Clinical trials: Multimodal Intervention
Menopause, Cancer
The Menopause After Cancer Study
This study will recruit women with vasomotor symptoms of menopause and a prior cancer diagnosis, for whom conventional menopausal hormone therapy (MHT) is contraindicated for any reason.
- Conditions
- Menopause, Cancer, Insomnia
- Trial name
- MACS (NCT04766229)
- Testing
- Citalopram +/- Gabapentin + Sleepio + support person
- Where
- 2 sites in Ireland
- Volunteers
- 205 people
- Sponsor
- University College Dublin
Breast Cancer Prevention
MELIORA Virtual Coach Intervention for Breast Cancer Prevention
Breast cancer (BC) is the most commonly diagnosed cancer in women worldwide, with early-onset cases increasing due to genetic and lifestyle factors.
- Trial name
- MELIORA (NCT07200427)
- Testing
- MELIORA Virtual Coach Intervention, Control (generic advice)
- Where
- 7 sites in Greece, Lithuania and 2 more
- Volunteers
- 2,080 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Solitary Lung Nodule, Multiple Pulmonary Nodules
A Prospective, Non-interventional Cohort Study of Subsolid Pulmonary Nodules
Some studies have shown that the model for judging and predicting the growth of sub-solid pulmonary nodules through big data and deep learning can detect nodule growth earlier.
- Trial name
- NCT06458673
- Where
- China
- Volunteers
- 1,184 people
- Sponsor
- Guangdong Provincial People's Hospital
Alzheimer Disease, Cognitive Decline
Prevention of Cognitive Decline in ApoE4 Carriers With Subjective Cognitive Decline After EGCG and a Multimodal Intervention
Alzheimer's disease (AD) neuropathology is characterized by deposits of insoluble amyloid β-peptide (Aβ) in extracellular plaques and aggregated tau protein, which is found largely in the intracellular neurofibrillary tangles.
- Trial name
- (PENSA) (NCT03978052)
- Testing
- EGCG, Healthy lifestyle recommendations, Multimodal lifestyle intervention
- Where
- 2 sites in Spain
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Major Abdominal Surgeries, Mechanical Ventilation
Intraoperative Multimodal Monitoring as a Means in Reducing the Duration of Mechanical Ventilation in High-Risk Patients Undergoing Major Abdominal Procedures - A Pilot Study
This study will include patients aged 50 and older scheduled for elective abdominal oncologic surgery, classified as ASA II and III due to increased anaesthetic and surgical risk. Gender will not be a stratification factor.
- Trial name
- IMMEDIUM (NCT07339449)
- Testing
- Multimodal monitoring
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- University Hospital Dubrava
Anesthesia, Anesthesia and Procedure Related Time Intervals
Multimodal Anesthesia in Robotic Laparoscopic Nephrectomy
It is a prospective, randomized, controlled and superiority clinical trial, with the objective of comparing the effectiveness of multimodal anesthesia versus conventional anesthesia in patients undergoing oncological robotic…
- Conditions
- Anesthesia, Anesthesia and Procedure Related Time Intervals, Nephrectomy / Methods
- Trial name
- MANTRA (NCT07558226)
- Testing
- Multimodal anesthesia, Conventional anesthesia
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Fundacio Puigvert
C.Surgical Procedure; Cardiac, Right-Sided Heart Failure
Evaluation of Monitoring TECHNOlogies in the PERI-OPerative Care of Cardiac Surgical Patients
The purpose of this prospective observational cohort study is to evaluate multimodal monitoring technologies in the perioperative care of cardiac surgical patients.
- Conditions
- C.Surgical Procedure; Cardiac, Right-Sided Heart Failure, Acute Kidney Injury, Respiratory Insufficiency
- Trial name
- TechnoPeriOp (NCT02658006)
- Testing
- Cardiac surgery
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Montreal Heart Institute
Inflammatory Bowel Diseases
A Multimodal Wearable Device-based Study to Evaluate the Efficacy of an Exercise Prescription Intervention in IBD
This project is a multimodal wearable device-based evaluation of the efficacy of an exercise prescription intervention for inflammatory bowel disease in a This is a single-center, randomized controlled clinical study to evaluate…
- Trial name
- NCT06427135
- Testing
- Exercise interventions
- Volunteers
- 56 people
- Sponsor
- Ping An
Diabetic Macular Edema
A Study to Investigate Aqueous Humor and Multimodal Imaging Biomarkers in Treatment-Naïve Participants With Diabetic Macular Edema Treated With Faricimab
This is an exploratory, prospective, multicenter, open-label, single-arm, interventional, Phase IIb study designed to explore the associations over time between clinical assessments, multimodal imaging assessments, aqueous humor…
- Trial name
- ALTIMETER (NCT04597918)
- Testing
- Faricimab
- Where
- 23 sites in United States, Argentina and 5 more
- Volunteers
- 99 people
- Sponsor
- Hoffmann-La Roche
Postoperative Delirium, Cardiac Surgical Procedures
Dynamic Multimodal Delirium Warning After Cardiac Surgery
After heart surgery, up to half of all patients may develop a state of sudden confusion called postoperative delirium. This condition can lead to longer time on a breathing machine, extended stays in the intensive care unit…
- Trial name
- DEW-POD (NCT07686900)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Southeast University, China
Laparoscopic Cholecystectomy
Multimodal Analgesia for Cholecystectomy
It is important to decrease the postoperative pain in patients undergoing laparoscopic cholecystectomy. We will compare the pharmacologic analgesia with the parmacologic and surgical analgesia in patients undergoing laparoscopic…
- Trial name
- NCT04788654
- Testing
- Celebrex, acetaminophen, and dexamethasone, Saline irrigation, aspiration of pneumoperitoneum, and low pressure penumoperitoneum
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Gangnam Severance Hospital
Clinical Decision Support System
ICU Cockpit Apps: Interventional Study With First ICU Cockpit Software Applications
In neurocritical care, besides the standard intensive care monitoring, even more data are obtained from the very complex pathophysiological changes in brain disease.
- Trial name
- ICUCockpiApp (NCT04748289)
- Testing
- ICU Cockpit software testing
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- Emanuela Keller
Vulvodynia, Provoked Vestibulodynia
Biomodulation and Rehabilitation Interventions to tarGet Pelvic Health
This trial will provide evidence for the effective management of pain and pain-related domains among those who experience provoked vestibulodynia (PVD) using photobiomodulation (PBM) and multimodal physiotherapy (mPT) in a…
- Conditions
- Vulvodynia, Provoked Vestibulodynia, Dyspareunia
- Trial name
- BRIGHT (NCT06660212)
- Testing
- Photobiomodulation, Multimodal physiotherapy
- Where
- 2 sites in Canada
- Volunteers
- 240 people
- Sponsor
- University of Ottawa
Chronic Refractory Plantar Fasciopathy
Multimodal Conservative Intervention Versus Surgery for Chronic Refractory Plantar Fasciopathy
Chronic refractory plantar fasciopathy is a common musculoskeletal condition that can cause persistent heel pain and functional limitations despite conservative treatment.
- Trial name
- NCT07654660
- Testing
- Multimodal Conservative Intervention, Endoscopic Plantar Fascial Release
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Universidad Europea de Valencia
Cancer Surgery, Prehabilitation
Preoperative Physical Exercise, Nutritional Support, and Psychological Intervention (Multimodal Prehabilitation) to Strengthen Patients' Overall Health and Reduce Postoperative Complications
In this prospective, randomized, controlled trial patients undergoing major gastrointestinal cancer surgery will be exercised (intervention group) 4 weeks before surgery with a high-intensity interval training (HIIT).
- Trial name
- PREHAB (NCT07389746)
- Testing
- Multimodal Prehabilitation
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- University Hospital of Cologne
Urinary Incontinence,Stress, Urinary Incontinence, Urge
RCT on Multimodal Self-treatment for Women With Incontinence Using a Digital Health Application
This study, titled "Prospective Randomized Study on Multimodal Self-Treatment for Women with Incontinence Symptoms Using a Digital Health Application," abbreviated as DINKS, aims to investigate the efficacy of a digital health…
- Conditions
- Urinary Incontinence,Stress, Urinary Incontinence, Urge, Urinary Incontinence, Overactive Bladder Syndrome
- Trial name
- DINKS (NCT06389838)
- Testing
- Kranus Mictera
- Where
- Germany
- Volunteers
- 194 people
- Sponsor
- Kranus Health GmbH
Health Care Workers
Hand Hygiene Intervention Study
Infections acquired by patients in hospitals are a major cause of illness and death worldwide, and particularly so in hospitals with very limited resources.
- Trial name
- HAND (NCT01933087)
- Testing
- Hand hygiene promotion
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Sexual Dysfunction
A Multimodal Intervention to Address Sexual Dysfunction in Hematopoietic Stem Cell Transplant Survivors
This research study is evaluating the feasibility and impact of an intervention to improve sexual function in stem cell transplant survivors on participants' sexual function, quality of life, and mood.
- Trial name
- NCT02492100
- Testing
- Multi-modality sexual dysfunction intervention
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Massachusetts General Hospital
Diet, Healthy, Adolescent Overweight
Impact an Educational Multimodal Intervention to Improve Healthy Habits in Adolescents.
Background: Adolescence is a critical period to promote healthy habits. Objective: To know the impact that a multimodal educational intervention has on the knowledge and modification of healthy habits (HS) (Mediterranean diet…
- Conditions
- Diet, Healthy, Adolescent Overweight, Child Nutrition Sciences, Exercise
- Trial name
- NCT07065097
- Testing
- A multimodal intervention in which they worked on self-esteem, self-concept and body image and nutrition.
- Where
- 2 sites in Spain
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- University of Extremadura
Dementia
A Culturally Appropriate Multimodal Non-pharmacological Intervention for Chinese People With Mild-to-Moderate Dementia
This is a mixed-methods research that includes a single-blind three-arms randomized control trials and a focus group study. The quantitative study aims to investigate the additional clinical benefits of the Six Arts intervention…
- Trial name
- NCT03937297
- Testing
- Six Arts, Cognitive Stimulation Therapy (CST), Usual Care
- Where
- Hong Kong
- Volunteers
- 216 people
- Sponsor
- The University of Hong Kong