Clinical trials: Muscle Damage
Muscle Disuse Atrophy
Muscle Damage and Disuse Atrophy
Limb injury generally requires a period of recovery during which time the limb is often immobilised (e.g. with a cast or brace) resulting in a rapid loss of skeletal muscle.
- Trial name
- NCT03559452
- Testing
- Eccentric exercise
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Type 2 Diabetes, Healthy Individuals
The Effects of Orally Ingesting Branched Chained Amino Acids on Delayed Onset Muscle Soreness in Diabetic Patients
The purpose of this study is to determine the effectiveness of the 3 Branched Chained Amino Acids (isoleucine, leucine, and valine) on treating Delayed Onset Muscle Soreness, a type of muscle pain which usually develops after…
- Trial name
- NCT01211717
- Testing
- Branched Chained Amino Acids
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Exercise, Damage Muscle
Fuel Selection During Eccentric Cycling With Glucose Ingestion
This study compares fuel selection during eccentric and concentric cycling, with (placebo) or without glucose ingestion during exercise.
- Conditions
- Exercise, Damage Muscle, Nutrition
- Trial name
- NCT03995693
- Testing
- Solution ingestion, Constant load arm cranking, Expired gas sampling
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
Roam Rolling, Muscle Recovery
Effects of Foam Rolling on Plantar Flexor Recovery in Healthy Individuals
Foam rolling (FR) is a self-myofascial release technique that involves using body weight to apply pressure to soft tissues through a foam roller.
- Trial name
- NCT07759388
- Testing
- Foam rolling
- Where
- Brazil
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Muscle Damage, Muscle
The Effect of Vicia Faba Hydrolysate Supplementation on Muscle Strength Recovery
To investigate the effect of Vicia faba protein concentrate, a protein derived from Fava bean extract, on delayed onset muscle soreness (DOMS).
- Trial name
- NCT06837298
- Testing
- PeptiStrong® supplement capsules following muscle damaging exercise on Day 14
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Sprint Training
Recovery Kinetics After Different Sprint Training Protocols (STRecovery)
Speed is one of the most important physical capacities for many sports, especially those that include speed and power as a major element, and plays a major role on performance.
- Trial name
- STRecovery (NCT04766411)
- Testing
- Unresisted sprint training, Resisted sprint training with load equal to 10% of body weight, Resisted sprint training with load equal to 20% of body weight
- Where
- Greece
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Muscle Spasticity, Hypertonia, Muscle
Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals
To assess the safety and tolerability of single and multiple doses of MTR-601 in normal healthy volunteers under fed and fasted conditions. To evaluate the plasma and urine pharmacokinetics (PK) of MTR-601.
- Conditions
- Muscle Spasticity, Hypertonia, Muscle, Cerebral Palsy, Multiple Sclerosis
- Trial name
- NCT06117020
- Testing
- MTR-601
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Motric Bio
Muscle Damage
Protein Distribution and Leucine Supplementation Effects on Body Composition and Performance in Tactical Athletes
This randomized controlled trial will examine the effects of within-day protein distribution and leucine supplementation on body composition, physical performance, and biomarkers of muscle damage in tactical athletes during an…
- Trial name
- NCT07438158
- Testing
- L-leucine supplementation, Even Protein Distribution, Skewed Protein Distribution (16-hour Protein-Fasting Window)
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Menstrual Cycle, Exercise Performance Impairment
Eccentric Exercise, Muscle Damage, and Oxygen Uptake Across Menstrual Cycle Phases
The existing literature examining the effect of female sex hormones across the phases of the menstrual cycle on muscle microdamage and oxygen uptake is limited.
- Trial name
- EEMDO-MC (NCT07581067)
- Testing
- Isokinetic eccentric exercise using knee extensors of the right lower limb, Isokinetic eccentric exercise using knee extensors of the left lower limb
- Where
- Greece
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Aseptic Muscle Injury
Effects of Protein and NAC Co-ingestion on Skeletal Muscle Recovery
Previous evidence suggests that though N-acetylcysteine (NAC) supplementation following eccentric exercise-induced muscle damage disrupts the skeletal muscle's repair and remodelling process at 8 days of recovery, it attenuates…
- Trial name
- PRoNAC (NCT06367413)
- Testing
- NAC, NAC + Whey Protein
- Where
- Greece
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Recovery Methods, Exercise and Recovery
Effects of Carnitine Supplementation on Exercise-Induced Muscle Damage: A Randomized Controlled Trial
This clinical study aims to investigate the effects of L-carnitine supplementation on recovery following high-intensity interval exercise in young athletes.
