Clinical trials: Muscle Atrophy or Weakness
Muscle Weakness or Atrophy, Mechanical Ventilation Complication
NMES Role to Prevent Respiratory Muscle Weakness in Critically Ill Patients and Its Association to Changes in Myokines.
Particularly, muscle respiratory wasting will occur early (18 to 69 hours) in up to 60% of patients with mechanical ventilation (MV), leading rapidly to diaphragmatic weakness, which is associated with prolonged MV use, longer…
- Conditions
- Muscle Weakness or Atrophy, Mechanical Ventilation Complication, Electrical Stimulations
- Trial name
- NCT05536531
- Testing
- Neuromuscular electrical stimulation (NMES)
- Where
- Chile
- Volunteers
- 32 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Muscle Atrophy or Weakness
Metformin and Muscle Recovery
A hallmark of aging is an impaired ability to adequately recover following a stressor, such as muscle disuse, resulting in muscle fibrosis and weakness thereby increasing the risk for falls and loss of independence.
- Trial name
- NCT06185179
- Testing
- Metformin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Utah
Aging, Muscle Atrophy or Weakness
C-Protein in Fatigue and Aging
This study is investigating changes to the proteins in skeletal muscle that contribute to reduced muscle size and muscle function that occurs with aging.
- Conditions
- Aging, Muscle Atrophy or Weakness, Sarcopenia in Elderly, Sarcopenia
- Trial name
- NCT05926219
- Testing
- Fatiguing Exercise
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Cancer, Cancer Cachexia
Effects of WB-EMS and Specific Dietary Supplements on Cancer Patients
Patients suffering from cancer often experience a loss of muscle mass and strength during disease and its therapy. Muscle wasting is the main characteristic of the so-called cancer cachexia syndrome and responsible for many…
- Conditions
- Cancer, Cancer Cachexia, Weight Loss, Muscle Loss
- Trial name
- NCT03151291
- Testing
- β-hydroxy-β-methylbutyrate (HMB), L-carnitine (LC), Eicosapentaenoic acid (EPA)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Stroke, Ischemic, Stroke Hemorrhagic
Exploring Accessible Beauty for Individuals With Upper Extremity Deficits
The purpose of this study is to investigate the accessibility of beauty products for individuals with upper extremity disabilities.
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Stroke (CVA) or TIA, Stroke, Acute
- Trial name
- NCT05945784
- Testing
- Use of Rare Beauty makeup products
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Intensive Care Units (ICUs), Muscle Atrophy or Weakness
Neuromuscular Electrical Stimulation in Critically Ill Patients Aged 80 and Over
The aim of this clinical trial is to evaluate the effectiveness of Medium-Frequency Neuromuscular Electrical Stimulation, in combination with standard physical therapy, compared to standard physical therapy alone, on muscle mass…
- Conditions
- Intensive Care Units (ICUs), Muscle Atrophy or Weakness, Old and Very Old People
- Trial name
- NMES-ICU80 (NCT07127991)
- Testing
- Medium Frequency Neuromuscular Electrical Stimulation (NMES), Standard physical therapy
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Universidad de La Frontera
Cancer, Cancer Cachexia
Effects of WB-EMS and Dietetic Treatment on Cancer Patients
This study evaluates the effects of a 12-week whole-body electromyostimulation (WB-EMS) training combined with individualized nutritional support on body composition, muscle strength and function and quality of life of patients…
- Conditions
- Cancer, Cancer Cachexia, Weight Loss, Muscle Loss
- Trial name
- NCT02293239
- Testing
- Whole-Body Electromyostimulation (WB-EMS)
- Where
- Germany
- Volunteers
- 278 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Pre-Frailty, Sarcopenia
TCM Formula vs. HMB in Pre-Frail Elders: Muscle Strength and Bone Status
The purpose of this study is to compare the effects of a standardized Traditional Chinese Medicine (TCM) formula versus beta-hydroxy-beta-methylbutyrate (HMB) on muscle strength and bone health in pre-frail older adults .
- Conditions
- Pre-Frailty, Sarcopenia, Muscle Atrophy or Weakness, Osteoporosis
- Trial name
- TCM-HMB-PF (NCT07597850)
- Testing
- TCM Formula, HMB (beta-Hydroxy-beta-methylbutyrate)
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Muscle Atrophy or Weakness, Muscle Contraction
Core Exercises Effects on Muscle Imbalances
This study aims in investigating the effects of a core muscles' strengthening program on core muscles' atrophy and contraction ability.
- Conditions
- Muscle Atrophy or Weakness, Muscle Contraction, Core Stability
- Trial name
- NCT04450615
- Testing
- Core stability
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Athanasios Ellinoudis
ACL Reconstruction, ACL Surgery
Post Operative Use of Neuromuscular Electrical Stimulation (NMES) Device for ACLR Patients
This study is being conducted to learn about how neuromuscular electrical stimulation (NMES) in addition to standard of care aids in the recovery of muscle strength in patients undergoing ACLR procedure.
