Clinical trials: Muscle Protein Synthesis
Aging
Combined Nutrient Intake and Muscle Protein Synthesis
Dietary intervention to prevent sarcopenia in elderly people. The objective of this study is to test whether combined nutrient intake plays an important role in stimulation of the muscle protein growth in elderly people; and…
- Trial name
- NCT01239277
- Testing
- protein, protein and carbohydrate, protein and leucine
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy
The Implementation of Novel 'Heavy' Water Techniques for Determining Modulation of Muscle Protein, DNA and Lipid Synthesis Due to Ageing
Maintenance of body's skeletal muscle is key to a healthy older age. However, as we age we lose on average 1-2% of our muscle each year.
- Trial name
- NCT02152839
- Testing
- Resistance Exercise
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Physical Inactivity, Vascular Dysfunction
Heat Therapy During Reduced Physical Activity
The purpose of this randomized controlled trial is to determine whether daily Finnish dry sauna therapy attenuates the adverse cardiovascular, muscular, and metabolic effects of seven days of experimentally reduced physical…
- Conditions
- Physical Inactivity, Vascular Dysfunction, Skeletal Muscle Atrophy
- Trial name
- HEAT-RPA (NCT07847424)
- Testing
- Sauna, Reduced Physical Activity
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brigham Young University
Muscle Mass, Protein Intake
Distribution of Nutrient Derived Amino Acids
The project examines over several days how the distribution pattern of dietary protein stimulate and affect the protein turnover of important proteins in the aging perspective, such as skeletal muscle proteins.
- Conditions
- Muscle Mass, Protein Intake, Diet Modification, Protein Synthesis
- Trial name
- NCT03870425
- Testing
- Distribution pattern of dietary proteins (minced meat)
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Spinal Muscular Atrophy
Motor Function and Activity of Daily Life in Spinal Muscular Atrophy
This study will incorporate patients/ caregivers' perspectives to investigate the performance in daily activities of individuals with SMA and how it relates to their motor function abilities.
- Trial name
- NCT05931211
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
COPD
Casein Protein and Leucine Supplementation in Chronic Obstructive Pulmonary Disease (COPD)
Weight loss commonly occurs in patients with COPD, negatively influencing their quality of life, treatment response and survival.
- Trial name
- NCT01734473
- Testing
- Hydrolyzed casein protein, Hydrolyzed casein protein + carbohydrates, Hydrolyzed casein protein + leucine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Healthy
The Impact of Enteral Versus Oral Protein Feeding on Muscle Protein Synthesis in Healthy Young Males and Females
The present study will seek to quantify the muscle protein synthetic response to a protein beverage consumed orally or through a nasogastric tube in healthy, young individuals.
- Trial name
- NCT03571425
- Testing
- Oral Protein, Enteral Protein
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Type 2 Diabetes
"Effect of High Fat and High Glycemic Diets
The investigators will determine whether people with high muscle mitochondrial capacity produce higher amount of reactive oxygen species (ROS) on consuming high fat /high glycemic diet and thus exhibit elevated cellular oxidative…
- Trial name
- NCT01494935
- Testing
- High Glycemic Diet, Control diet
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Anterior Cruciate Ligament Reconstruction, Muscular Atrophy
Nutritional Intervention to Enhance Recovery After Arthroscopic Knee Surgery in Adults
Loss of skeletal muscle mass (atrophy) and strength in the lower limb are consequences of elective knee surgery as result of prolonged disuse from limb immobilization and impaired mobility, as well as pathophysiological trauma.
- Trial name
- NCT06233825
- Testing
- Omega-3 Fatty Acids and Essential Amino Acids, Safflower Oil and Non-Essential Amino Acids
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr. Chris McGlory, PhD
Hyperglycaemia (Non Diabetic), Prediabetes
Effects of Lean Pork Loin Intake on Protein Homeostasis and Glucose Regulation in Prediabetic Adults
We will be directly comparing a high-quality protein diet composed primarily of lean pork loin (PORK) to a lower-quality plant-based protein diet (PLANT) in individuals with prediabetes on muscle and whole-body protein turnover…
- Trial name
- PORK (NCT06025292)
- Testing
- Lean Pork vs Plant-Based Protein
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Arkansas
Aging
The Effects of Whey vs. Collagen on MPS
With aging there is a natural loss of muscle mass and strength called sarcopenia, which increases the risk of falls and metabolic disease (i.e. Type II diabetes) and decreases the ability to perform activities of daily living.
