Clinical trials: Muscle Health
Aging, Insulin Sensitivity
Antecedent Metabolic Health and Metformin Aging Study
Aging is the number one risk factor for the majority of chronic diseases. There are no pharmaceutical treatments to slow aging and prolong healthspan.
- Conditions
- Aging, Insulin Sensitivity, Chronic Disease, Mitochondria
- Trial name
- ANTHEM (NCT04264897)
- Testing
- Metformin
- Where
- 2 sites in United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Oklahoma Medical Research Foundation
Widespread Chronic Pain
The Maintaining Musculoskeletal Health Study
It is known from many studies that when patients have developed chronic widespread pain (CWP) or fibromyalgia that managing such symptoms is extremely challenging for both doctors and patients.
- Trial name
- MAmMOTH (NCT02668003)
- Testing
- Cognitive Behavioural Therapy
- Where
- 3 sites in United Kingdom
- Volunteers
- 1,002 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Hypertension With Complications and Secondary Hypertension, Overweight and Obesity
Study of the Long-term Effects of Exercise on Heath Indicators in Older People
Cardiovascular diseases (CVD) represent the most frequent cause of death among the elderly population. Hypertension, unfavorable lipid profile, obesity and physical inactivity are among the main risk factors for CVD.
- Conditions
- Hypertension With Complications and Secondary Hypertension, Overweight and Obesity, Lipid Metabolism Disorders, Sarcopenia
- Trial name
- NCT01874132
- Testing
- Exercise training
- Where
- Portugal
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Trás-os-Montes and Alto Douro
Sarcopenia, Osteoporosis
Muscle Impact of Treating Osteoporosis
Osteosarcopenia is a geriatric musculoskeletal syndrome characterized by co-existence of osteoporosis and sarcopenia (low skeletal muscle mass, strength, and/or functional capacity).
- Trial name
- MITO (NCT05666310)
- Testing
- Denosumab, Zoledronic Acid
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Nami Safai Haeri
Chronic Pain, Musculoskeletal Pain
Improving Health for Older Adults With Pain Through Engagement (Open-pilot)
The goal of this project is to conduct an open-pilot (N=30) to evaluate the feasibility, acceptability, and fidelity of a mind-body and activity program (GetActive+) with older adults with chronic pain.
- Trial name
- iHOPE (NCT05782231)
- Testing
- GetActive+
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Massachusetts General Hospital
Dysmenorrhea (Disorder), Dysmenorrhea Primary
Mechanistic Characterization of Uterine Pain
There are limited treatment options for management of dysmenorrhea, and the physiological processes they affect are not completely understood.
- Conditions
- Dysmenorrhea (Disorder), Dysmenorrhea Primary, Dysmenorrhea Secondary, Endometrial Diseases
- Trial name
- MCUP (NCT04145518)
- Testing
- Naproxen Sodium
- Where
- United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Musculoskeletal Pain, Mental Health Issue
Work And Vocational advicE Study - Effectiveness of Adding a Brief Vocational Support Intervention to Usual Primary Care
Maintaining the population's fitness for work is a priority for the UK Government. People with poor health often struggle at work and take sick leave. Work brings financial, social and health benefits.
- Conditions
- Musculoskeletal Pain, Mental Health Issue, Mental Health Disorder, Other Physical Health Condition
- Trial name
- WAVE (NCT04543097)
- Testing
- Vocational Support
- Where
- United Kingdom
- Volunteers
- 130 people
- Sponsor
- Keele University
Blood Pressure
Health Effects of Increasing Muscle Activation While Sitting in Office Workers
Previous research suggests that prolonged sitting increases risk for cardiometabolic diseases and the risk factors associated with cardiometabolic diseases.
- Trial name
- NCT02855541
- Testing
- DeskCycle
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Spinal Cord Injuries
Musculoskeletal Plasticity After Spinal Cord Injury
Patients with spinal cord injury (SCI) experience metabolic syndrome, diabetes, obesity, pressure ulcers, and cardiovascular disease at far greater rates than the general population.
- Trial name
- NCT02622295
- Testing
- Single-session electrically induced exercise, Electrically-induced exercise training
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Richard K Shields
Dupuytren's Contracture
Treatment Of Dupuytren's Contracture With Collagenase Clostridium Histolyticum Injection (Xiapex)
This study will evaluate the impact of Xiapex treatment on the range of motion (ROM) of the affected fingers and the patient and physician reported treatment satisfaction and disease severity and their relation to ROM.
- Trial name
- POINT X (NCT01229436)
- Testing
- Xiapex
- Where
- 28 sites in Denmark, France and 6 more
- Volunteers
- 254 people
- Sponsor
- Pfizer
Tennis Elbow, Epicondylitis, Lateral Humeral
Treatment Study of Steroid Injection and Physical Therapy for Acute Lateral Epicondylitis
The purpose of this study is to compare the clinical effect of physiotherapy alone or combined with corticosteroid injection in the initial treatment of lateral epicondylitis in a primary care setting.