- Conditions
- ACL Reconstruction, ACL Surgery, ACL Injury, Electrotherapy
- Trial name
- NCT07171346
- Testing
- Zynex NexWave Electrotherapy Device
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Kansas Medical Center
Muscle Fatigue (C23.888.592.612.612), Muscle Weakness or Atrophy
A Biomechanical Study of Collaborative FES on Lower Limb Motor Function in the Elderly
This study will first conduct a precise assessment of the differences in muscle coordination among the elderly through muscle synergy analysis; then, based on this, it will extract abnormal synergy patterns and muscle activation…
- Trial name
- NCT07245602
- Testing
- Collaborative Functional Electrical Stimulation, Traditional functional electrical stimulation
- Volunteers
- 30 people
- Sponsor
- Chen Xuan
Mechanical Ventilation, Expiratory Muscle
Expiratory Muscle Function in Critically Ill Ventilated Patients
Inspiratory muscle weakness develops rapidly in ventilated critically ill patients and is associated with adverse outcome, including prolonged duration of mechanical ventilation and mortality.
- Conditions
- Mechanical Ventilation, Expiratory Muscle, Critical Illness, Muscle Atrophy or Weakness
- Trial name
- EMFIC (NCT04333186)
- Testing
- Data from ultrasound measurements
- Where
- Netherlands
- Volunteers
- 113 people
- Sponsor
- Amsterdam UMC, location VUmc
Hospital Mobility, Mobility Limitation
An INtervention TO Improve MOBility of Older Hospitalized Patients
Low mobility during an acute care hospitalization is very frequent, particularly among older patients, and associated with adverse outcomes, such as persistent functional decline, institutionalization and death.
- Conditions
- Hospital Mobility, Mobility Limitation, Life-Space, Functional Status
- Trial name
- INTOMOB (NCT05639231)
- Testing
- INTOMOB intervention
- Where
- 4 sites in Switzerland
- Volunteers
- 383 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Weakness, Muscle, Delirium in Old Age
YOOMI: Effect of Gamified Physical Therapy Exercise Software on Inpatient Mobility
Patients admitted to the hospital often develop functional impairments due to being in bed most of the day. Each day of bedrest leads to significant muscle loss.
- Conditions
- Weakness, Muscle, Delirium in Old Age, Muscle Atrophy or Weakness, Muscle Loss
- Trial name
- YOOMI (NCT05815017)
- Testing
- Yoomi Physical Therapy Software
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Thumb Osteoarthritis, Muscle Atrophy or Weakness
Investigation of Thenar Muscles Morphometric Parameters in Patients With TMC OA
In this study, investigators aimed to investigate the morphometric parameters tenar muscles and joint configuration in patients with trapeziometacarpal osteoarthritis (TMC OA) osteoarthritis stages, thenar muscle parameters…
- Trial name
- NCT04913935
- Testing
- Muscle-Skeleton Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Critical Illness, Muscle Atrophy or Weakness
Redefining Survivorship: POWER to Maximize Physical Function for Survivors of Critical Illness
Patients surviving critical illness experience significant skeletal muscle dysfunction and weakness. Muscle atrophy suffered during critical illness has a long-term impact on the functionality and mobility of these individuals.
- Trial name
- POWER (NCT04058977)
- Testing
- Power training
- Where
- United States
- Sponsor
- Kirby Mayer
Rotator Cuff Tears, Muscle Atrophy or Weakness
E-CEL UVEC Cells as an Adjunct Cell Therapy for the Arthroscopic Rotator Cuff Repair in Adults
This is a phase 1b investigator-initiated clinical trial that will evaluate the safety and feasibility of E-CEL UVEC® cells with the aim of improving outcomes for patients with full-thickness rotator cuff tears who undergo…
- Conditions
- Rotator Cuff Tears, Muscle Atrophy or Weakness, Tendon Rupture - Shoulder, Safety Issues
- Trial name
- NCT04057833
- Testing
- E-CEL UVEC
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hospital for Special Surgery, New York
Muscle Atrophy or Weakness, Ventilator-associated Lung Injury
Serial Daily Diaphragm Ultrasounds in Ventilated Patients
When a person is put on a breathing machine the investigators think that the breathing muscles can get weaker. The investigators are not sure how quickly this happens but in some people this leads to problems when they try to…
- Trial name
- NCT02174029
- Testing
- Ventilation- mandatory, Ventilation- voluntary mode only, Voluntary with preceding mandatory
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- Steve Reynolds
Sarcopenia, Aging
STRIDE: Strength of The Calf Muscles and Their Role In Declining Effectiveness of Movement With Aging
The calf muscles (plantarflexors) are the most important muscles for walking, running and daily activities. Weakness of these muscles through aging and disease significantly impact a person's ability to walk and complete daily…
- Conditions
- Sarcopenia, Aging, Muscle Weakness or Atrophy, Frailty
- Trial name
- STRIDE (NCT07726498)
- Testing
- No intervention (observational study)
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Leicester