- Trial name
- NCT03281434
- Testing
- Collagen peptide, Whey protein isolate
- Where
- 2 sites in Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Low-back Pain
Correlation Between Posterior Oblique Sling Activation and Contralateral Glenohumeral Stability in Low Back Pain
Objective: This study will be conducted to investigate the relationship between the amplitude of posterior oblique sling muscles; ipsilateral gluteus maximus (GM) and contralateral latissmus Dorsi (LD), and the amount of anterior…
- Trial name
- NCT05050695
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Shaimaa Ramadan Ibrahim Abdul-ghani El Deab
Healthy
Effect of Whey Protein Hydrolysate on Human Muscle Protein Synthesis
Muscle protein synthesis can be stimulated by ingestion of protein sources, such as whey, casein or soy. Protein supplementation can be useful to restore protein turnover after exercise but also to preserve skeletal muscle mass…
- Trial name
- NCT03313830
- Testing
- Whey Protein Hydrolysate (WPH), Intact Whey Protein (WHEY)
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Stroke
Exercise For Sub-acute Stroke Patients in Jamaica
Chronic hemiparetic stroke is associated changes in body composition, skeletal muscle and cardiometabolic health; specific changes include paretic limb muscular atrophy, increased intramuscular fat deposition, elevated prevalence…
- Trial name
- JAMMS (NCT01392391)
- Testing
- Task Oriented Exercise Training, Stroke Care "Get with the Guidelines"
- Where
- 2 sites in United States, Jamaica
- Volunteers
- 150 people
- Sponsor
- Baltimore VA Medical Center
Sarcopenia
Assessing the Dose-response of Muscle Protein Synthesis to "Super-whey" in Older Adults
Skeletal muscle accounts for approximately 45-55% of total body mass in healthy adults and plays a pivotal role in whole-body metabolic health, locomotion and physical independence.
- Trial name
- ARLA-WHEY (NCT05700058)
- Testing
- Dietary protein supplement
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sarcopenia
Passive Heat Treatment and Skeletal Muscle Reconditioning Older Adults
Rationale: Aging is accompanied by impairments in the sensitivity of skeletal muscle tissue to respond to the anabolic properties of protein feeding, which is suggested to result in age-related loss in muscle mass.
- Trial name
- Sauna (NCT05129995)
- Testing
- Passive heat treatment
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy
Two-day Bed Rest, Insulin Sensitivity and Muscle Protein Synthesis
The impact of two days bed rest versus two days of habitual activity on insulin sensitivity and cumulative muscle protein synthesis will be investigated in healthy young males
- Trial name
- 2d-BR (NCT03877822)
- Testing
- Habitual activity, Bed rest
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Exeter
Hypertrophy
Muscle Protein Synthesis After Whole Egg vs. Egg White Consumption
In crossover trials, ten (N=10) young men (18-35 y) will receive stable isotope tracer infusions and perform a single bout of resistance exercise.
- Trial name
- NCT03117127
- Testing
- Resistance Exercise, Whole Eggs, Egg Whites
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Nutrition
Impact of Protein Formulations on the Stimulation of Muscle Protein Synthesis
The overall objective of this study is to determine the effects of ingesting protein that slowly releases amino acids into the blood vs.
- Trial name
- NCT07501403
- Testing
- Control Protein then Extended Release Nutritional Protein, Extended Release Protein then Control Nutritional Protein
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- VitaKey Inc.
Muscle Protein Synthesis, Muscle Atrophy
Exogenous Ketosis During Bed Rest in Older Adults
The goal of this randomized, double-blind, parallel group interventional study is to evaluate the effect of ketone bodies on healthy older adults (65-85 y) during 5 days of bed rest.
- Conditions
- Muscle Protein Synthesis, Muscle Atrophy, Insulin Sensitivity, Mitochondrial Function
- Trial name
- KBR (NCT05679596)
- Testing
- ketone monoester (R)-3-hydroxybutyl (R)-3- hydroxybutyrate
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McGill University