis (AVN) Long-Term Follow-up
Long-term follow-up of IDE patients for publication
- Trial name
- NCT00833430
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Hemiplegia
Comparison of the Effects of Extracorporeal Shock Wave Therapy and Dry Needing
Effective treatment of spasticity after stroke is a very important and serious problem. Some of the therapeutic approach include physiotherapy and medication.
- Trial name
- NCT05952830
- Testing
- ESWT group, DN group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Osteoarthritis, Knee
Evaluation of the Effectiveness of Manual Therapy in Patients With Knee Osteoarthritis
The aim of this study is to investigate the effects of three different applications (Manual therapy, electrotherapy and home program) on long-term pain, joint range of motion and, secondarily, the functional level of the knee.
- Trial name
- NCT06329128
- Testing
- Experimental: Study Group, Active Comparator: Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University