- Conditions
- Recovery Methods, Exercise and Recovery, Exercise Fatigue, Carnitine Ingestion
- Trial name
- NCT07492446
- Testing
- L-Carnitine
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Sabahattin Zaim University
Metabolic Syndrome
Beneficial Effects of Exercise and Healthy Diets on Muscle and Adipose Tissue
Both dietary caloric restriction (CR) and physical exercise (PE) exert beneficial effects, which retard or prevent age-related diseases and prolong life span.
- Trial name
- NCT01793896
- Testing
- Control period, Diet Group, Exercise group
- Where
- Chile
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Chile
Muscle Damage
Tart Cherry Juice for Exercise Performance and Recovery
This study evaluates the effects of tart cherry juice consumption on endurance exercise performance, fat metabolism during exercise, blood pressure, and recovery from exercise as assessed by muscle pain, muscle strength and…
- Trial name
- NCT03313388
- Testing
- Drink
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Skeletal Muscle Damage, Exercise-induced Aseptic Inflammation
NAC Supplementation and Soccer Specific Performance
In this investigation the investigators utilized NAC supplementation to boost GSH availability during an one-week-microcycle consisting of three soccer games, in order to test the hypotheses that: i) antioxidant supplementation…
- Conditions
- Skeletal Muscle Damage, Exercise-induced Aseptic Inflammation, Skeletal Muscle Performance, Antioxidant Status
- Trial name
- NCT04523675
- Testing
- N-acetylcysteine
- Where
- Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Healthy
Short-term Effects of Broccoli-derived Glucoraphanin on Recovery From Eccentric Muscle Damage
Eccentric exercise induces muscle damage and delay functional recovery. Broccoli-derived glucoraphanin (a sulforaphane precursor that activates Nrf2 defenses) may aid repair; however, its short-term effects in humans remains…
- Trial name
- NCT07373106
- Testing
- broccoli powder consumption
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Cerebral Palsy (CP), Spasticity
Predictors of Motor İmagery Performance in Cerebral Palsy
There are very few studies in the literature examining the effect of age on motor imagery ability in children with cerebral palsy. To our knowledge, no studies have investigated the impact of other related factors.
- Conditions
- Cerebral Palsy (CP), Spasticity, Motor Learning
- Trial name
- NCT07002567
- Testing
- Implicit motor imagery, Explicit motor imagery
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Sleep, Sleep Restriction
Effects of Sleep Restriction on Female Soccer Players: Physical Performance, Muscle Damage, Inflammation, and BDNF Levels.
This research aims to investigate the interplay between menstrual cycles, sleep patterns, and athletic performance. Before experimental sessions, participants will maintain menstrual diaries for three months and complete…
- Trial name
- NCT06251362
- Testing
- Sleep restriction
- Where
- 2 sites in Poland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University School of Physical Education, Krakow, Poland
Exercise Induced Muscle Damage, Cryotherapy
Acute Cryotherapy on Musculoskeletal Function and Biomarkers
In 2020, Dubois and Esculier proposed a paradigm shift in the acute management of musculoskeletal injuries, advocating for the transition from the traditional PRICE protocol- Protect, Rest, Ice, Compression, Elevation-to the more…
- Trial name
- NCT07211412
- Testing
- Cryotherapy, Eccentric exercise-induced muscle damage
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas, El Paso
Wrist Injuries
Effects of Low Level Laser Therapy On Exercise Induced Muscle Damage in Wrist Flexors Of Untrained Young Adults
The main aim of the current study is to investigate the effects of Low-level Laser Therapy on exercise-induced muscle damage of wrist flexors in untrained young adults.
- Trial name
- NCT04842669
- Testing
- low level laser therapy, Conservative treatment
- Where
- Pakistan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Cerebral Palsy
HMB Cerebral Palsy Pilot Study
This is a pilot study of β-hydroxy-β-methylbutyrate (HMB) + Vitamin D3 supplementation in adolescents with cerebral palsy. The primary objective is to quantify safety, compliance, and acceptability of daily combined HMB + Vitamin…
- Trial name
- NCT05384951
- Testing
- HMB + Vitamin D3
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Gillette Children's Specialty Healthcare