- Trial name
- NCT00826462
- Testing
- triamcinolone, Lidocaine, Physiotherapy
- Where
- Norway
- Volunteers
- 177 people
- Sponsor
- University of Oslo
Fibromyalgia
Combined Behavioral and Analgesic Trial for Fibromyalgia
This is a randomized control study that involves a combination of a drug treatment, behavioral health, and placebo controls. Some participants will receive a medication approved by the Food and Drug Administration for treatment…
- Trial name
- COMBAT-FM (NCT01598753)
- Testing
- Tramadol, Cognitive Behavior Therapy for FM, Health Education
- Where
- 2 sites in United States
- Volunteers
- 134 people
- Sponsor
- University of Washington
Temporomandibular Joint Dysfunction Syndrome
Tailored Self-Management of Temporomandibular Disorders (TMD) Using Health Information Technology
The purpose of this pilot project is to determine the feasibility and acceptability of proposed methods for a subsequent clinical trial of a tailored self-management program (PACT) designed to decrease pain in participants with…
- Trial name
- TMDPACT (NCT03036215)
- Testing
- PACT Experimental Arm
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Fibromyalgia
Evaluating Mindfulness-Based Interventions With New Fibromyalgia Patients
The purpose of this study is to study the feasibility of a wearable brain sensing wellness device to provide mindfulness training to fibromyalgia patients who have failed medical therapy.
- Trial name
- NCT04720053
- Testing
- Wearable brain sensing wellness device headband system
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Mayo Clinic
Activities of Daily Living, Accidental Fall
Bingocize: A Novel Mobile Application for Older Adult Health
This study tests the effectiveness of using a new mobile application (Bingocize®) to improve older adults' (a) adherence to an engaging exercise program, and (b) aspects of functional performance, health knowledge, dietary…
- Conditions
- Activities of Daily Living, Accidental Fall, Sarcopenia, Arteriosclerosis
- Trial name
- Bingocize (NCT03629912)
- Testing
- Socially-Based Exercise Intervention for Older Adults
- Where
- 4 sites in United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Western Kentucky University
Peripheral Artery Disease, Vascular Function
Impacts of Aquatic vs Land Walking on Vascular Health and Exercise Tolerance in Patients With Peripheral Artery Disease
The purpose of this study was to examine the impacts of a 12-week aquatic walking exercise program on body composition, vascular function, cardiorespiratory capacity, exercise tolerance, muscular strength, and physical function…
- Conditions
- Peripheral Artery Disease, Vascular Function, Exercise Tolerance, Peripheral Arterial Disease
- Trial name
- NCT03849300
- Testing
- Aquatic walking exercise program group 1, Aquatic walking exercise program group 2, Land-based walking exercise group
- Volunteers
- 147 people
- Sponsor
- Pusan National University
Post-polio Syndrome, Physical Activity
Glutathione and Health With Post-Polio Syndrome
In this study, people who have symptoms of post polio will take oral glutathione supplements for three months. Their levels of fatigue, physical activity and sleep efficiency will be assessed.
- Conditions
- Post-polio Syndrome, Physical Activity, Depression, Pain
- Trial name
- NCT01402570
- Testing
- Glutathione
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
Blood Pressure, Vascular Function
Smartphone App-guided Inspiratory Muscle Strength Training for Lowering Systolic Blood Pressure
This clinical trial aims to assess the efficacy of inspiratory muscle strength training (IMST) guided by a smartphone app vs. IMST delivered in a clinical research setting for lowering systolic blood pressure in adults 18 years…
- Conditions
- Blood Pressure, Vascular Function, Adherence, Treatment
- Trial name
- NCT06229873
- Testing
- App-Based Inspiratory Muscle Strength Training, Clinic-Based Inspiratory Muscle Strength Training
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Frailty, Sarcopenia
FrAilty Care and wEll-funcTion in Community Dwelling Older Adults
This study is looking at whether older people could benefit from an online monitoring platform to support their individual ambitions to maintain or improve functional ability.
- Conditions
- Frailty, Sarcopenia, Aging
- Trial name
- FACET (NCT03707145)
- Testing
- Consultation, Online Support, Empowered
- Where
- United Kingdom
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Aberystwyth University
Chronic Fatigue Syndrome
Myalgic Encephalomyelitis Chronic Fatigue at the National Institutes of Health
Background: Post-Infectious Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (PI-ME/CFS) refers to long-lasting and disabling fatigue or malaise, inability to recover after exercise, and physical and emotional discomfort that…
- Trial name
- NCT02669212
- Testing
- Cardiopulmonary Exercise Test (CPET)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)