Clinical trials: Muscle Soreness, active
Chronic Fatigue Syndrome (CFS)
Controlled Trial of Hydrogen Water as a Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
This is a 16-week controlled treatment trial of an over-the -counter supplement, hydrogen water, for individuals with ME/CFS patients. An active treatment condition will be compared to a placebo-control condition.
- Trial name
- ME/CFS (NCT07753122)
- Testing
- Molecular hydrogen produced by a metallic magnesium tablet, consumed 3x a day dissolved in water. Treatment duration is 16 weeks.
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Fred Friedberg
Long COVID, Postural Orthostatic Tachycardia Syndrome
The Long COVID-19 Wearable Device Study
To further characterize Long COVID-19 by collecting data from individuals who already own wearable devices or are provided with a wearable device along with basic and enhanced educational materials to determine if both can…
- Conditions
- Long COVID, Postural Orthostatic Tachycardia Syndrome, Dysautonomia, Myalgic Encephalomyelitis
- Trial name
- NCT05741112
- Testing
- Wearable device
- Where
- United States
- Volunteers
- 100,500 people
- Sponsor
- Scripps Translational Science Institute
Exercise-induced Muscle Soreness, Exercise-induced Joint Pain
Effects of Eggshell Membrane and Curcumin Extract Supplementation, Separately or Combined, on Recovery From Intense Exercise
Eggshell membrane and Curcumin supplementation prior to intense exercise may reduce inflammation, muscle and joint pain, and promote recovery.
- Conditions
- Exercise-induced Muscle Soreness, Exercise-induced Joint Pain, Exercise-induced Joint Stiffness, Exercise-induced Cartilage Turnover
- Trial name
- NCT07766720
- Testing
- NEM® brand eggshell membrane powder, curQ+® brand highly absorbable curcumin, NEM® plus curQ+® combination
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ESM Technologies, LLC
TMD/Orofacial Pain, Fibromyalgia (FM)
Diagnostic and Prognostic Salivary Biomarkers in Chronic Muscle Pain
A large proportion of the adult population worldwide currently lives with chronic muscle pain, with more than half of those affected experiencing pain localized to the face and jaw.
- Trial name
- NCT06994156
- Where
- Sweden
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Myalgia, Muscle Pain
Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin
The main aim of the presented project will be to examine the concentration of selected receptors (CB1, CB2, TRPV-1) showing affinity for binding to cannabidol (CBD) and cannabinol (CBN) in blood samples collected from people with…
- Conditions
- Myalgia, Muscle Pain, Orofacial Pain, Headache, Tension
- Trial name
- NCT06405646
- Testing
- Blood CB1, CB2, TRPV-1 concentration measurement
- Where
- Poland
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
COVID-19, Long COVID
Effectiveness of Transcranial Direct Current in Patients With Persistent COVID-19 With Headaches and Chronic Pain.
This study aims to verify the efficacy/effectiveness of treatment with transcranial direct current stimulation (TDCS) in patients with Long Covid who experience headaches, migraines, and chronic pain, such as arthralgia and…
- Conditions
- COVID-19, Long COVID, Long Covid19, SARS CoV 2 Infection
- Trial name
- NCT05780450
- Testing
- Transcranial Direct Current Therapy (tDCS)
- Where
- 2 sites in Spain
- Volunteers
- 87 people
- Sponsor
- Fundación Universidad Católica de Valencia San Vicente Mártir
Chronic Fatigue Syndrome/ Myalgic Encephalitis (CFS/ME), Post COVID Syndrome
Effectiveness and Safety of a Tele-Rehabilitation Program on Fatigue and Related Variables in Chronic Fatigue Syndrome and Post COVID Syndrome
This is a randomized, single-blind clinical trial that aims to evaluate the effectiveness of a tele-rehabilitation program based on mindful and conscious movement-based exercise (including adapted yoga, breathing exercises, and…
- Trial name
- NCT06978582
- Testing
- Mindful and conscious movement-based exercise, Conventional exercise
- Where
- Spain
- Volunteers
- 147 people
- Sponsor
- University of Seville
Trigger Point in Trapezius Muscle
The Impact of Dry Needling on Electrophysiological and Ultrasound-based Biomarkers for Myofascial Pain
The goal of this interventional study is to determine how well dry-needling can treat pain in people with Myofascial Pain Syndrome.
- Trial name
- ENCOMPASS-2 (NCT07270276)
- Testing
- Dry Needling
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Beth Israel Deaconess Medical Center
Fatigue Syndrome, Chronic, Cardiovascular Diseases
Is Post-exertional Symptom Exacerbation Specific to Patients With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome? A Study Comparing Patients With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome and Patients With Cardiac Diseases Who Underwent an Exercise Test.
Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) is a disease characterized by persistent and unexplained fatigue associated with diffuse pain, sleep disorders, neurocognitive and autonomic symptoms, musculoskeletal…
- Trial name
- MAPEMCAR (NCT07491315)
- Testing
- Exercise test on ergocycle, Near Infrared Spectroscopy (NIRS)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hôpital Européen Marseille
Chronic Musculoskeletal Pain, Delayed Onset Muscle Soreness (DOMS)
Real-world Evidence of Cannabinoid for Observed Pain Relief
Chronic muscle pain is one of the most prevalent clinical challenges in sports medicine, significantly affecting training capacity, competitive performance, and quality of life in athletes.
- Trial name
- RECOVER (NCT07733791)
- Volunteers
- 60 people
- Sponsor
- Associação Pan-Americana Multidisciplinar de Endocanabinologia
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
RCT of Mind-body in Long COVID and Myalgic Encephalomyelitis
We are studying the effect of a mind-body treatment for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with or without Long COVID (LC).
- Trial name
- MILES (NCT06933173)
- Testing
- Dynamic neural retraining system
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- University of Alberta
Cognitive Dysfunction, Acquired Brain Injury
Fareon Open Label Device Clinical Trial
The purpose of this study is to assess the safety and feasibility of an at-home MMT treatment in patients with cognitive dysfunction related to acquired brain injury, Long COVID, traumatic brain injury, myalgic encephalomyelitis…
- Conditions
- Cognitive Dysfunction, Acquired Brain Injury, Traumatic Brain Injury
- Trial name
- NCT07600320
- Testing
- Fareon device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Muscle Fatigue (C23.888.592.612.612), Delayed Onset Muscle Soreness (DOMS)
Therapeutic Ultrasound for Muscle Recovery After Muscle Fatigue Exercise
This randomized, parallel, placebo-controlled, double-blind clinical trial will evaluate the effects of low-intensity therapeutic ultrasound on muscle recovery after a fatiguing handgrip exercise protocol in healthy adults.
- Trial name
- NCT07871942
- Testing
- Pulsed Low-Intensity Therapeutic Ultrasound
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Santa Maria
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
ME/CFS, IBS - Irritable Bowel Syndrome
The Use of Directed Probiotics in ME/CFS: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
This clinical study aims to evaluate the use of i3.1 probiotic in participants who meet the Institute of Medicine (Canadian Consensus Criteria) case definition for ME/CFS and who may or may not be diagnosed with irritable bowel…
- Trial name
- NCT06211062
- Testing
- Floradapt Intensive GI
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Nova Southeastern University
Temporomandibular Disorders (TMDs), Myofascial Pain - Dysfunction Syndrome of TMJ
Comparison of Conventional,3D Printed and Novel Hybrid Stabilization Splints in the Management of Temporomandibular Joint Disorders
Occlusal splint therapy is a well-established conservative approach for the management of temporomandibular disorders (TMDs); however, variability in clinical outcomes suggests that no single splint design is universally optimal.
- Conditions
- Temporomandibular Disorders (TMDs), Myofascial Pain - Dysfunction Syndrome of TMJ, Myofascial Pain Dysfunction Syndrome, Temporomandibular Joint, Anterior Disc Displacement
- Trial name
- NCT07760428
- Testing
- Conventional Stabilization Splints, 3d printed Stabilization splint, Novel hybrid stabilization splint
- Where
- India
- Volunteers
- 36 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Upper Extremity Muscle Pain, Upper Extremity Bone Pain
A Randomized Controlled Trial of Oral CBD for the Treatment of Upper Extremity Musculoskeletal Pain
The goal of this clinical trial is to learn about the use of cannabidiol (CBD) capsules as a treatment for musculoskeletal pain. CBD is commonly being used as an over-the-counter treatment for musculoskeletal pain.
- Conditions
- Upper Extremity Muscle Pain, Upper Extremity Bone Pain, Upper Extremity Pain
- Trial name
- NCT06695195
- Testing
- Cannabidiol (CBD)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Brent DeGeorge
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (ICD-10 G93.3)
Investigating the Effects of Intermittent Hypoxia-Hyperoxia Treatment (IHHT) in People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) to Improve Fatigue, Pain, and Quality of Life by Targeting Mitochondrial Dysfunction and Autonomic Nervous System Impairment
This study is testing a new treatment for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and long-term symptoms after COVID-19.
- Trial name
- REenergizeME (NCT07317401)
- Testing
- Intermittent hypoxia-hyperoxia treatment (IHHT)
- Where
- Denmark
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
SARS-CoV-2 Acute Respiratory Disease, Myalgic Encephalomyelitis
Does a Technology Enabled Multi-disciplinary Team-based Care Model for the Management of Long COVID and Other Fatiguing Illnesses Improve Clinical Care of Patients and Represent a Sustainable Approach Within a Federally Qualified Health Center?
The primary objective of the present research is to determine the effectiveness of Family Health Center of San Diego's Long COVID and Fatiguing Illness Recovery Program (LC\&FIRP) on clinician- and patient-level outcomes.
- Conditions
- SARS-CoV-2 Acute Respiratory Disease, Myalgic Encephalomyelitis, Chronic Fatigue Syndrome, Post-acute Sequelae of SARS-COV-2 Infection
- Trial name
- LC&FIRP (NCT05167227)
- Testing
- Extension for Community Healthcare Outcomes
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Family Health Centers of San Diego
Itch, Pain
The Effects of Performing a Motor Imagery Task on Cortical Excitability During Acute Experimental Muscle Pain and Acute Itch
The aim of this project is to determine the effects of performing a motor imagery task on cortical excitability during acute experimental muscle pain (induced by hypertonic saline), acute histaminergic itch (induced by…
- Trial name
- NCT06503523
- Testing
- Hypertonic Saline, Histamine, Cowhage
- Where
- 2 sites in Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University