Clinical trials: Multimorbidity
Chronic Kidney Disease, Overactive Bladder
Urinary Function and Multimorbidity Risks: A Longitudinal Study in Beijing Community-Dwelling Elderly
This study focuses on Beijing community residents aged 60 and above, aiming to understand how urinary function (like bladder or kidney function) and multiple health problems (such as high blood pressure, diabetes) affect each…
- Conditions
- Chronic Kidney Disease, Overactive Bladder, Benign Prostatic Hyperplasia, Female Pelvic Floor Dysfunction
- Trial name
- UFMR-BE (NCT07357714)
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Diabetes
The Effect of Clinic Visit Audio Recordings for Self-management in Older Adults
The objective of this study is to conduct a multisite trial evaluating the impact of adding an audio recording of clinic visits (AUDIO) to usual care in older adults with multimorbidity, including diabetes, compared to After…
- Trial name
- REPLAY (NCT05824572)
- Testing
- Clinic visit audio recordings for self-management in older adults, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 336 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Multimorbidity, Physical Deconditioning
Multicomponent Telerehabilitation to Engage Veterans in Effective Self-Management of Complex Health Conditions
Medically complex older Veterans are at greater risk for progressive declines in physical function, lower quality of life, and increasing care needs.
- Trial name
- NCT06288438
- Testing
- Motivational Interviewing Techniques, Physical Therapy Interventions, Education
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- VA Office of Research and Development
Heart Diseases, Type 2 Diabetes
Effectiveness of Tele-exercise Training on Cardiorespiratory Fitness in Patients With Cardiometabolic Multimorbidity
This trial aimed to assess whether assumed increase in physical activity after tele-exercise training can improve cardiorespiratory fitness of patients with cardiometabolic multimorbidity.
- Conditions
- Heart Diseases, Type 2 Diabetes, Metabolic Syndrome, Coronary Artery Disease
- Trial name
- NCT05245110
- Testing
- tele-exercise training
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Diabetes Mellitus, Comorbidities and Coexisting Conditions
MDT Conferences for People With Diabetes and Multimorbidity
The goal of this observational study is to test if regular meetings (multidisciplinary team conferences) between several different medical doctors can work well in everyday hospital life.
- Trial name
- NOMAD (NCT05913726)
- Where
- Denmark
- Volunteers
- 55 people
- Sponsor
- Odense University Hospital
Chronic Disease
Trajectories of Chronic Multimorbidity Patterns in Older Patients
Following the MRisk-COVID project, MTOP (Multimorbidity Trajectories in Older Patients) study was developed. It is a retrospective observational study using Real World Data that aims to identify patterns of chronic multimorbidity…
- Trial name
- MTOP (NCT05717309)
- Where
- Spain
- Volunteers
- 3,988 people
- Sponsor
- Corporacion Parc Tauli
Chronic Heart Failure With Reduced and Mildly Reduced Ejection Fraction (HFrEF and HFmrEF)
Polypharmacy, Safety, and Medication Adherence in Patients With Chronic Heart Failure With Reduced and Mildly Reduced Ejection Fraction
This prospective registry study (FARAON) aims to assess the prevalence, structure, safety profile, and dynamics of polypharmacy, as well as its association with medication adherence, quality of life, and clinical outcomes in…
- Trial name
- FARAON (NCT07640854)
- Where
- Russia
- Volunteers
- 130 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Multimorbidity
Living With Multimorbidity: Care Coordination and Symptom Management Program (COORDINATE)
The goal of this clinical trial is to learn if a new care program, called the COORDINATE Program, can help older adults with two or more chronic health conditions.
- Trial name
- NCT07157982
- Testing
- COORDINATE Program, Enhanced Usual Care
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Statin Treatment for Primary Prevention
STREAM Trial - Biomarker
Statins are among the most widely used drugs. While they were found to be effective for primary and secondary prevention of cardiovascular disease (CVD) in middle-aged subjects, their benefits for primary prevention in older…
- Trial name
- STREAM-Bio (NCT05482386)
- Testing
- Statin discontinuation
- Where
- Switzerland
- Volunteers
- 500 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Chronic Cardiovascular Disease, Acute Cardiovascular Disease
Chronic and Acute Cardiovascular Diseases in Elderly Intensive Care Patients
Very old patients are a rapidly growing and vulnerable population in acute cardiovascular care but remain underrepresented in clinical trials.
- Conditions
- Chronic Cardiovascular Disease, Acute Cardiovascular Disease, Frailty
- Trial name
- NCT07385482
- Where
- Germany
- Volunteers
- 4,000 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Kidney Disease, Kidney Failure
Older Kidney Patient Optimisation Pretransplant
The goal of this clinical trial is to learn if a kidney transplant-specific comprehensive geriatric assessment (KT-CGA) can improve the way older adults are assessed for kidney transplantation.
- Conditions
- Kidney Disease, Kidney Failure, Frailty, Cognitive Impairment
- Trial name
- OK-POP (NCT07419945)
- Testing
- Kidney transplant-specific comprehensive geriatric assessment
- Volunteers
- 50 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Multimorbidity
Identification of Multimorbid Patients With a Higher Probability of Readmission and Mortality
A prospective qualitative quantitative study was designed to create predictive models of readmission in multimorbid patients.
- Trial name
- NCT05574790
- Testing
- annual follow up
- Where
- 4 sites in Spain
- Volunteers
- 500 people
- Sponsor
- Hospital Galdakao-Usansolo
Sleep Disordered Breathing (SDB), Sleep Apnea
Sleep Disordered Breathing and Multimorbidity: The Xiangya SDB Cohort Study
Sleep disordered breathing (SDB) is one of the most common sleep disorders, including obstructive sleep apnea (OSA), central sleep apnea (CSA), sleep-related hypoventilation, hypoxemia, etc., with OSA being the most prevalent.
- Conditions
- Sleep Disordered Breathing (SDB), Sleep Apnea, Cardiometabolic Diseases, Multimorbidity
- Trial name
- NCT06755840
- Where
- China
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Multimorbidity, Comorbidity
Use of a Hypercaloric and Hyperprotein Supplement Enriched with Immunonutrients in Multi-pathological Malnourished Patients to Improve the Incidence and Prevalence of Pressure Sores
The goal of this study is to evaluate the efficacy of a hypercaloric, hyperproteic enteral formula enriched with immunonutrients in preventing and treating pressure injuries in hospitalized malnourished patients.
- Conditions
- Multimorbidity, Comorbidity, Malnutrition, Pressure Ulcer Prevention
- Trial name
- NCT06726486
- Testing
- Atémpero, Control (Standard treatment)
- Where
- Spain
- Volunteers
- 69 people
- Sponsor
- University of Cadiz
Chronic Disease
Pilot Evaluation of "KeepWell" Using a Hybrid Effectiveness-Implementation Pragmatic Randomized Controlled Trial
The burden of chronic disease is a global phenomenon, particularly amongst seniors. Aging is an expensive process. In Canada, 10% of seniors who have the most complex health needs account for 60% of the total annual health care…
- Trial name
- NCT04437238
- Testing
- KeepWell tool, Control - Usual care
- Where
- Canada
- Volunteers
- 456 people
- Sponsor
- North York General Hospital
Kidney Transplant, Cardiovascular (CV) Risk
Multimorbidity and Cardiovascular Risk Factors After Renal Transplant
Who can participate? Any adults over the age of 18 who have received a kidney transplant at the research centre are eligible for recruitment within the first month after transplant What does the study involve? The study involves…
- Conditions
- Kidney Transplant, Cardiovascular (CV) Risk, Multimorbidity
- Trial name
- MCaRT (NCT07205692)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Multi-morbidity, Medication Therapy Management
Team Approach to Polypharmacy Evaluation and Reduction
In an aging population, most seniors suffer from multiple chronic conditions. When the number of medications taken is ≥5 (polypharmacy), the burden of taking multiple concurrent medications can do more harm than good.
- Conditions
- Multi-morbidity, Medication Therapy Management, Polypharmacy
- Trial name
- TAPER-RCT (NCT02942927)
- Testing
- Medication reduction
- Where
- Canada
- Volunteers
- 345 people
- Sponsor
- McMaster University
Elderly, Cancer
Suitability of an Organization With an Onco-geriatric Team to a Whole Region (Region Midt) of Denmark
A Feasibility study Geriatric assessment applied to patients with cancer of the head and neck, lung cancer, upper gastrointestinal cancer or colo-rectal cancer.
- Trial name
- NCT02072733
- Testing
- Comprehensive geriatric assessment
- Where
- Denmark
- Volunteers
- 320 people
- Sponsor
- University of Aarhus
Chronic Obstructive Pulmonary Disease (COPD), Asthma
Mitigating Chronic Respiratory Disease Through the Lens of Multimorbidity
The investigators aim to evaluate whether it is feasible for healthcare professionals to implement a case-finding tool to identify individuals at high risk for chronic respiratory diseases (CRDs) during routine care for…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Asthma, Preserved Ratio Impaired Spirometry
- Trial name
- MARES2 (NCT07093021)
- Where
- 2 sites in Brazil
- Volunteers
- 1,000 people
- Sponsor
- University College, London
Polypharmacy, Multimorbidity
Reduction of Polypharmacy in Elderly People With Multiple Diseases
Elderly GP patients are often treated with five or more medications and therefore prone to adverse drug reactions (ADR). Potentially inappropriate prescriptions (PIPs) lead to increased adverse events like falls, hospitalizations…
- Trial name
- RED (NCT05526963)
- Testing
- Medication plan review, Adherence support
- Where
- Germany
- Volunteers
- 1,146 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg