Clinical trials: Muscle Loss
Muscle Loss
Muscle Protein Synthesis in Dialysis Patients
The most severe form of chronic renal failure is end-stage-renal-disease with maintenance hemodialysis (MHD) as the most common treatment strategy.
- Trial name
- NCT03478722
- Testing
- Protein Meal, Stable Isotope Amino Acid Infusion
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
ICU Acquired Weakness, Quadriceps Muscle Atrophy
Ultrasound Measurement of Quadriceps Shortening During Neuromuscular Electrical Stimulation in Critically Ill Patients
ICU-Aw is highly prevalent (50%) among critically ill patients. Its diagnosis is usually delayed as it requires patients' awakening and collaboration to provide accurate measurement.
- Trial name
- DETECT (NCT04722445)
- Testing
- Early ultrasound measurement of quadriceps shortening during neuromuscular electrical stimulation (NMES)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Groupe Hospitalier du Havre
Aging, Rehabilitation
Physical Function of Older Citizens During Municipality-based Rehabilitation
When choosing outcomes to assess rehabilitation's effect or progress, it is essential to consider the constructs being measured and their value to the patient and the psychometric properties.
- Conditions
- Aging, Rehabilitation, Frailty, Sarcopenia
- Trial name
- NCT04862481
- Where
- Denmark
- Volunteers
- 115 people
- Sponsor
- University College Absalon
Knee Arthritis
Preventive Effect of Proprioceptive Stimulation on Muscle Atrophy
Confinement to bed, which occurs in many pathological situations, induces a muscle atrophy and a loss of muscle strength. Muscle atrophy is associated to impaired performance in motor tasks, such as posture and locomotion, and is…
- Trial name
- PrevAtrophy (NCT01641627)
- Testing
- proprioceptive stimulation
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Lille
Muscle Disuse, Neuromuscular Electrical Stimulation (NMES)
The Efficacy of Neuromuscular Electrical Stimulation to Attenuate Muscle Loss
Subjects who are hospitalized in the ICU will be included after 24 hours of intubation during their ICU stay. Twice-daily Neuromuscular Electrical Stimulation (NMES) will be performed on one leg for 2x40 min per day to assess…
- Conditions
- Muscle Disuse, Neuromuscular Electrical Stimulation (NMES), Critical Illness
- Trial name
- NCT01521637
- Testing
- Neuromuscular Electrical Stimulation of m. quadriceps femoris
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Hasselt University
Covid19, Sarcopenia
Muscular Rehabilitation by Eccentric Exercise After Severe COVID-19 Infection
With the COVID-19 pandemic, the number of patients to be treated in rehabilitation increased . Hospitalization for severe infection can induce muscular atrophy and muscular dysfunction that persists for several months and…
- Conditions
- Covid19, Sarcopenia, Muscle Weakness
- Trial name
- CovExc (NCT04649086)
- Testing
- Rehabilitation by Eccentric exercises, Rehabilitation by Concentric exercises
- Where
- 3 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Patient With an Appointment for an Abdominal CT Scan and Able to Stand up for Height Measurement
Automated and Reliable Estimation of Patient Height From CT Scan Using an Artificial Intelligence Algorithm
The TAILLE study is a single-center, non-interventional (RIPH3), uncontrolled, non-randomized, open-label study.prospective study conducted at CHU Grenoble Alpes.
- Trial name
- TAILLE (NCT07864857)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Grenoble
Anterior Cruciate Ligament Reconstruction, Volumetric Muscle Loss
Blood Flow Restriction Training in Rehabilitation Patients
Occlusion training, resistance exercise performed with a specialized venous tourniquet, leads to beneficial changes in muscle at low resistance and minimal stress on the nearby joint.
- Conditions
- Anterior Cruciate Ligament Reconstruction, Volumetric Muscle Loss, Chronic Thigh Muscle Weakness, Knee Arthroscopy
- Trial name
- NCT02174770
- Testing
- Blood Flow Restriction (BFR) Training, Standard ACSM-guided strength training
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Brooke Army Medical Center
Frailty, Sarcopenia
Development of Continuous Assessment of Frailty and Muscle Quality in Older Subjects: ECOFRAIL Protocol
We are conducting a study in different centers in Spain in elderly people, in order to assess the effectiveness of a physical exercise intervention program in people in a situation of frailty.
- Conditions
- Frailty, Sarcopenia, Ultrasonography, Exercise
- Trial name
- ECOFRAIL (NCT05294757)
- Testing
- Physical exercise
- Where
- 3 sites in Spain
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Deusto
Non-small-cell Lung Cancer, Sarcopenia
Nutritional Assessment of Patients With Non-small Cell Lung Cancer Treated With Osimertinib
Nutritional assessment of patients with non-small cell lung cancer treated with osimertinib. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases and is a leading cause of morbidity and…
- Conditions
- Non-small-cell Lung Cancer, Sarcopenia, Quality of Life
- Trial name
- NUTRI-CPNM (NCT07559526)
- Testing
- Unic group
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Fundacin Biomedica Galicia Sur
Myoma
Safety of Tranexamic Acid in Reducing Blood Loss Myomectomy.
Uterine leiomyomas (fibroids) are the most common benign tumors among women . Fibroids are found in approximately 15% to 30% of women in the reproductive age group
- Trial name
- NCT04694677
- Testing
- women receiving tranexamic acid, women receiving misoprostol
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aljazeera Hospital
Severe Sepsis, Respiratory Failure
Muscle Atrophy in Patients With Severe Sepsis
This study is being done to help determine whether patients with severe sepsis (overwhelming inflammation in the body as a result of an infection) lose muscle and become weak more rapidly than patients with other severe…
- Trial name
- NCT01717651
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Ohio State University
Sarcopenia
Clinical Trial of Astaxanthin Formulation With Exercise in Sarcopenia Elderly
The primary objective of this trial is to evaluate the effect of oral administration of an Astaxanthin formulation compared to placebo after one month alone and after an additional 3 months of exercise training on mitochondrial…
- Trial name
- NCT03368872
- Testing
- Astaxanthin formulation, Exercise training
- Where
- 2 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Astavita, Inc.
Sarcopenia
Evaluation of Safety and Efficacy of a Digital Therapeutic Device to Improve Strength in Sarcopenia (Sarc-DTx)
This clinical trial aims to demonstrate that the use of a digital therapeutic device (exoDTx) in patients with sarcopenia is superior to self-exercise in terms of muscle strength improvement and safety.
- Trial name
- NCT07319377
- Testing
- exoDTx, Self-exercise (Educational Material)
- Where
- 2 sites in South Korea
- Volunteers
- 130 people
- Sponsor
- Exosystems
Stroke, Sarcopenia
Effects of Overground Robot-Assisted Gait Training on Stroke-Related Sarcopenia
This single-center randomized controlled trial evaluates the effects of combining overground robot-assisted gait training (o-RAGT) with recumbent cycling (RC) compared with RC alone in patients with subacute stroke at risk of…
- Conditions
- Stroke, Sarcopenia, Muscle Atrophy, Mobility Limitation
- Trial name
- oRAGT-PSS (NCT06910254)
- Testing
- Overground Robot-Assisted Gait Training (o-RAGT), Recumbent Bicycle Training
- Where
- South Korea
- Volunteers
- 53 people
- Sponsor
- Sahmyook University
CHRONIC LIVER DISEASE
ASSESSMENT OF SURGICAL RISK IN PATIENTS WITH CHRONIC LIVER DISEASE USING VOCAL PENN SCORE
4a. Primary To assess postoperative mortality at 30 and 90 days using the VOCAL PENN score 4b. Secondary To assess potential differences in prediction accuracy between VOCAL-Penn and MELD for 30 and 90-day mortality
- Trial name
- vocal penn 01 (NCT06227988)
- Testing
- patients with liver disease who undergoing surgery, patients with liver disease who do not undergoing surgery
- Where
- India
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Nutritional Support, Muscle Loss
The Correlation Between Nutrients and Muscle Mass
Patients who are suffer from CIF often develop muscle wasting because of hypercatabolism.The relationship between different nutrition support formulas and lean body mass is still unclear.
- Trial name
- NCT03400046
- Testing
- Nutritional Product Supplementation
- Volunteers
- 223 people
- Sponsor
- Jinling Hospital, China
Obesity, Sarcopenia
Evaluation of Physical Performance in Old Adults With Sarcopenic Obesity
The primary objectives of the present study are to estimate the sarcopenic proportion in a cohort of obese older subjects who have been hospitalized.
- Trial name
- PREFISAR (NCT06299241)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Istituto Auxologico Italiano
Sarcopenia, Cirrhosis, Liver
The Effect of Calcium β-hydroxy-β-methylbutyrate (CaHMB) Supplementation in Sarcopenia in Liver Cirrhosis
This study is to evaluate the effect of CaHMB in the treatment of sarcopenia in liver cirrhosis.
- Trial name
- CaHMB (NCT03605147)
- Testing
- CaHMB
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Zhongshan Hospital
Obesity, Cardiovascular Disease
IMPACT: Inactivity Monitoring and Physical Activity Controlled Trial
As individuals age, their physical activity decreases and sedentary time increases. Even small changes in these two behaviors can greatly decrease risks for several major health problems, including cardiovascular disease…
- Conditions
- Obesity, Cardiovascular Disease, Cancer, Diabetes
- Trial name
- IMPACT (NCT01869348)
- Testing
- Monitor intervention
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston